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Allergen components

Naina Gour, Ursula Smole, Hwan-Mee Yong, Ian P Lewkowich, Nu Yao, Anju Singh, Edward Gabrielson, Marsha Wills-Karp, Stephane Lajoie
Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited. Recent evidence suggests that dysregulated innate immune factors can perpetuate asthma pathogenesis. In susceptible individuals, allergen exposure triggers the activation of complement, a major arm of innate immunity, leading to the aberrant generation of the C3a anaphylatoxin. C3 and C3a have been shown to be important for the development of Th2 responses, yet remarkably, the mechanisms by which C3a regulates type 2 immunity are relatively unknown...
August 13, 2018: Mucosal Immunology
Olesia Besh, Dmytro Besh, Olena Sorkopud, Marta Kondratiuk, Oksana Slaba, Irina Zhakun, Larysa Strilchuk, Jerzy Robert Ładny, Barbara Rafałowicz, Łukasz Szarpak, Robert Gałązkowski, Klaudiusz Nadolny
OBJECTIVE: The aim: To compare the treatment adherence of patients with Bronchial Asthma (BA) receiving basic treatment and its combination with allergen-specific immunotherapy. PATIENTS AND METHODS: Materials and methods: The study included 104 patients aged from 18 to 50 with BA. All patients were divided into two groups. The main group (MG) consisted of 51 patients receiving basic medical treatment and ASIT. 38 of them received subcutaneous ASIT and 13 patients received sublingual ASIT...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Angel San Miguel-Rodríguez, Alicia Armentia, Sara Martín-Armentia, Blanca Martín-Armentia, Alfredo Corell, Mª Carmen Lozano Estevan, Irene Iglesias Peinado
Component resolved diagnosis (CRD) is a microarray-based diagnostic solution capable of simultaneously analysing specific IgE antibodies against 112 allergenic components, providing sensitivity patterns for multi-sensitised or complex patients. The CRD is indicated for these patients, especially those with concomitant respiratory and food allergies. This study reivews the method, its utility, limitations, and our experience in allergic diseases with difficult etiologic diagnosis (eosinophilic esophagitis, occupational asthma and drug allergy)...
August 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kyoung Yong Jeong, Jongsun Lee, Gianni Mistrello, Kyung Hee Park, Jung Won Park
PURPOSE: Japanese hop (Humulus japonicus) is a major cause of weed pollinosis in East Asia. However, supplies of commercial allergen extract from this plant have not met clinical demand. The pollen of common hop (Humulus lupulus), a closely related species, may provide an alternative source if there is strong IgE cross-reactivity between these two species. We aimed to compare the IgE cross-reactivity and allergenicity of common hop and Japanese hop pollen. MATERIALS AND METHODS: Cross-reactivity was measured by inhibition ELISA...
September 2018: Yonsei Medical Journal
Ioannis Bakolis, Richard Hooper, Claus Bachert, Bibi Lange, Tari Haahtela, Thomas Keil, Stephanie Hofmaier, Wytske Fokkens, Barbara Rymarczyk, Christer Janson, Peter G J Burney, Vanessa Garcia-Larsen
BACKGROUND: Dietary patterns defined using Principal Component Analysis (PCA) offer an alternative to the analysis of individual foods and nutrients and have been linked with asthma and allergic disease. However, results have not been reproducible in different settings. OBJECTIVE: To identify dietary patterns common to different European countries and examine their associations with asthma and allergic symptoms. METHODS: In sixteen study centres in nine European countries, 3206 individuals aged 15-77 years completed a common, internationally validated, Food Frequency Questionnaire and a respiratory symptoms questionnaire...
August 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Ken Arae, Hideaki Morita, Hirotoshi Unno, Kenichiro Motomura, Sumika Toyama, Naoko Okada, Tatsukuni Ohno, Masato Tamari, Keisuke Orimo, Yuko Mishima, Hajime Suto, Ko Okumura, Katsuko Sudo, Hiroshi Miyazawa, Haruhiko Taguchi, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
Chitin, which is a major component of house dust mites (HDM), fungi, crustaceans, etc., can activate immune cells, suggesting that it contributes to development of allergic disorders such as asthma. Although the pathophysiological sensitization route of asthmatic patients to allergens is considered via the respiratory tract, the roles of intranasally-administered chitin in development of asthma remain unclear. After ovalbumin (OVA) challenge, development of airway inflammation was profoundly exacerbated in mice sensitized with OVA in the presence of chitin...
August 6, 2018: Scientific Reports
Min Young Park, Wong Jeong Kim, Hoon Soo Kim, Byung Soo Kim, Moon Bum Kim, Hyung Chang Ko
Dear Editor, Exposure to hair-dye is the most frequent route of sensitization to para-phenylenediamine (PPD), a common contact allergen (1). Patients allergic to PPD often worry about the use of hairdressings and usually ask about safe alternative agents and the use of other hairdressing materials such as permanent wave agents, shampoos, and bleaching agents. However, there have been no studies on this issue. The aim of the present study was to investigate the positivity of hair-related allergens and identify safe alternatives...
December 2017: Acta Dermatovenerologica Croatica: ADC
Huey-Jy Huang, Yvonne Resch-Marat, Azahara Rodriguez-Dominguez, Kuan-Wei Chen, Renata Kiss, Petra Zieglmayer, René Zieglmayer DI, Patrick Lemell, Friedrich Horak, Rudolf Valenta, Susanne Vrtala
We identified 6 house dust mite (HDM) allergen molecules to comprising the majority of HDM IgE-binding components and show that molecular ImmunoCAPs based on these six allergens are superior to allergen extract-based ImmunoCAPs for quantifying HDM-specific IgE.
July 27, 2018: Journal of Allergy and Clinical Immunology
Mey-Fann Lee, Chu-Hui Chiang, Ying-Lan Li, Nancy M Wang, Pei-Pong Song, Shyh-Jye Lin, Yi-Hsing Chen
BACKGROUND: American cockroaches (Periplaneta americana) are an important indoor allergen source and a major risk factor for exacerbations and poor control of asthma. We previously reported that allergen components from American cockroaches exhibit varying levels of pathogenicity. Sensitization to major American cockroach allergen, Per a 2, correlated with more severe clinical phenotypes among patients with allergic airway diseases. MATERIALS AND METHODS: In this study, we examined whether oral plant vaccine-encoding full-length Per a 2 clone-996 or its hypoallergenic clone-372 could exert a prophylactic role in Per a 2-sensitized mice...
2018: PloS One
Dimphna N Ezikanyi, Gloria Sakwari, Catherine V Nnamani
INTRODUCTION AND OBJECTIVES: Aeroallergens are airborne organic substances which are responsible for allergenic diseases in hypersensitive individuals. People are exposed to their allergens either directly or after their entrance into the interiors. The spatio-temporal pattern of aeroallergens and their relationship with weather variability in Abuja and Nassarawa, North-Central Nigeria was studied. MATERIALS AND METHODS: Aerosamples were trapped with modified Tauber-like pollen traps...
July 25, 2018: Allergologia et Immunopathologia
Pawel Dubiela, Stefan Kabasser, Nicolas Smargiasso, Sabine Geiselhart, Merima Bublin, Christine Hafner, Gabriel Mazzucchelli, Karin Hoffmann-Sommergruber
Walnuts are ranked high in the list of the culprit foods inducing severe allergic reactions. Jug r 2 has been identified as a major allergen in common walnut by cDNA cloning from a somatic cell line. So far, studies were performed on the allergenic activity of recombinant Jug r 2, yet there is still no evidence about the physicochemical characteristics of the natural allergen. Therefore, we aimed to purify and deeply characterize natural Jug r 2 and to assess IgE cross-reactivity among vicilins from different tree nuts...
July 27, 2018: Scientific Reports
Thanh D Dang, Rachel L Peters, Jennifer J Koplin, Shyamali C Dharmage, Lyle C Gurrin, Anne-Louise Ponsonby, David J Martino, Melanie Neeland, Mimi L K Tang, Katrina J Allen
BACKGROUND: IgE-mediated egg allergy presents as one of the most common food allergies in children. Measurement of egg white-specific IgE levels in serum or skin prick test has been shown to be a poor predictor of clinical allergy to raw egg white, and also to baked or cooked egg. Recent developments in component resolved diagnostic (CRD) technology have enabled us to improve the way in which we diagnose and predict peanut allergy through examining IgE specificity to individual peptides...
July 23, 2018: Allergy
Paul J Dowling, Hannah Neuhaus, Brooke I Polk
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disease with incompletely understood pathogenesis. Though disease manifestations were initially ascribed to a delayed reaction to food allergens, emerging evidence suggests that modifiable host factors and environmental allergen exposure may also play critical roles in the pathogenesis and ongoing manifestations of EoE. As with other atopic diseases, lack of early-life exposure to microbial pathogens leads to an immune tolerance defect and reprograms the commensal gut microflora toward a type 2 T helper (Th2) phenotype; the esophageal microbiota, a rich environment consisting of diverse bacterial species, is greatly altered by inflammation...
July 21, 2018: Clinical Reviews in Allergy & Immunology
Gloria Solano-Aguilar, Terez Shea-Donohue, Kathleen B Madden, Alejandro Quinoñes, Ethiopia Beshah, Sukla Lakshman, Yue Xie, Harry Dawson, Joseph F Urban
An evaluation of a localized intestinal allergic type-2 response concomitant with consumption of probiotic bacteria is not well documented. This study investigated the effect of feeding probiotic Bifidobacterium animalis subspecies lactis (Bb12) or a placebo in weaned pigs that were also inoculated with Ascaris suum (A. suum) eggs to induce a strong Th2-dependent allergic type 2 immune response. Sections of jejunal mucosa were mounted in Ussing chambers to determine changes in permeability and glucose absorption, intestine and liver samples were collected for analysis of type-2 related gene expression, jejunum examined histologically, and sera and intestinal fluid were assayed for parasite antigen specific antibody...
July 19, 2018: Gut Microbes
F W Ismail, S Abid, S Awan, F Lubna
BACKGROUND AND STUDY AIMS: Food hypersensitivity (FH), irritable bowel syndrome (IBS) and functional dyspepsia (FD) have many overlapping symptoms, including abdominal discomfort, bloating, and altered bowel habits. We aimed to determine the frequency of FH in patients with IBS and functional FD. PATIENTS AND METHODS: Adult patients of either gender diagnosed with IBS and/or FD as per the Rome III criteria were recruited. Patients underwent serological testing against 6 food allergens: beef, shrimp, egg white, milk, peanut, and soy-bean...
April 2018: Acta Gastro-enterologica Belgica
Genoveva Del-Río Camacho, Ana María Montes Arjona, José Fernández-Cantalejo Padial, Rodríguez Catalán Jesús
INTRODUCTION: Specific immunotherapy (SIT) is used to treat asthma and allergic rhinitis, and a dose-response relationship has been found for SIT efficacy, creating a need to accurately select the allergen used in therapy. This need is especially pronounced in poly-sensitized children living in areas where different pollen allergen sources coexist in the same season, as this circumstance complicates diagnostic efforts. In such cases, component-resolved diagnosis (CRD) can increase diagnostic accuracy and aid in SIT prescription...
July 12, 2018: Allergologia et Immunopathologia
M Giovannini, P Comberiati, M Piazza, E Chiesa, G L Piacentini, A Boner, G Zanoni, D G Peroni
BACKGROUND: Serum IgE evaluation of peanut, hazelnut and walnut allergens through the use of component-resolved diagnosis (CRD) can be more accurate than IgE against whole food to associate with severe or mild reactions. OBJECTIVES: The aim of the study was to retrospectively define the level of reaction risk in children with peanut, hazelnut and walnut sensitization through the use of CRD. METHODS: 34 patients [n=22 males, 65%; median age eight years, interquartile range (IQR) 5...
July 13, 2018: Allergologia et Immunopathologia
Abida Zahirović, Mojca Lunder
Allergen-specific immunotherapy represents the only available curative approach to allergic diseases. The treatment has proven effective, but it requires repetitive administrations of allergen extracts over 3-5 years and is often associated with adverse events. This implies the need for novel therapeutic strategies with reduced side effects and decreased treatment time, which would improve patients' compliance. Development of vaccines that are molecularly well defined and have improved safety profile in comparison to whole allergen extracts represents a promising approach...
2018: Frontiers in Microbiology
Maria J Rodriguez, Andrea Wangorsch, Francisca Gomez, Stefan Schülke, Maria J Torres, Stefan Vieths, Stephan Scheurer, Masako Toda, Cristobalina Mayorga
Background: The use of hypoallergenic derivatives is considered beneficial to promote the safety and efficacy of allergen-specific immunotherapy. We aimed to assess the efficacy of reduced and alkylated (R/A) Pru p 3, a hypoallergenic folding variant of the major peach allergen, in subcutaneous immunotherapy (SCIT) using a murine model of peach allergy. Methods and Results: After sensitization with Pru p 3, BALB/c mice received SCIT with Pru p 3 or R/A Pru p 3 and were challenged with Pru p 3...
2018: Journal of Immunology Research
Yongshi Yang, Rongfei Zhu, Nan Huang, Wenjing Li, Wei Zhang, Yin Wang, Lin Yang
Background House dust mites (HDMs) are the major aeroallergens in patients with rhinitis and/or asthma in China. However, the molecular sensitization of HDM is varied in different regions. Objective To investigate the Dermatophagoides pteronyssinus ( Der p) molecular sensitization profile of allergic rhinitis (AR) patients in Central China. Methods AR patients with positive skin prick tests to Der p were enrolled in our study. Specific immunoglobulin E (sIgE) for Der p, Dermatophagoides farinae ( Der f), Acarus siro ( Aca s), Blomia tropicalis ( Blo t), and Der p components Der p1, Der p2, and Der p10 were measured in all patients...
January 1, 2018: American Journal of Rhinology & Allergy
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