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Prevention of adhesion formation

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https://www.readbyqxmd.com/read/30332939/the-erm-complex-a-new-player-involved-in-diabetes-induced-vascular-leakage
#1
Olga Simo-Servat, Cristina Hernández, Rafael Simó
BACKGROUND: Microvascular complications remain an important cause of morbidity in diabetic patients, and they are associated with a significant economic burden for healthcare systems. Vascular leakage is one of the earlier hallmarks in diabetic microvascular complications. Ezrin, radixin and moesin (ERM) proteins have recently been involved in vascular dysfunction under the effect of molecular mediators of diabetes complications. In this review we will present the available evidence regarding the role of these proteins in vascular leakage and their putative implication in diabetic microvascular complications...
October 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30327774/f806-suppresses-the-invasion-and-metastasis-of-esophageal-squamous-cell-carcinoma-via-downregulating-f-actin-assembly-related-rho-family-proteins
#2
Lei Xie, Li-Yan Li, Duo Zheng, Yang-Min Xie, Xiu-E Xu, Li-Hua Tao, Lian-Di Liao, Ying-Hua Xie, Yin-Wei Cheng, Li-Yan Xu, En-Min Li
Invasion and metastasis are critical pathological and mortal processes in esophageal squamous cell carcinoma (ESCC). Novel drugs, targeting the two cancer migration stages, will augment the treatment options for ESCC therapy and improve overall survival. A novel natural macrolide F806 specifically promotes apoptosis of various ESCC cells. However, whether F806 can inhibit metastasis of ESCC cells needs further evaluation. Here, our data showed that F806 inhibits dynamic F-actin assembly and then suppresses the migration of ESCC cells in vitro and their invasion and metastasis in vivo...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30321630/pore-size-directs-bone-marrow-stromal-cell-fate-and-tissue-regeneration-in-nanofibrous-macroporous-scaffolds-by-mediating-vascularization
#3
Melanie J Gupte, W Benton Swanson, Jiang Hu, Xiaobing Jin, Haiyun Ma, Zhanpeng Zhang, Zhongning Liu, Kai Feng, Ganjun Feng, Guiyong Xiao, Nan Hatch, Yuji Mishina, Peter X Ma
In the U.S., 30% of adults suffer joint pain, most commonly in the knee, which severely limits mobility and is often attributed to injury of cartilage and underlying bone in the joint. Current treatment methods such as microfracture result in less resilient fibrocartilage with eventual failure; autografting can cause donor site morbidity and poor integration. To overcome drawbacks in treatment, tissue engineers can design cell-instructive biomimetic scaffolds using biocompatible materials as alternate therapies for osteochondral defects...
October 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30311864/assessment-of-functional-nanomaterials-in-medical-applications-can-time-mend-public-and-occupational-health-risks-related-to-the-products-fate
#4
Christophe Bressot, Alexandra Aubry, Cécile Pagnoux, Olivier Aguerre-Chariol, Martin Morgeneyer
Surface coatings are one promising option to prevent bacterial adhesion and biofilm formation given the prevalence of antibiotic resistant bacterial strains. Titanium dioxide (TiO2 ) is presently considered to be the only photocatalytic material suitable for commercial use, although the toxicity risks of TiO2 , particularly in its nanoparticulate form, have not been fully addressed. The aim of this study was to determine release of nanoparticles (NPs) from functional materials for medical applications and their aerosol formation...
October 12, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30310081/par-1-is-a-novel-mechano-sensor-transducing-laminar-flow-mediated-endothelial-signaling
#5
Suji Kim, Jung-Hwa Han, Dae-Hwan Nam, Geun-Young Kim, Jae Hyang Lim, Jae-Ryong Kim, Chang-Hoon Woo
Recent studies have indicated that protease-activated receptor-1 (PAR-1) is involved in cytoprotective and anti-inflammatory responses in endothelial cells (ECs). However, the role of PAR-1 in laminar flow-mediated atheroprotective responses remains unknown. Herein, we investigated whether PAR-1 regulates laminar flow-mediated mechanotransduction in ECs. Confocal analysis showed that PAR-1 was internalized into early endosomes in response to laminar flow. In addition, flow cytometry analysis showed that cell surface expression of PAR-1 was reduced by laminar flow, suggesting that PAR-1 was activated in response to laminar flow...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30288962/uterine-receptivity-in-merriam-s-kangaroo-rat-dipodomys-merriami
#6
Jessica S Dudley, Christopher R Murphy, Michael B Thompson, Bronwyn M Mcallan
The uterine surface undergoes significant remodeling, termed the "plasma membrane transformation," during pregnancy to allow for implantation of the blastocyst and formation of the placenta in viviparous amniote vertebrates. Unlike other species within the superorder Euarchontoglires, which have a hemochorial (highly invasive) placenta, kangaroo rats (Dipodomys spp.) exhibit a less invasive endotheliochorial placenta. We characterized the changes that occur to membrane molecules and the cellular ultrastructure of the uterine epithelium during early pregnancy in Merriam's kangaroo rat, Dipodomys merriami using electron microscopy and immunofluorescence microscopy...
October 5, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30284101/effect-of-anaerobic-cure-of-self-etch-adhesive-on-degree-of-conversion-and-shear-bond-strength
#7
Melissa Phaneuf, Asmaa Haimeur, Rodrigo França
OBJECTIVE: The main aim was to evaluate the effect of postponing the curing of the adhesive layer until the first layer of composite resin is applied-hereby oxygen-inhibited layer (OIL) formation and its detrimental effect on the degree of conversion (DC) of self-etch adhesives should be prevented. For this purpose, the degree of conversion and shear bond strength of four current market self-etch adhesives were evaluated, assessing the effect of curing the adhesives anaerobically and then under two different thicknesses of composite resin, and compare this to the samples cured alone and in air...
October 3, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/30277619/multivalent-fucosides-with-nanomolar-affinity-for-the-aspergillus-fumigatus-lectin-flea-prevent-spore-adhesion-to-pneumocytes
#8
Sébastien G Gouin, Victor Lehot, Yoan Brissonnet, Christophe Dussouy, Sami Brument, Aurore Cabanettes, Emilie Gillon, David Deniaud, Annabelle Varrot, Patrice Le Pape
FleA (or AFL), a fucose lectin, was recently identified in the opportunistic mold Aspergillus fumigatus that causes fatal lung infections in immunocompromised patients. We designed di-, hexa- and octavalent fucosides with various spacer arm lengths to block the hexameric FleA via chelation. Microcalorimetry measurements showed that the ethylene glycol (EG) spacer arm length has a strong influence on the binding affinity of the divalent fucosides. The relationship between the EG length and chelate binding efficiency to FleA was explored according to polymer theory...
October 2, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30269818/assessment-of-the-subcutaneous-degradation-process-of-insoluble-hyaluronic-acid-in-rats
#9
Akiko Uemura, Masahito Takiguchi, Kengo Funakoshi, Yasuharu Noishiki, Shingo Ogawa, Ryou Tanaka
Insoluble hyaluronic acid (IHA) may prevent adhesions by forming a physical barrier during the period when postoperative adhesions form. This study was performed to verify the changes that a solid IHA membrane undergoes as it is degraded in vivo, and to ascertain the swelling rate of IHA required for it to function as a physical barrier during the postoperative adhesion formation period. Nine female WI rats weighing 300-400 g were used. Discs 8 mm in diameter were cut out of dry IHA membranes made of IHA with a swelling rate (wet weight/dry weight) of either 2...
September 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30262433/zip9-but-not-the-androgen-receptor-mediates-testosterone-induced-migratory-activity-of-metastatic-prostate-cancer-cells
#10
Ahmed Bulldan, Joerg-Walter Bartsch, Lutz Konrad, Georgios Scheiner-Bobis
LNCaP cells are derived from a metastatic lesion of human prostate adenocarcinoma. They express the classical androgen receptor (AR) and ZIP9, a Zn2+ transporter that also binds testosterone and mediates signaling by interacting with G-proteins. Our results show that LNCaP cells respond to testosterone by mobilizing their migratory machinery. Their exposure to testosterone triggers the formation of lamellipodia, reorganization of the actin cytoskeleton, phosphorylation of focal adhesion kinase (FAK) at Tyr925 and of paxillin at Tyr118, expression of matrix metalloproteinase 2 (MMP-2), and cell migration...
September 15, 2018: Biochimica et biophysica acta. Molecular cell research
https://www.readbyqxmd.com/read/30251940/antifibrotic-effects-of-decellularized-and-lyophilized-human-amniotic-membrane-transplant-on-the-formation-of-intrauterine-adhesion
#11
Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Yingfang Zhou, Lei Cui, Wenpei Bai
OBJECTIVES: Intrauterine adhesion is a disease involving endometrial fibrosis that arises from injury to the basal layer of the endometrium. Here, we aimed to explore the preventive effects of decellularized and lyophilized amniotic membrane on endometrial fibrosis in a rat model of intrauterine adhesion. MATERIALS AND METHODS: Twenty-four Sprague-Dawley rats were randomly divided into 2 groups. For the intrauterine adhesion group, endometria of left uteri were scraped without treatment...
September 25, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/30251351/water-soluble-nacmc-napaa-binder-for-exceptional-improvements-of-sodium-ion-battery-with-sno2-ordered-mesoporous-carbon-anode
#12
Jagabandhu Patra, Purna Chandra Rath, Chi Li, Hsien-Ming Kao, Fu-Ming Wang, Ju Li, Jeng-Kuei Chang
SnO2@CMK-8 composite, a highly promising anode for Na-ion batteries (NIBs), is incorporated with polyvinylidene difluoride (PVDF), sodium carboxymethylcellulose (NaCMC), sodium polyacrylate (NaPAA), and NaCMC/NaPAA mixed binders to optimize the electrode sodiation/desodiation properties. Synergistic effects between NaCMC and NaPAA lead to the formation of an effective protective film on the electrode. This coating layer not only increases the charge-discharge Coulombic efficiency, suppressing the accumulation of solid-electrolyte interphases, but also keeps the SnO2 nanoparticles in the CMK-8 matrix, preventing oxide agglomeration and falling off upon cycling...
September 24, 2018: ChemSusChem
https://www.readbyqxmd.com/read/30245725/an-improved-method-for-temporary-suture-medialisation-of-the-middle-turbinates-following-endoscopic-sinus-surgery
#13
Eugene Wong, Narinder Singh
Background: Middle turbinate (MT) lateralisation with adhesion formation (MiTLAF) is a common complication following endoscopic sinus surgery, frequently resulting in surgical failure, persistence of preoperative symptoms, and delayed secondary complications. Packing materials, splints, or spacers reduce the risk of MiTLAF but often result in postoperative nasal obstruction and discomfort, along with reduced access for irrigation. Temporary suture medialisation of the MTs reduces the risk of MiTLAF and prevents the problems encountered with packing, splints, or spacers...
2018: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/30242034/cell-polarity-and-adherens-junction-formation-inhibit-epithelial-fas-cell-death-receptor-signaling
#14
Laurent Gagnoux-Palacios, Hala Awina, Stéphane Audebert, Aurélie Rossin, Magali Mondin, Franck Borgese, Carlota Planas-Botey, Amel Mettouchi, Jean-Paul Borg, Anne-Odile Hueber
Finely tuned regulation of epithelial cell death maintains tissue integrity and homeostasis. At the cellular level, life and death decisions are controlled by environmental stimuli such as the activation of death receptors. We show that cell polarity and adherens junction formation prevent proapoptotic signals emanating from the Fas death receptor. Fas is sequestered in E-cadherin actin-based adhesion structures that are less able to induce downstream apoptosis signaling. Using a proteomic-based approach, we find that the polarity molecule Dlg1 interacts with the C-terminal PDZ-binding site in Fas and that this interaction decreases formation of the death-inducing complex upon engagement with Fas ligand (FasL), thus acting as an additional cell death protection mechanism...
September 21, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/30241439/nanostructured-biomedical-selenium-at-the-biological-interface-review
#15
Victoria le Ching Tan, Angelica Hinchman, Richard Williams, Phong A Tran, Kate Fox
This paper critically reviews the current evidence of research in biomedical applications of selenium nanoparticles (SeNPs) and their effects at cellular and tissue levels. In recent years, interest in SeNPs as a natural trace element nanomaterial for nanomedicine has resulted in a number of studies evaluating their bioactivities, such as anticancer, antimicrobial, and antioxidant properties. Significant data have been generated to demonstrate the effectiveness of SeNPs alone or in combination with other reagents...
September 21, 2018: Biointerphases
https://www.readbyqxmd.com/read/30238737/-integrative-analysis-of-gene-expression-profile-and-dna-methylation-profile-of-long-term-cultivated-porcine-bone-marrow-mesenchymal-stem-cells
#16
Ying He, Lijin Zou, Manman Gao, Tangzhao Liang, Xuenong Zou
Objective: To integrate the result of whole genome expression data and whole genome promoter CpG island methylation data, to screen the epigenetic modulated differentially expressed genes from transformed porcine bone marrow mesenchymal stem cells (BMSCs) after long-term cultivation. Methods: Bone marrow from 6 landrace pigs, 3-month-old about 50 kg weight, was aspirated from the medullary cavity of the proximal tibia. The BMSCs were isolated, and purified by Ficoll density gradient centrifugation combined with adherent culture method...
August 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/30232279/neutrophil-accumulation-and-net-release-contribute-to-thrombosis-in-hit
#17
Kandace Gollomp, Minna Kim, Ian Johnston, Vincent Hayes, John Welsh, Gowthami M Arepally, Mark Kahn, Michele P Lambert, Adam Cuker, Douglas B Cines, Lubica Rauova, M Anna Kowalska, Mortimer Poncz
Heparin-induced thrombocytopenia (HIT) is an immune-mediated thrombocytopenic disorder associated with a severe prothrombotic state. We investigated whether neutrophils and neutrophil extracellular traps (NETs) contribute to the development of thrombosis in HIT. Using an endothelialized microfluidic system and a murine passive immunization model, we show that HIT induction leads to increased neutrophil adherence to venous endothelium. In HIT mice, endothelial adherence is enhanced immediately downstream of nascent venous thrombi, after which neutrophils undergo retrograde migration via a CXCR2-dependent mechanism to accumulate into the thrombi...
September 20, 2018: JCI Insight
https://www.readbyqxmd.com/read/30223566/microstructure-and-mechanical-properties-of-nano-carbon-reinforced-titanium-matrix-hydroxyapatite-biocomposites-prepared-by-spark-plasma-sintering
#18
Feng Li, Xiaosong Jiang, Zhenyi Shao, Degui Zhu, Zhiping Luo
Nano-carbon reinforced titanium matrix/hydroxyapatite (HA) biocomposites were successfully prepared by spark plasma sintering (SPS). The microstructure, mechanical properties, biocompatibility, and the relationship between microstructure and properties of biocomposites were systematically investigated. Results showed there are some new phases in sintered composites, such as β-Ti, TiO₃, ZrO₂, etc. Moreover, a small amount of Ti17 P10 , CaTiO₃, Ca₃(PO₄)₂ were also detected. The reaction that may occur during the preparation process is suppressed to some extent, which is because that the addition of second phases can prevent the direct contact of titanium with HA and reduce the contact areas...
September 15, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30222754/destabilization-of-the-von-willebrand-factor-a2-domain-under-oxidizing-conditions-investigated-by-molecular-dynamics-simulations
#19
Gianluca Interlandi
The protein von Willebrand factor (VWF) is key for the adhesion of blood platelets to sites of vascular injury. Recent studies have shown that the release of oxidative agents during inflammation increases the platelet-tethering activity of VWF contributing to a pro-thrombotic state. This has been linked to the oxidation of methionine residues in the A1, A2 and A3 domains of VWF. The A1 domain binds to platelet surface receptors glycoprotein Ib α (GpIbα). This interaction has been shown to be inhibited under static conditions by the neighboring A2 domain...
2018: PloS One
https://www.readbyqxmd.com/read/30221276/morphology-of-soft-and-rough-contact-via-fluid-drainage
#20
Yumo Wang, Joelle Frechette
The dynamic of contact formation between soft materials immersed in a fluid is accompanied by fluid drainage and elastic deformation. As a result, controlling the coupling between lubrication pressure and elasticity provides strategies to design materials with reversible and dynamic adhesion to wet or flooded surfaces. We characterize the elastic deformation of a soft coating with nanometer-scale roughness as it approaches and contacts a rigid surface in a fluid environment. The lubrication pressure during the approach causes elastic deformation and prevents contact formation...
September 26, 2018: Soft Matter
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