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https://www.readbyqxmd.com/read/29475179/comprehensive-characteristics-of-the-anticoagulant-activity-of-dabigatran-in-relation-to-its-plasma-concentration
#1
Willemijn J Comuth, Linda Ø Henriksen, Daan van de Kerkhof, Steen E Husted, Steen D Kristensen, Moniek P M de Maat, Anna-Marie B Münster
BACKGROUND: Issues with laboratory measurement of dabigatran include: 1. Do coagulation assays reflect dabigatran plasma concentrations? 2. Do samples from patients treated with dabigatran have the same coagulability as dabigatran-spiked samples from healthy volunteers? 3. What is the long-term stability of dabigatran after storage at -80 °C? This study aims to evaluate these questions. MATERIALS AND METHODS: Ecarin chromogenic assay (ECA), a laboratory-developed diluted thrombin time (LD-dTT), prothrombin time (PT) and activated partial thromboplastin time (APTT) and ROTEM® were used to measure dabigatran anticoagulant activity and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure dabigatran plasma concentrations...
February 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29467474/an-in-vitro-proof-of-principle-study-of-sonobactericide
#2
Kirby R Lattwein, Himanshu Shekhar, Willem J B van Wamel, Tammy Gonzalez, Andrew B Herr, Christy K Holland, Klazina Kooiman
Infective endocarditis (IE) is associated with high morbidity and mortality rates. The predominant bacteria causing IE is Staphylococcus aureus (S. aureus), which can bind to existing thrombi on heart valves and generate vegetations (biofilms). In this in vitro flow study, we evaluated sonobactericide as a novel strategy to treat IE, using ultrasound and an ultrasound contrast agent with or without other therapeutics. We developed a model of IE biofilm using human whole-blood clots infected with patient-derived S...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462691/factor-x-activating-atractaspis-snake-venoms-and-the-relative-coagulotoxicity-neutralising-efficacy-of-african-antivenoms
#3
Brice Oulion, James S Dobson, Christina N Zdenek, Kevin Arbuckle, Callum Lister, Francisco C P Coimbra, Bianca Op den Brouw, Jordan Debono, Aymeric Rogalski, Aude Violette, Rudy Fourmy, Nathaniel Frank, Bryan G Fry
Atractaspis snake species are enigmatic in their natural history, and venom effects are correspondingly poorly described. Bite reports are scarce but bites have been described as causing severe hypertension, profound local tissue damage leading to amputation, and deaths are on record. Clinical descriptions have largely concentrated upon tissue effects, and research efforts have focused upon the blood-pressure affecting sarafotoxins. However, coagulation disturbances suggestive of procoagulant functions have been reported in some clinical cases, yet this aspect has been uninvestigated...
February 17, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29461277/clinical-relevance-of-histopathologic-analysis-of-heartmate-ii-thrombi
#4
Lisa Baumann Kreuziger, Mark S Slaughter, Kartik Sundareswaran, Alan E Mast
Left ventricular assist device (LVAD) thrombosis is a devastating complication that occurs in about 10% of patients despite anticoagulation and antiplatelet treatment. How the thrombus initiates and propagates is unknown. We pathologically and immunohistochemically examined 28 thrombi removed from 17 HeartMate II LVADs. Two groups of thrombi were found: those formed in the inlet/outlet and those on the rotor. The four thrombi found at the inlet (three inlet conduit and one inlet tube) and outlet (three at outlet elbow and one outlet graft) appeared similar and were composed of a loose meshwork of fibrin(ogen), von Willebrand factor, leukocytes, and aggregated platelets...
February 15, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29461035/heparin-eluting-electrospun-nanofiber-yarns-for-antithrombotic-vascular-sutures
#5
Sooneon Bae, Michael J DiBalsi, Nicole Meilinger, Chengqi Zhang, Erica Beal, Guzeliya Korneva, Robert O Brown, Konstantin G Kornev, Jeoung Soo Lee
The surgical connection of blood vessels, anastomosis, is a critical procedure in many reparative, transplantation, and reconstructive surgical procedures. However, effective restoration of circulation is complicated by pathological clotting (thrombosis) or progressive occlusion due to excess cell proliferation that often leads to additional surgeries and increases morbidity and mortality risk for patients. Pharmaceutical agents have been tested to prevent these complications, but many have unacceptable systemic side effects...
February 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29459207/a-small-group-of-sulfated-benzofurans-induces-steady-state-submaximal-inhibition-of-thrombin
#6
Daniel K Afosah, Stephen Verespy, Rami A Al-Horani, Rio S Boothello, Rajesh Karuturi, Umesh R Desai
Despite the development of promising direct oral anticoagulants, which are all orthosteric inhibitors, a sizable number of patients suffer from bleeding complications. We have hypothesized that allosterism based on the heparin-binding exosites presents a major opportunity to induce sub-maximal inhibition of coagulation proteases, thereby avoiding/reducing bleeding risk. We present the design of a group of sulfated benzofuran dimers that display heparin-binding site-dependent partial allosteric inhibition of thrombin against fibrinogen (ΔY = 55-75%), the first time that a small molecule (MW < 800) has been found to thwart macromolecular cleavage by a monomeric protease in a controlled manner...
February 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29454898/dietary-values-of-forsythia-suspensa-extract-in-penaeus-monodon-under-normal-rearing-and-vibrio-parahaemolyticus-3hp-vp-3hp-challenge-conditions-effect-on-growth-intestinal-barrier-function-immune-response-and-immune-related-gene-expression
#7
Jia-Jun Xie, Xu Chen, Tian-Yu Guo, Shi-Wei Xie, Hao-Hang Fang, Zhen-Lu Liu, Yan-Mei Zhang, Li-Xia Tian, Yong-Jian Liu, Jin Niu
Two trials were conducted to determine the effects of dietary Forsythia suspensa extract (FSE) on shrimp, Penaeus monodon, first on growth performance, second on the immune response and immune related gene expression of shrimp. In trial 1, shrimp (mean initial wet weight about 3.02 g) were fed with five diets containing 0% (basal diet), 0.01%, 0.02%, 0.04% and 0.06% FSE in triplicate for 60 days. Growth performance (final body wet weight, FBW; weight gain, WG; biomass gain, BG) of shrimp fed FSE diets were higher (P < 0...
February 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29453138/increased-coagulation-index-as-measured-by-thromboelastography-during-ovarian-stimulation-for-in-vitro-fertilization-influence-of-the-final-oocyte-maturation-triggering-agent
#8
Ronit Beck-Fruchter, Israel Gavish, Shira Baram, Yoel Geslevich, Amir Weiss
OBJECTIVE: Thromboelastography (TEG) is a viscoelastic test of hemostasis which allows measurement of the processes of clot initiation, propagation, stabilization, and dissolution in real time. In this study we aimed to evaluate the alterations in coagulation as measured by TEG during In Vitro Fertilization (IVF) stimulation cycles and to investigate whether final oocyte maturation with recombinant hCG (rhCG) versus GnRH agonist results in a different coagulation state. STUDY DESIGN: This is a prospective observational study which included fifty-three normogonadotrophic women...
February 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29450732/combined-prostatic-urethral-lift-and-remodeling-of-the-prostate-and-bladder-neck-a-modified-transurethral-approach-in-the-treatment-of-symptomatic-lower-urinary-tract-obstruction
#9
Martin Schoenthaler, Karl-Dietrich Sievert, Dominik Stefan Schoeb, Arkadiusz Miernik, Thomas Kunit, Simon Hein, Thomas R W Herrmann, Konrad Wilhelm
PURPOSE: The aim of the study was to evaluate the feasibility and safety of combining prostatic urethral lift (PUL) and a limited resection of the prostatic middle lobe or bladder neck incision in the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). METHODS: Twenty-eight patients were treated at two tertiary centers and followed prospectively. Patient evaluations included patient characteristics, relief of LUTS symptoms, erectile and ejaculatory function, continence, operative time and adverse events...
February 15, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29449126/thrombelastography-suggests-hypercoagulability-in-patients-with-renal-dysfunction-and-intracerebral-hemorrhage
#10
Kevin Meier, Daniel M Saenz, Glenda L Torres, Chunyan Cai, Mohammed H Rahbar, Mark McDonald, Stuart Fraser, Elena Espino, H Alex Choi, Nancy J Edwards, Kiwon Lee, James C Grotta, Tiffany R Chang
BACKGROUND: The objective of this study was to quantify coagulopathy using thrombelastography (TEG) in patients with renal dysfunction and intracerebral hemorrhage (ICH). METHODS: We reviewed patients admitted with spontaneous ICH between November 2009 and May 2015. TEG was performed at the time of admission. Creatinine clearance (CCr) was calculated using the Cockroft-Gault equation. Patients were divided into 2 groups based on normal (CCr ≥ 90) or reduced renal function (CCr < 90)...
February 12, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29444200/loss-of-sirt3-accelerates-arterial-thrombosis-by-increasing-formation-of-neutrophil-extracellular-traps-and-plasma-tissue-factor-activity
#11
Daniel S Gaul, Julien Weber, Lambertus J Van Tits, Susanna Sluka, Lisa Pasterk, Martin F Reiner, Natacha Calatayud, Christine Lohmann, Roland Klingenberg, Jürgen Pahla, Daria Vdovenko, Felix C Tanner, Giovanni G Camici, Urs Eriksson, Johan Auwerx, François Mach, Stephan Windecker, Nicolas Rodondi, Thomas F L Uuml Scher, Stephan Winnik, Christian M Matter
BACKGROUND: Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in mice in an inflammatory setting and assessed the clinical relevance of these findings in patients with ST-elevation myocardial infarction (STEMI). Methods and Results: Using a laser-induced carotid thrombosis model with lipopolysaccharide (LPS) challenge, in vivo time to thrombotic occlusion in Sirt3-/- mice (n = 6) was reduced by half compared to Sirt3+/+ wildtype (WT, n = 8, p<0...
February 10, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29442714/silver-nanoparticles-modified-with-sodium-triphosphate-antibacterial-activity-hemocompatibility-and-cytotoxicity
#12
Chuhan Cheng, Cheng Liu, Bing Han, Zhijun Sun, Yutong Wang, Zhenshuai Li, Hong Mo, Jun Zhang
In this study, we report silver nanoparticles (Ag NPs) modified with sodium triphosphate (STTP) (Ag-STPP NPs) prepared by a simple surface modification and chemical reduction method. It was confirmed by 31P NMR spectroscopy that STPP was successfully introduced to the surface of Ag NPs. It was revealed by conductivity change measurements, bacterial growth kinetics and antibacterial efficiency tests that Ag-STPP NPs still retained the strong antibacterial ability. It was demonstrated by hemolysis assays, red blood cell morphology measurements, plasma recalcification time and in vitro clotting times that Ag-STPP NPs had improved hemocompatibility...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442531/the-impact-of-pneumatic-tube-transport-on-whole-blood-coagulation-and-platelet-function-assays
#13
Peter H Nissen, Dorte E Wulff, Niels Tørring, Anne-Mette Hvas
Pneumatic tube is an attractive way to transport blood samples from the emergency department to the central laboratory facility. We aimed to investigate the impact of pneumatic tube transportation on blood samples for analysis of whole blood coagulation and platelet function. We included 21 healthy adult individuals and measured global coagulation assays by rotational thromboelastometry (ROTEM) and platelet aggregation induced by arachidonic acid (AA) and adenosine diphosphate (ADP) using impedance aggregometry (ROTEM Platelet), on samples transported manually or by pneumatic tube transport...
February 14, 2018: Platelets
https://www.readbyqxmd.com/read/29439739/sex-difference-in-clot-lysability-and-association-to-coronary-artery-calcification
#14
Ramshanker Ramanathan, Niels Peter R Sand, Johannes J Sidelmann, Bjarne L Nørgaard, Jørgen B Gram
BACKGROUND: Incidence and prevalence of cardiovascular disease (CVD) differ between sexes, and women experience CVD later than men. Changes in fibrin clot lysability are associated with CVD, and the present study addresses sex differences in fibrin clot lysability in asymptomatic middle-aged individuals and the relation to coronary artery calcification (CAC). METHODS: Participants free of morbidities and medication, N = 163, were randomly chosen from a national registry among citizens, 50 or 60 years of age, and were followed for 5 years...
February 13, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29437487/swim-exercise-inhibits-hemostatic-abnormalities-in-a-rat-model-of-obesity-and-insulin-resistance
#15
Mohammad Dallak, Ismaeel Bin-Jaliah, Hussein F Sakr, Bahjat Al-Ani, Mohamed A Haidara
BACKGROUND: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis. MATERIAL AND METHODS: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-'treated' rats started swim exercise training from the 11th week until being sacrificed, on Week 15. RESULTS: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers...
February 13, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29435797/phacoemulsification-cataract-surgery-in-patients-receiving-novel-oral-anticoagulant-medications
#16
Janice J C Cheung, Shasha Liu, Kenneth K W Li
INTRODUCTION: An increasing number of patients are taking novel oral anticoagulant (NOAC) medication, making perioperative management in phacoemulsification surgery an important issue. This study reports the haemorrhagic complications of NOAC in phacoemulsification surgery. DESIGN: Retrospective case study over a 4-year period. METHODS: Consecutive cases receiving NOAC during the time of phacoemulsification were reviewed. Patients were either advised to continue medications (continued group) or withhold medications before surgery (withheld group)...
February 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29434525/detecting-clinically-relevant-rivaroxaban-or-dabigatran-levels-by-routine-coagulation-tests-or-thromboelastography-in-a-cohort-of-patients-with-atrial-fibrillation
#17
Yvonne M C Henskens, Anouk J W Gulpen, René van Oerle, Rick Wetzels, Paul Verhezen, Henri Spronk, Simon Schalla, Harry J Crijns, Hugo Ten Cate, Arina Ten Cate-Hoek
Background: Traditional coagulation tests are included in emergency guidelines for management of patients on direct oral anticoagulants (DOACs) who experience acute bleeding or require surgery. We determined the ability of traditional coagulation tests and fast whole blood thromboelastography (ROTEM®) to screen for anticoagulation activity of dabigatran and rivaroxaban as low as 30 ng/mL. Methods: One hundred eighty-four citrated blood samples (75 dabigatran, 109 rivaroxaban) were collected from patients with non-valvular atrial fibrillation (NVAF), to perform screening tests from different manufacturers, (diluted, D) PT, aPTT, TT and ROTEM®...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/29434171/association-between-intra-circuit-activated-clotting-time-and-incidence-of-bleeding-complications-during-continuous-renal-replacement-therapy-using-nafamostat-mesilate-a-retrospective-pilot-observational-study
#18
Yuji Miyatake, Shohei Makino, Kenta Kubota, Moritoki Egi, Satoshi Mizobuchi
It has been proposed that anticoagulant activity during continuous renal replacement therapy with nafamostat mesilate can be monitored by using intra-circuit activated clotting time. However, it is still unclear whether activated clotting time would be useful for this purpose. We conducted a retrospective study and included 76 patients who required continuous renal replacement therapy using nafamostat mesilate. We obtained information for pre- and post-filter activated clotting times and bleeding complications...
August 30, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29433878/the-effect-of-resident-involvement-on-bariatric-surgical-outcomes-an-acs-nsqip-analysis
#19
Ivy N Haskins, Jihad Kudsi, Kathleen Hayes, Richard L Amdur, Paul P Lin, Khashayar Vaziri
BACKGROUND: Surgical residency training programs in the United States are modeled on the principle of graduated responsibility. Residents are given greater responsibility and autonomy in the operating room and during perioperative care as they gain surgical skills and progress through their training. The impact of this method of surgical training on patient outcomes remains unknown. The purpose of this study is to compare early patient morbidity and mortality after bariatric surgery in cases with and without resident participation using the American College of Surgeons National Surgical Quality Improvement Program database...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433148/international-council-for-standardization-in-haematology-icsh-recommendations-for-laboratory-measurement-of-direct-oral-anticoagulants
#20
Robert C Gosselin, Dorothy M Adcock, Shannon M Bates, Jonathan Douxfils, Emmanuel J Favaloro, Isabelle Gouin-Thibault, Cecilia Guillermo, Yohko Kawai, Edelgard Lindhoff-Last, Steve Kitchen
This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH) for providing haemostasis-related guidance documents for clinical laboratories. This inaugural coagulation ICSH document was developed by an ad hoc committee, comprised of international clinical and laboratory direct acting oral anticoagulant (DOAC) experts. The committee developed consensus recommendations for laboratory measurement of DOACs (dabigatran, rivaroxaban, apixaban and edoxaban), which would be germane for laboratories assessing DOAC anticoagulation...
February 12, 2018: Thrombosis and Haemostasis
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