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https://www.readbyqxmd.com/read/30087600/hippocampal-mechanisms-underlying-impairment-in-spatial-learning-long-after-establishment-of-noise-induced-hearing-loss-in-cba-mice
#1
Lijie Liu, Chuanying Xuan, Pei Shen, Tingting He, Ying Chang, Lijuan Shi, Shan Tao, Zhiping Yu, Richard E Brown, Jian Wang
Sensorineural hearing loss (SNHL) has been demonstrated in many clinical reports as a risk factor that promotes the development of cognitive impairment. However, the underlying neurological mechanisms are not clear. Noise exposure is one of the most common causes of SNHL. Although noise exposure causes relatively less damage to general health as compared with other methods for creating hearing loss (such as ototoxicity), it does impair cognitive function. Many studies have shown that the noise-induced cognitive impairment occur via the oxidative stress induced by the noise...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/30086623/two-compound-heterozygous-were-identified-in-slc26a4-gene-in-two-chinese-families-with-enlarged-vestibular-aqueduct
#2
Yongbo Yu, Yang Yang, Jie Lu, Yaqiong Jin, Yeran Yang, Enyu Hong, Jin Shi, Feng Chen, Shujing Han, Ping Chu, Yongli Guo, Xin Ni
Objectives: To investigate the genetic causes of hearing loss with enlarged vestibular aqueduct (EVA) in two children from unrelated two Chinese families. Methods: Sanger sequencing of all coding exons in SLC26A4 (encoding Pendrin protein) was performed on the two patients, their sibling and parents respectively. To predict and visualize the potential functional outcome of the novel variant, model building, structure analysis, and in silico analysis were further conducted...
August 9, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/30067790/multiple-time-scales-of-the-ventriloquism-aftereffect
#3
Adam K Bosen, Justin T Fleming, Paul D Allen, William E O'Neill, Gary D Paige
The ventriloquism aftereffect (VAE) refers to a shift in auditory spatial perception following exposure to a spatial disparity between auditory and visual stimuli. The VAE has been previously measured on two distinct time scales. Hundreds or thousands of exposures to a an audio-visual spatial disparity produces enduring VAE that persists after exposure ceases. Exposure to a single audio-visual spatial disparity produces immediate VAE that decays over seconds. To determine if these phenomena are two extremes of a continuum or represent distinct processes, we conducted an experiment with normal hearing listeners that measured VAE in response to a repeated, constant audio-visual disparity sequence, both immediately after exposure to each audio-visual disparity and after the end of the sequence...
2018: PloS One
https://www.readbyqxmd.com/read/30055211/wishful-hearing-the-effect-of-chronic-dieting-on-auditory-perceptual-biases-and-eating-behavior
#4
Lauren Mayor Poupis
In this research, I propose a novel theoretical phenomenon called "wishful hearing," which establishes that ambient product sounds can be perceived as more spatially proximal when internal motivations (i.e., chronic dieting) render the product more desirable and as a result, lead to increased purchase intentions and consumption. Across three studies, I document the existence of wishful hearing and demonstrate how this phenomenon influences people's food consumption decisions. The first study provides field evidence of the phenomenon of "wishful hearing"...
July 25, 2018: Appetite
https://www.readbyqxmd.com/read/30053517/neural-tracking-of-auditory-motion-is-reflected-by-delta-phase-and-alpha-power-of-eeg
#5
Adam Bednar, Edmund C Lalor
It is of increasing practical interest to be able to decode the spatial characteristics of an auditory scene from electrophysiological signals. However, the cortical representation of auditory space is not well characterized, and it is unclear how cortical activity reflects the time-varying location of a moving sound. Recently, we demonstrated that cortical response measures to discrete noise bursts can be decoded to determine their origin in space. Here we build on these findings to investigate the cortical representation of a continuously moving auditory stimulus using scalp recorded electroencephalography (EEG)...
July 24, 2018: NeuroImage
https://www.readbyqxmd.com/read/30052557/working-memory-and-extended-high-frequency-hearing-in-adults-diagnostic-predictors-of-speech-in-noise-perception
#6
Ingrid Yeend, Elizabeth Francis Beach, Mridula Sharma
OBJECTIVE: The purpose of this study was to identify the main factors that differentiate listeners with clinically normal or "near-normal" hearing with regard to their speech-in-noise perception and to develop a regression model to predict speech-in-noise difficulties in this population. We also aimed to assess the potential effectiveness of the formula produced by the regression model as a "diagnostic criterion" for clinical use. DESIGN: Data from a large-scale behavioral study investigating the relationship between noise exposure and auditory processing in 122 adults (30 to 57 years) was re-examined...
July 26, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/30052097/the-use-of-self-report-measures-to-examine-changes-in-perception-in-response-to-fittings-using-different-signal-processing-parameters
#7
Melinda Anderson, Varsha Rallapalli, Tim Schoof, Pamela Souza, Kathryn Arehart
Clinicians have long used self-report methods to assess hearing aid benefit. However, there are fewer data as to whether self-report instruments can be used to compare differences between signal processing settings. This study examined how self-perceived performance varied as a function of modifications in signal processing using two self-report measures. Data were collected as part of a double-blind randomised crossover clinical trial. Participants were fit with two fittings: mild processing (slow time constants, disabled frequency lowering) and strong processing (fast time constants, frequency lowering enabled)...
July 27, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/30031354/development-of-electrophysiological-and-behavioural-measures-of-electrode-discrimination-in-adult-cochlear-implant-users
#8
Rajeev Mathew, Deborah Vickers, Patrick Boyle, Azhar Shaida, David Selvadurai, Dan Jiang, Jaime Undurraga
The plasticity of the auditory system enables it to adjust to electrical stimulation from cochlear implants (CI). Whilst speech perception may develop for many years after implant activation, very little is known about the changes in auditory processing that underpin these improvements. Such an understanding could help guide interventions that improve hearing performance. In this longitudinal study, we examine how electrode discrimination ability changes over time in newly implanted adult CI users. Electrode discrimination was measured with a behavioural task as well as the spatial auditory change complex (ACC), which is a cortical response to a change in place of stimulation...
July 4, 2018: Hearing Research
https://www.readbyqxmd.com/read/30022731/adjusting-expectations-hearing-abilities-in-a-population-based-sample-using-an-ssq-short-form
#9
Petra von Gablenz, Fabian Otto-Sobotka, Inga Holube
The German short form of the Speech, Spatial, and Qualities of Hearing Scale (SSQ) was administered in a cross-sectional study based on stratified random samples complemented by audiometric tests and a general interview. Data from 1,711 unaided adults aged 18 to 97 years were analyzed in order to determine a distribution of hearing abilities considered as normal and the main factors that impact self-assessments. An innovative mathematical approach was used to overcome the constraints of statistics based on the mean...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/30020266/a-prospective-randomized-crossover-study-in-single-sided-deafness-on-the-new-non-invasive-adhesive-bone-conduction-hearing-system
#10
Griet Mertens, Annick Gilles, Rajae Bouzegta, Paul Van de Heyning
BACKGROUND: Recently, an adhesive bone conduction hearing system has been developed for conductive hearing loss or single-sided deafness (SSD). In SSD cases, this device may be a good solution for patients who are unsuitable for, or who do not wish to undergo, bone conduction implant or cochlear implant surgery. The study aimed to investigate the hearing outcomes with the adhesive hearing system in SSD. PURPOSE OF THE STUDY: The study aimed to investigate the hearing outcomes with the adhesive hearing system in SSD...
July 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30008200/ctcf-regulates-otic-neurogenesis-via-histone-modification-in-the-neurog1-locus
#11
Jeong-Oh Shin, Jong-Joo Lee, Mikyoung Kim, Youn Wook Chung, Hyehyun Min, Jae-Yoon Kim, Hyoung-Pyo Kim, Jinwoong Bok
The inner ear is a complex sensory organ responsible for hearing and balance. Formation of the inner ear is dependent on tight regulation of spatial and temporal expression of genes that direct a series of developmental processes. Recently, epigenetic regulation has emerged as a crucial regulator of the development of various organs. However, what roles higher-order chromatin organization and its regulator molecules play in inner ear development are unclear. CCCTC-binding factor (CTCF) is a highly conserved 11-zinc finger protein that regulates the three-dimensional architecture of chromatin, and is involved in various gene regulation processes...
July 31, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29997248/optogenetic-stimulation-of-cochlear-neurons-activates-the-auditory-pathway-and-restores-auditory-driven-behavior-in-deaf-adult-gerbils
#12
Christian Wrobel, Alexander Dieter, Antoine Huet, Daniel Keppeler, Carlos J Duque-Afonso, Christian Vogl, Gerhard Hoch, Marcus Jeschke, Tobias Moser
Cochlear implants partially restore hearing via direct electrical stimulation of spiral ganglion neurons (SGNs). However, spread of excitation from each electrode limits spectral coding. We explored the use of optogenetics to deliver spatially restricted and cell-specific excitation in the cochlea of adult Mongolian gerbils. Adeno-associated virus carrying the gene encoding the light-sensitive calcium translocating channelrhodopsin (CatCh) was injected into the cochlea of adult gerbils. SGNs in all cochlea turns showed stable and long-lasting CatCh expression, and electrophysiological recording from single SGNs showed that light stimulation up to few hundred Hertz induced neuronal firing...
July 11, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29988571/the-nature-and-nurture-of-congenital-amusia-a-twin-case-study
#13
Jasmin Pfeifer, Silke Hamann
In this article, we report the first documented case of congenital amusia in dizygotic twins. The female twin pair was 27 years old at the time of testing, with normal hearing and above average intelligence. Both had formal music lesson from the age of 8-12 and were exposed to music in their childhood. Using the Montreal Battery of Evaluation of Amusia (Peretz et al., 2003), one twin was diagnosed as amusic, with a pitch perception as well as a rhythm perception deficit, while the other twin had normal pitch and rhythm perception...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29988011/an-evaluation-of-the-world-health-organization-and-american-medical-association-ratings-of-hearing-impairment-and-simulated-single-sided-deafness
#14
Andrew J Vermiglio, Stephanie Griffin, Courtney Post, Xiangming Fang
BACKGROUND: According to the World Health Organization (WHO), a pure-tone threshold average (PTA) ≤25 dB HL for the better ear represents "no impairment." This implies that patients with single-sided deafness (SSD) would have "no or very slight hearing problems." According to the American Medical Association (AMA), a patient with SSD would receive a binaural hearing impairment rating of 16.7%. The premise of the WHO and AMA methods is that PTA is related to the ability to perceive speech in everyday environments...
July 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29960491/a-binaural-auditory-steering-strategy-based-hearing-aid-algorithm-design
#15
Tobias Piechowiak, Changxue Ma, Rob de Vries, Andrew Dittberner
Beamforming techniques are widely used in hearing aids to enhance the intelligibility of speech from a target direction, but they tend to isolate the listener from their acoustic environment and distort spatial cues. The main reason for this is that a typical beamformer method alters the head-related transfer function of the individual users' ears and functions under monaural assumptions instead of a binaural model. In this letter, a binaural auditory steering strategy (BASS) is proposed for the design of asymmetrically presented spatial filters which improves awareness of the surrounding acoustic environment while preserving intelligibility from a target direction...
June 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29956589/coherent-coding-of-enhanced-interaural-cues-improves-sound-localization-in-noise-with-bilateral-cochlear-implants
#16
Ben Williges, Tim Jürgens, Hongmei Hu, Mathias Dietz
Bilateral cochlear implant (BCI) users only have very limited spatial hearing abilities. Speech coding strategies transmit interaural level differences (ILDs) but in a distorted manner. Interaural time difference (ITD) information transmission is even more limited. With these cues, most BCI users can coarsely localize a single source in quiet, but performance quickly declines in the presence of other sound. This proof-of-concept study presents a novel signal processing algorithm specific for BCIs, with the aim to improve sound localization in noise...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29954636/binaural-sensitivity-to-temporal-fine-structure-and-lateralization-ability-in-children-with-suspected-central-auditory-processing-disorder
#17
Yones Lotfi, Tayebeh Ahmadi, Abdollah Moossavi, Enayatollah Bakhshi
OBJECTIVE: Previous studies have shown that a subgroup of children with suspected (central) auditory processing disorder (SusCAPD) have insufficient ability to use binaural cues to benefit from spatial processing. Thus, they experience considerable listening difficulties in challenging auditory environments, such as classrooms. Some researchers have also indicated the probable role of binaural temporal fine structure (TFS) in the perceptual segregation of target signal from noise and hence in speech perception in noise...
June 25, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29944479/hearing-in-real-life-environments-here-structure-and-reliability-of-a-questionnaire-on-perceived-hearing-for-older-adults
#18
Antje Heinrich, Tuija M Mikkola, Hannele Polku, Timo Törmäkangas, Anne Viljanen
OBJECTIVES: The ability to hear in a variety of social situations and environments is vital for social participation and a high quality of life. One way to assess hearing ability is by means of self-report questionnaire. For questionnaires to be useful, their measurement properties, based on careful validation, have to be known. Only recently has consensus been reached concerning how to perform such validation and been published as COSMIN (consensus-based standards for the selection of health status measurement instruments) guidelines...
June 25, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29929187/one-year-results-for-patients-with-unilateral-hearing-loss-and-accompanying-severe-tinnitus-and-hyperacusis-treated-with-a-cochlear-implant
#19
Angel Ramos Macías, Juan Carlos Falcón-González, Manuel Manrique Rodríguez, Constantino Morera Pérez, Luis García-Ibáñez, Carlos Cenjor Español, Chrystelle Coudert-Koall, Matthijs Killian
OBJECTIVE: To show that patients with unilateral hearing loss (UHL), with one ear fulfilling cochlear implant (CI) indication criteria, and an additional severe tinnitus handicap can be treated effectively with a CI. METHOD: A prospective multi-centre study was conducted in five Spanish centres. Sixteen adult patients with UHL and a mean Tinnitus Handicap Inventory (THI) score of at least 58 were implanted. The study design included repeated within-subject measures of quality of life (Health Utility Index Mark 3 [HUI3]), tinnitus (THI, Visual Analogue Scale [VAS] on tinnitus loudness), hearing (Speech, Spatial, and Qualities of Hearing Scale- [SSQ]), and hyperacusis (Test de Hipersensibilidad al Sonido [THS]) up to 12 months after the initial CI fitting...
June 21, 2018: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29925849/different-audio-spatial-metric-representation-around-the-body
#20
Elena Aggius-Vella, Claudio Campus, Monica Gori
Vision seems to have a pivotal role in developing spatial cognition. A recent approach, based on sensory calibration, has highlighted the role of vision in calibrating hearing in spatial tasks. It was shown that blind individuals have specific impairments during audio spatial bisection tasks. Vision is available only in the frontal space, leading to a "natural" blindness in the back. If vision is important for audio space calibration, then the auditory frontal space should be better represented than the back auditory space...
June 20, 2018: Scientific Reports
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