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Cannabis psychosis

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https://www.readbyqxmd.com/read/30118824/the-interaction-between-the-znf804a-gene-and-cannabis-use-on-the-risk-of-psychosis-in-a-non-clinical-sample
#1
Jordi Soler, Bárbara Arias, Jorge Moya, Manuel Ignacio Ibáñez, Generós Ortet, Lourdes Fañanás, Mar Fatjó-Vilas
The ZNF804A gene and cannabis use are risk factors for psychosis and both have also been associated with schizotypal traits. This study aimed to investigate: i) the association of lifetime cannabis use (and its dose effect) with schizotypal personality traits, and ii) whether the genetic variability at ZNF804A gene modulates that association. Our sample consisted of 385 Spanish non-clinical subjects (43.1% males, mean age = 21.11(2.19)). Schizotypy was evaluated using the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (SPQ-CP), Interpersonal (SPQ-I) and Disorganized (SPQ-D)...
August 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30118435/first-break-psychosis-in-a-young-military-veteran-with-cannabis-use-disorder-an-educational-case-report
#2
Paulina Riess, Leo Sher
No abstract text is available yet for this article.
August 17, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/30086471/impact-of-comprehensive-treatment-for-first-episode-psychosis-on-substance-use-outcomes-a-randomized-controlled-trial
#3
Corinne Cather, Mary F Brunette, Kim T Mueser, Steven F Babbin, Robert Rosenheck, Christoph U Correll, Piper Kalos-Meyer
Lifetime co-occurring substance use disorders are common at the time of presentation for treatment of a first episode of primary psychosis and persistent substance use disorder (SUD) leads to poorer outcomes. We assessed whether the NAVIGATE program, a coordinated specialty care service that includes optional substance abuse content reduced substance use compared to usual care in 404 individuals in the Recovery After Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study. Participants were randomized to two years of NAVIGATE (n = 223) or usual care (n = 181) and assessed monthly for substance use...
July 24, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30055217/overlaps-in-pharmacology-for-the-treatment-of-chronic-pain-and-mental-health-disorders
#4
REVIEW
Ainsley M Sutherland, Judith Nicholls, James Bao, Hance Clarke
There is significant overlap in the pharmacological management of pain and psychological disorders. Appropriate treatment of patients' comorbid psychological disorders, including sleep disturbances often leads to an improvement in reported pain intensity. The three first line agents for neuropathic pain include tricyclic antidepressants and serotonin norepinephrine reuptake inhibitors which are medications originally developed as antidepressants. The other first line medication for chronic neuropathic pain are anticonvulsant medications initially brought to the market-place for the treatment of epilepsy and are also now being used for the treatment of anxiety disorders and substance withdrawal symptoms...
July 25, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30053703/age-moderates-the-association-between-frequent-cannabis-use-and-negative-schizotypy-over-time
#5
Lucy Albertella, Mike E Le Pelley, Murat Yücel, Jan Copeland
The current study examined whether age and frequent cannabis use interact to influence the trajectories of positive and negative schizotypy over time. Participants were 155 cannabis users, aged 15-24 years old, assessed over a 12-month period at 6-monthly intervals. The analyses examined the influence of age, frequent use, and time on positive and negative schizotypy. The current study found that among frequent cannabis users, younger age was associated with increased negative schizotypy over time, while among occasional cannabis users, younger age was associated with decreasing negative schizotypy over time...
July 19, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/30042029/parcellating-cognitive-heterogeneity-in-early-psychosis-spectrum-illnesses-a-cluster-analysis
#6
Jacob J Crouse, Ahmed A Moustafa, Sophia E R Bogaty, Ian B Hickie, Daniel F Hermens
Cognitive impairment is argued to represent a core feature of psychosis-spectrum illnesses. However, within-diagnosis heterogeneity is common, and risk factors for poor cognition remain to be examined after statistically accounting for heterogeneity. Accordingly, we used a data-driven technique (cluster analysis) to empirically-derive cognitive clusters across diagnoses and examined whether concurrent substance use or a history of a neurodevelopmental/behavioral disorder differed between clusters. Data from 135 young help-seekers (aged 12-30 years) with a psychosis-spectrum illness were retrospectively analyzed...
July 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/30022956/cannabis-a-significant-risk-factor-for-violent-behavior-in-the-early-phase-psychosis-two-patterns-of-interaction-of-factors-increase-the-risk-of-violent-behavior-cannabis-use-disorder-and-impulsivity-cannabis-use-disorder-lack-of-insight-and-treatment-adherence
#7
Valerie Moulin, Philipp Baumann, Mehdi Gholamrezaee, Luis Alameda, Julie Palix, Jacques Gasser, Philippe Conus
Background: Previous literature suggests that prevalence of cannabis use in the early phase of psychosis is high, and that early psychosis patients are at high-risk for violent behavior. However, the link between cannabis use and violent behavior in early psychosis patients is unclear. We carried out a study on a sample of early psychosis patients, in order to explore the impact of cannabis use on the risk of violent behavior (VB), while taking into account (1) potential confounding factors and, (2) interactions with other dynamic risk factors of VB...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29977266/illicit-drug-use-and-violence-in-acute-psychosis-among-acute-adult-admissions-at-a-south-african-psychiatric-hospital
#8
Robert Wicomb, Lyndall Jacobs, Naasika Ebrahim, Megan Rensburg, Muiruri Macharia
Background and objective: The prevalence of mental illness and illicit substance use has increased markedly in South Africa's Western Cape Province, over the last 2 decades; potentially increasing demand for psychiatric care. This paper describes the demographic and substance use profile of patients admitted to Lentegeur (LGH), the largest of the four psychiatric hospitals in the Province. Methods: Medical records, patient interviews and other clinical notes were used to collect data on demographics, illicit substance use, violent behaviour and utilization of rehabilitative services for patients (n=535) admitted to LGH between 1 August 2012 and 31 January 2013...
March 2018: African Health Sciences
https://www.readbyqxmd.com/read/29965876/cannabis-use-psychotic-like-experiences-and-aberrant-salience-in-a-sample-of-belgian-students
#9
Francesco Bernardini, Chiara Gobbicchi, Luigi Attademo, Severin Puchalski, Riccardo Trezzi, Patrizia Moretti, Alfonso Tortorella, Gwenolé Loas
The main goal of our study was to investigate the association between psychotic-like experiences, aberrant salience, and cannabis use in a nonclinical sample of Belgian students. The participants were asked to complete a self-report questionnaire on cannabis use. The Community Assessment of Psychic Experiences and the Aberrant Salience Inventory were used to assess psychotic-like experiences and aberrant salience. The final sample was of 257 students. Cannabis users showed significantly higher Aberrant Salience Inventory score and, concerning the Community Assessment of Psychic Experiences, higher total, positive, and negative dimension scores...
July 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29935939/modulation-of-acute-effects-of-delta-9-tetrahydrocannabinol-on-psychotomimetic-effects-cognition-and-brain-function-by-previous-cannabis-exposure
#10
Marco Colizzi, Philip McGuire, Vincent Giampietro, Steve Williams, Mick Brammer, Sagnik Bhattacharyya
Cannabis use has been associated with psychosis and cognitive dysfunction. Some evidence suggests that the acute behavioral and neurocognitive effects of the main active ingredient in cannabis, (-)-trans-Δ9-tetrahydrocannabinol (∆9-THC), might be modulated by previous cannabis exposure. However, this has not been investigated either using a control group of non-users, or following abstinence in modest cannabis users, who represent the majority of recreational users. Twenty-four healthy men participated in a double-blind, randomized, placebo-controlled, repeated-measures, within-subject, ∆9-THC challenge study...
July 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29930934/synthetic-and-non-synthetic-cannabinoid-drugs-and-their-adverse-effects-a-review-from-public-health-prospective
#11
REVIEW
Koby Cohen, Aviv M Weinstein
There is a growing use of novel psychoactive substances containing synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis, yet, these drugs are more potent and dangerous, and have been associated with dangerous adverse effects. Here, we review current literature on the epidemiology, acute, and chronic effects of synthetic and natural cannabinoid-based drugs. Synthetic drugs contain a mixture of psychoactive compounds that mostly bind cannabinoid receptors with high potency...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29927066/cannabis-use-as-a-risk-factor-for-psychotic-like-experiences-a-systematic-review-of-non-clinical-populations-evaluated-with-the-community-assessment-of-psychic-experiences
#12
REVIEW
Taciana C C Ragazzi, Rosana Shuhama, Paulo R Menezes, Cristina M Del-Ben
AIM: Epidemiological data have provided evidence that psychotic-like experiences (PLEs) can occur in the general population, not necessarily accompanied by the impairment and suffering observed in formal psychiatric diagnoses. According to the psychosis continuum hypothesis, PLEs would be subject to the same risk factors as frank psychosis. The aim of this review was to summarize observational studies that evaluated cannabis use as a risk factor for PLEs as determined by the Community Assessment of Psychic Experiences in non-clinical samples...
June 21, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#13
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29861266/age-of-onset-of-cannabis-use-and-cognitive-function-in-first-episode-non-affective-psychosis-patients-outcome-at-three-year-follow-up
#14
Esther Setién-Suero, Obdulia Martínez-García, Víctor Ortiz-García de la Foz, Javier Vázquez-Bourgon, Patricia Correa-Ghisays, Adele Ferro, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola
BACKGROUND: In recent years, the effects of cannabis use on cognitive functions in patients with psychosis have been widely studied. Recently, special emphasis has been placed on the impact of age at the onset of consumption on cognition in these patients. METHOD: 349 patients with a first episode of non-affective psychosis were studied. Patients were classified as cannabis users and non-users. Users were divided, according to their age when they began using cannabis, into: early-onset (age < 16) and late-onset (age ≥ 16) users...
May 31, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29808787/links-between-psychotic-and-neurotic-symptoms-in-the-general-population-an-analysis-of-longitudinal-british-national-survey-data-using-directed-acyclic-graphs
#15
J Kuipers, G Moffa, E Kuipers, D Freeman, P Bebbington
BACKGROUND: Non-psychotic affective symptoms are important components of psychotic syndromes. They are frequent and are now thought to influence the emergence of paranoia and hallucinations. Evidence supporting this model of psychosis comes from recent cross-fertilising epidemiological and intervention studies. Epidemiological studies identify plausible targets for intervention but must be interpreted cautiously. Nevertheless, causal inference can be strengthened substantially using modern statistical methods...
May 29, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29807550/childhood-trauma-and-cannabis-associated-microstructural-white-matter-changes-in-patients-with-psychotic-disorder-a-longitudinal-family-based-diffusion-imaging-study
#16
Patrick Domen, Stijn Michielse, Sanne Peeters, Wolfgang Viechtbauer, Jim van Os, Machteld Marcelis
BACKGROUND: Decreased white matter (WM) integrity in patients with psychotic disorder has been a consistent finding in diffusion tensor imaging (DTI) studies. However, the contribution of environmental risk factors to these WM alterations is rarely investigated. The current study examines whether individuals with (increased risk for) psychotic disorder will show increased WM integrity change over time with increasing levels of childhood trauma and cannabis exposure. METHODS: DTI scans were obtained from 85 patients with a psychotic disorder, 93 non-psychotic siblings and 80 healthy controls, of which 60% were rescanned 3 years later...
May 29, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29799917/association-of-urbanicity-with-psychosis-in-low-and-middle-income-countries
#17
Jordan E DeVylder, Ian Kelleher, Monique Lalane, Hans Oh, Bruce G Link, Ai Koyanagi
Importance: Urban residence is one of the most well-established risk factors for psychotic disorder, but most evidence comes from a small group of high-income countries. Objective: To determine whether urban living is associated with greater odds for psychosis in low- and middle-income countries (LMICs). Design, Setting, and Participants: This international population-based study used cross-sectional survey data collected as part of the World Health Organization (WHO) World Health Survey from May 2, 2002, through December 31, 2004...
July 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29785763/is-bdnf-val66met-polymorphism-associated-with-psychotic-experiences-and-psychotic-disorder-outcome-evidence-from-a-6-years-prospective-population-based-cohort-study
#18
Umut Kirli, Tolga Binbay, Marjan Drukker, Hayriye Elbi, Bülent Kayahan, Duygu Keskin Gökçelli, Ferda Özkınay, Hüseyin Onay, Köksal Alptekin, Jim van Os
There is little research on genetic risk for the extended psychosis phenotype ranging from psychotic experiences (PEs) to psychotic disorders (PDs). In this general population-based prospective cohort study, the longitudinal associations between BDNF-Val66Met polymorphism and the different levels of the extended psychosis phenotype were investigated. Addresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighborhoods at baseline (n = 4011). A nested case-control study (n = 366) recruited individuals with PEs and PDs as well as individuals with no psychotic symptoms...
May 21, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29769496/substance-use-among-the-patients-with-first-episode-psychosis
#19
M S Ahsan, M S Mullick, K Begum, S M Arafat, M A Shah, B R Podder, J Roy
Substance Use Disorder is a frequent problem in Bangladesh and many of these patients develop psychosis. Substance use can cause psychosis and it can modify the course of psychosis. This cross-sectional study was done to see the proportion of substance use in patients with First-Episode Psychosis (FEP) in two tertiary care hospitals in Dhaka, Bangladesh mentioned here as Bangabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital; from November 2007 March 2009. Fifty consecutive FEP patients were taken as subjects and 50 healthy attendants were recruited as control...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29766209/is-cannabis-a-risk-factor-for-suicide-attempts-in-men-and-women-with-psychotic-illness
#20
A Waterreus, P Di Prinzio, J C Badcock, M Martin-Iverson, A Jablensky, V A Morgan
OBJECTIVE: To investigate whether recent cannabis use by men and women with psychotic disorders was associated with increased risk of suicide attempt, and to determine associated factors, stratified by sex. METHODS: Data from 1065 men and 725 women interviewed in the Australian national survey of psychosis were analysed to model separately, for each sex, the impact of daily, casual or no past-year cannabis use and other risk factors including age, on a past-year suicide attempt...
May 16, 2018: Psychopharmacology
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