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https://www.readbyqxmd.com/read/30342316/isolation-and-identification-of-peptides-from-simulated-gastrointestinal-digestion-of-preserved-egg-white-and-their-anti-inflammatory-activity-in-tnf-%C3%AE-induced-caco-2-cells
#1
Mengya Zhang, Yan Zhao, Yao Yao, Mingsheng Xu, Huaying Du, Na Wu, Yonggang Tu
Simulated gastrointestinal digestion of preserved egg white (SGD-PEW) exerts anti-inflammatory effects on Caco-2 cells and a mouse model of DSS-induced colitis. Here, we aimed to separate peptides derived from SGD-PEW and evaluate their anti-inflammatory effects using an in vitro inflammatory model. Six peptides were isolated and identified. DEDTQAMPFR (DR-10), DEDTQAMPF (DF-9), MLGATSL (ML-7) and MSYSAGF (MF-7) significantly inhibited IL-8 secretion and markedly decreased gene expression, including TNF-α, IL-8, IL-6, IL-1β and IL-12 and promoted IL-10 gene expression in Caco-2 cells...
September 27, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/30342120/structure-bioactivities-and-applications-of-the-polysaccharides-from-tremella-fuciformis-mushroom-a-review
#2
REVIEW
Yu-Ji Wu, Zheng-Xun Wei, Fu-Ming Zhang, Robert J Linhardt, Pei-Long Sun, An-Qiang Zhang
Tremella fuciformis is an important edible mushroom that has been widely cultivated and used as food and medicinal ingredient in traditional Chinese medicine. In the past decades, many researchers have reported that T. fuciformis polysaccharides (TPS) possess various bioactivities, including anti-tumor, immunomodulatory, anti-oxidation, anti-aging, repairing brain memory impairment, anti-inflammatory, hypoglycemic and hypocholesterolemic. The structural characteristic of TPS has also been extensively investigated using advanced modern analytical technologies such as NMR, GC-MS, LC-MS and FT-IR to dissect the structure-activity relationship (SAR) of the TPS biomacromolecule...
October 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30342053/microbiome-and-diabetes-where-are-we-now
#3
REVIEW
Natalia G Vallianou, Theodora Stratigou, Stylianos Tsagarakis
Alterations in the diversity or structure of gut microbiota known as dysbiosis, may affect metabolic activities, resulting in metabolic disorders, such as obesity and diabetes. The development of more sophisticated methods, such as metagenomics sequencing, PCR-denaturing gradient gel electrophoresis, microarrays and fluorescence in situ hybridization, has expanded our knowledge on gut microbiome. Dysbiosis has been related to increased plasma concentrations of gut microbiota-derived lipopolysaccharide (LPS), which triggers the production of a variety of cytokines and the recruitment of inflammatory cells...
October 17, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30340811/melinjo-gnetum-gnemon-l-seed-extract-induces-uncoupling-protein-1-expression-in-brown-fat-and-protects-mice-against-diet-induced-obesity-inflammation-and-insulin-resistance
#4
Takeshi Yoneshiro, Ryuji Kaede, Kazuki Nagaya, Manami Saito, Julia Aoyama, Mohamed Elfeky, Yuko Okamatsu-Ogura, Kazuhiro Kimura, Akira Terao
Dietary supplementation with melinjo (Gnetum gnemon L.) seed extract (MSE) has been proposed as an anti-obesity strategy. However, it remains unclear how MSE modulates energy balance. We tested the hypothesis that dietary MSE reduces energy intake and/or increases physical activity and metabolic thermogenesis in brown and white adipose tissue (BAT and WAT) in mice. Twenty-four C57BL/6 J mice were provided with normal diet, high-fat diet (HFD), or HFD with 1% MSE added, for 17 weeks. Food intake, spontaneous locomotor activity, hepatic triglyceride (TG) content, and blood parameters were examined...
October 2018: Nutrition Research
https://www.readbyqxmd.com/read/30340395/dietary-effects-on-microbiota-new-trends-with-gluten-free-or-paleo-diet
#5
REVIEW
Yurdagül Zopf, Dejan Reljic, Walburga Dieterich
A well-balanced diet is the basis for a healthy life. Both the western diet and special diets can have a relevant impact on the microbiome and promote the development of various diseases. There has been an increase in food-related disorders in recent years, largely associated with dramatic changes in food consumption trends and main nutrients. A major response to food intolerances has been the adoption of new dietary trends involving the reduction or exclusion of specific food ingredients. Especially gluten-containing, but also gluten-free cereals are in the cross-fire...
October 18, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/30339818/does-a-carrot-a-day-keep-the-allergy-away
#6
REVIEW
Karin Hufnagl, Erika Jensen-Jarolim
Vitamin A is an important micronutrient, from plants diet taken up as carotenoids, from animal food sources as retinol. Its active metabolite retinoic acid (RA) binds to nuclear hormone receptors, thereby regulating gene transcription programs in various cells. Adequate nutritional intake of vitamin A is essential for pre- and postnatal development, eyesight and reproduction, and it contributes to the maintenance and regulation of the immune system. Recent molecular studies indicate that lipocalins play an important role in the bioavailability of RA and its immune modulation against Th2 responses...
October 16, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30338529/ginkgo-biloba-sarcotesta-polysaccharide-inhibits-inflammatory-responses-through-suppressing-both-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathway
#7
Jing Ye, Changqing Ye, Yayan Huang, Na Zhang, Xueqin Zhang, Xiao Meitian
BACKGROUND: Polysaccharides, common components of natural products extensively studied as dietary supplements and functional foods, have been found to have various activities. In the present study, a water-soluble polysaccharide, namely GBSP3a, was isolated and purified from G. biloba sarcotesta. Then the anti-inflammatory activity of GBSP3a in LPS-induced RAW264.7 macrophages and the potential underlying molecular mechanisms were assessed. RESULTS: GBSP3a exerted its anti-inflammatory effect by remarkably inhibiting the secretion of pro-inflammatory mediators and cytokines including nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and interleukin- 1 beta (IL-1β) in LPS-stimulated RAW264...
October 18, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/30337931/aflatoxin-b-1-promotes-influenza-replication-and-increases-virus-related-lung-damage-via-activation-of-tlr4-signaling
#8
Yuhang Sun, Jiarui Su, Zixuan Liu, Dandan Liu, Fang Gan, Xingxiang Chen, Kehe Huang
Aflatoxin B1 (AFB1 ), which alters immune responses to mammals, is one of the most common mycotoxins in feeds and food. Swine influenza virus (SIV) is a major pathogen of both animals and humans. However, there have been few studies about the relationship between AFB1 exposure and SIV replication. Here, for the first time, we investigated the involvement of AFB1 in SIV replication in vitro and in vivo and explored the underlying mechanism using multiple cell lines and mouse models. In vitro studies demonstrated that low concentrations of AFB1 (0...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30337914/six-week-endurance-exercise-alters-gut-metagenome-that-is-not-reflected-in-systemic-metabolism-in-over-weight-women
#9
Eveliina Munukka, Juha P Ahtiainen, Pere Puigbó, Sirpa Jalkanen, Katja Pahkala, Anniina Keskitalo, Urho M Kujala, Sami Pietilä, Maija Hollmén, Laura Elo, Pentti Huovinen, Giuseppe D'Auria, Satu Pekkala
Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks endurance exercise, without changing diet, affected the gut metagenome and systemic metabolites of overweight women. Previously sedentary overweight women ( n = 19) underwent a six-weeks endurance exercise intervention, but two were excluded due to antibiotic therapy. The gut microbiota composition and functions were analyzed by 16S rRNA gene amplicon sequencing and metagenomics. Body composition was analyzed with DXA X-ray densitometer and serum metabolomics with NMR metabolomics...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30336572/relationship-between-mediterranean-dietary-polyphenol-intake-and-obesity
#10
REVIEW
Sara Castro-Barquero, Rosa M Lamuela-Raventós, Mónica Doménech, Ramon Estruch
Obesity is a multifactorial and complex disease defined by excess of adipose mass and constitutes a serious health problem. Adipose tissue acts as an endocrine organ secreting a wide range of inflammatory adipocytokines, which leads to systemic inflammation, insulin resistance, and metabolic disorders. The traditional Mediterranean diet is characterized by a high phenolic-rich foods intake, including extra-virgin olive oil, nuts, red wine, vegetables, fruits, legumes, and whole-grain cereals. Evidence for polyphenols' effect on obesity and weight control in humans is inconsistent and the health effects of polyphenols depend on the amount consumed and their bioavailability...
October 17, 2018: Nutrients
https://www.readbyqxmd.com/read/30336375/combination-of-phenolic-profiles-pharmacological-properties-and-in-silico-studies-to-provide-new-insights-on-silene-salsuginea-from-turkey
#11
Gokhan Zengin, Maria João Rodrigues, Hassan H Abdallah, Luisa Custodio, Azzurra Stefanucci, Muhammad Zakariyyah Aumeeruddy, Adriano Mollica, Kannan R R Rengasamy, Mohamad Fawzi Mahomoodally
The genus Silene is renowned in Turkey for its traditional use as food and medicine. Currently, there are 138 species of Silene in Turkey, amongst which have been several studies for possible pharmacological potential and application in food industry. However, there is currently a paucity of data on Silene salsuginea Hub.-Mor. This study endeavours to access its antioxidant, enzyme inhibitory, and anti-inflammatory properties. Besides, reversed-phase high-performance liquid chromatography-diode array detector (RP-HPLC-DAD) was used to detect phenolic compounds, and molecular docking was performed to provide new insights for tested enzymes and phenolics...
October 9, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30336163/dietary-fibers-and-their-fermented-short-chain-fatty-acids-in-prevention-of-human-diseases
#12
REVIEW
Kedar N Prasad, Stephen C Bondy
Many studies show that daily consumption of high-fiber diet is associated with a reduced risk of developing kidney stones, inflammatory disease, colon cancer and other malignancies, obesity, type II diabetes, and cardiovascular disease. Dietary fibers are non-digestible polysaccharides that are composed of complex carbohydrates. Based on their relative solubility in water, dietary fibers can be divided into insoluble and soluble forms. An important property of insoluble fibers is their ability to bind with carcinogens, mutagens, and other toxic chemicals that are formed during digestion of food and eliminate them through the feces...
October 15, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/30335609/metabolomic-fingerprint-of-mentha-rotundifolia-l-leaf-tissues-promotes-this-species-as-a-potential-candidate-for-sustainable-production-of-biologically-active-molecules
#13
Leila Riahi, Hanen Chakroun, Imen Klay, Ahmed Slaheddine Masmoudi, Ameur Cherif, Nejia Zoghlami
Background The Mentha rotundifolia L. (Lamiaceae family), is a medicinal herb used since the ancient times as an antiseptic, analgesic and anti-inflammatory agent. In the present work, metabolomic profiling of two Mentha rotundifolia L. ecotypes leaf tissues spontaneously growing in the North of Tunisia was achieved. Methods Phenolic contents (TPC, TFC and TTC) were assessed using colorimetric methods. Metabolomic profiling of leaf tissues extracts was assessed based on Gas Chromatography-Mass Spectrometry (GC/MS) analysis...
October 17, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/30335476/obesity-and-sleep-disturbance-the-chicken-or-the-egg
#14
Giovanna Muscogiuri, Luigi Barrea, Giuseppe Annunziata, Carolina Di Somma, Daniela Laudisio, Annamaria Colao, Silvia Savastano
Epidemiological studies suggested an association between obesity and sleep disturbances. Obstructive sleep apnea is the most prevalent type of obesity-related sleep disorder that lead to an increased risk for numerous chronic health conditions. In addition the increased visceral adipose tissue might be responsible for the secretion of inflammatory cytokines that could contribute to alter the sleep-wake rhythm. Unhealthy food characterized by high consumption of fat and carbohydrate seems to negatively influence the quality of sleep while diet rich of fiber is associated to more restorative and deeper sleep...
October 18, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/30333662/structural-characterization-and-raw264-7-murine-macrophage-stimulating-activity-of-a-fucogalactoglucan-from-colpomenia-peregrina
#15
Zeynab Rostami, Mehdi Tabarsa, SangGuan You, Masoud Rezaei
Water-soluble polysaccharides were isolated from Colpomenia peregrina to determine their chemical characteristics and immunomodulatory properties. High extraction yields were obtained for CP1 (17.6%) and CP2 (5.2%) polysaccharides. Polysaccharides were mainly consisted of neutral sugars (67.01-73.79%), uronic acids (9.43-14.89%), proteins (3.44-14.89%) and small amounts of sulfates (4.87-4.91%). Polysaccharides were composed of fucose (20.62-24.56%), galactose (25.5-26.94%) and glucose (50.00-52.91%) residues...
November 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/30333073/association-between-dietary-intake-and-inflammatory-markers-results-from-the-colaus-study
#16
Eva Piccand, Peter Vollenweider, Idris Guessous, Pedro Marques-Vidal
OBJECTIVE: To assess the associations between single foods, nutrients, dietary patterns and dietary scores, and inflammatory markers (C-reactive protein (CRP), IL-6, TNF-α and leucocyte count). DESIGN: Cross-sectional, population-based study. SETTING: City of Lausanne, Switzerland, years 2009-2012. SUBJECTS: Adults (n 4027; 46·5 % men), mean age 57·2 (sd 10·2) years. Dietary intake was collected using a semi-quantitative FFQ...
October 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/30328397/rosmarinic-acid-as-potential-anti-inflammatory-agent
#17
EDITORIAL
Carmela Colica, Laura Di Renzo, Vincenzo Aiello, Antonino De Lorenzo, Ludovico Abenavoli
Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring, and in folk medicine, as an antispasmodic, analgesic, anti-rheumatic, diuretic, and antiepileptic agent. Rosemary is an herb widely used in folk medicine, cosmetics, and phytotherapy and for flavoring of food products. Studies have focused on various biological activities of the secondary metabolites of this plant, such as rosmarinic acid, which have powerful antioxidant, hepato-protective, antimicrobial, anti-nociceptive, and anti-inflammatory properties...
2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/30327755/kynurenic-acid-protects-against-thioacetamide-induced-liver-injury-in-rats
#18
Sebastian Marciniak, Artur Wnorowski, Katarzyna Smolińska, Beata Walczyna, Waldemar Turski, Tomasz Kocki, Piotr Paluszkiewicz, Jolanta Parada-Turska
Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted...
2018: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/30325855/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-knowledge-gaps-and-research-opportunities-overview-summary-of-a-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#19
Aliye Uc, Dana K Andersen, Drucy Borowitz, Marshall J Glesby, Julia Mayerle, Robert Sutton, Stephen J Pandol
A workshop was sponsored by the Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, on July 25, 2018, in Pittsburgh, Penn. The workshop was designed to bring together a multidisciplinary group of experts to accelerate the development of therapeutics for clinical application in inflammatory diseases of the exocrine pancreas. Three separate working groups (acute pancreatitis, recurrent acute pancreatitis, and chronic pancreatitis) were formed to address the needs, gaps, and opportunities...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30324543/bioactive-compounds-from-theobroma-cacao-effect-of-isolation-and-safety-evaluation
#20
María de la Luz Cádiz-Gurrea, Ignacio Fernández de Las Nieves, Luis Manuel Aguilera Saez, Salvador Fernández-Arroyo, Laurence Legeai-Mallet, Mohamed Bouaziz, Antonio Segura-Carretero
Plants, including most food and feed plants, produce a broad range of bioactive chemical compounds. Among these compounds, polyphenols are reported to provide beneficial effects as anti-carcinogenic, anti-atherogenic, anti-inflammatory, immune modulating, anti-microbial, vasodilatory and analgesic. Cocoa (Theobroma cacao), a major, economically important, international crop, has been related to several nutritional benefits, which have been associated with the phenolic fraction. The main subclass of flavonoids found in cocoa is flavanols, particularly (epi)catechins monomers, and their oligomers, also known as procyanidins...
October 15, 2018: Plant Foods for Human Nutrition
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