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Allergen components

Wai Sze Tong, Agatha Wt Yuen, Christine Yy Wai, Nicki Yh Leung, Ka Hou Chu, Patrick Sc Leung
Seafood allergy is a hypersensitive disorder with increasing prevalence worldwide. Effective and accurate diagnostic workup for seafood allergy is essential for clinicians and patients. Parvalbumin and tropomyosin are the most common fish and shellfish allergens, respectively. The diagnosis of seafood allergies is complicated by cross-reactivity among fish allergens and between shellfish allergens and other arthropods. Current clinical diagnosis of seafood allergy is a complex algorithm that includes clinical assessment, skin prick test, specific IgE measurement, and oral food challenges...
2018: Journal of Asthma and Allergy
Jun-Pyo Choi, Seong Gyu Jeon, Yoon-Keun Kim, You Sook Cho
BACKGROUND: House dust mite (HDM) is the major source of indoor allergens that cause airway disease. Recent evidence suggests that Gram-negative/positive bacteria produce nano-sized extracellular vesicles (EVs) containing diverse components, including various immunostimulatory molecules. However, the association between bacteria-derived EVs and development of airway disease is unclear. OBJECTIVE: To identify and isolate HDM derived EVs and to evaluate their effect on the development of airway inflammation...
October 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Morris Gordon, Elena Biagioli, Miriam Sorrenti, Carla Lingua, Lorenzo Moja, Shel Sc Banks, Simone Ceratto, Francesco Savino
BACKGROUND: Infantile colic is typically defined as full-force crying for at least three hours per day, on at least three days per week, for at least three weeks. This condition appears to be more frequent in the first six weeks of life (prevalence range of 17% to 25%), depending on the specific location reported and definitions used, and it usually resolves by three months of age. The aetiopathogenesis of infantile colic is unclear but most likely multifactorial. A number of psychological, behavioural and biological components (food hypersensitivity, allergy or both; gut microflora and dysmotility) are thought to contribute to its manifestation...
October 10, 2018: Cochrane Database of Systematic Reviews
Luis Caraballo, Nathalie Acevedo, Josefina Zakzuk
Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and the same effects have been detected on the underlying immune responses. In this review we analyze the work on this field performed in Colombia, a Latin American tropical country, including aspects such as the molecular genetics of the IgE response to Ascaris; the allergenic activity of Ascaris IgE-binding molecular components and the immunological and clinical influences of ascariasis on asthma...
October 8, 2018: Parasite Immunology
Lixin Huang, Zhaoying Wang, Na Yu, Jingjing Li, Zewen Liu
The pond wolf spider, Pardosa pseudoannulata, is one of the most dominant predators of several agriculture insect pests including mainly the rice planthoppers and leafhoppers in paddy fields in Asia. Venom has been an attractive subject as the powerful weapon of spiders due to the complex components secreted from venom gland. The transcriptome of P. pseudoannulata venom gland was sequenced in order to understand the diversity of venom components at the molecular level and provide a new perspective for insect pest management...
September 22, 2018: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
Karine Adel-Patient, Guillaume Lezmi, Florence Anne Castelli, Sibylle Blanc, Hervé Bernard, Pascale Soulaines, Pascale Dumond, Sandrine Ah-Leung, Florence Lageix, Delphine de Boissieu, Naima Cortes-Perez, Stéphane Hazebrouck, François Fenaille, Christophe Junot, Christophe Dupont
Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is considered to be a non-IgE mediated food allergy. However, its pathogenesis remains poorly understood and biomarkers are lacking. We aimed to perform in-depth characterization of humoral and cellular immune responses in children with cow's milk (CM)-FPIES and investigated whether there is a FPIES metabolomic signature. Methods: Children with CM-FPIES and control subjects with an IgE-mediated CM allergy (IgE-CMA), both avoiding CM, were recruited on the day of an oral food challenge...
2018: Clinical and Translational Allergy
Jaclyn Quirt, Kyla J Hildebrand, Jorge Mazza, Francisco Noya, Harold Kim
Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICS) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2 -agonist inhalers are preferred for most adults who fail to achieve control with ICS therapy...
2018: Allergy, Asthma, and Clinical Immunology
Lian Willetts, Lindsey C Felix, Elizabeth A Jacobsen, Lakshmi Puttagunta, Rachel M Condjella, Katie R Zellner, Sergei I Ochkur, John D Kim, Huijun Luo, Nancy A Lee, James J Lee, Redwan Moqbel, Paige Lacy
Eosinophil degranulation is a determining factor in allergy-mediated airway pathology. Receptor-mediated degranulation in eosinophils requires vesicle-associated membrane protein 7 (VAMP-7), a principal component of the SNARE fusion machinery. The specific contribution of eosinophil degranulation to allergen-induced airway responses remains poorly understood. We generated mice with VAMP-7 gene deficiency exclusively in eosinophils ( eoCRE/V7 ) from a cross using eosinophil-specific Cre recombinase-expressing mice crossed with VAMP-7 f/f mice...
2018: Communications biology
G Ciprandi, M Silvestri, A Pistorio, R Olcese, P Del Barba, M A Tosca
Background Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults. This study aimed to evaluate the impact of Bet v 1 sensitization on sensitization pattern in a large sample of children. Methods Serum IgE molecular components were assessed by ISAC method. Sera from 1,205 children, 708 males (58...
September 24, 2018: European Annals of Allergy and Clinical Immunology
S Peveri, S Pattini, M T Costantino, C Incorvaia, M Montagni, C Roncallo, D Villalta, E Savi
BACKGROUND: Component resolved diagnosis (CRD) allows to precisely identify the sensitization to specific molecules of a given allergenic source, resulting in an important improvement in clinical management, particularly of polysensitized subjects. This will end in the correct prescription of allergen immunotherapy (AIT) for respiratory allergy and in adequate avoidance diets or prescription of self-injectable adrenaline in food allergy. OBJECTIVE: The aim of this multicenter, real life study is to evaluate the percentage change of the diagnostic-therapeutic choice in polysensitized patients with respiratory allergy and in patients with food allergy, after using CRD compared to a first level diagnosis, along with an economic analysis of the patient's overall management according to the two different approaches...
September 20, 2018: Allergologia et Immunopathologia
Cassandra Johnson, Michael Zumwalt, Nancy Anderson
An allergic reaction provoked by reexposure to an allergen or antigen is known as a type I or immediate hypersensitivity reaction. Latex allergy is a common cause of type I hypersensitivity reactions. Allergic responses to latex in psoriasis patients receiving frequent injections with biologic agents are not commonly reported in the literature. We report the case of a patient with a long history of psoriasis who developed an allergic response after exposure to injection devices that contained latex components while undergoing treatment with biologic agents...
August 2018: Cutis; Cutaneous Medicine for the Practitioner
Anthony J Frew, Oliver Pfaar
Placebo effects are common in medicine. Randomised clinical trials help us to understand their magnitude in different therapies. There are particular problems with placebo effects in allergen immunotherapy (AIT) as it is difficult to blind the active treatment and the endpoints are largely subjective. This may explain why large placebo effects are often found in AIT trials. Patients receiving open label AIT get the benefit of the active and placebo components but it can be difficult to say how much benefit is due to the active component...
2018: Allergo Journal International
Karin A Pacheco
Surgical implants are essential elements of repair procedures to correct worn out joints, damaged spinal components, heart and vascular disease, and chronic pain. However, many of the materials that provide stability, flexibility, and durability to the implants are also immunogenic. Fortunately, allergic responses to surgical implants are infrequent. When they do occur, however, the associated pain, swelling, inflammation, and decreased range of motion can significantly impair the implant function. Given the high numbers of joint replacements performed in the developed world, allergic reactions to orthopedic implants form the largest category of allergic responses...
September 15, 2018: Clinical Reviews in Allergy & Immunology
Cunxi Wang, Wenze Li, Colton R Kessenich, Jay S Petrick, Timothy J Rydel, Eric J Sturman, Thomas C Lee, Kevin C Glenn, Thomas C Edrington
The lepidopteran-active Cry1A.105 protein is a chimeric three-domain insecticidal toxin with distinct structural domains derived from the naturally occurring Cry1Ab, Cry1Ac and Cry1F proteins from the soil bacterium Bacillus thuringiensis (Bt). The X-ray crystal structure of the Cry1A.105 tryptic core at 3.0 Å resolution demonstrates its high structural similarity to the tryptic core of Cry1Ac. Bioinformatics analyses demonstrate that Cry1A.105 has no significant amino acid sequence similarity to known allergens or mammalian toxins, which is the same conclusion reached for its component domains...
September 6, 2018: Regulatory Toxicology and Pharmacology: RTP
D Gellrich, C Meßmer, S Becker, M Gröger
BACKGROUND AND OBJECTIVE: Recently, an increasing number of studies focus on the debate whether provocation tests might be replaceable by specific IgE serology in patients sensitized to airborne allergens. Objective: Our study aimed to analyse the concordance between a nasal provocation test with Dermatophagoides pteronyssinus and specific IgE measurements in real-life data. MATERIAL AND METHODS: In 223 patients with proven sensitization to Dermatophagoides pteronyssinus, the concordance between the result of the provocation test and the IgE titer against several house dust mite components and extracts was retrospectively analysed...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
L Alvela-Suarez, J Campos, I Carballo, J Gomez-Rial, M Lombardero, A Linneberg, C Vidal, A Gonzalez-Quintela
BACKGROUND: Alcohol consumption is associated with enhanced Th2 immune responses. Aim: To investigate the frequency of false-positive serological tests of allergy in alcoholics. METHODS: A total of 138 alcoholic patients consecutively admitted to hospital underwent a panel of allergy tests that included serum total IgE, a multiallergen IgE test (UniCAP Phadiatop), and skin prick tests to relevant aeroallergens in the area, which were considered the standard reference for atopy...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
Hathairat Srisong, Sophida Sukprasert, Sompong Klaynongsruang, Jureerut Daduang, Sakda Daduang
Background: Fire ant venom is a complex mixture consisting of basic piperidine alkaloids, various biologically active peptides and protein components, including a variety of major allergenic proteins. Tropical fire ant Solenopsis geminata is an important stinging ant species that causes anaphylaxis and serious medical problems. Although the biological activities of allergenic venom proteins that are unique to ant venom, particularly Solenopsis 2 and 4, are still unknown, these proteins are believed to play important roles in mediating the effects of the piperidine derivatives in the venom...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
Thomas Holzhauser
In food allergy, a common immunological disease with a potentially severe outcome, a causative cure is not available. Correct ingredient labeling and risk assessment of unlabeled allergen cross-contact is a prerequisite for effective allergen avoidance. Specific and sensitive analytical methods, which allow for unequivocal identification and accurate quantification of allergenic components, are important tools in allergen risk management. Both protein- and DNA-based methods are in place and reveal pros and cons depending upon the application and individual analytical question...
September 26, 2018: Journal of Agricultural and Food Chemistry
James M Tracy, David Bk Golden
Venom immunotherapy is the only treatment for the prevention of anaphylaxis and remains the prototypical model for its diagnosis and management. Unlike other causes of anaphylaxis, such as foods and drugs, preventative treatment is highly effective and widely available. Hymenoptera venoms are also unique in that the primary allergens are directly measurable in terms of micrograms, rather than labeled based on potency. As such, venoms were the first truly standardized extracts. However, Hymenoptera venom presents unique challenges in collection, processing and stabilization of the venom extract product...
September 1, 2018: Journal of Allergy and Clinical Immunology in Practice
Martina Vachová, Petr Panzner, Peter Kopac, Urska Bidovec Stojkovič, Peter Korošec
No abstract text is available yet for this article.
August 31, 2018: Journal of Allergy and Clinical Immunology in Practice
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