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Prevention of adhesion formation

Svetlana I Galkina, Ekaterina A Golenkina, Galina M Viryasova, Yulia M Romanova, Galina F Sud'ina
BACKGROUND: Nitric oxide (NO) is a key signalling molecule that has an important role in inflammation. It can be secreted by endothelial cells, neutrophils, and other cells, and once in circulation, NO plays important roles in regulating various neutrophil cellular activities and fate. OBJECTIVE: To describe neutrophil cellular responses influenced by NO and its concomitant compound peroxynitrite and signalling mechanisms for neutrophil apoptosis. METHODS: Literature was reviewed to assess the effects of NO on neutrophils...
December 12, 2018: Current Medicinal Chemistry
H Chouirfa, H Bouloussa, V Migonney, C Falentin-Daudré
Implanted biomaterials play a key role in the current success of orthopedic and dental procedures. Pure titanium and its alloys are the most commonly used materials for permanent implants in contact with bone. However, implant-related infections remain among the leading reasons for failure. The most critical pathogenic event in the development of infection on biomaterials is biofilm formation, which starts immediately after bacterial adhesion. In the last decade, numerous studies reported the ability of titanium surface modifications and coatings to minimize bacterial adhesion, inhibit biofilm formation and provide effective bacterial killing to protect implanted biomaterials...
January 1, 2019: Acta Biomaterialia
Gokce Acun, Hakan Ozdemir, Oguzhan Sunamak, Zehra Unal Ozdemir, Emel Baskan, Mete Yazi, Berna Savas, Ugur Berberoglu
Background: Intra-abdominal adhesions and their complications following abdominal surgery are serious problems, with an incidence of 67-93%. Prevention of peritoneal adhesion formation may eliminate the need for surgical intervention, decreasing complications, morbidity, and cost. Bevacizumab is a recombinant monoclonal antibody which specifically binds vascular endothelial growth factor, an important cytokine in adhesion formation, and neutralizes its biological activity. We developed an experimental model in rats to determine the effect of bevacizumab in preventing adhesion formation and analyzed its effect both micro- and macroscopically...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Jimin Park, Minjung Park, Hyunseon Seo, Hyung-Seop Han, Ji-Young Lee, Dongkyu Koo, Kyeongsoo Kim, Pil-Ryung Cha, James Edwards, Young-Woon Kim, Kang-Sik Lee, Myoung-Ryul Ok, Hojeong Jeon, Hyun-Kwang Seok, Yu-Chan Kim
Utilization of biodegradable metals in biomedical fields is emerging because it avoids high-risk and uneconomic secondary surgeries for removing implantable devices. Mg and its alloys are considered optimum materials for biodegradable implantable devices because of their high biocompatibility; however, their excessive and uncontrollable biodegradation is a difficult challenge to overcome. Here, we present a novel method of inhibiting Mg biodegradation by utilizing reduced nicotinamide adenine dinucleotide (NADH), an endogenous cofactor present in all living cells...
December 10, 2018: Scientific Reports
Sebastiaan Zijl, Aliaksei S Vasilevich, Priyalakshmi Viswanathan, Ayelen Luna Helling, Nick R M Beijer, Gernot Walko, Ciro Chiappini, Jan de Boer, Fiona M Watt
Human epidermal stem cells initiate terminal differentiation when spreading is restricted on ECM-coated micropatterned islands, soft hydrogels or hydrogel-nanoparticle composites with high nanoparticle spacing. The effect of substrate topography, however, is incompletely understood. To explore this, primary human keratinocytes enriched for stem cells were seeded on a topographical library with over 2000 different topographies in the micrometre range. Twenty-four hours later the proportion of cells expressing the differentiation marker Transglutaminase-1 was determined by high content imaging...
December 5, 2018: Acta Biomaterialia
Konstantinos Bouliaris, Eftihia Asprodini, Panagiotis Liakos, Alexandros Diamantis, Georgios Koukoulis, Christina Befani, Stella Tzika, Konstantinos Tepetes
BACKGROUND: The use of surgical meshes in ventral hernia repair has significantly reduced hernia recurrence rates. However, when placed intraperitoneally prosthetic materials can trigger the development of peritoneal adhesions. The present experimental study evaluated the combined icodextrin 4% and dimetindene maleate treatment in preventing peritoneal adhesion formation to polypropylene and titanium-coated polypropylene meshes. MATERIALS AND METHODS: Sixty female white rabbits were divided into four groups...
February 2019: Journal of Surgical Research
Yong Fan, Beatrice Xuan Ho, Jeremy Kah Sheng Pang, Nicole Min Qian Pek, Jin Hui Hor, Shi-Yan Ng, Boon-Seng Soh
BACKGROUND: The Wnt/β-catenin signaling pathway plays an important role in the development of second heart field (SHF Isl1+) that gives rise to the anterior heart field (AHF) cardiac progenitor cells (CPCs) for the formation of the right ventricle, outflow tract (OFT), and a portion of the inflow tract (IFT). During early cardiogenesis, these AHF CPCs reside within the pharyngeal mesoderm (PM) that provides a microenvironment for them to receive signals that direct their cell fates. Here, N-cadherin, which is weakly expressed by CPCs, plays a significant role by promoting the adhesion of CPCs within the AHF, regulating β-catenin levels in the cytoplasm to maintain high Wnt signaling and cardioproliferation while also preventing the premature differentiation of CPCs...
December 7, 2018: Stem Cell Research & Therapy
Michael Spartalis, Eleftherios Spartalis, Eleni Tzatzaki, Diamantis I Tsilimigras, Demetrios Moris, Christos Kontogiannis, Vaios Vasileios Kaminiotis, Stavroula A Paschou, Sofia Chatzidou, Gerasimos Siasos, Vassilis Voudris, Dimitrios C Iliopoulos
BACKGROUND: Lipid-lowering therapy and control of cardiovascular risk factors are the current recommendations of atherosclerotic disease management. Despite optimal treatment though the rate of acute coronary syndrome events remains high. Inflammation plays an essential role in the pathophysiology of atherosclerotic plaque formation, progression and rupture, which conclusively causes acute clinical episodes. OBJECTIVE: This review aims to give a conceptual description of the potential therapeutic benefits and effects of colchicine in inflammation-mediated atherosclerotic disease and hypertriglyceridemia...
December 10, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
Sultan Can, Gamze Kirpinar, Ozlem Dural, Burcin Balci Karamustafaoglu, Inci Sema Tas, Cenk Yasa, Funda Gungor Ugurlucan
Background and Objectives: The authors sought to assess the effect of the use of a new crosslinked hyaluronan (NCH) gel on the prevention of intrauterine adhesions (IUAs) in women underwent curettage in the second trimester. Methods: Between June 2016 and September 2017, 60 patients who underwent curettage for retained placental tissue after medically induced or spontaneous pregnancy loss in the second trimester were enrolled in the study. The patients were randomly assigned to 1 of 2 groups: Group 1 patients received curettage plus NCH gel (intervention group), and group 2 patients received curettage alone (control group)...
October 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Peixi Liu, Yuan Shi, Zhiyuan Fan, Yingjie Zhou, Yaying Song, Yingjun Liu, Guo Yu, Qingzhu An, Wei Zhu
Cerebral aneurysm growth is characterized by vessel wall frailness, although the underlying cellular mechanisms are unclear. Here, we examined the relationship between inflammatory smooth muscle cells (SMCs) and endothelial cells (ECs) in cerebral aneurysms, including the mechanisms underlying inflammatory SMC-induced changes in ECs. Five saccular cerebral aneurysms were collected and five temporal artery samples were used as controls. Cells and cytokines were detected by immunohistochemistry and TUNEL (transferase dUTP nick end labeling) assays performed to evaluate apoptosis...
November 30, 2018: Cell Transplantation
Hosseinali Jelveh Moghaddam, Marjan Aghajani, Ehsan Raeis-Abdollahi, Mahdieh Faghihi, Ali Dabbagh, Alireza Imani
OBJECTIVES: Some degrees of postoperative cardiac adhesions occur in response to the first cardiac surgery in patients that may limit surgeons for subsequent operations and increase the risk of heart injury. In this article, we established a model of postoperative pericardial adhesions, and because vascular endothelial growth factor (VEGF) seems to initiate adhesion formation through inflammatory responses, we used an anti-VEGF antibody, that is, bevacizumab, to examine its effects on postoperative adhesion formation...
November 26, 2018: Surgical Innovation
Myung-Hyun Park, Ji-Hwan Ha, Moonwoo La, Young-Bae Ko, Dongearn Kim, Sung-Hoon Park
Frost presents a serious problem for the human environment, resulting in such phenomena as downed power lines, damaged crops and stalled aircraft. In addition, frost and ice accumulation significantly decrease the performance of ships, wind turbines, and HVAC systems with high failure risk. Super-hydrophobic (SH) surface can be an appropriate solution for frost problems, due to its anti-icing properties that can prevent ice nucleation on the surface. In addition, in the case of conducting SH surface using carbon nanotubes (CNTs) as a filler, it can form an excellent heating unit, owing to the resistive heating effect...
March 1, 2019: Journal of Nanoscience and Nanotechnology
Pei-Pei Lin, You-Miin Hsieh, Cheng-Chih Tsai
PURPOSE: Consumption of refined foods and beverages high in sugar make the teeth susceptible to the formation of biofilm and may lead to dental caries. The aim of the present study was to determine the ability of selected probiotics to inhibit growth and biofilm formation by the cariogenic bacterium Streptococcus mutans in vitro. MATERIALS AND METHODS: Strains of latic acid bacteria (LAB) (n = 120) from the Bioresources Collection and Research Center (BCRC), saliva of healthy adults and infant stool were screened...
2018: Oral Health & Preventive Dentistry
Young-Tae Kwon, Yun-Sung Kim, Yongkuk Lee, Shinjae Kwon, Minseob Lim, Yoseb Song, Yong-Ho Choa, Woon-Hong Yeo
Inkjet-printed electronics using metal particles typically lack electrical conductivity and interfacial adhesion with an underlying substrate. To address the inherent issues of printed materials, this paper introduces advanced materials and processing methodologies. Enhanced adhesion of the inkjet-printed copper (Cu) on a flexible polyimide film is achieved by using a new surface modification technique, a nanostructured self-assembled monolayer (SAM) of (3-mercaptopropyl)trimethoxysilane. A standardized adhesion test reveals the superior adhesion strength (1192...
November 19, 2018: ACS Applied Materials & Interfaces
Michael Adam Meledeo, Qiyong Peter Liu, Grantham C Peltier, Ryan C Carney, Colby S McIntosh, Ashley S Taylor, James A Bynum, Anthony E Pusateri, Andrew P Cap
BACKGROUND: Dried plasmas can overcome logistical barriers that prevent fresh frozen plasma (FFP) usage in acute resuscitation, but processing of these products can detrimentally alter the composition. Spray-dried plasma (SpDP) from single units is deficient in high-molecular-weight multimers of von Willebrand factor (vWF), a critical facilitator of platelet adhesion and thrombus formation. We hypothesized that converting high-molecular-weight multimers to smaller-molecular-weight multimers would retain vWF's capacity to mediate platelet adhesion...
November 19, 2018: Transfusion
Xiaoyun Zhang, Xiaodong Cui, Xin Li, Hong Yan, Hong Li, Xiumei Guan, Yuzhen Wang, Shunmei Liu, Xuebin Qin, Min Cheng
AIMS: Endothelial progenitor cells (EPCs) play a crucial role in postnatal angiogenesis and neovascularization. Inward rectifier potassium channel 2.1 (Kir2.1) have been identified in EPCs. However, the effect of Kir2.1 on EPC function is not known. Here, we try to establish the role of Kir2.1 channels in EPC function and to provide first insights into the mechanisms. METHODS AND RESULTS: We first observed that the expression of Kir2.1 gradually decreased with the differentiation of EPCs into ECs in gene and protein levels...
November 14, 2018: Journal of Molecular and Cellular Cardiology
Donato Gemmati, Savino Occhionorelli, Veronica Tisato, Marco Vigliano, Giovanna Longo, Arianna Gonelli, Maria G Sibilla, Maria L Serino, Paolo Zamboni
Abdominal adhesions (AA) account for the most common complication of peritoneal surgery with bowel obstruction being the severest problem in the absence of effective predicting biomarkers. Anti-AA-barriers or adhesiolysis did not completely prevent bowel obstruction, although there is evidence they might reduce related complications requiring reoperation. In addition, gender-related predispositions have not been adequately investigated. We explored the role of coagulation Factor XIII (F13A1 and F13B subunit-genes) in patients following laparotomy, mostly median/lower median incision line...
November 16, 2018: Scientific Reports
Wei Zhuo, Yiman Liu, Shuang Li, Dongyang Guo, Qiang Sun, Juan Jin, Xianping Rao, Mengjie Li, Meng Sun, Mingchun Jiang, Yanjun Xu, Lisong Teng, Yongfeng Jin, Jianmin Si, Wei Liu, Yibin Kang, Tianhua Zhou
BACKGROUND & AIMS: We aimed to identify long non-coding RNAs (lncRNAs) that are upregulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS: We collected gastric tumor and non-tumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, proteins by immunohistochemistry, and RNAs by quantitative reverse transcription-PCR; we compared these with survival times of patients and tumor progression...
November 13, 2018: Gastroenterology
Wan Jung Lu, Chi Li Chung, Ray Jade Chen, Li Ting Huang, Li Ming Lien, Chao Chien Chang, Kuan Hung Lin, Joen Rong Sheu
Phospholipase D (PLD) is involved in many biological processes. PLD1 plays a crucial role in regulating the platelet activity of mice; however, the role of PLD in the platelet activation of humans remains unclear. Therefore, we investigated whether PLD is involved in the platelet activation of humans. Our data revealed that inhibition of PLD1 or PLD2 using pharmacological inhibitors effectively inhibits platelet aggregation in humans. However, previous studies have showed that PLD1 or PLD2 deletion did not affect mouse platelet aggregation in vitro , whereas only PLD1 deletion inhibited thrombus formation in vivo ...
November 14, 2018: Journal of Clinical Medicine
Valentina Palmieri, Francesca Bugli, Margherita Cacaci, Giordano Perini, Flavio De Maio, Giovanni Delogu, Riccardo Torelli, Claudio Conti, Maurizio Sanguinetti, Marco De Spirito, Robertino Zanoni, Massimiliano Papi
AIM: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. METHODS: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO-CU-PEG) were drop-casted on surfaces and antifungal efficacy was assessed...
November 15, 2018: Nanomedicine
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