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Diabetes Infertility

Barbara Luke, Morton B Brown, Ethan Wantman, David B Seifer, Amy T Sparks, Paul C Lin, Kevin J Doody, Bradley J Van Voorhis, Logan G Spector
PURPOSE: To evaluate the risk of prematurity and infant mortality by maternal fertility status, and for in vitro fertilization (IVF) pregnancies, by oocyte source and embryo state combinations. METHODS: Women in 14 States who had IVF-conceived live births during 2004-13 were linked to their infant's birth and death certificates; a 10:1 sample of non-IVF births was selected for comparison; those with an indication of infertility treatment on the birth certificate were categorized as subfertile, all others were categorized as fertile...
October 17, 2018: Journal of Assisted Reproduction and Genetics
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Filippo Pederzoli, Nicola Frego, Walter Cazzaniga, Francesco Chierigo, Massimo Alfano, Lorenzo Piemonti, Paola Viganò, Marina Pontillo, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
OBJECTIVE: To study the prevalence and the risk associated with prediabetes (PreDM) in primary infertile men. PATIENTS AND METHODS: Data from 744 infertile men were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Serum hormones were measured in every man. Semen analysis was based on 2010 World Health Organization (WHO) reference criteria. PreDM was defined according to the clinical criteria detailed by the American Diabetes Association (Diabetes Care 2014; 37 (Suppl...
October 16, 2018: BJU International
Walaa Hassan Nazmy, Eman Abdelmonem Elbassuoni, Fatma Farrag Ali, Rehab Ahmed Rifaai
Diabetes mellitus (DM) is closely associated with male infertility and sexual dysfunction. Recent data indicate that the proinsulin C-peptide (CP) exerts important physiological effects and shows the characteristics of an endogenous peptide hormone. So, this study was done to investigate the effect of C-peptide with or without insulin treatment on testicular function and architecture in diabetic rats. Rats were divided into the following groups: control, diabetic, and diabetic groups treated with either CP alone or combined with insulin...
October 14, 2018: Journal of Cellular Physiology
Laura G Cooney, Anuja Dokras
Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with symptoms of oligomenorrhea or hirsutism or when presenting for infertility care. The health risks associated out of PCOS, however, go far beyond management of these common presenting symptoms or fertility treatment and likely extend past the reproductive years through and beyond menopause. International surveys suggest that most patients are dissatisfied with long-term counseling related to medical and psychologic issues...
October 2018: Fertility and Sterility
Kurt T Barnhart
Infertility has long-term effects beyond the inability to conceive. Infertility may be a harbinger of future disease and altered longevity. Understanding the mechanisms of how fertility is a window to health opens new avenues of important investigation addressing interdependent physiologic processes. Identification of healthy persons at risk for future cardiovascular disease, diabetes, or cancer could allow a change in reproductive medical care by altering long-term surveillance and reduction of risk.
October 2018: Fertility and Sterility
Young Jun Koh, Ju-Hee Lee, Sung Yun Park
Background: Obesity is a pathological condition associated with various diseases including diabetes, stroke, arthritis, infertility, and heart disease. Moxibustion is widely used to prevent and manage obesity in traditional Asian medicine. We tested our hypothesis that moxibustion-simulating bipolar radiofrequency (M-RF) can suppress total body and white adipose tissue (WAT) weight gain via induction of WAT browning in a mouse model of diet-induced obesity (DIO). Methods: We designed an M-RF device that could accurately adjust the depth and temperature at which heat stimulation was administered into the abdomen of DIO mice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Chien-Feng Mao, Xiu-Ru Zhang, Athira Johnson, Jia-Ling He, Zwe-Ling Kong
Diabetes mellitus is a major health problem that affects a patient's life quality throughout the world due to its worst complications. It was recognized that chronic hyperglycemia with oxidative stress was the major cause of male infertility. Echinacea purpurea ethanol extract (EE) contains phenolic acid and isobutylamides had been proven to ameliorate diabetic complications. Chitosan/silica nanoparticles are well-known in the medicinal field because of its controlled release and drug delivery properties. This study was aimed at investigating whether the EE encapsulated chitosan/silica nanoparticle (nano-EE) can enhance the amelioration of male infertility...
2018: BioMed Research International
Mary Lourdes Montenegro, Camila M Bonocher, Juliana Meola, Rafael L Portella, Alfredo Ribeiro-Silva, Mariangela O Brunaldi, Rui Alberto Ferriani, Julio Cesar Rosa-E-Silva
OBJECTIVE: Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The prevalence of endometriosis among women experiencing pain, infertility, or both is as high as 35% to 50%. The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Evidence has suggested that endometriosis symptoms result from a local inflammatory peritoneal reaction caused by ectopic endometrial implants that undergo cyclic bleeding...
September 19, 2018: Reproductive Sciences
Meliha Salahuddin, Dorothy J Mandell, David L Lakey, Catherine S Eppes, Divya A Patel
BACKGROUND: Cesarean delivery accounts for over one-third of the ~400 000 annual births in Texas, with first-time cesarean accounting for 20% of the overall cesareans. We examined associations of maternal medical comorbidities with cesarean delivery among nulliparous, term, singleton, vertex (NTSV) deliveries in Texas. METHODS: Nulliparous, term, singleton, vertex deliveries to women aged 15-49 years were identified using the 2015 Texas birth file (Center for Health Statistics, Texas Department of State Health Services)...
September 9, 2018: Birth
Julius Fink, Masahito Matsumoto, Yoshifumi Tamura
Sedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of muscle mass, adipose tissue, inflammation and insulin sensitivity and is therefore indirectly regulating several metabolic pathways, while T2D is commonly triggered by insulin resistance, increased adipose tissue and inflammation, showing a negative correlation between testosterone levels and T2D...
October 2018: Steroids
Hiroaki Tanaka, Shinji Katsuragi, Junichi Hasegawa, Kazuhiro Osato, Masahiko Nakata, Takeshi Murakoshi, Akihiko Sekizawa, Naohiro Kanayama, Isamu Ishiwata, Tomoaki Ikeda
AIM: To investigate the influence of reproductive medicine in maternal death cases in Japan. METHODS: This retrospective study investigated the incidence of maternal deaths related to reproductive medicine in Japan from 2013 to 2015, and the relationship between fertility treatment and maternal death. RESULTS: Fifteen out of 134 women (11.2%) involved in this study who underwent treatment for infertility died. Four experienced pregnancy with severe maternal complications (26...
August 16, 2018: Journal of Obstetrics and Gynaecology Research
Judy E Stern, Chia-Ling Liu, Howard J Cabral, Elliott G Richards, Charles C Coddington, Stacey A Missmer, Hafsatou Diop
OBJECTIVE: To quantify the effect of medical and obstetrical factors on the odds of cesarean delivery, comparing assisted reproductive technology (ART)-treated women and women with subfertility not treated with ART versus fertile women. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Singleton deliveries to primiparous women; with the source of this data being the Massachusetts vital and hospital records linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System data (2004-2010)...
August 2018: Fertility and Sterility
James Kent, William C Dodson, Allen Kunselman, Jaimey Pauli, Alicia Stone, Michael P Diamond, Christos Coutifaris, William D Schlaff, Ruben Alvero, Peter Casson, Gregory M Christman, R Mitchell Rosen, Karl R Hansen, Randall Robinson, Valerie Baker, Rebecca Usadi, Nanette Santoro, Heping Zhang, Esther Eisenberg, Richard S Legro
Context: Women with PCOS are at increased risk for pregnancy complications possibly related to pre-existing obesity and potentially to excessive gestational weight gain (GWG). Objectives: To assess the contributions of pre-existing diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS(N =164) and ovulatory controls(N = 176) conceiving from infertility treatment. Main Outcome measures: GWG, birthweight, pregnancy complications...
August 1, 2018: Journal of Clinical Endocrinology and Metabolism
Daniel Ferguson, Mitchell Blenden, Irina Hutson, Yingqiu Du, Charles A Harris
The global obesity epidemic is fueling alarming rates of diabetes, associated with increased risk of cardiovascular disease and cancer. Leptin is a hormone secreted by adipose tissue that is a key regulator of body weight (BW) and energy expenditure. Leptin-deficient humans and mice are obese, diabetic, and infertile and have hepatic steatosis. Although leptin replacement therapy can alleviate the pathologies seen in leptin-deficient patients and mouse models, treatment is costly and requires daily injections...
September 1, 2018: Endocrinology
Ewa Otto-Buczkowska, Karolina Grzyb, Natalia Jainta
Polycystic ovary syndrome (PCOS) usually arises during puberty and is marked by insulin resistance, hyperinsulinemia, and hyperandrogenism. The principle is that the diagnosis of PCOS must be based on the presence of at least two of the following three criteria: chronic anovulation, hyperandrogenism (clinical or biological), and polycystic ovaries. The diagnosis of PCOS in adolescents is particularly difficult due to developmental problems in this group. Many symptoms of PCOS, including acne, menstrual irregularities, and hyperinsulinemia, are common in normal puberty...
2018: Pediatric Endocrinology, Diabetes, and Metabolism
Tsai-Bei Lin, Men-Fong Hsieh, Ying-Chung Hou, Yu-Ling Hsueh, Hui-Ping Chang, Yuan-Tsung Tseng
The aim of this study was to quantitatively estimate the long-term risk of abortion-related consequences and comorbidities.We identified 36,375 patients with at least 2 diagnosed abortions from 2000 to 2013 and included them in the abortion group. This group was further subdivided into 4 subgroups: spontaneous abortion, induced abortion, nonspecific abortion, and mixed-type abortion groups. For comparison, another 36,375 pregnant women from the National Health Insurance Research Database of Taiwan were included in the nonabortion group...
August 2018: Medicine (Baltimore)
Reza Zarezadeh, Amir Mehdizadeh, Jo L M R Leroy, Mohammad Nouri, Shabnam Fayezi, Masoud Darabi
Infertility is a growing problem worldwide. Currently, in vitro fertilization (IVF) is widely performed to treat infertility. However, a high percentage of IVF cycles fails, due to the poor developmental potential of the retrieved oocyte to generate viable embryos. Fatty acid content of the follicular microenvironment can affect oocyte maturation and the subsequent developmental competence. Saturated and monounsaturated fatty acids are mainly used by follicle components as primary energy sources whereas polyunsaturated fatty acids (PUFAs) play a wide range of roles...
August 2, 2018: Journal of Cellular Physiology
Madhusudan Dey, Monica Saraswat
Background: Higher-order multiple (HOM) pregnancies are associated with increased incidences of pregnancy complications mainly abortions, pre-eclampsia, preterm delivery and fetal death. Multifetal reduction (MFR) during first trimester and subsequent delivery of twins can reduce pregnancy associated morbidities. This study was conducted to evaluate the maternal and fetal outcomes of MFR procedure in patients with HOMs those managed in a tertiary care hospital. Methods and Material: It was a prospective observational study carried out in a tertiary care military hospital, India, and all women with higher-order multiples (triplets or more) conceived spontaneously or after infertility treatment (ovulation induction, intra-uterine insemination, or in vitro fertilization) during the 3-year period from Jan 2014 to Dec 2016 were included for MFR...
August 2018: Journal of Obstetrics and Gynaecology of India
Aleksandra Marciniak, Katarzyna Lejman-Larysz, Jolanta Nawrocka-Rutkowska, Agnieszka Brodowska, Dorota Songin
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder, affecting 5-10% women of reproductive age. It is one of the most common causes of functional infertility and a clinical problem that can be faced by doctors of many specialities. PCOS is characterized by hyperandrogenism, oligoovulations and metabolic disorders. ESHRE/ASRM (2003) or AES (2006) criteria are used to diagnose a patient with polycystic ovary syndrome. Although a lot of studies are carried out, ethiology and pathogenesis of PCOS is still not clear...
June 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
D Warzecha, I Szymusik, B Grzechocińska, A Cyganek, B Kociszewska-Najman, N Mazanowska, A Madej, J Pazik, M Wielgoś, B Pietrzak
INTRODUCTION: Kidney transplantation (KTx) is the treatment of choice in patients with end-stage renal failure. Among various medical issues in female graft recipients, the need for maternity can become an overriding one. Gonadal dysfunction usually resolves within 6 months after transplantation; however, the prevalence of infertility is similar to this in the general population. MATERIALS AND METHODS: This case series describes the experience in infertility treatment and following perinatal care among KTx women who underwent successful in vitro fertilization (IVF)...
July 2018: Transplantation Proceedings
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