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https://www.readbyqxmd.com/read/30515967/direct-assessment-of-adherence-and-drug-interactions-in-patients-with-hypertensive-crisis-a-cross-sectional-study-in-the-emergency-department
#1
Manuel Wallbach, Nadine Lach, Johanna Stock, Henrik Hiller, Eirini Mavropoulou, Myra-Lynn Chavanon, Hartmud Neurath, Sabine Blaschke, Elena Lowin, Christoph Herrmann-Lingen, Gerhard A Müller, Michael J Koziolek
Though drug adherence is supposed to be low in hypertensive crisis (HTN-C), there are no data available from direct adherence assessments. The aim of the present study was to evaluate adherence to prescribed antihypertensives and potential interactions of concomitant drugs and foods with prescribed antihypertensives in patients with HTN-C by a direct evaluation via biochemical urine analysis. In the present cross-sectional study, 100 patients with HTN-C, admitted to the emergency department (ED), were included...
December 5, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30515809/hormetic-effects-of-curcumin-what-is-the-evidence
#2
REVIEW
Nazanin Sadat Aghili Moghaddam, Mohammad Nosrati Oskouie, Alexandra E Butler, Patrice X Petit, George E Barreto, Amirhossein Sahebkar
Curcumin (diferuloylmethane), a component of the yellow powder prepared from the roots of Curcuma longa or Zingiberaceae (known as turmeric) is not only widely used to color and flavor food but also used as a pharmaceutical agent. Curcumin demonstrates anti-inflammatory, anticarcinogenic, antiaging, and antioxidant activity, as well as efficacy in wound healing. Notably, curcumin is a hormetic agent (hormetin), as it is stimulatory at low doses and inhibitory at high doses. Hormesis by curcumin could be also a particular function at low doses (i...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30515276/evaluation-of-in-vitro-anti-oxidant-and-anti-inflammatory-activities-of-korean-and-chinese-lonicera-caerulea
#3
You-Suk Lee, Il Je Cho, Joo Wan Kim, Sun-Kyoung Lee, Sae Kwang Ku, Hae-Jeung Lee
BACKGROUND/OBJECTIVES: The honeysuckle berry (HB) contains ascorbic acid and phenolic components, especially anthocyanins, flavonoids, and low-molecular-weight phenolic acids. In order to examine the potential of HB as a hepatoprotective medicinal food, we evaluated the in vitro anti-oxidant and anti-inflammatory activities of Korean HB (HBK) and Chinese HB (HBC). MATERIALS/METHODS: Antioxidant and anti-inflammatory effects of the extracts were examined in HepG2 and RAW 264...
December 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/30515275/anti-inflammatory-effects-of-agar-free-gelidium-amansii-ga-extracts-in-high-fat-diet-induced-obese-mice
#4
Yunkyoung Lee, Hyunhee Oh, Myoungsook Lee
BACKGROUND/OBJECTIVES: Gelidium amansii ( GA ) contains plenty of agars and various biological substances, which make them a popular functional food to control body weight in previous studies. Unlike previous studies focused on agar in GA, objectives of this study were to investigate the effects of agar-free GA extract ( AfGAE ) on preventive and treatment models by using diets-induced obese (DIO) C57BL/6J mice. MATERIALS/METHODS: Af GAE were used to test their effects on the prevention ( Exp-1 ) and treatment ( Exp-2 ) against obesity after pilot study in DIO mice...
December 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/30514970/therapeutic-strategies-for-sickle-cell-disease-towards-a-multi-agent-approach
#5
REVIEW
Marilyn J Telen, Punam Malik, Gregory M Vercellotti
For over 100 years, clinicians and scientists have been unravelling the consequences of the A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the systemic manifestations of sickle cell disease (SCD), including vaso-occlusion, anaemia, haemolysis, organ injury and pain. However, despite growing understanding of the mechanisms of haemoglobin S polymerization and its effects on red blood cells, only two therapies for SCD - hydroxyurea and L-glutamine - are approved by the US Food and Drug Administration...
December 4, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30513929/the-healing-promoting-properties-of-selected-cyclitols-a-review
#6
REVIEW
Agnieszka Owczarczyk-Saczonek, Lesław Bernard Lahuta, Magdalena Ligor, Waldemar Placek, Ryszard Józef Górecki, Bogusław Buszewski
INTRODUCTION: Myo -inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits. AIM: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols...
December 3, 2018: Nutrients
https://www.readbyqxmd.com/read/30513922/health-effects-of-resveratrol-results-from-human-intervention-trials
#7
REVIEW
Sonia L Ramírez-Garza, Emily P Laveriano-Santos, María Marhuenda-Muñoz, Carolina E Storniolo, Anna Tresserra-Rimbau, Anna Vallverdú-Queralt, Rosa M Lamuela-Raventós
The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe...
December 3, 2018: Nutrients
https://www.readbyqxmd.com/read/30513869/one-health-fermented-foods-and-gut-microbiota
#8
REVIEW
Victoria Bell, Jorge Ferrão, Lígia Pimentel, Manuela Pintado, Tito Fernandes
Changes in present-day society such as diets with more sugar, salt, and saturated fat, bad habits and unhealthy lifestyles contribute to the likelihood of the involvement of the microbiota in inflammatory diseases, which contribute to global epidemics of obesity, depression, and mental health concerns. The microbiota is presently one of the hottest areas of scientific and medical research, and exerts a marked influence on the host during homeostasis and disease. Fermented foods and beverages are generally defined as products made by microbial organisms and enzymatic conversions of major and minor food components...
December 3, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/30513810/dietary-advanced-glycation-endproducts-induce-an-inflammatory-response-in-human-macrophages-in-vitro
#9
Timme van der Lugt, Antje R Weseler, Wouter A Gebbink, Misha F Vrolijk, Antoon Opperhuizen, Aalt Bast
Advanced glycation endproducts (AGEs) can be found in protein- and sugar-rich food products processed at high temperatures, which make up a vast amount of the Western diet. The effect of AGE-rich food products on human health is not yet clear and controversy still exists due to possible contamination of samples with endotoxin and the use of endogenous formed AGEs. AGEs occur in food products, both as protein-bound and individual molecules. Which form exactly induces a pro-inflammatory effect is also unknown...
December 2, 2018: Nutrients
https://www.readbyqxmd.com/read/30513714/selenium-status-is-not-associated-with-cognitive-performance-a-cross-sectional-study-in-154-older-australian-adults
#10
Barbara R Cardoso, Ewa A Szymlek-Gay, Blaine R Roberts, Melissa Formica, Jenny Gianoudis, Stella O'Connell, Caryl A Nowson, Robin M Daly
Selenium was suggested to play a role in modulating cognitive performance and dementia risk. Thus, this study aimed to investigate the association between selenium status and cognitive performance, as well as inflammatory and neurotrophic markers in healthy older adults. This cross-sectional study included 154 older adults (≥60 years) from Victoria, Australia. Participants were assessed for cognitive performance (Cogstate battery), dietary selenium intake (two 24-h food recalls), plasma selenium concentration, inflammatory markers (interleukin (IL)-6, -8, -10, tumor necrosis factor-alpha and adiponectin) and neurotrophic factors (brain-derived neurotrophic factor, vascular endothelial growth factor and insulin-like growth factor 1)...
December 1, 2018: Nutrients
https://www.readbyqxmd.com/read/30513345/phytochemical-composition-antioxidant-and-antiproliferative-activities-and-effects-on-nuclear-dna-of-ethanolic-extract-from-an-italian-mycelial-isolate-of-ganoderma-lucidum
#11
Roberta Saltarelli, Francesco Palma, Anna Maria Gioacchini, Cinzia Calcabrini, Umberto Mancini, Roberta De Bellis, Vilberto Stocchi, Lucia Potenza
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst. (also known as Linghzhi and Reishi) is the most appreciated and revered medicinal mushroom across many Asian countries, but its properties have also attracted interest in Western countries. Indeed, in the West, it is now commercially available as a dietary supplement in preparations mainly made from spores, fruiting bodies and mycelia. It is employed in both nutraceutical and pharmacological formulations either for its immuno-modulating anti-inflammatory properties or as an effective adjuvant therapy in the treatment of several chronic diseases as well as in cancer treatment...
December 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30511707/the-prophylactic-effect-of-a-eugenia-aquea-extract-against-oxidative-stress-and-inflammation-associated-with-the-development-of-arthritis-in-an-adjuvant-induced-arthritis-rat-model
#12
Eman A Abd El-Ghffar, Omayma A Eldahshan, Alaa Barakat, Thomas Efferth
Rheumatoid arthritis (RA) is the most common human autoimmune disease. A petroleum ether extract of Eugenia aquea (E. aquea) was analyzed by GC/MS. Antioxidant and anti-inflammatory activities were investigated in rats with adjuvant-induced arthritis (AIA). An AIA rat model received orally/daily a vehicle, diclofenac (100 mg per kg b.w.), and E. aquea extract (50 or 100 or 200 mg per kg b.w.; for 21 days). Fifty-five out of 70 compounds (97.77%) were identified: eucalyptol (34.14%), α-pinene (15.91%), l-verbenone (8...
December 4, 2018: Food & Function
https://www.readbyqxmd.com/read/30510705/protective-effects-of-a-triple-fermented-barley-extract-fbe-against-hcl-etoh-induced-gastric-mucosa-damage-in-mice
#13
Jong-Min Lim, Chang-Hyun Song, Su-Jin Park, Dong-Chan Park, Hyung-Rae Cho, Go-Woon Jung, Khawaja Muhammad Imran Bashir, Sae Kwang Ku, Jae-Suk Choi
This study was designed to observe the possible protective effects of a triple-fermented barley ( Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed...
November 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/30510617/multifunctional-phytocompounds-in-cotoneaster-fruits-phytochemical-profiling-cellular-safety-anti-inflammatory-and-antioxidant-effects-in-chemical-and-human-plasma-models-in-vitro
#14
Agnieszka Kicel, Joanna Kolodziejczyk-Czepas, Aleksandra Owczarek, Magdalena Rutkowska, Anna Wajs-Bonikowska, Sebastian Granica, Pawel Nowak, Monika A Olszewska
The work presents the results of an investigation into the molecular background of the activity of Cotoneaster fruits, providing a detailed description of their phytochemical composition and some of the mechanisms of their anti-inflammatory and antioxidant effects. GS-FID-MS and UHPLC-PDA-ESI-MS3 methods were applied to identify the potentially health-beneficial constituents of lipophilic and hydrophilic fractions, leading to the identification of fourteen unsaturated fatty acids (with dominant linoleic acid, 375...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30508579/brain-tumor-necrosis-factor-%C3%AE-mediates-anxiety-like-behavior-in-a-mouse-model-of-severe-obesity
#15
Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon
Although the high prevalence of anxiety in obesity increasingly emerges as significant risk factor for related severe health complications, the underlying pathophysiological mechanisms remain poorly understood. Considering that chronic inflammation is a key component of obesity and is well known to impact brain function and emotional behavior, we hypothesized that it may similarly contribute to the development of obesity-related anxiety. This hypothesis was experimentally tested by measuring whether chronic food restriction, a procedure known to reduce inflammation, or chronic anti-inflammatory treatment with ibuprofen improved anxiety-like behavior and concomitantly decreased peripheral and/or hippocampal inflammation characterizing a model of severe obesity, the db/db mice...
November 30, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/30507260/exercise-induced-illness-and-inflammation-can-immunonutrition-and-iron-help
#16
Lindy M Castell, David C Nieman, Stéphane Bermon, Peter Peeling
The main focus of this review is illness amongst elite athletes, how and why it occurs, and whether any measures can be taken to combat it or to prevent its onset. In particular, there is particular interest in exercise-induced immunodepression which is a result of the immune system regarding exercise (for example, prolonged, exhaustive exercise) as a challenge to its function. This promotes the inflammatory response. There is often a high incidence of illness in athletes after undertaking strenuous exercise, particularly among those competing in endurance events, mainly in terms of upper respiratory tract illness (URTI) but also involving gastrointestinal problems...
December 3, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/30504010/the-dietary-inflammatory-index-and-insulin-resistance-or-metabolic-syndrome-in-young-adults
#17
Carolina A Carvalho, Antônio Augusto M Silva, Maria Cecília F Assunção, Poliana Cristina A Fonseca, Marco Antonio Barbieri, Heloisa Bettiol, Nitin Shivappa, James R Hébert
OBJECTIVE: The aim of this study was to assess the association between the inflammatory potential of diet, as measured by the dietary inflammatory index (DII) and insulin resistance (IR) or metabolic syndrome (MetS). METHODS: A cross-sectional study (nested within a cohort) was conducted on 2017 adults 23 to 25 y of age in Ribeirão Preto, Brazil. Food consumption was assessed using a validated food frequency questionnaire. DII scores were calculated from 35 available food parameters...
August 23, 2018: Nutrition
https://www.readbyqxmd.com/read/30503586/alternariol-induced-proliferation-in-primary-mouse-keratinocytes-and-inflammation-in-mouse-skin-is-regulated-via-pge-2-ep2-camp-p-creb-signaling-pathway
#18
Megha Bansal, Neha Singh, Shamshad Alam, Saurabh Pal, G N V Satyanarayana, Dhirendra Singh, Kausar Mahmood Ansari
Alternariol (AOH) is a mycotoxin that contaminates various food stuffs as well as animal feed and may cause toxicity after consumption. However, a dermal toxic potential of AOH has not been explored so far. In the present study, skin toxicity after topical exposure of AOH and the involved mechanism/s are revealed. Single topical application of different AOH doses (12.5, 25, 50 µg/animal) caused increased bi-fold thickness as well as hyperplasia and higher production of prostaglandin E2 (PGE2 ) along with cAMP in the skin demonstrating its inflammatory potential...
November 29, 2018: Toxicology
https://www.readbyqxmd.com/read/30502515/bacterial-vaginosis-an-insight-into-the-prevalence-alternative-regimen-treatments-and-it-s-associated-resistance-patterns
#19
REVIEW
Ayesha Javed, Fahed Parvaiz, Sobia Manzoor
Bacterial Vaginosis (BV) is a complex polymicrobial infection of vagina that shifts the paradigms of vaginal flora from lactobacilli to opportunistic pathogens. BV is catagorized by greyish white discharge, pH greater than 4.5. It results in the preterm labor, abortion, pelvic inflammatory disorders, post cesarean infections. BV is associated with Sexually Transmitted Diseases (STDs) or immune deficiency disorders like Human Immunodeficiency Virus, Human Papilloma Virus, Herpes Simplex Virus 1 and 2, and Neisseria gonorrhoeae...
November 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30502207/antioxidant-and-anti-inflammatory-properties-of-flavonoids-from-lotus-plumule
#20
Gui-Lin Chen, Min-Xia Fan, Jian-Lin Wu, Na Li, Ming-Quan Guo
The antioxidant and anti-inflammatory mechanisms of action of flavonoids in lotus plumule were systematically analyzed using radical scavenging assays and ELISA kits. By this means, flavonoids displayed significant antioxidant activity by donating electron, H atom as well as capturing DPPH and ABTS+ free radicals, and anti-inflammatory effect by inhibiting the production of the inflammatory mediators (NO radicals, PGE2 and TNF-α) and pro-inflammatory cytokines (IL-1β and IL-6). Meanwhile, the bioactive components against inflammation targeting COX-2 were also revealed using ultrafiltration coupled to LC-MS (UF-LC/MS)...
March 30, 2019: Food Chemistry
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