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A V Quintero Salvago, J D Leal Del Ojo Del Ojo, L Barrios Rodríguez, J J Fedriani de Matos, I Morgado Muñoz
McArdle disease or type V glycogenosis is a rare metabolic myopathy consisting of muscle loss and weakness. These patients have risks associated with anaesthesia. They can present with hypoglycaemia, rhabdomyolysis, acute renal failure, and electrolyte changes. It has also been associated with a higher incidence of malignant hyperthermia during the anaesthetic procedure. Intermittent compression due to the measurement of non-invasive pressure, postures on the operating table that may cause muscle contractures, or tremor caused by hypothermia or anaesthesia itself, may trigger rhabdomyolysis in these patients...
November 30, 2018: Revista Española de Anestesiología y Reanimación
Anne McArdle, Natalie Pollock, Caroline A Staunton, Malcolm J Jackson
Age-associated frailty is predominantly due to loss of muscle mass and function. The loss of muscle mass is also associated with a greater loss of muscle strength, suggesting that the remaining muscle fibres are weaker than those of adults. The mechanisms by which muscle is lost with age are unclear, but in this review we aim to pull together various strands of evidence to explain how muscle contractions support proteostasis in non-muscle tissues, particularly focussed on the production and potential transfer of Heat Shock Proteins (HSPs) and how this may fail during ageing, Furthermore we will identify logical approaches, based on this hypothesis, by which muscle loss in ageing may be reduced...
November 30, 2018: Free Radical Biology & Medicine
Philipp Kolb, Steven Sijmons, Matthew R McArdle, Husam Taher, Jennie Womack, Colette Hughes, Abigail Ventura, Michael A Jarvis, Christiane Stahl-Hennig, Scott Hansen, Louis J Picker, Daniel Malouli, Hartmut Hengel, Klaus Früh
Receptors recognizing the Fc part of immunoglobulin G (FcγRs) are key determinants in antibody-mediated immune responses. Members of the Herpesviridae interfere with this immune regulatory network by expressing viral FcγRs (vFcγRs). Human cytomegalovirus (HCMV) encodes four distinct vFcγRs that differ with respect to their IgG-subtype specificity and their impact on antibody-mediated immune function in vitro The impact of vFcγRs on HCMV pathogenesis and immunomodulation in vivo is not known. The evolutionary closest animal model of HCMV is rhesus CMV (RhCMV) infection of rhesus macaques...
November 28, 2018: Journal of Virology
Sarah C Cottin, Guenievre Roussel, Lorraine Gambling, Helen E Hayes, Valerie J Currie, Harry J McArdle
Fe deficiency is relatively common in pregnancy and has both short- and long-term consequences. However, little is known about the effect on the metabolism of other micronutrients. A total of fifty-four female rats were fed control (50 mg Fe/kg) or Fe-deficient diets (7·5 mg/kg) before and during pregnancy. Maternal liver, placenta and fetal liver were collected at day 21 of pregnancy for Cu and Zn analysis and to measure expression of the major genes of Cu and Zn metabolism. Cu levels increased in the maternal liver (P=0·002) and placenta (P=0·018) of Fe-deficient rats...
November 28, 2018: British Journal of Nutrition
Lara Clare Diepeveen, Elise Fraser, Anna Jane Elizabeth Croft, Angela Jacques, Adelle M McArdle, Kathy Briffa, Leanda McKenna
BACKGROUND: Little information has been documented regarding interventions for mastitis by Australian physiotherapists. It is currently not known if physiotherapy interventions vary across Australian regions and types of healthcare facilities. RESEARCH AIMS: (1) To identify the interventions used by Australian physiotherapists treating mothers with mastitis and (2) to determine the variability in interventions used across regions and facilities. METHODS: A retrospective observational design was used...
November 27, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Ciaran M Hurley, Adrian McArdle, Kenneth M Joyce, Eoin O'Broin
BACKGROUND: Nipple-areolar complex (NAC) reconstruction following curative mastectomy is traditionally performed as a second-stage procedure several months after initial breast reconstruction. The recent literature has documented the increasing popularity of immediate nipple reconstruction carried out simultaneously during autologous reconstruction. The aim of this study was to evaluate the surgical outcomes and patient satisfaction with immediate breast and nipple reconstruction performed in a single stage after skin-sparing mastectomy...
November 2018: Archives of Plastic Surgery
Jole Martino, Maria Teresa Segura, Luz García-Valdés, M C Padilla, Ricardo Rueda, Harry J McArdle, Helen Budge, Michael E Symonds, Cristina Campoy
Dietary methyl donors, including folate, may modify the placenta and size at birth but the influence of maternal body weight has not been widely investigated. We therefore examined whether maternal or fetal folate status, together with indices of placental folate transport, were modulated by either maternal pre-pregnancy body mass index (BMI i.e., overweight: 25 ≤ BMI < 30 or obesity: BMI ≥ 30 kg/m²) and/or gestational diabetes mellitus (GD). We utilised a sub-sample of 135 pregnant women participating in the Spanish PREOBE survey for our analysis (i...
November 13, 2018: Nutrients
P D McArdle, S M Greenfield, S K Rilstone, P Narendran, M Sayeed Haque, P S Gill
AIM: To conduct a systematic review and meta-analysis to evaluate the effect of carbohydrate restriction on glycaemic control in Type 2 diabetes. METHODS: We searched Medline, EMBASE and CINAHL for the period between 1976 and April 2018. We included randomized controlled trials comparing carbohydrate restriction with a control diet which aimed to maintain or increase carbohydrate intake, and that reported HbA1c as an outcome and reported the amount of carbohydrate consumed during or at the end of the study, with outcomes reported at ≥3 months...
November 13, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
William Olsufka, Danielle Cabral, Megan McArdle, Rebecca Kavanagh
Drug-induced oral ulcers are lesions of the oral mucosa accompanied by painful symptoms, such as burning mouth, metallic taste, dysgeusia, or ageusia. This report demonstrates the first documented case of drug-induced oral ulcers with the tricyclic antidepressant nortriptyline. In this case, a 49-year-old female initiated treatment for refractory neuropathy with nortriptyline. Within 2 weeks of therapy, painful, oral, bubble-like ulcers developed. Complete symptom resolution occurred approximately 1 month after discontinuation of nortriptyline...
November 2018: The mental health clinician
Rana Raoof, Sebastian Bauer, Hany El Naggar, Niamh M C Connolly, Gary P Brennan, Elizabeth Brindley, Thomas Hill, Hazel McArdle, Elaine Spain, Robert J Forster, Jochen H M Prehn, Hajo Hamer, Norman Delanty, Felix Rosenow, Catherine Mooney, David C Henshall
BACKGROUND: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression, mechanistic links to brain excitability, and stable detection in biofluids. Altered levels of circulating microRNAs have been reported in human epilepsy, but most studies collected samples from one clinical site, used a single profiling platform or conducted minimal validation...
November 2, 2018: EBioMedicine
John W Cole, Huichun Xu, Kathleen Ryan, Thomas Jaworek, Nicole Dueker, Patrick McArdle, Brady Gaynor, Yu-Ching Cheng, Jeffrey O'Connell, Steve Bevan, Rainer Malik, Naveed Uddin Ahmed, Philippe Amouyel, Sheraz Anjum, Joshua C Bis, David Crosslin, John Danesh, Stefan T Engelter, Myriam Fornage, Philippe Frossard, Christian Gieger, Anne-Katrin Giese, Caspar Grond-Ginsbach, Weang Kee Ho, Elizabeth Holliday, Jemma Hopewell, M Hussain, W Iqbal, S Jabeen, Jim Jannes, Ayeesha Kamal, Yoichiro Kamatani, Sandip Kanse, Manja Kloss, Mark Lathrop, Didier Leys, Arne Lindgren, W T Longstreth, Khalid Mahmood, Christa Meisinger, Tiina M Metso, Thomas Mosley, Martina Müller-Nurasyid, Bo Norrving, Eugenio Parati, Annette Peters, Alessandro Pezzini, I Quereshi, Asif Rasheed, A Rauf, T Salam, Jess Shen, Agnieszka Słowik, Tara Stanne, Konstantin Strauch, Turgut Tatlisumak, Vincent N Thijs, Steffen Tiedt, Matthew Traylor, Melanie Waldenberger, Matthew Walters, Wei Zhao, Giorgio Boncoraglio, Stéphanie Debette, Christina Jern, Christopher Levi, Hugh Markus, James Meschia, Arndt Rolfs, Peter Rothwell, Danish Saleheen, Sudha Seshadri, Pankaj Sharma, Cathie Sudlow, Bradford Worrall, O Colin Stine, Steven J Kittner, Braxton D Mitchell
BACKGROUND AND PURPOSE: Polymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (THBD and PROCR) may similarly be associated with early-onset ischemic stroke. We explored this hypothesis utilizing a multi-stage design of discovery and replication. METHODS: Discovery was performed in the Genetics-of-Early-Onset Stroke (GEOS) Study, a biracial population-based case-control study of ischemic stroke among men and women aged 15-49 including 829 cases of first ischemic stroke (42...
2018: PloS One
Michael J McArdle, Anne L Abbott, Zvonimir Krajcer
No abstract text is available yet for this article.
August 2018: Texas Heart Institute Journal
Aleksandra Pietrusz, Renata S Scalco, Ros Quinlivan
McArdle disease is a metabolic myopathy mainly characterised by symptom onset during physical activities or isometric muscle contraction. Resistance (also termed strength) training is a type of physical exercise focusing on the use of resistance (e.g., lifting weights) to induce muscular contraction, which builds muscle mass and strength. Historically people with McArdle disease were advised to avoid resistance exercises and any other form of physical activity involving high mechanical loads such as prolonged isometric contraction...
2018: Case Reports in Neurological Medicine
Martin Sweeney, Lee-Ann J Keane, Michael Gurry, Patrick McArdle, Fawaz Aldabbagh
3,6-Dimethoxy-2-(cycloamino)anilines undergo 4- or 6-electron oxidations to afford novel ring-fused halogenated benzimidazoles or benzimidazolequinones using H2 O2 /HCl or H2 O2 /HBr. Cl2 and Br2 are capable of the same oxidative transformation to the benzimidazolequinones. Labeling experiments indicate that water is necessary for oxidation of the para-dimethoxybenzenes to the corresponding quinones.
November 2, 2018: Organic Letters
Omar A Mahroo, Kamron N Khan, Genevieve Wright, Zoe Ockrim, Renata S Scalco, Anthony G Robson, Adnan Tufail, Michel Michaelides, Ros Quinlivan, Andrew R Webster
No abstract text is available yet for this article.
October 10, 2018: Ophthalmology
Peter J Houweling, Ioannis D Papadimitriou, Jane T Seto, Laura M Pérez, Juan Del Coso, Kathryn N North, Alejandro Lucia, Nir Eynon
A common null polymorphism in the ACTN3 gene (rs1815739:C>T) results in replacement of an arginine (R) with a premature stop codon (X) at amino acid 577 in the fast muscle protein α-actinin-3. The ACTN3 p.Arg577Ter allele (aka p.R577* or R577X) has undergone positive selection, with an increase in the X allele frequency as modern humans migrated out of Africa into the colder, less species-rich Eurasian climates suggesting that the absence of α-actinin-3 may be beneficial in these conditions. Approximately 1...
December 2018: Human Mutation
Vidanelage Nimmi De Mel, Nicole Korman, Peter McArdle, Dan J Siskind
No abstract text is available yet for this article.
October 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Qiong Ou, Baixin Chen, Kelly A Loffler, Yuanming Luo, Xilong Zhang, Rui Chen, Qian Wang, Luciano F Drager, Geraldo Lorenzi-Filho, Michael Hlavac, Nigel McArdle, Sutapa Mukherjee, Olga Mediano, Ferran Barbe, Craig S Anderson, R Doug McEvoy, Richard J Woodman
BACKGROUND: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. METHODS: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included...
September 27, 2018: Chest
P Dyson, P McArdle, D Mellor, N Guess
AIMS: To assess the role played by carbohydrates, fat and proteins in the management of Type 2 diabetes. BACKGROUND: Diabetes research tends to reflect the interests of academics or the pharmaceutical industry, rather than those of people living with Type 2 diabetes. The James Lind Alliance and Diabetes UK addressed this issue by defining the research priorities of people living with Type 2 diabetes. Three of the top 10 research priority questions focused on lifestyle...
September 27, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Benjamin Bullen, Matthew Young, Carla McArdle, Mairghread Ellis
Background: This evaluation sought to determine current Charcot neuroarthropathy (CN) diabetes patient education practices among Scottish National Health Service (NHS) and academic podiatrists and evaluate novel visual tools and develop expert consensus for future practice. Methods: Questionnaires collected mixed qualitative and quantitative responses, analysed concurrently within a convergence coding matrix. Delphi methodology permitted member-checking and agreement of consensus over two rounds...
2018: Journal of Foot and Ankle Research
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