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Anne B Kruse, Dodji L Akakpo, Rabie Maamar, Johan P Woelber, Ali Al-Ahmad, Kirstin Vach, Petra Ratka-Krueger
BACKGROUND: Air-polishing appears to be a promising procedure for subgingival biofilm removal in periodontal treatment. The aim of this study was to compare trehalose powder for subgingival air-polishing with sonic debridement in residual periodontal pockets during maintenance therapy. METHODS: In this blinded, randomized, controlled clinical trial conducted over 6 months with a split-mouth design, single-rooted teeth in 44 participants with residual pocket depths of 5 mm and bleeding or > 5 mm with and without bleeding were included in this study...
October 12, 2018: Journal of Periodontology
Claire E Garabedian, Fiona Kelly
This paper reports on research exploring the effects of music played for 12 dyads: a care home resident ('resident') with dementia and someone closely connected to him/her ('carer'). Six individualised music interventions (3 live and 3 pre-recorded) were played by the first author on solo cello within five Scottish non-NHS care homes. All interventions were video-recorded. Semi-structured interviews with carer participants, key staff, and managers explored their responses to interventions. Thick descriptions of video recordings and interview transcripts were thematically coded using Nvivo...
October 11, 2018: Dementia
Juan Bautista Blanco-Canosa, Judith Palà-Pujadas, Fernando Albericio
A simple procedure for C-terminal activation of peptides in solution and its application in native chemical ligation and protein synthesis is described. This method involves a mild thioesterification based on the conversion of an aryloxy-o-methylaminoanilide to thioester under aqueous conditions and in situ ligation with an N-terminal cysteine peptide. The versatility is shown in ph-controlled sequential ligations. To illustrate the usefulness of this methodology, we synthesized the palmitoylated N-terminal domain of human Sonic Hedgehog, a morphogen protein that binds the transmembrane receptor Patched and activates the Hedgehog signaling pathway, involved in embryonic development and in the proliferation of many tumors...
October 11, 2018: Angewandte Chemie
Xiao-Li Niu, Xin Jiang, Guo-Dong Xu, Gui-Min Zheng, Zhi-Peng Tang, Nan Yin, Xiu-Qin Li, Yan-Yan Yang, Pei-Yuan Lv
BACKGROUND: DL-3-n-butylphthalide (NBP) has been approved to be effective in improving cognitive deficits. The aim of the current study was to determine whether NBP protects against cognitive deficits in a rat model of vascular dementia (VD) induced by chronic cerebral hypoperfusion (CCH) by regulating the sonic hedgehog (Shh)/patched1 (Ptch1) pathway and endoplasmic reticulum stress (ERS)-related markers. METHODS: Adult male Sprague-Dawley rats were subjected to permanent bilateral occlusion of the common carotid arteries (2VO) to established the model of VD...
October 10, 2018: Journal of Cellular Physiology
Shuyun Wang, Shan Huang, Lianghui Gong, Zhize Yuan, Joshua Wong, Jeffrey Lee, Ming-Sing Si
Newborns with critical congenital heart disease are at significant risk of developing heart failure later in life. Because treatment options for end-stage heart disease in children are limited, regenerative therapies for these patients would be of significant benefit. During neonatal cardiac surgery, a portion of the thymus is removed and discarded. This discarded thymus tissue is a good source of MSCs that we have previously shown to be proangiogenic and to promote cardiac function in an in vitro model of heart tissue...
2018: Stem Cells International
Nicaellen Roberta da Silva Souza, Sandro Navickiene
Background : A simple and effective extraction method based on ultrasonic solvent extraction and liquid-liquid microextraction (as the cleaning step) was developed to determine seven pesticide residues in roasted coffee ( Coffea arabica ) using ultra-performance LC-tandem MS. Objective : Different parameters of the method were evaluated, including solvent type and amount and sonication time. The best results were obtained using 1.0 g roasted coffee and acetonitrile (5 mL) as the extraction solvent with sonication for 15 min...
October 10, 2018: Journal of AOAC International
Alexander Okrut, Martina Aigner, Christian Schöttle, Nicolás A Grosso-Giordano, Son-Jong Hwang, Xiaoying Ouyang, Stacey Zones, Alexander Katz
We report a scalable delamination procedure for a SSZ-70-framework layered-zeolite precursor, which for the first time does not involve either sonication or long-chain surfactants. Our approach instead relies on the mild heating of layered zeolite precursor B-SSZ-70(P) in an aqueous solution containing Zn(NO3)2 and tetrabutylammonium fluoride. Powder X-ray diffraction data are consistent with a loss of long-range order along the z-direction, while 29Si MAS NMR spectroscopy demonstrates preservation of the zeolite framework crystallinity during delamination...
October 10, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Anne-Laure Védie, Olivier Sutter, Marianne Ziol, Jean-Charles Nault
Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10-20%) and malignant transformation into hepatocellular carcinoma (<5%). A molecular classification has been recently updated in six major subgroups, linked to risk factors, histology, imaging and clinical features: adenomas inactivated for HNF1A , inflammatory adenomas, β-catenin-activated adenomas mutated in exon 3, β-catenin-activated adenomas mutated in exon 7-8, sonic hedgehog adenomas, and unclassified adenomas...
January 2018: Hepatic Oncology
Amankeldi A Salybekov, Ainur K Salybekova, Roberto Pola, Takayuki Asahara
The Hedgehog (HH) signaling pathway plays an important role in embryonic and postnatal vascular development and in maintaining the homeostasis of organs. Under physiological conditions, Sonic Hedgehog (SHH), a secreted protein belonging to the HH family, regulates endothelial cell growth, promotes cell migration and stimulates the formation of new blood vessels. The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed...
October 5, 2018: International Journal of Molecular Sciences
Didier Frappaz, Cécile Faure-Conter, David Meyronet, Alice Levard-Bonneville, Pierre-Aurélien Beuriat, Marie P Sunyach, Marc Barritault
PURPOSE OF REVIEW: Medulloblastoma is no more a unique disease. Clinical and biologic classification used so far are challenged by molecular classification(s). Following the consensus article that described four molecular groups of medulloblastoma in 2012, several articles in 2017 provided more relevant classifications that may impact on further clinical trial design. RECENT FINDINGS: Though wingless (WNT) and sonic hedgehog (SHH) are defined by the activation of their respective pathways, the age and type of activation define various subgroups with specific features and outcome...
October 8, 2018: Current Opinion in Neurology
Maria Tsoli, Carol Wadham, Mark Pinese, Tim Failes, Swapna Joshi, Emily Mould, Julia X Yin, Velimir Gayevskiy, Amit Kumar, Warren Kaplan, Paul G Ekert, Federica Saletta, Laura Franshaw, Jie Liu, Andrew Gifford, Martin A Weber, Michael Rodriguez, Richard J Cohn, Greg Arndt, Vanessa Tyrrell, Michelle Haber, Toby Trahair, Glenn M Marshall, Kerrie McDonald, Mark J Cowley, David S Ziegler
Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges in their treatment is inter- and intra-tumoral heterogeneity. Precision medicine approaches have the potential to enhance diagnostic, prognostic and/or therapeutic information. In this case study we describe the molecular characterization of a pediatric HGG and the use of an integrated approach based on genomic, in vitro and in vivo testing to identify actionable targets and treatment options...
October 9, 2018: Cancer Biology & Therapy
Sandra S Gkermpoura, Konstantinia D Papadimitriou, Emmanuel N Skountzos, Ioannis Polyzos, Maria Giovanna Pastore Carbone, Athanasios Kotrotsos, Vlasis G Mavrantzas, Costas Galiotis, Constantinos Tsitsilianis
3-Arm PMMAs end-functionalized by pyrene were designed as dispersing/stabilizing agents for the liquid-phase exfoliation of graphite in low-boiling point solvents like chloroform. The synthetic procedure comprised ARGET ATRP controlled polymerization, click chemistry and the quaternization reaction of triazole, ensuring tailor-made, well-defined pyrene-functional star PMMAs. Among a series of different pyrene-functional macromolecular topologies, the (PMMA-py2)3 proved the most efficient exfoliation agent giving relatively high graphene concentration (0...
October 9, 2018: Nanoscale
Shahram Seidi, Negar Sabahi Moosavi, Maryam Shanehsaz, Marzieh Abdolhosseini, Seyed Jamal Sadeghi
This study describes an ultrasonic assisted magnetic dispersive solid phase extraction based on oleic acid functionalized magnetic graphene oxide followed by HPLC-UV. The method was applied for simultaneous determination of ibuprofen, diclofenac, naproxen and mefenamic acid in urine. Applying of sonication led to well-dispersion of the sorbent and consequently, significant shortening of the extraction time. The sorbent was successfully characterized by different instrumental analysis. The influence of adsorption parameters were optimized using a rotational central composite design...
October 9, 2018: Journal of Separation Science
Baozhen Zhang, Mingbin Zheng, Lintao Cai, Xiujun Fan
An effective cancer therapeutic method reduces and eliminates tumors with minimal systemic toxicity. Actively targeting nanoparticles offer a promising approach to cancer therapy. The glycosaminoglycan placental chondroitin sulfate A (plCSA) is expressed on a wide range of cancer cells and placental trophoblasts, and malarial protein VAR2CSA can specifically bind to plCSA. A reported placental chondroitin sulfate A binding peptide (plCSA-BP), derived from malarial protein VAR2CSA, can also specifically bind to plCSA on cancer cells and placental trophoblasts...
September 18, 2018: Journal of Visualized Experiments: JoVE
R C D Swimberghe, A De Clercq, R J G De Moor, M A Meire
AIM: To evaluate the efficacy of sonically, ultrasonically, and laser-activated irrigation in removing a biofilm-mimicking hydrogel from the isthmus in a root canal model. METHODOLOGY: Transparent resin blocks containing 2 standardized root canals (apical diameter of 0.3 mm, 6% taper, 16 mm long, with a coronal reservoir) connected by an isthmus (0.15 mm wide, 2 mm high) were used as the test model. The isthmus was filled with a hydrogel containing dentine debris...
October 8, 2018: International Endodontic Journal
Jian-Ping Xia, Ding Jia, Hong-Xiang Sun, Shou-Qi Yuan, Yong Ge, Qiao-Rui Si, Xiao-Jun Liu
Topological acoustics has recently revolutionized fundamental concepts of acoustic propagation, giving rise to strikingly unique acoustic edge modes immune to backscattering. Despite the rapid progress in this field, simultaneous realization of reconfigurability, intelligentization, and automatic control over acoustic propagation paths is posing a great challenge. This challenge is overcome by proposing the concept of a programmable acoustic topological insulator based on two digital elements "0" or "1," which consist of honeycomb-lattice sonic crystals made of cylindrical rods with different diameters...
October 8, 2018: Advanced Materials
Daniélen Dos Santos Silva, Carine Souza Dos Santos, Luzia Aparecida Pando, Mário Sérgio Rocha Gomes, Cleber Galvão Novaes, Walter Nei Lopes Dos Santos, Marcos Almeida Bezerra
Doehlert design and desirability function were used in the optimization of an ultrasound assisted dissolution method of fish fillet samples with tetramethyl ammonium hydroxide (TMAH) for the determination of Ca, Fe, Zn and Mg by flame atomic absorption spectrometry. The variables values after optimization were 620 μL (volume of TMAH), 25 min (sonication time) and 46 °C (bath temperature). The quantification limits for Ca, Mg, Fe and Zn were 56, 107, 23 and 2.9 μg g-1 , respectively. Accuracy was evaluated by comparing the results generated from the analysis of the samples treated by the proposed method and by wet digestion...
February 1, 2019: Food Chemistry
Jorge S Almeida, Gabriel L Santos, Geovani C Brandão, Maria G A Korn, Leonardo S G Teixeira
A method for simultaneous determination of Fe (232.036 nm) and Ni (232.195 nm) in vegetable oil samples by high-resolution continuum source graphite furnace atomic absorption spectrometry (HR-CS GF AAS) after an acid extraction of the analytes is proposed. In the extraction step, hydrochloric, nitric and acetic acid solutions were tested. The optimization of the procedure was performed by applying Doehlert matrix, and multiple response was used for simultaneous evaluation of the performance of the extraction...
February 1, 2019: Food Chemistry
Atsushi Matsumoto, Yukifumi Uesono
The cutoff phenomenon that long-chain alcohols are unable to induce anesthesia is observed for various antimicrobial activities, although its mechanism has remained unknown for over eight decades. The minimum inhibitory concentrations at 25°C for budding yeast growth exponentially decreased with increasing chain length of the n-alcohols (C1 - C12), whereas alcohols (≥C13) lost the inhibitory effect. Thus, the growth inhibition by n-alcohols obeys the Meyer - Overton correlation up to C12 and exhibits a cutoff phenomenon...
October 5, 2018: Molecular Pharmacology
Tanya S Corman, Solsire E Bergendahl, Douglas J Epstein
Sonic hedgehog (Shh) plays well characterized roles in brain and spinal cord development, but its functions in the hypothalamus have been more difficult to elucidate due to the complex neuroanatomy of this brain area. Here, we utilize fate-mapping and conditional deletion models in mice to define requirements for dynamic Shh activity at distinct stages of tuberal hypothalamic development, a brain region with important homeostatic functions. At early time points, Shh signaling regulates dorsoventral patterning, neurogenesis, and the size of the ventral midline...
October 5, 2018: Development
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