Ahmed A Shokeir, Amira Awadalla, Eman T Hamam, Abdelaziz M Hussein, Mohamed R Mahdi, Alyaa Naeem Abosteta, Mirna Shahin, Nashwa Barakat, Mohamed El-Adl, Mohamed El-Sherbiny, Mamdouh Eldesoqui, Moneer AlMadani, Sahar K Ali, El-Said El-Sherbini, Salma M Khirallah
OBJECTIVE: To determine whether WJ-MSCs pretreated with VPA would enhance their migration to improve functional recovery of renal IRI in rats. METHODS: 150 Sprague-Dawley rats were distributed into 5 groups; Sham, IRI, WJ-MSC, VPA, and WJ-MSCs + VPA. 10 rats were sacrificed after 3, 5, and 7 days. Role of WJ-MSCs pretreated with VPA was evaluated by assessment of renal function, antioxidant enzymes together with renal histopathological and immunohistopathological analyses and finally by molecular studies...
April 3, 2024: Archives of Biochemistry and Biophysics