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Guilherme de Souza E Cassia, César Augusto Pinheiro Ferreira Alves, Ajay Taranath, Nicolás Sgarbi López, Ozgur Oztekin, Fabrício Guimarães Gonçalves, Zoltan Patay
Medulloblastoma is the most common malignant solid tumor in childhood and the most common embryonal neuroepithelial tumor of the central nervous system. Several morphological variants are recognized: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity. Recent advances in transcriptome and methylome profiling of these tumors led to a molecular classification that includes 4 major genetically defined groups. Accordingly, the 2016 revision of the World Health Organization's Classification of Tumors of the Central Nervous System recognizes the following medulloblastoma entities: Wingless (WNT)-activated, Sonic hedgehog (SHH)-activated, Group 3, and Group 4...
December 2018: Topics in Magnetic Resonance Imaging: TMRI
Christina Erbe, Collin Jacobs, Malgorzata Klukowska, Hans Timm, Julie Grender, Heinrich Wehrbein
OBJECTIVE: To compare the plaque removal efficacy of an oscillating-rotating electric toothbrush with an orthodontic brush head versus a sonic toothbrush in adolescent patients with fixed orthodontic appliances. MATERIALS AND METHODS: This was a randomized, examiner-blind, replicate single-use, two-treatment, four-period, crossover study with a washout period between visits of approximately 24 hours. Forty-four adolescent patients with fixed orthodontic appliances in both arches were randomized based on a computer-generated randomization schedule to one of four toothbrush treatment sequences...
December 5, 2018: Angle Orthodontist
Yang Tao, Hongbin Han, Wangxin Liu, Lu Peng, Yue Wang, Shekhar Kadam, Pau Loke Show, Xiaosong Ye
In this work, sonication (20-kHz) was conducted to assist the biosorption of phenolics from blueberry pomace extracts by brewery waste yeast biomass. The adsorption capacity of yeast increased markedly under ultrasonic fields. After sonication at 394.2 W/L and 40 °C for 120 min, the adsorption capacity was increased by 62.7% compared with that under reciprocating shaking. An artificial neural network was used to model and visualize the effects of different parameters on yeast biosorption capacity. Both biosorption time and acoustic energy density had positive influences on yeast biosorption capacity, whereas no clear influence of temperature on biosorption process was observed...
November 24, 2018: Ultrasonics Sonochemistry
Arshad Mehmood, Muhammad Ishaq, Lei Zhao, Sanabil Yaqoob, Bushra Safdar, Muhammad Nadeem, Masooma Munir, Chengtao Wang
The present study was conducted to evaluate the influence of ultrasound on bioactive compounds and biological activities of blue butterfly pea flower (Clitoria ternatea L.). For this purpose, optimized conditions (temperature 50 °C, time 150 min, solid to liquid ratio 1 g:15 ml, 70% amplitude and 240 W, 20 kHz frequency, 3 s on and 3 s off) of ultrasound (US) and conventional extraction (AGE: Agitation, water bath for 150 min, 50 °C at 150 rmp) were used. The results showed significant (p < 0...
March 2019: Ultrasonics Sonochemistry
Mahboobeh Zargazi, Mohammad H Entezari
In the present work, an ultrasound-assisted hydrothermal method was applied as a new approach for the synthesis of Bi2 WO6 nanostructures. In sonication, a cup horn system as an indirect high intensity sonicator was used. To determine the influence of ultrasonic waves on the morphology, Bi2 WO6 was also synthesized using the hydrothermal method. The conventional and sonochemical products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), Fourier transform infrared (FTIR), Raman, photoluminescence (PL), and UV-Vis (UV-Vis) spectroscopies...
March 2019: Ultrasonics Sonochemistry
Fazli Amin, Shahzeb Khan, Syed Muhammad Hassan Shah, Haroon Rahim, Zahid Hussain, Muhammad Sohail, Riaz Ullah, Mansour S Alsaid, Abdelaaty A Shahat
Background: The obnoxious bitter taste of orally taken antibiotics is one of the biggest problems in the treatment of children. The pediatric population cannot tolerate the bitter taste of drugs and vomit out which ultimately leads to suboptimal therapeutic value, grimace and mental stress so it is the challenging task for the formulation scientists to formulate a palatable formulation particularly to overcome address the issue. Purpose of study: The study aimed to mask and evaluate the unpleasant bitter taste of azithro-mycin (AZ) in the dry suspension dosage form by physisorption technique...
2018: Drug Design, Development and Therapy
Leila Oliveira Santos, Aldenor Gomes Santos, Jailson B de Andrade
Conventional methods for determination of polycyclic aromatic compounds (PACs) in sediments usually require large sample sizes (grams) and solvent volumes (at least 100 mL) through the employment of Soxhlet extraction, which is both time (hours) and energy consuming, among other disadvantages. We developed a new analytical protocol for the determination of PACs in sediments using microextraction, which requires small sample masses (25 mg), 500 μL of acetonitrile-dichloromethane mix and sonication for 23 min, followed by GC-MS analysis...
November 2018: Marine Pollution Bulletin
Sunil Unnikrishnan, Zhongmin Du, Galina Diakova, Alexander L Klibanov
For preparation of ligand-decorated microbubbles for targeted ultrasound contrast imaging it is important to maximize the amount of ligand associated with the bubble shell. We describe optimization of the use of a biocompatible co-surfactant in the microbubble formulation media to maximize the incorporation of targeting ligand-lipid conjugate into the microbubble shell, and thus reduce the fraction of ligand not associated with microbubbles, following amalgamation preparation. The influence of the concentration of a helper co-surfactant propyleneglycol (PG) on the efficacy of microbubble preparation by amalgamation and on the degree of association of fluorescent PEG-lipid with the microbubble shell was tested...
December 3, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Kien Tiek Wong, Pichiah Saravanan, In Wook Nah, Jaeyoung Choi, Chulhwan Park, Namchan Kim, Yeomin Yoon, Min Jang
In this study, magnetic layered double hydroxides (mag-LDHs) were synthesized through compositing magnetite with three different metals (Mg, Cu and Al) under ultrasound (US, 100 kHz frequency and 50 W power). For the first time, mag-LDHs were applied to sonocatalytic reduction of nitrate (NO3 - ) and the reduction mechanism were determined by conducting kinetic tests and various spectroscopic analyses. Based on the kinetic data, NO3 - reduction and the selectivity for N2 highly depends on the ratio between Mg/Al, solution pH and sonication frequency...
November 27, 2018: Chemosphere
Ludwig Knabl, Bettina Kuppelwieser, Astrid Mayr, Wilfried Posch, Michaela Lackner, Débora Coraҫa-Huber, Adrian Danita, Michael Blauth, Cornelia Lass-Flörl, Dorothea Orth-Höller
Stabilization of fractures with internal fixation devices is a common procedure and implant-associated infections are a dreaded complication. The exact pathomechanism is not completely understood; however, microbial colonization of osteosynthesis material is considered a trigger for infection. This study aimed to determine the colonization rate of osteosynthesis implants in patients with no clinical or laboratory signs of infection, using two methods, conventional culture and polymerase chain reaction (PCR) of sonication fluid...
December 3, 2018: MicrobiologyOpen
Artem Kim, Clara Savary, Christèle Dubourg, Wilfrid Carré, Charlotte Mouden, Houda Hamdi-Rozé, Hélène Guyodo, Jerome Le Douce, Laurent Pasquier, Elisabeth Flori, Marie Gonzales, Claire Bénéteau, Odile Boute, Tania Attié-Bitach, Joelle Roume, Louise Goujon, Linda Akloul, Sylvie Odent, Erwan Watrin, Valérie Dupé, Marie de Tayrac, Véronique David
Holoprosencephaly is a pathology of forebrain development characterized by high phenotypic heterogeneity. The disease presents with various clinical manifestations at the cerebral or facial levels. Several genes have been implicated in holoprosencephaly but its genetic basis remains unclear: different transmission patterns have been described including autosomal dominant, recessive and digenic inheritance. Conventional molecular testing approaches result in a very low diagnostic yield and most cases remain unsolved...
November 30, 2018: Brain: a Journal of Neurology
Chang-Min Yoon, Kyung Hee Cho, Yoonsun Jang, Jungwon Kim, Kisu Lee, Haejun Yu, Seungae Lee, Jyongsik Jang
Inverted conducting polymer/metal oxide core/shell structured pPPy/SiO2-TiO2 nanoparticles were prepared as electrorheological (ER) materials using sequential experimental methods. The core was synthesized via low-temperature self-assembly of PPy and SiO2 materials, and the outer TiO2 shell was easily coated onto the core part using a sol-gel method and a titanium isopropoxide precursor. Sonication-mediated etching and re-deposition was employed to etch out SiO2 portions from the core part to blend with TiO2 shells...
December 3, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Laura Bianco, Federica Romano, Marina Maggiora, Loretta Bongiovanni, Nicoletta Guzzi, Elena Curmei, Paolo Giacomo Arduino, Mario Aimetti
OBJECTIVES: The aim of this randomized, parallel-design, clinical trial was to investigate the effectiveness of an intensive plaque control program with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients. METHODS: A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group...
December 2, 2018: International Journal of Dental Hygiene
Mubeena Mariyath P M, Mehdi H Shahi, Mohd Tayyab, Shirin Farheen, Nabeela Khanam, Sartaj Tabassum, Asif Ali
BACKGROUND: Cadmium is a nonessential toxic heavy metal, which enters the body easily and damages the cellular system. The sonic hedgehog (Shh) signaling pathway is one of the key regulatory pathways, which define neural growth and development. OBJECTIVES: This study aimed to explore how cadmium exposure affects neural activities, Shh signaling cascade, and its downstream target genes. METHODS: Total 18 male Wistar rats were randomly divided into two groups, control and test groups...
December 1, 2018: Journal of Biochemical and Molecular Toxicology
Teija Sainio, Gaber Komar, Jani Saunavaara, Visa Suomi, Kirsi Joronen, Antti Perheentupa, Antti Viitala, Roberto Blanco Sequeiros
Background: Magnetic resonance guided high-intensity focused ultrasound (MR-HIFU) therapy is not feasible in all patients with uterine fibroids because of limiting anatomical factors such as scar tissue, bowel loops or other obstacles in the sonication path. These may prevent the treatment or limit the treatment window, and therefore, also the volume where HIFU therapy can be delivered. Bowel loops present a particular problem because of bowel gas bubbles and hard particles which may cause reflection or absorption of ultrasound energy, potentially leading to thermal damage and even bowel perforation...
2018: Journal of Therapeutic Ultrasound
Hyung-Jin Park, Hee-June Kim, Shukho Kim, Seong-Min Kim, Jong-Uk Mun, Jungmin Kim, Hee-Soo Kyung
Background: The purpose of this study was to evaluate the usefulness of sonication technique for microbiological diagnosis and the sterility of the recycled autoclaved femoral components from infected total knee arthroplasty (TKA) using a sonication method. Methods: Nineteen femoral implants explanted from patients with infected TKA were sterilized with a standard autoclave method. Standard culture of the fluid before and after sonication of the sterilized implants was performed to detect pathogenic microorganisms...
December 2018: Clinics in Orthopedic Surgery
Neil Forbes, Maryam T Hussain, Maria L Briuglia, Darren Y Edwards, Joop H Ter Horst, Nicolas Szita, Yvonne Perrie
Within this paper we present work that has the ability to de-risk the translation of liposomes from bench to the clinic. We have used microfluidics for the rapid and scale-independent manufacture of liposomes and have incorporated in-line purification and at-line monitoring of particle size. Using this process, we have manufactured a range of neutral and anionic liposomes incorporating protein. Factors investigated include the microfluidics operating parameters (flow rate ratio (FRR) and total flow rate (TFR)) and the liposome formulation...
November 29, 2018: International Journal of Pharmaceutics
Zhonghua Yang, Linlin Gao, Huimin Jia, Yuzuo Bai, Weilin Wang
BACKGROUND: Postoperative incontinence and constipation still remain the major complications of anorectal malformations (ARMs), despite improvements in their treatment. One of the most important factors that affect postoperative anorectal function is malformations in the lumbosacral spinal cord. However, far too little attention has been paid to the underlying mechanism that produces these malformations. MATERIALS AND METHODS: The levels of sonic hedgehog (Shh), patched homolog 1 (Ptch1), and zinc finger-containing transcription factors 1 (Gli1) expression were investigated in the lumbosacral spinal cord in ethylenethiourea-exposed rat fetus with ARMs, and Shh, Ptch1, and Gli1 expression was confirmed with immunohistochemical staining, quantitative real-time polymerase chain reaction, and western blot analyses during lumbosacral spinal cord development both in the ARMs and normal rat embryos...
January 2019: Journal of Surgical Research
Antonio Bevilacqua, Angela Racioppo, Milena Sinigaglia, Barbara Speranza, Daniela Campaniello, Maria Rosaria Corbo
The main topic of this paper was to study the effect of ultrasound-attenuation (US) on the surface properties of propionibacteria (Acidipropionibacterium jensenii DSM 20535 and Propionibacterium freudenreichii DSM 20271). A preliminary screening was done by using different power levels (40 and 60%) and treatment times (4, 6, and 8 min); immediately after sonication, acidification and viable count were tested. The best combinations to avoid post-acidification after 6 h were the following: A. jensenii DSM 20535: power, 40%; time, 8 min; P...
April 2019: Food Microbiology
(no author information available yet)
Hypothalamic hamartomas are benign tumors known to cause gelastic or dacrystic seizures, precocious puberty, developmental delay, and medically refractory epilepsy. These tumors are most often sporadic but rarely can be associated with Pallister-Hall syndrome, an autosomal dominant familial syndrome caused by truncation of glioblastoma transcription factor 3, a downstream effector in the sonic hedgehog pathway. In this clinical report, the authors describe two brothers with a different familial syndrome. To the best of the authors' knowledge, this is the first report in the literature describing a familial syndrome caused by germline mutations in the Smoothened (SMO) gene and the first familial syndrome associated with hypothalamic hamartomas other than Pallister-Hall syndrome...
October 1, 2018: Journal of Neurosurgery. Pediatrics
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