Read by QxMD icon Read

temporal specification

Dolors Mateo-Ortega, Joaquín T Limonero, Jorge Maté-Méndez, Elba Beas, Jesús González-Barboteo, Elisabeth Barbero, Sara Ela, Xavier Gómez-Batiste
OBJECTIVE: The goal of this study is to describe the development of a new tool, the Psychosocial and Spiritual Needs Evaluation scale Instrumento de Evaluación de Necesidades Psicosociales y Espirituales del Enfermo al Final de Vida (ENP-E), designed to assess the psychosocial needs of end-of-life (EOL) patients. And, secondarily, to describe the face validity and psychometric properties of this instrument in the Spanish-speaking context. METHOD: The scale was developed through a seven-stage process: (1) literature review; (2) expert panel establishment; (3) discussion and agreement on the most relevant dimensions of psychosocial care; (4) description of key indicators and consensus-based questions to evaluate such dimensions; (5) assessment of the scale by external palliative care (PC) professionals; (6) evaluation by patients; and (7) analysis of scale's psychometrics properties...
October 16, 2018: Palliative & Supportive Care
Lauren E Blake, Samantha M Thomas, John D Blischak, Chiaowen Joyce Hsiao, Claudia Chavarria, Marsha Myrthil, Yoav Gilad, Bryan J Pavlovic
BACKGROUND: There is substantial interest in the evolutionary forces that shaped the regulatory framework in early human development. Progress in this area has been slow because it is difficult to obtain relevant biological samples. Induced pluripotent stem cells (iPSCs) may provide the ability to establish in vitro models of early human and non-human primate developmental stages. RESULTS: Using matched iPSC panels from humans and chimpanzees, we comparatively characterize gene regulatory changes through a four-day time course differentiation of iPSCs into primary streak, endoderm progenitors, and definitive endoderm...
October 15, 2018: Genome Biology
Robert Jacksteit, Anett Mau-Moeller, Antje Völker, Rainer Bader, Wolfram Mittelmeier, Ralf Skripitz, Tino Stöckel
OBJECTIVE: To explore differences in gait-specific long-term memory structures and actual gait performance between patients with hip osteoarthrosis, patients seen six months after total hip arthroplasty and healthy controls to gain insights into the role of the gait-specific mental representation for rehabilitation. DESIGN: Cross-sectional study Subjects: Twenty hip osteoarthrosis patients, 20 patients seen six months after total hip arthroplasty and 20 healthy controls Methods: Spatio-temporal (gait speed, step length) and temporophasic (stance time, swing time, single support time, total double support time) gait parameters, and gait variability were measured with an electronic walkway (OptoGait)...
October 16, 2018: Clinical Rehabilitation
Manuela De Sario, Roberto Pasetto, Simona Vecchi, Ariana Zeka, Gerard Hoek, Paola Michelozzi, Ivano Iavarone, Tony Fletcher, Lisa Bauleo, Carla Ancona
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Industrial contaminated sites (ICSs) are of high concern since industrial plants have produced widespread contamination potentially affecting the health of local population OBJECTIVES: to assess the types of epidemiological designs applied in studies of health effects related to ICSs according to time periods, type of ICS, and geography. METHODS: a literature search was conducted in Medline (OVID) through June 30th, 2018, using MeSH and customized terms, and no restrictions on publication year or language...
September 2018: Epidemiologia e Prevenzione
Alex I Wiesman, Tony W Wilson
The ability to dynamically allocate neural resources within the visual space is supported by a number of spectrally-specific oscillatory responses, and such visuospatial processing has been found to decline moderately with age and differ by sex. However, the direct effects of age and sex on these oscillatory dynamics remains poorly understood. Using magnetoencephalography (MEG), structural magnetic resonance imaging, and advanced source reconstruction and statistical methods, we investigated the impact of aging and sex on behavioral performance and the underlying neural dynamics during visuospatial processing...
October 12, 2018: NeuroImage
Dallas P Veitch, Michael W Weiner, Paul S Aisen, Laurel A Beckett, Nigel J Cairns, Robert C Green, Danielle Harvey, Clifford R Jack, William Jagust, John C Morris, Ronald C Petersen, Andrew J Saykin, Leslie M Shaw, Arthur W Toga, John Q Trojanowski
INTRODUCTION: The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite, longitudinal, observational study that has collected many biomarkers since 2004. Recent publications highlight the multifactorial nature of late-onset AD. We discuss selected topics that provide insights into AD progression and outline how this knowledge may improve clinical trials. METHODS: We used standard methods to identify nearly 600 publications using ADNI data from 2016 and 2017 (listed in Supplementary material and searchable at http://adni...
October 12, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Björn Machner, Inga Könemund, Janina von der Gablentz, Paul M Bays, Andreas Sprenger
OBJECTIVE: Right-hemisphere stroke may cause an ipsilesional attention bias and left hemispatial neglect. Computerized time-limited tasks are more sensitive than conventional paper-pencil tests in detecting these spatial attention deficits. However, their frequency in the acute stage of stroke, the neuroanatomical basis and functional relevance for patients' everyday life are unclear. METHOD: A realistic visual search task is introduced, in which eye movements are recorded while the patient searches for paperclips among different everyday objects on a computer display...
October 2018: Neuropsychology
Jarred Yasuhara-Bell, Kerry F Pedley, Mark Farman, Barbara Valent, James P Stack
Wheat blast, caused by the Magnaporthe oryzae Triticum pathotype, is an economically important fungal disease of wheat. Wheat blast symptoms are similar to Fusarium head scab and can cause confusion in the field. Currently, no in-field diagnostic exists for M. oryzae Triticum. Loop-mediated isothermal amplification (LAMP) primers were designed to target the PoT2 and MoT3 loci, previously shown to be specific for M. oryzae and M. oryzae Triticum, respectively. Specificity was determined using 158 M. oryzae strains collected from infected wheat and other grasses and representing geographic and temporal variation...
October 15, 2018: Plant Disease
Hongming Li, Yong Fan
Decoding brain functional states underlying different cognitive processes using multivariate pattern recognition techniques has attracted increasing interests in brain imaging studies. Promising performance has been achieved using brain functional connectivity or brain activation signatures for a variety of brain decoding tasks. However, most of existing studies have built decoding models upon features extracted from imaging data at individual time points or temporal windows with a fixed interval, which might not be optimal across different cognitive processes due to varying temporal durations and dependency of different cognitive processes...
September 2018: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Annie Lee, Yusuke Hirabayashi, Seok-Kyu Kwon, Tommy L Lewis, Franck Polleux
Mitochondria play numerous critical physiological functions in neurons including ATP production, Ca2+ regulation, lipid synthesis, ROS signaling, and the ability to trigger apoptosis. Recently developed technologies, including in vivo 2-photon imaging in awake behaving mice revealed that unlike in the peripheral nervous system (PNS), mitochondrial transport decreases strikingly along the axons of adult neurons of the central nervous system (CNS). Furthermore, the improvements of genetically-encoded biosensors have enabled precise monitoring of the spatial and temporal impact of mitochondria on Ca2+ , ATP and ROS homeostasis in a compartment-specific manner...
June 2018: Current Opinion in Physiology
Pattarawadee Prayuenyong, John A Taylor, Stephanie E Pearson, Rachel Gomez, Poulam M Patel, Deborah A Hall, Anand V Kasbekar, David M Baguley
Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer. Methods: Inclusion criteria followed the PICO principles: Participants, adult, and pediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects...
2018: Frontiers in Oncology
Kim Blom, Angelica Cuapio, J Tyler Sandberg, Renata Varnaite, Jakob Michaëlsson, Niklas K Björkström, Johan K Sandberg, Jonas Klingström, Lars Lindquist, Sara Gredmark Russ, Hans-Gustaf Ljunggren
Tick-borne encephalitis virus (TBEV) is a flavivirus that belongs to the Flaviviridae family. TBEV is transmitted to humans primarily from infected ticks. The virus causes tick-borne encephalitis (TBE), an acute viral disease that affects the central nervous system (CNS). Infection can lead to acute neurological symptoms of significant severity due to meningitis or meningo(myelo)encephalitis. TBE can cause long-term suffering and has been recognized as an increasing public health problem. TBEV-affected areas currently include large parts of central and northern Europe as well as northern Asia...
2018: Frontiers in Immunology
Peng Wang, Maarten L Wijnants, Simone M Ritter
The aim of the current study is to enhance our understanding of cognitive creativity, specifically divergent thinking, by employing an interdisciplinary methodological approach. By integrating methodology from computational linguistics and complex systems into creativity research, the current study aims to shed light on the relationship between divergent thinking and the temporal structure of semantic associations. In complex systems, temporal structures can be described on a continuum from random to flexible-stable and to persistent...
2018: Frontiers in Psychology
Andrea Gerbino, Giuseppe Procino, Maria Svelto, Monica Carmosino
Nuclear lamin A/C are crucial components of the intricate protein mesh that underlies the inner nuclear membrane and confers mainly nuclear and cytosolic rigidity. However, throughout the years a number of other key physiological processes have been associated with lamins such as modulation of both genes expression and the activity of signaling mediators. To further solidify its importance in cell physiology, mutations in the lamin A/C gene ( LMNA ) have been associated to diverse pathological phenotypes with skeletal muscles and the heart being the most affected systems...
2018: Frontiers in Physiology
Alessandro Scano, Andrea Chiavenna, Lorenzo Molinari Tosatti, Henning Müller, Manfredo Atzori
Background: Kinematic and muscle patterns underlying hand grasps have been widely investigated in the literature. However, the identification of a reduced set of motor modules, generalizing across subjects and grasps, may be valuable for increasing the knowledge of hand motor control, and provide methods to be exploited in prosthesis control and hand rehabilitation. Methods: Motor muscle synergies were extracted from a publicly available database including 28 subjects, executing 20 hand grasps selected for daily-life activities...
2018: Frontiers in Neurorobotics
Tanvi Bhatt, Prakruti Patel, Shamali Dusane, Sophie R DelDonno, Scott A Langenecker
Background: Behavioral evidence for cortical involvement in reactive balance control in response to environmental perturbation is established, however, the neural correlates are not known. This study aimed to examine the neural mechanisms involved in reactive balance control for recovery from slip-like perturbations using mental imagery and to evaluate the difference in activation patterns between imagined and observed slipping. Methods: Ten healthy young participants after an exposure to regular walking and slip-perturbation trial on a treadmill, performed mental imagery and observation tasks in the MR scanner...
2018: Frontiers in Behavioral Neuroscience
Neha Sinha, Zachariah M Reagh, Nicholas J Tustison, Chelsie N Berg, Ashlee Shaw, Catherine E Myers, Diane Hill, Michael A Yassa, Mark A Gluck
Using high-resolution resting state fMRI, the present study tested the hypothesis that ABCA7 genetic risk differentially affects intra-medial temporal lobe (MTL) functional connectivity between MTL subfields, versus internetwork connectivity of the MTL with the medial prefrontal cortex (mPFC), in non-demented older African Americans. Although the association of ABCA7 risk variants with Alzheimer's disease (AD) has been confirmed worldwide, its effect size on the relative odds of being diagnosed with AD is significantly higher in African Americans...
October 14, 2018: Hippocampus
Sara Alicia González Porto, María Teresa Silva Díaz, Ana Reguera Arias, Jorge Pombo Otero, Alba González Rodríguez, Javier Valero Gasalla, Francisco Javier de Toro Santos
BACKGROUND: Giant cell arteritis (GCA) is a vasculitis that affects medium- and large-sized arteries. Temporal artery biopsy is the gold standard for diagnosis. In view of the high demand for temporal biopsies, the purpose of this study is to evaluate the usefulness of Doppler ultrasonography in patients with suspected giant cell arteritis, to determine its sensitivity and specificity as a diagnostic test and to determine whether it would be possible to substitute biopsy for ultrasonography...
October 11, 2018: Reumatología Clinica
R Peyron, C Fauchon
Brain functional imaging has been applied to the study of pain since 1991. Then, a plethora of studies around the world looking at pain sensations and their brain correlates was published. Four kinds of studies can be distinguished: i) A first set investigated brain responses to noxious heat stimulations (above the pain threshold) relative to an equivalent warm innocuous stimulation (below the pain threshold). The aim of these studies was to identify the pattern of brain regions involved in the nociceptive processes and they may be considered as descriptive studies rather than explanative studies...
October 11, 2018: Revue Neurologique
Masashi Tabuchi, Joseph D Monaco, Grace Duan, Benjamin Bell, Sha Liu, Qili Liu, Kechen Zhang, Mark N Wu
Neurons use two main schemes to encode information: rate coding (frequency of firing) and temporal coding (timing or pattern of firing). While the importance of rate coding is well established, it remains controversial whether temporal codes alone are sufficient for controlling behavior. Moreover, the molecular mechanisms underlying the generation of specific temporal codes are enigmatic. Here, we show in Drosophila clock neurons that distinct temporal spike patterns, dissociated from changes in firing rate, encode time-dependent arousal and regulate sleep...
September 27, 2018: Cell
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"