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Allergen components

Peipei Guo, Fang Yu, Yuan Ren, Dong Liu, Jia Li, Zhiyun Ouyang, Xiaoke Wang
Anthropogenic activities have weakened the invasion of ruderals and increased the number of non-native species in urban areas. Ruderals are an important component of urban plant diversity and are of great significance to the sustainable development of urban green space. We used the tessellation⁻randomized plot method to examine the composition and biodiversity of ruderal species among urban land use types (LUTs) in the built-up areas of Beijing. Soil samples from the surface to a depth of 10 cm were taken from each site to examine the impact of soil characteristics on ruderal species diversity...
December 12, 2018: International Journal of Environmental Research and Public Health
Mayte Suárez-Fariñas, Maria Suprun, Helena L Chang, Gustavo Gimenez, Galina Grishina, Robert Getts, Kari Nadeau, Robert A Wood, Hugh A Sampson
BACKGROUND: In a recent trial of milk oral immunotherapy (MOIT) with or without omalizumab in 55 patients with milk allergy treated for 28 months, 44 of 55 subjects passed a 10-g desensitization milk protein challenge; 23 of 55 subjects passed the 10-g sustained unresponsiveness (SU) challenge 8 weeks after discontinuing MOIT. OBJECTIVE: We sought to determine whether IgE and IgG4 antibody binding to allergenic milk protein epitopes changes with MOIT and whether this could predict the development of SU...
December 7, 2018: Journal of Allergy and Clinical Immunology
Maksymilian Chruszcz, A Brenda Kapingidza, Coleman Dolamore, Krzysztof Kowal
Among the vast number of identified protein families, allergens emanate from relatively few families which translates to only a small fraction of identified protein families. In allergy diagnostics and immunotherapy, interactions between immunoglobulin E and allergens are crucial because the formation of an allergen-antibody complex is necessary for triggering an allergic reaction. In allergic diseases, there is a phenomenon known as cross-reactivity. Cross-reactivity describes a situation where an individual has produced antibodies against a particular allergenic protein, but said antibodies fail to discriminate between the original sensitizer and other similar proteins that usually belong to the same family...
2018: PloS One
Haisheng Hu, Wenting Luo, Zehong Wu, Chuanxu Cai, Huimin Huang, Baoqing Sun
OBJECTIVE: Using multiplex microarray-based component resolved diagnosis (CRD) to investigate the allergen sensitization profile of allergic asthma patients in southern China. METHOD: Serum samples from 57 polysensitized mite allergic asthmatic patients in a tertiary referral centre of southern China were tested with multiplex CRD (ISAC) for specific immunoglobulin E (sIgE) against 112 single allergen and components. Result was then compared with those from singleplex ImmunoCAP...
November 24, 2018: Molecular Immunology
Fabiano M Teixeira, Mohibullah Shah, Gilberto B Domont, Fábio C S Nogueira, Francisco A P Campos
Pollen grains are the tiny structures vital for sexual reproduction and consequently seed and fruit production in angiosperms, and a source of many allergenic components responsible deleterious implications for health worldwide. Current pollen research is mainly focused on unraveling the molecular mechanisms underlying the pollen germination and tube formation passing from the quiescent stage. In this context, an in-depth proteome analysis of the pollens from Ricinus communis at three different stages i.e. mature, hydrated and in-vitro germinated was performed...
November 25, 2018: Proteomics
Małgorzata Bulanda, Magdalena Leśniak, Judyta Szałkowska, Weronika Madej, Agata Wojtyna, Maria Czarnobilska, Daniel Bulanda, Ewa Czarnobilska
Anaphylaxis is an increasing problem in public health. The food allergens (mainly milk, eggs, and peanuts) are the most frequent cause of anaphylaxis in children and youth. In order to define the cause of anaphylaxis, skin tests, the determination of the concentration of specific IgE in the blood and basophil activation test are conducted. In vitro tests are preferred due to the risk of allergic response during in vivo tests. Component-resolved diagnosis (CRD) is an additional tool in allergology, recommended in the third level of diagnostics when there are diagnostic doubts after the above mentioned tests have been carried out...
2018: Folia Medica Cracoviensia
Katharina Eder, Donata Gellrich, Catalina Meßmer, Martin Canis, Moritz Gröger
Background: Sensitization to ash pollen is underestimated in various regions. The prevalence in Germany is about 10%. However, allergy to ash pollen is widely overlooked by allergists, since the pollination period of ash and birch in central Europe closely overlap and rhinoconjunctival symptoms during April/May are often assigned to birch pollen. Component resolved analysis of the different ash allergens is not routinely available. Therefore, we would like to question the usefulness of component resolved diagnostic via olive components, as ash and olive are both part of the Oleaceae family...
2018: Allergy, Asthma, and Clinical Immunology
Silvio Tundo, Roberta Lupi, Mickael Lafond, Thierry Giardina, Colette Larré, Sandra Denery-Papini, Martine Morisset, Raviraj Kalunke, Francesco Sestili, Stefania Masci
Although wheat is a staple food for most of the human population, some of its components trigger adverse reactions. Among wheat components, the alpha-amylase/trypsin inhibitors (ATI) are important triggers of several allergies and activators of innate immunity. ATI are a group of exogenous protease inhibitors and include several polypeptides. The three ATI polypeptides named CM3, CM16 and 0.28 are considered major allergens, and might also play a role in other common wheat-related pathologies, such as Non Celiac Wheat Sensitivity and even Celiac Disease...
November 16, 2018: Plants (Basel, Switzerland)
Tanmoy Basak, Arindom Chakraborty, Kashinath Bhattacharya
An attempt has been made to detect airborne pollen of Lagerstroemia speciosa (LS) and Spathodea campanulata (SC) - two common avenue trees of India as potential sources of aeroallergens and also to identify the major IgE-reactive components present in them. The airborne pollen concentration was assessed using a Burkard sampler. A detailed questionnaire on clinical data of 1490 patients was recorded based on hospital data. We assessed the allergenicity of pollen by in vivo and in vitro tests. The correlation among meteorological factors, pollen seasons and allergenic potency of patients was assessed by multiple regression analysis...
November 18, 2018: International Journal of Environmental Health Research
Natalia R Kunst, Helene Lindvik, Kai-Håkon Carlsen, Geir Håland, Eivind Jørgensen, Karin C Lødrup Carlsen
Incorporating component-resolved allergen diagnosis and peanut conjunctival allergen provocation test in the diagnostic algorithm appears to improve health-related quality of life at an acceptable increase in costs, representing the optimal cost-effective diagnostic strategy.
November 13, 2018: Journal of Allergy and Clinical Immunology
Mohamed H Shamji, Jasper Kappen, Hisham Abubakar-Waziri, Jinjin Zhang, Esther Steveling, Shelley Watchman, Lubna Kouser, Aarif Eifan, Amy Switzer, Gilda Varrichi, Gianni Marone, Natália C Couto-Francisco, Moises Calderon, Stephen R Durham
BACKGROUND: Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG4 -associated inhibitory antibodies that prevent IgE-facilitated allergen binding to B cells. OBJECTIVE: To determine whether SCIT induces nasal allergen-specific IgG4 antibodies with inhibitory activity that correlate closely with clinical response. METHODS: In a cross-sectional, controlled study, nasal fluid and sera were collected during the grass pollen season from 10 SCIT-treated patients, 13 untreated allergics (SAR) and 12 non-atopic controls (NA)...
November 13, 2018: Journal of Allergy and Clinical Immunology
Jihui Zhang, Jie Chen, Clive Robinson
Serodominant group 1 allergens of house dust mites (HDMs) are cysteine protease digestive enzymes. By increasing the detection of any allergen by dendritic antigen presenting cells, upregulating inflammatory signalling molecules, and activating cells crucial to the transition from innate to acquired immune responses, the proteolytic activity of these HDM allergens also underlies their behaviour as inhalant allergens. The significance of this property is underlined by the attenuation of allergic responses to HDMs by novel inhibitors in experimental models...
November 10, 2018: International Journal of Molecular Sciences
Sara Fontanella, Clément Frainay, Clare S Murray, Angela Simpson, Adnan Custovic
BACKGROUND: The relationship between allergic sensitisation and asthma is complex; the data about the strength of this association are conflicting. We propose that the discrepancies arise in part because allergic sensitisation may not be a single entity (as considered conventionally) but a collection of several different classes of sensitisation. We hypothesise that pairings between immunoglobulin E (IgE) antibodies to individual allergenic molecules (components), rather than IgE responses to 'informative' molecules, are associated with increased risk of asthma...
November 2018: PLoS Medicine
Alicia Armentia, Sara Martín Armentia, Rafael Álvarez-Nogal, Blanca Martín Armentia, Manuel José Gayoso, Delia Fernández-González
BACKGROUND: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is no a clear etiologic treatment. EoE exacerbations are often seasonal. We hypothesized that the inflammatory response of the esophageal mucosa in patients with high levels of antibodies to pollen allergens and worsened seasonal EoE might be due to swallowing airborne pollen and the intrusion into the esophageal mucosa of pollen allergens and pollen tubes, which encounter a pH and humidity resembling the stigma at pollination...
November 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Kinga Lis, Magdalena Żbikowska-Gotz, Łukasz Sokołowski, Zbigniew Bartuzi
Background: An allergy to mango is extremely rare. The antigenic composition of the fruit is not fully known. Profilin from mango has a structure similar to birch tree profiling: it is responsible for cross-reactions between mango and pear, apple, and peach. A panallergen with a structure similar to mugwort defensin (Art v 1) which cross-reacts with celery, carrot, peanuts, pepper, aniseed, and caraway has been previously described. Case study: A female patient, 30 years old, was admitted in February 2017 because of recurrent allergic reactions following consumption of various foods...
2018: Allergy, Asthma, and Clinical Immunology
Marcella Nebbioso, Marta Sacchetti, Guia Bianchi, Anna Maria Zicari, Marzia Duse, Paola Del Regno, Alessandro Lambiase
Background: Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life. Clinical observations show that it generally regresses spontaneously with the onset of puberty, but therapeutic measures must be taken before then to control the course of the disease. Purpose: To evaluate the role of the lacrimal mucous component in VKC patients and compare tear ferning test (TFT) modifications, MUC5AC levels in tears, and density of conjunctival goblet cells to clinical characteristics before and after treatment with cyclosporine A (CY) in eye drops...
2018: Journal of Ophthalmology
Martin F Bachmann, Aadil El-Turabi, Antonia Fettelschoss-Gabriel, Monique Vogel
Allergen-specific T helper type 2 (Th2) responses followed by eosinophilic inflammation of the lung are important causes of allergic asthma. Interleukin-5 (IL-5) is a master regulator of eosinophil differentiation as well as activation. Blocking IL-5 using monoclonal antibodies (mAbs) against IL-5 is a powerful way to improve asthmatic symptoms in patients with an eosinophilic component of the disease. We have previously shown that vaccination against IL-5 can abrogate eosinophilic inflammation of the lung in allergic mice...
2018: Frontiers in Microbiology
Zhong-Jian Shen, Jie Hu, Venkatesh Kashi, Yury A Bochkov, James E Gern, James S Malter
The response of eosinophils (Eos) to respiratory virus has emerged as an important link between pulmonary infection and allergic asthmatic exacerbations. Eos activate innate immune responses through TLR signaling. In this study, using mouse and human Eos and mice lacking the prolyl isomerase Pin1 selectively in Eos, we show that Pin1 is indispensable for eosinophilopoiesis in the bone marrow (BM) and mature cell function in the presence of TLR7 activation. Unbiased in vivo analysis of mouse models of allergic airway inflammation revealed that TLR7 activation in knockout mice resulted in systemic loss of Eos, reduced IFN production, and an inability to clear respiratory viruses...
November 5, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Edward J Marr, Harry W Wright, Neil D Sargison, Alasdair J Nisbet, Stewart T G Burgess
The presence of components of the RNA interference (RNAi) pathway in Psoroptes ovis, an ectoparasitic mite responsible for psoroptic mange, was investigated through interrogation of the P. ovis genome. Homologues of transcripts representing critical elements for achieving effective RNAi in the mite, Tetranychus urticae and the model organisms Caenorhabditis elegans and Drosophila melanogaster were identified and, following the development of a non-invasive immersion method of double stranded RNA delivery, gene silencing by RNAi was successfully demonstrated in P...
November 1, 2018: Veterinary Research
Helga Magnusdottir, Anna Gudrun Vidarsdóttir, Bjorn Runar Ludviksson, Michael Clausen, Sigrun Helga Lund, Anders B Jensen, Sigurveig T Sigurdardottir
BACKGROUND: Of the major peanut allergens, sensitivity to Ara h 2 has the highest prediction for clinical allergy. In this study, we evaluated sensitization to peanut components in Iceland and related Ara h 2-negative sensitization to clinical allergy. METHODS: Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Bet v 1 IgEs were measured (ImmunoCAP) in 220 peanut IgE (Pn-IgE)-positive serum samples. Ara h 2 IgE-negative individuals were invited to an open peanut challenge and evaluated for Ara h 6 and 9 sensitization (ISAC microarray)...
October 26, 2018: International Archives of Allergy and Immunology
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