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Nicolas Richard, Marie Hudson, Mianbo Wang, Geneviève Gyger, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Murray Baron
Objectives: To examine the incidence, predictors and outcomes associated with severe gastrointestinal (GI) disease in a large inception SSc cohort. Methods: SSc subjects with <2 years of disease duration were identified from two multicentre cohorts. Severe GI disease was defined as: malabsorption, hyperalimentation, pseudo-obstruction and/or ⩾10% weight loss in association with the use of antibiotics for bacterial overgrowth or oesophageal stricture. Kaplan-Meier, multivariate logistic regression and Cox proportional hazard analyses were performed to determine the cumulative incidence rate, independent clinical correlates and mortality rate associated with severe GI disease...
December 4, 2018: Rheumatology
Ömür İlban, Faruk Çiçekçi, Jale Bengi Çelik, Mehmet Ali Baş, Ateş Duman
BACKGROUND/AIMS: When conservative methods fail, neostigmine is recommended in the pharmacological treatment of acute colonic pseudo-obstruction (ACPO). The objective of this study was to analyze the response of patients to different neostigmine protocols. MATERIALS AND METHODS: Patients diagnosed with ACPO in the intensive care unit between January 2015 and September 2017 were retrospectively studied. Either of the two neostigmine protocols, the bolus dose (BD) or continuous infusion (CI), was applied to the ACPO patients who were unresponsive to conservative treatments, and the results were analyzed...
November 20, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Susanna Every-Palmer, Stephen J Inns, Eve Grant, Pete M Ellis
BACKGROUND: Gastrointestinal hypomotility in people taking clozapine is common, poorly understood and potentially dangerous. It causes distress and sometimes sudden death, with greater associated morbidity than the better known adverse effect of clozapine, agranulocytosis. Neither the mechanism nor prevalence of clozapine-induced gastrointestinal hypomotility is well understood. Previous studies show clozapine impedes colon transit, likely owing to anticholinergic and anti-serotonergic properties...
November 19, 2018: CNS Drugs
Satoshi Obata, Koichiro Yoshimaru, Kosuke Kirino, Tomoko Izaki, Satoshi Ieiri, Atsuyuki Yamataka, Tsugumichi Koshinaga, Jun Iwai, Hitoshi Ikeda, Hiroshi Matsufuji, Yoshinao Oda, Tomoaki Taguchi
PURPOSE: Acquired isolated hypoganglionosis (A-IH) is a late-onset intestinal pseudo-obstruction disorder and shows different pathophysiological findings from congenital isolated hypoganglionosis (C-IH). In this study, we retrospectively examined five cases of A-IH and investigated the features of A-IH. METHODS: Five cases of A-IH were extracted from a nationwide retrospective cohort study in 10 years, from which totally 355 cases of Allied Disorders of Hirschsprung's Disease (ADHD) were collected...
November 19, 2018: Pediatric Surgery International
Awni D Shahait, Gamal Mostafa
No abstract text is available yet for this article.
January 1, 2018: American Surgeon
Mehmet A Erdogan, Yuksel Seckin, Muhsin M Harputluoglu, Melih Karincaoglu, Murat Aladag, Ali R Caliskan, Yilmaz Bilgic, Oguzhan Yildirim, Yasir F Cagin, Yahya Atayan, Ayse N Cengiz, Cihat Emul, Zeynep Esener, Mehmet F Erbay, Ibrahim Tekedereli
Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is an autosomal recessive disorder characterized by gastrointestinal dysmotility, cachexia, ptosis, peripheral neuropathy and leukoencephalopathy. The diagnosis is often not made until 5-10 years after the onset of symptoms. MNGIE is caused by mutations in thymidine phosphorylase gene TYMP. Here, we present a 19-year-old boy with MNGIE who had a chronic intestinal pseudo-obstruction, and we describe his family history. Genetic analysis revealed a novel homozygous c...
November 6, 2018: Clinical Dysmorphology
Awni D Shahait, Gamal Mostafa
No abstract text is available yet for this article.
January 1, 2018: American Surgeon
Hong Wang, Ran Jing, Christa Trexler, Yali Li, Huayuan Tang, Zhixiang Pan, Siting Zhu, Beili Zhao, Xi Fang, Jie Liu, Ju Chen, Kunfu Ouyang
BACKGROUND: Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a family of intracellular Ca2+ release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological functions. However, their function in regulating gastrointestinal (GI) tract motility in vivo remains unknown. Here, we investigated the physiological function of IP3 R1 in the GI tract using genetically engineered mouse models. METHODS: Pdgfrb-Cre mice were bred with homozygous Itpr1 floxed (Itpr1f/f ) mice to generate conditional IP3 R1 knockout (pcR1KO) mice...
October 31, 2018: Journal of Gastroenterology
Lucas W Smedley, Dana B Foster, Colleen A Barthol, Reed Hall, G Christina Gutierrez
PURPOSE: To compare clinical response of intermittent bolus versus continuous infusion neostigmine for acute colonic pseudo-obstruction (ACPO). Acute colonic pseudo-obstruction occurs due to reduced colonic parasympathetic activity. Neostigmine is an acetylcholinesterase inhibitor that increases frequency of smooth muscle contraction by increasing acetylcholine at autonomic nervous system synapses. Although these administration modalities have been studied separately, they have never been compared...
October 29, 2018: Journal of Intensive Care Medicine
Serkan Özsoylu, Başak Nur Akyıldız, Adem Dursun
Özsoylu S, Akyıldız BN, Dursun A. Ogilvie syndrome presenting with septic shock. Turk J Pediatr 2018; 60: 225-227. Acute colonic pseudo-obstruction (ACPO) is also known as Ogilvie`s. We report a 10-year-old child with an unremarkable past history who presented with septic shock including hypotension, prolonged capillary refill time, decreased urine output ( < 0.5 ml/kg/h), metabolic acidosis, liver failure, respiratory failure. The symptoms resolved with supportive therapy. In our patient septic shock contributed to Ogilvie syndrome...
2018: Turkish Journal of Pediatrics
Ming Li Yee, Rosemary Wong, Mineesh Datta, Timothy Nicholas Fazlo, Mina Mohammad Ebrahim, Elissa Claire Mcnamara, Gerard De Jong, Christopher Gilfillan
Mitochondrial diseases are rare, heterogeneous conditions affecting organs dependent on high aerobic metabolism. Presenting symptoms and signs vary depending on the mutation and mutant protein load. Diabetes mellitus is the most common endocrinopathy, and recognition of these patients is important due to its impact on management and screening of family members. In particular, glycemic management differs in these patients: the use of metformin is avoided because of the risk of lactic acidosis. We describe a patient who presented with gradual weight loss and an acute presentation of hyperglycemia complicated by the superior mesenteric artery syndrome...
September 25, 2018: Endocrinology, Diabetes & Metabolism Case Reports
Fang-Jie Zhang, Juan Zhang, Li-Ping Zhou, Ai-Min Wang, Xiang-Min Li
Small bowel obstruction is common in emergency departments. However, the exact cause of intestinal pseudo-obstruction (IPO) is often misdiagnosed. IPO is considered a severe manifestation of systemic lupus erythematosus (SLE). However, IPO is rare as the initial manifestation of SLE. This paper reports a female patient who presented with IPO as the initial manifestation and was ultimately diagnosed with SLE. The 31-year-old female was definitively diagnosed with SLE after IPO symptoms for 1 month. She then presented multiple organ dysfunction syndrome (MODS) leading to a poor prognosis...
September 30, 2018: American Journal of Emergency Medicine
Dipesh H Vasant, Ramya Kalaiselvan, Joanne Ablett, Ashley Bond, Arun Abraham, Antje Teubner, Darren Green, Peter A Paine, Simon Lal
BACKGROUND & AIMS: Severe gastrointestinal dysmotility (GID) is a significant cause of chronic intestinal failure (CIF) with unclear benefits of sub-classifying into Chronic Intestinal Pseudo-obstruction (CIPO) and non-CIPO sub-types. We compared outcomes between CIPO and non-CIPO sub-types in a tertiary cohort of patients with CIF resulting from severe GID. METHODS: Adults with primary GID, commenced on home parenteral nutrition (HPN) over a 16-year period at a national referral centre, were included...
September 22, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Larry Miller, Aydin Farajidavar, Anil Vegesna
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for >40% of patients seen in gastroenterology clinics and affect >20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail...
September 24, 2018: Cold Spring Harbor Perspectives in Medicine
Tomoya Iida, Daisuke Hirayama, Gota Sudo, Kei Mitsuhashi, Hisayoshi Igarashi, Kentaro Yamashita, Hiroo Yamano, Hiroshi Nakase
A 59-year-old woman presented to our hospital with a 6-month history of nausea, weight loss, and abdominal distension. Physical examination revealed abdominal distension without tenderness, and edema, numbness, and multiple peripheral neuropathy in the limbs. Blood test results showed anemia, hypoproteinemia, and hypoalbuminemia. Immunoelectrophoresis detected kappa-type Bence-Jones protein in both the serum and urine. Bone marrow examination did not reveal an increase of plasma cells. Computed tomography showed intestinal distension and retention of intestinal contents...
September 19, 2018: Clinical Journal of Gastroenterology
Wenjuan Fan, Guijun Fei, Xiaoqing Li, Xiyu Wang, Chaojun Hu, Haiwei Xin, Xiaohong Sun, Yongzhe Li, Jackie D Wood, Xiucai Fang
BACKGROUND: Sera anti-enteric neuronal antibodies (AENA), neuronal inflammation, and degeneration in myenteric plexus in patients with irritable bowel syndrome (IBS) were reported. Effects of sera AENA in patients with IBS are unclear. METHODS: Patients with IBS met Rome III criteria were enrolled. Controls included healthy subjects (HS) and patients with slow transit functional constipation, inflammatory bowel disease, chronic intestinal pseudo-obstruction, and autoimmune diseases...
September 17, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Jiří Dolina, Aleš Hep, Lumír Kunovský, Štefan Konečný
Gastrointestinal motility disorders are reflected in clinical medicine not only in the form of functional disorders but also as primary organic units or secondary manifestations of other diseases and physicochemical effects. Recent sophisticated diagnostic methods and basic research in the field of digestive tract motility have shown significant development. However, causal treatment of prokinetic motility disorders is still marginalized. A number of new effective drugs have been withdrawn from the market due to their significant side effects...
2018: Vnitr̆ní Lékar̆ství
Diana Gallego, Carolina Malagelada, Anna Accarino, Alessandra Gori, Juan Ramón Malagelada, Fernando Azpiroz, Roberto De Giorgio, Marcel Jimenez
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) and enteric dysmotility (ED) are severe intestinal motility disorders usually associated with underlying neuromuscular abnormalities. OBJECTIVE: To evaluate the in vitro neuromuscular function of patients with severe intestinal motility disorders. METHODS: Full-thickness intestinal biopsies (16 jejunum and 3 ileum) obtained from patients with CIPO (n = 10) and ED (n = 9) were studied using muscle bath and microelectrode techniques...
September 3, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Hans Raj Pahadiya, Manoj Lakhotia, Ronak Gandhi
No abstract text is available yet for this article.
July 2018: Indian Journal of Endocrinology and Metabolism
Toshiyuki Itai, Hiroshi Ishikawa, Kenji Kurosawa, Yu Tsuyusaki
Chronic intestinal pseudo-obstruction (CIPO) is a major sign of mitochondrial disorders. We present the first reported case of fetal bowel dilation associated with Leigh syndrome. The possibility of CIPO should be taken into consideration even when mild fetal bowel dilation is detected.
August 2018: Clinical Case Reports
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