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Prevention of adhesion formation

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https://www.readbyqxmd.com/read/30100305/transabdominal-ultrasound-can-it-be-used-to-detect-and-quantify-adhesions-reported-pain-following-caesarean-section
#1
Katharine Spens, Lance Bird, Philip Bright
BACKGROUND: Caesarean section is common in the UK with post-procedural adhesions causing life-long clinical symptoms and impacting future pregnancies. This study's aim was to explore associations between these surgical adhesions, via transabdominal ultrasound findings, and perceived symptoms. METHOD: Females demonstrating 1-3 transverse, lower-segment Caesareans were included. Visceral slide transabdominal ultrasound elicited positive adhesions (<1 cm movement) and negative adhesions (>1 cm movement)...
July 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/30097559/clinical-use-of-a-new-nano-hydroxyapatite-polyamide66-composite-artificial-lamina-in-spinal-decompression-surgery-more-than-4-years-follow-up
#2
Zenghui Zhao, Liang Guo, Yong Zhu, Wei Luo, Yunsheng Ou, Zhengxue Quan, Dianming Jiang
BACKGROUND Long-term follow-up results showed that epidural scar formation and adhesion after laminectomy always affected the outcomes of repeat operations. The establishment of a barrier between scar tissue and dura was effective in preventing epidural scar formation. MATERIAL AND METHODS A nano-hydroxyapatite/polyamide66 (n-HA/PA66) artificial lamina was designed and fabricated and used to cover the opened spinal canal in patients who received laminectomy. The visual analogue scale (VAS) and Japanese Orthopedic Association (JOA) Scores, X-ray, computed tomography, and magnetic resonance imaging results were periodically recorded and evaluated...
August 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30096958/neutrophil-extracellular-traps-as-an-adhesion-substrate-for-different-tumor-cells-expressing-rgd-binding-integrins
#3
Marcello Monti, Viviana De Rosa, Francesca Iommelli, Maria Vincenza Carriero, Cristina Terlizzi, Rosa Camerlingo, Stefania Belli, Rosa Fonti, Giovanni Di Minno, Silvana Del Vecchio
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis...
August 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30092363/the-role-of-ovarian-suspension-in-preventing-post-surgical-ovarian-adhesions-in-patients-with-stage-iii-iv-pelvic-endometriosis-a-systematic-review
#4
REVIEW
Pierluigi Giampaolino, Luigi Della Corte, Gabriele Saccone, Amerigo Vitagliano, Giuseppe Bifulco, Gloria Calagna, Jose Carugno, Attilio Di Spiezio Sardo
Endometriosis is a benign complex gynecological condition with high morbidity that affects women of reproductive age. Pelvic adhesion formation represents a serious clinical challenge in the management of patients with endometriosis. Several interventions have been proposed over the last few years aiming to reduce post-operative ovarian adhesions formation. The aim of this study is to summarize the evidence of the efficacy of ovarian suspension in the prevention of post-operative ovarian adhesions formation in women undergoing laparoscopic surgery for stage III-IV endometriosis...
August 6, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/30092110/potential-usefulness-of-losartan-as-an-antifibrotic-agent-and-adjunct-to-platelet-rich-plasma-therapy-to-improve-muscle-healing-and-cartilage-repair-and-prevent-adhesion-formation
#5
Johnny Huard, Ioanna Bolia, Karen Briggs, Hajime Utsunomiya, Walter R Lowe, Marc J Philippon
Postoperative tissue fibrosis represents a major complication in orthopedics. Transforming growth factor beta 1 is a key molecule in the development of postoperative fibrosis. High concentrations of transforming growth factor beta 1 have also been implicated in various diseases. Agents that counteract the actions of transforming growth factor beta 1 have been investigated as potential antifibrotic medications and as adjunct treatment to platelet-rich plasma injections (increased amounts of transforming growth factor beta 1) to improve their effectiveness and/or safety profile...
August 9, 2018: Orthopedics
https://www.readbyqxmd.com/read/30091651/the-leucine-rich-region-of-flightless-i-interacts-with-r-ras-to-regulate-cell-extension-formation
#6
P D Arora, T He, K Ng, C A McCulloch
Flightless I (FliI) is a calcium-dependent, actin severing and capping protein that localizes to cell matrix adhesions, contributes to the generation of cell extensions and co-localizes with Ras. Currently the mechanism by which FliI interacts with Ras to enable assembly of actin-based cell protrusions is not defined. R-Ras but not K-ras, H-ras or N-ras, associated with the leucine-rich region (LRR) of FliI. Mutations of the proline-rich region of R-ras (P202A, P203A) prevented this association. Knockdown of Ras-GTPase-activating SH3 domain binding protein (G3BP1) or Rasgap120 by siRNA inhibited the formation of cell extensions and prevented interaction of R-ras and G3BP1 in FliI WT cells...
August 9, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/30089157/cranberry-derived-proanthocyanidins-induce-a-differential-transcriptomic-response-within-candida-albicans-urinary-biofilms
#7
Anitha Sundararajan, Hallie S Rane, Thiruvarangan Ramaraj, Johnny Sena, Amy B Howell, Stella M Bernardo, Faye D Schilkey, Samuel A Lee
Candida albicans is one of the most common causes of hospital-acquired urinary tract infections (UTIs). However, azoles are poorly active against biofilms, echinocandins do not achieve clinically useful urinary concentrations, and amphotericin B exhibits severe toxicities. Thus, novel strategies are needed to prevent Candida UTIs, which are often associated with urinary catheter biofilms. We previously demonstrated that cranberry-derived proanthocyanidins (PACs) prevent C. albicans biofilm formation in an in vitro urinary model...
2018: PloS One
https://www.readbyqxmd.com/read/30078425/ultra-dense-polymer-brush-coating-reduces-staphylococcus-epidermidis-biofilms-on-medical-implants-and-improves-antibiotic-treatment-outcome
#8
Sandra M Skovdal, Nis Pedersen Jørgensen, Eskild Petersen, Søren Jensen-Fangel, Ryosuke Ogaki, Guanghong Zeng, Mikkel Illemann Johansen, Mikala Wang, Holger Rohde, Rikke L Meyer
Staphylococcal biofilm formation is a severe complication of medical implants, leading to high antibiotic tolerance and treatment failure. Ultra-dense poly(ethylene glycol) (udPEG) coating resists adsorption of proteins, polysaccharides and extracellular DNA. It is therefore uniquely resistant to attachment by Staphylococcus epidermidis, which remains loosely adhered to the surface. Our aim was to determine if S. epidermidis remains susceptible to antibiotics when adhering to udPEG, and if udPEG coatings can improve the treatment outcome for implant-associated infections...
August 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30062880/nanoplasmonics-for-real-time-and-label-free-monitoring-of-microbial-biofilm-formation
#9
Riccardo Funari, Nikhil Bhalla, Kang-Yu Chu, Bill Söderström, Amy Q Shen
Microbial biofilms possess intrinsic resistance against conventional antibiotics and cleaning procedures, thus a better understanding of their complex biological structures is crucial in both medical and industrial applications. Existing laboratory methodologies have focused on macroscopic and mostly indirect characterization of mechanical and microbiological properties of biofilms adhered on a given substrate. However, the kinetics underlying the biofilm formation is not well understood, while such information is critical to understand how drugs and chemicals influence the biofilm formation...
July 31, 2018: ACS Sensors
https://www.readbyqxmd.com/read/30056334/construction-of-a-bilayered-vascular-graft-with-smooth-internal-surface-for-improved-hemocompatibility-and-endothelial-cell-monolayer-formation
#10
Xianhao Dong, Xingyu Yuan, Lina Wang, Jinlong Liu, Adam C Midgley, Zhihong Wang, Kai Wang, Jianfeng Liu, Meifeng Zhu, Deling Kong
Formation of a continuous endothelial cell (EC) monolayer inside the luminal surface with enhanced hemocompatibility, is a promising solution for improving performance and overall patency of small-diameter vascular grafts. There has been much debate regarding the ideal substrate surface topography to achieve this. Here, we investigated different polycaprolactone (PCL)-derived substrate surfaces fabricated from nanofibers, microfibers, or with smooth surfaces, and evaluated their effect on hemocompatibility and EC behavior...
July 20, 2018: Biomaterials
https://www.readbyqxmd.com/read/30046749/integrating-platelet-and-coagulation-activation-in-fibrin-clot-formation
#11
REVIEW
Frauke Swieringa, Henri M H Spronk, Johan W M Heemskerk, Paola E J van der Meijden
Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus. This review discusses current concepts of platelet control of thrombin generation, fibrin formation and structure, and anticoagulation. Indicated are how combined signalling via the platelet receptors for collagen (glycoprotein VI) and thrombin induces the secretion of (anti)coagulation factors, as well as surface exposure of phosphatidylserine, thereby catalysing thrombin generation...
July 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30044011/building-a-total-bioartificial-heart-harnessing-nature-to-overcome-the-current-hurdles
#12
Doris A Taylor, O H Frazier, Abdelmotagaly Elgalad, Camila Hochman-Mendez, Luiz C Sampaio
Engineering a bio-artificial heart has become a possibility in part because of the regenerative medicine approaches to repairing or replacing damaged organs that have evolved over the past two decades. With the advent of inducible pluripotent stem cell technology, it is now possible to generate personalized cells that make the concept of autologous tissue engineering imaginable. Scaffolds, that provide form, function, and biological cues to cells likewise potentially enable the engineering of biocompatible vascularized solid organs...
July 25, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30023948/role-of-the-surface-nanoscale-roughness-of-stainless-steel-on-bacterial-adhesion-and-microcolony-formation
#13
Songmei Wu, Stefanie Altenried, Andi Zogg, Flavia Zuber, Katharina Maniura-Weber, Qun Ren
Hospital-acquired infections can cause serious complications and are a severe problem because of the increased emergence of antibiotic-resistant bacteria. Biophysical modification of the material surfaces to prevent or reduce bacteria adhesion is an attractive alternative to antibiotic treatment. Since stainless steel is a widely used material for implants and in hospital settings, in this work, we used stainless steel to investigate the effect of the material surface topographies on bacterial adhesion and early biofilm formation...
June 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/30023849/porous-polylactide-film-plus-atorvastatin-loaded-thermogel-as-an-efficient-device-for-peritoneal-adhesion-prevention
#14
Jiannan Li, Xiangru Feng, Jian Shi, Tongjun Liu, Jianxun Ding
Peritoneal adhesion is a common postoperative complication that causes many kinds of organ dysfunctions. It can be minimized by the integration of physical isolation and pharmaceutical treatment. However, the gas permeability of traditional medical devices for adhesion prevention is not satisfactory, which increases the risk of infection and inflammation, thus facilitating the formation of peritoneal adhesion. In this study, a device of porous polylactide (PLA) film plus atorvastatin (ATV)-loaded thermogel was developed for peritoneal adhesion prevention...
March 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/30013052/propolis-potentiates-the-effect-of-cranberry-vaccinium-macrocarpon-against-the-virulence-of-uropathogenic-escherichia-coli
#15
Jérémy Ranfaing, Catherine Dunyach-Remy, Laurence Louis, Jean-Philippe Lavigne, Albert Sotto
Uropathogenic Escherichia coli (UPEC), the most prevalent bacteria isolated in urinary tract infections (UTI), is now frequently resistant to antibiotics used to treat this pathology. The antibacterial properties of cranberry and propolis could reduce the frequency of UTIs and thus the use of antibiotics, helping in the fight against the emergence of antibiotic resistance. Transcriptomic profiles of a clinical UPEC strain exposed to cranberry proanthocyanidins alone (190 µg/mL), propolis alone (102.4 µg/mL) and a combination of both were determined...
July 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30011476/delamination-of-a-thin-sheet-from-a-soft-adhesive-winkler-substrate
#16
Oz Oshri, Ya Liu, Joanna Aizenberg, Anna C Balazs
A uniaxially compressed thin elastic sheet that is resting on a soft adhesive substrate can form a blister, which is a small delaminated region, if the adhesion energy is sufficiently weak. To analyze the equilibrium behavior of this system, we model the substrate as a Winkler or fluid foundation. We develop a complete set of equations for the profile of the sheet at different applied pressures. We show that at the edge of delamination, the height of the sheet is equal to sqrt[2]ℓ_{c}, where ℓ_{c} is the capillary length...
June 2018: Physical Review. E
https://www.readbyqxmd.com/read/30002310/aspirin-is-involved-in-the-cell-cycle-arrest-apoptosis-cell-migration-and-invasion-of-oral-squamous-cell-carcinoma
#17
Xiaoqi Zhang, Hao Feng, Ziyu Li, Jie Guo, Minqi Li
Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide. In China, its 5-year survival rate is roughly 50%, owing to acquired chemotherapeutic resistance and metastasis of the disease. Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC. To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin...
July 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29981331/wet-electrospun-alginate-gelatin-hydrogel-nanofibers-for-3d-cell-culture
#18
Sara Seidelin Majidi, Peter Slemming-Adamsen, Muhammad Hanif, Zhongyang Zhang, Zhiming Wang, Menglin Chen
Convergence of biological and biofabrication approaches is necessary to progress new biomaterials promoting three-dimensional (3D) cell growth and maturation towards tissue regeneration and integration. Here, we have developed a novel approach to fabricate 3D macroporous, alginate/gelatin hydrogel nanofibers (Alg/GelF-MA), which provide superior cell adhesion, motility, proliferation and maturation. The electrospinning process greatly depends on the ionic strength and viscoelastic behavior of the solution. The polyelectrolyte nature of alginate favors intramolecular bundles over intermolecular entanglement, which hinders its electrospinnability...
July 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29968072/poly-adp-ribose-polymerase-parp-and-parp-inhibitors-mechanisms-of-action-and-role-in-cardiovascular-disorders
#19
REVIEW
Robert J Henning, Marie Bourgeois, Raymond D Harbison
Poly(ADP-ribosyl)ation is an immediate cellular repair response to DNA damage and is catalyzed primarily by poly(ADP-ribose)polymerase-1 (PARP1), which is the most abundant of the 18 different PARP isoforms and accounts for more than 90% of the catalytic activity of PARP in the cell nucleus. Upon detection of a DNA strand break, PARP1 binds to the DNA, cleaves nicotinamide adenine dinucleotide between nicotinamide and ribose and then modifies the DNA nuclear acceptor proteins by formation of a bond between the protein and the ADP-ribose residue...
July 2, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29946347/bologna-guidelines-for-diagnosis-and-management-of-adhesive-small-bowel-obstruction-asbo-2017-update-of-the-evidence-based-guidelines-from-the-world-society-of-emergency-surgery-asbo-working-group
#20
REVIEW
Richard P G Ten Broek, Pepijn Krielen, Salomone Di Saverio, Federico Coccolini, Walter L Biffl, Luca Ansaloni, George C Velmahos, Massimo Sartelli, Gustavo P Fraga, Michael D Kelly, Frederick A Moore, Andrew B Peitzman, Ari Leppaniemi, Ernest E Moore, Johannes Jeekel, Yoram Kluger, Michael Sugrue, Zsolt J Balogh, Cino Bendinelli, Ian Civil, Raul Coimbra, Mark De Moya, Paula Ferrada, Kenji Inaba, Rao Ivatury, Rifat Latifi, Jeffry L Kashuk, Andrew W Kirkpatrick, Ron Maier, Sandro Rizoli, Boris Sakakushev, Thomas Scalea, Kjetil Søreide, Dieter Weber, Imtiaz Wani, Fikri M Abu-Zidan, Nicola De'Angelis, Frank Piscioneri, Joseph M Galante, Fausto Catena, Harry van Goor
Background: Adhesive small bowel obstruction (ASBO) is a common surgical emergency, causing high morbidity and even some mortality. The adhesions causing such bowel obstructions are typically the footprints of previous abdominal surgical procedures. The present paper presents a revised version of the Bologna guidelines to evidence-based diagnosis and treatment of ASBO. The working group has added paragraphs on prevention of ASBO and special patient groups. Methods: The guideline was written under the auspices of the World Society of Emergency Surgery by the ASBO working group...
2018: World Journal of Emergency Surgery: WJES
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