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Diabetes Infertility

Judy E Stern, Chia-Ling Liu, Howard J Cabral, Elliott G Richards, Charles C Coddington, Stacey A Missmer, Hafsatou Diop
OBJECTIVE: To quantify the effect of medical and obstetrical factors on the odds of cesarean delivery, comparing assisted reproductive technology (ART)-treated women and women with subfertility not treated with ART versus fertile women. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Singleton deliveries to primiparous women; with the source of this data being the Massachusetts vital and hospital records linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System data (2004-2010)...
August 2018: Fertility and Sterility
James Kent, William C Dodson, Allen Kunselman, Jaimey Pauli, Alicia Stone, Michael P Diamond, Christos Coutifaris, William D Schlaff, Ruben Alvero, Peter Casson, Gregory M Christman, R Mitchell Rosen, Karl R Hansen, Randall Robinson, Valerie Baker, Rebecca Usadi, Nanette Santoro, Heping Zhang, Esther Eisenberg, Richard S Legro
Context: Women with PCOS are at increased risk for pregnancy complications possibly related to pre-existing obesity and potentially to excessive gestational weight gain (GWG). Objectives: To assess the contributions of pre-existing diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS(N =164) and ovulatory controls(N = 176) conceiving from infertility treatment. Main Outcome measures: GWG, birthweight, pregnancy complications...
August 1, 2018: Journal of Clinical Endocrinology and Metabolism
Daniel Ferguson, Mitchell Blenden, Irina Hutson, Yingqiu Du, Charles A Harris
The global obesity epidemic is fueling alarming rates of diabetes, associated with increased risk of cardiovascular disease and cancer. Leptin is a hormone secreted by adipose tissue that is a key regulator of body weight and energy expenditure. Leptin-deficient humans and mice are obese, diabetic, infertile, and have hepatic steatosis. While leptin replacement therapy can rescue the pathologies seen in leptin-deficient patients and mouse models, treatment is very costly and requires daily injections. Since adipocytes are the source of leptin secretion we investigated whether mouse embryonic fibroblasts (MEFs), capable of forming adipocytes, could be injected into ob/ob mice and prevent the metabolic phenotype seen in these leptin-deficient mice...
July 31, 2018: Endocrinology
Ewa Otto-Buczkowska, Karolina Grzyb, Natalia Jainta
Polycystic ovary syndrome (PCOS) usually arises during puberty and is marked by insulin resistance, hyperinsulinemia, and hyperandrogenism. The principle is that the diagnosis of PCOS must be based on the presence of at least two of the following three criteria: chronic anovulation, hyperandrogenism (clinical or biological), and polycystic ovaries. The diagnosis of PCOS in adolescents is particularly difficult due to developmental problems in this group. Many symptoms of PCOS, including acne, menstrual irregularities, and hyperinsulinemia, are common in normal puberty...
2018: Pediatric Endocrinology, Diabetes, and Metabolism
Tsai-Bei Lin, Men-Fong Hsieh, Ying-Chung Hou, Yu-Ling Hsueh, Hui-Ping Chang, Yuan-Tsung Tseng
The aim of this study was to quantitatively estimate the long-term risk of abortion-related consequences and comorbidities.We identified 36,375 patients with at least 2 diagnosed abortions from 2000 to 2013 and included them in the abortion group. This group was further subdivided into 4 subgroups: spontaneous abortion, induced abortion, nonspecific abortion, and mixed-type abortion groups. For comparison, another 36,375 pregnant women from the National Health Insurance Research Database of Taiwan were included in the nonabortion group...
August 2018: Medicine (Baltimore)
Reza Zarezadeh, Amir Mehdizadeh, Jo L M R Leroy, Mohammad Nouri, Shabnam Fayezi, Masoud Darabi
Infertility is a growing problem worldwide. Currently, in vitro fertilization (IVF) is widely performed to treat infertility. However, a high percentage of IVF cycles fails, due to the poor developmental potential of the retrieved oocyte to generate viable embryos. Fatty acid content of the follicular microenvironment can affect oocyte maturation and the subsequent developmental competence. Saturated and monounsaturated fatty acids are mainly used by follicle components as primary energy sources whereas polyunsaturated fatty acids (PUFAs) play a wide range of roles...
August 2, 2018: Journal of Cellular Physiology
Madhusudan Dey, Monica Saraswat
Background: Higher-order multiple (HOM) pregnancies are associated with increased incidences of pregnancy complications mainly abortions, pre-eclampsia, preterm delivery and fetal death. Multifetal reduction (MFR) during first trimester and subsequent delivery of twins can reduce pregnancy associated morbidities. This study was conducted to evaluate the maternal and fetal outcomes of MFR procedure in patients with HOMs those managed in a tertiary care hospital. Methods and Material: It was a prospective observational study carried out in a tertiary care military hospital, India, and all women with higher-order multiples (triplets or more) conceived spontaneously or after infertility treatment (ovulation induction, intra-uterine insemination, or in vitro fertilization) during the 3-year period from Jan 2014 to Dec 2016 were included for MFR...
August 2018: Journal of Obstetrics and Gynaecology of India
Aleksandra Marciniak, Katarzyna Lejman-Larysz, Jolanta Nawrocka-Rutkowska, Agnieszka Brodowska, Dorota Songin
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder, affecting 5-10% women of reproductive age. It is one of the most common causes of functional infertility and a clinical problem that can be faced by doctors of many specialities. PCOS is characterized by hyperandrogenism, oligoovulations and metabolic disorders. ESHRE/ASRM (2003) or AES (2006) criteria are used to diagnose a patient with polycystic ovary syndrome. Although a lot of studies are carried out, ethiology and pathogenesis of PCOS is still not clear...
June 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
D Warzecha, I Szymusik, B Grzechocińska, A Cyganek, B Kociszewska-Najman, N Mazanowska, A Madej, J Pazik, M Wielgoś, B Pietrzak
INTRODUCTION: Kidney transplantation (KTx) is the treatment of choice in patients with end-stage renal failure. Among various medical issues in female graft recipients, the need for maternity can become an overriding one. Gonadal dysfunction usually resolves within 6 months after transplantation; however, the prevalence of infertility is similar to this in the general population. MATERIALS AND METHODS: This case series describes the experience in infertility treatment and following perinatal care among KTx women who underwent successful in vitro fertilization (IVF)...
July 2018: Transplantation Proceedings
Erfaneh Shaygannia, Marziyeh Tavalaee, Gholam R Akhavanfarid, Mahshid Rahimi, Maurizio Dattilo, Mohammad H Nasr-Esfahani
Alpha-lipoic acid (ALA) is a disulphide compound with multifunctional antioxidant properties and is soluble in both water and lipid. Several recent studies evaluated efficacy of ALA in various diseases related to oxidative damage such as diabetes, multiple sclerosis and Alzheimer and concluded that ALA can reduce oxidative stress by quenching reactive oxygen and nitrogen species, restoring antioxidants such as glutathione, vitamins C and E, and/or improving activity of antioxidant enzymes. Varicocele, an enlargement of the veins in scrotum, is considered as the most common repairable cause of male infertility and is associated with high levels of oxidative stress...
July 23, 2018: Andrologia
Wan-Ting Liao, Jen-Huai Chiang, Chia-Jung Li, Ming-Tsung Lee, Cheng-Chiung Su, Hung-Rong Yen
Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all its symptoms. Existing pharmaceutical agents, such as oral contraceptives (OCs), are suggested as a first-line therapy for menstrual irregularities; however, OCs are not appropriate for women pursuing pregnancy...
July 22, 2018: Journal of Clinical Medicine
Dan Jiao, Huan Zhang, Ziping Jiang, Wenlin Huang, Zhuo Liu, Zhaohui Wang, Yonggang Wang, Hao Wu
Testicular apoptotic cell death (TACD) contributes to diabetes mellitus (DM)-induced male infertility. MicroRNA-34a (miR-34a) is a pro-apoptotic RNA that targets sirtuin 1 (SIRT1) which provides protection against complications of (DM). However, the specific role of miR-34a in (DM)-induced TACD is unknown. MiR-34a targets Sirt1 mRNA, resulting in apoptosis. However, whether or not SIRT1 is a major target of miR-34a in (DM)-induced TACD is unclear. The present study aimed to define the role of miR-34a/SIRT1 in (DM)-induced TACD...
July 21, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Krina T Zondervan, Christian M Becker, Kaori Koga, Stacey A Missmer, Robert N Taylor, Paola Viganò
Endometriosis is a common inflammatory disease characterized by the presence of tissue outside the uterus that resembles endometrium, mainly on pelvic organs and tissues. It affects ~5-10% of women in their reproductive years - translating to 176 million women worldwide - and is associated with pelvic pain and infertility. Diagnosis is reliably established only through surgical visualization with histological verification, although ovarian endometrioma and deep nodular forms of disease can be detected through ultrasonography and MRI...
July 19, 2018: Nature Reviews. Disease Primers
Toshiya Matsuzaki, Takeshi Iwasa, Takako Kawakita, Yuri Yamamoto, Akiko Abe, Aki Hayashi, Kiyohito Yano, Masato Nishimura, Akira Kuwahara, Minoru Irahara
Case: Approximately 3%-25% of cases of endometrial carcinoma (EC) or atypical endometrial hyperplasia (AH) occur in women aged <40 years and conservative treatment with high-dose medroxyprogesterone acetate (MPA) is administered to women who wish to preserve their fertility. Here is reported the pregnancy outcomes of patients with EC or AH who received MPA therapy at Tokushima University Hospital, Tokushima, Japan. The frequency of pregnancy and live births among the patients with EC or AH who received conservative treatment, followed by fertility treatment, were analyzed retrospectively...
July 2018: Reproductive Medicine and Biology
Yung-Hsiang Lin, Ko-Jung Chen, Yun-Shing Peng, Pau-Chung Chen, Yao-Hsu Yang
AIMS: The aim of this study was to assess the fertility rate in Taiwanese women before and after a diagnosis of type 1 diabetes. The potential risk factors which may have influenced fertility were also investigated. METHODS: We conducted this retrospective, nationwide, population-based, matched cohort study using data from the Taiwan National Health Insurance Research Database. The diabetic group (n = 1191) included women with type 1 diabetes aged between 16 and 30 years in 2000...
July 9, 2018: Diabetes Research and Clinical Practice
Seyyed-Reza Sadat-Ebrahimi, Neda Parnianfard, Nafiseh Vahed, Hossein Babaei, Morteza Ghojazadeh, Sydney Tang, Amir Azarpazhooh
PURPOSE: Lisinopril is one of the angiotensin-converting-enzyme inhibitors that is largely being administered for its off-label uses. This study aims to provide a comprehensive review of off-label uses of lisinopril to aid physicians to make evidence-based decisions. METHODS: The following bibliographic databases were searched from inception until 30 March 2017: PubMed, EMBASE, the Cochrane Library, Cochrane Central Register of Controlled Trials, Scopus, Ovid, and Proquest...
July 3, 2018: British Journal of Clinical Pharmacology
Gianluca Catucci, Stefania Bortolussi, Giulia Rampolla, Debora Cusumano, Gianfranco Gilardi, Sheila J Sadeghi
Human flavin-containing monooxygenase 3 (hFMO3) is a drug-metabolising enzyme that oxygenates many drugs and xenobiotics in the liver. This enzyme is also known to exhibit single nucleotide polymorphisms (SNPs) that can alter the rates of monooxygenation of therapeutic agents. The purpose of this study was to investigate the effect of the three common polymorphic variants of hFMO3 (V257M, E158K and E308G) on the metabolism and clearance of 3 structurally similar compounds: tamoxifen (breast cancer medication), clomiphene (infertility medication) and GSK5182 (anti-diabetic lead molecule)...
June 30, 2018: Basic & Clinical Pharmacology & Toxicology
Apichakan Sampannang, Supatcharee Arun, Jaturon Burawat, Wannisa Sukhorum, Sitthichai Iamsaard
Background: The streptozotocin (STZ)-induced diabetic model is widely used to evaluate the adverse effects of diabetes mellitus (DM) on spermatogenesis and testicular steroidogenesis. However, the actual mechanism of sub/infertility in DM males needs to be elucidated. Objective: To conduct a detailed examination of the testicular histopathology, sperm acrosome reaction (AR) status, and tyrosine-phosphorylated protein expression in the testis of male mice induced with STZ...
April 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Nazar Ali Korejo, Quanwei Wei, Kaizhi Zheng, Dagan Mao, Rashid Ali Korejo, Atta Hussain Shah, Fangxiong Shi
BACKGROUND: Diabetes and hypothyroidism produce adverse effects on body weight and sexual maturity by inhibiting body growth and metabolism. The occurrence of diabetes is always accompanied with thyroid dysfunction. Thus, it is important to take hypo- or hyper-thyroidism into consideration when exploring the adverse effects caused by diabetes. Previous reports have found hypothyroidism inhibits testicular growth by delaying Sertoli cell differentiation and proliferation. Hence, by establishing a mouse model of diabetes combined with hypothyroidism, we provided evidence that poly glandular autoimmune syndrome affected testicular development and spermatogenesis...
June 26, 2018: BMC Developmental Biology
Anna Sara Oberg, Tyler J VanderWeele, Catarina Almqvist, Sonia Hernandez-Diaz
Background: To assess the extent to which multiple gestations mediate risk of pregnancy complications from fertility treatment and to address possible confounding by the underlying infertility. Methods: From the nearly 1.8 million pregnancies recorded in the Swedish Medical Birth Register between 1996 and 2013, we selected the 9.9% (N = 174 067) that occurred to couples with known trouble conceiving (clinical infertility). Fertility treatment was identified from self-reports, medical records and procedural information from fertility clinics...
June 22, 2018: International Journal of Epidemiology
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