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Nannan Gao, Tengyue Zhang, Jiadong Ji, Kai-Feng Xu, Xinlun Tian
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare lung disease and the mammalian target of the rapamycin (mTOR) inhibitors has been used as an effective therapy. Here we conducted a systematic review and meta-analysis with the aims to quantify the efficacy and safety of mTOR inhibitors in LAM patients. METHODS: The following databases were searched for clinical trials regarding LAM patients treated with mTOR inhibitors until December 2017: Pubmed, Embase, Cochrane Library and OVID medicine...
August 14, 2018: Orphanet Journal of Rare Diseases
Sungho Hwang, Kyung Jong Lee, Jae Bum Park
OBJECTIVES: This study aimed to examine the effects of chronic exposure to organic solvents on lung function in a shipyard painters. METHODS: Male workers in the shipyard painting department were selected as the organic solvents exposure group. Exposure was classified according to the type of work usually performed, and the cumulative exposure index was obtained using the results of biological monitoring. These were then used to divide the exposure group into low-exposure and high-exposure groups, and the dose-response relationships were examined for decreased lung function...
August 9, 2018: Journal of Occupational and Environmental Medicine
Michael I Polkey, Jens Praestgaard, Amy Berwick, Frits M E Franssen, Dave Singh, Michael C Steiner, Richard Casaburi, Hanns-Christian Tillmann, Estelle Lach-Trifilieff, Ronenn Roubenoff, Daniel S Rooks
RATIONALE: Bimagrumab is a fully human monoclonal antibody that blocks the activin type II receptors, preventing the activity of myostatin and other negative skeletal muscle regulators. OBJECTIVES: To assess the effects of bimagrumab on skeletal muscle mass and function in patients with COPD and reduced skeletal muscle mass. METHODS: Sixty-seven COPD patients (mean FEV1 1.05 L [41.6% predicted]; aged 40-80 years; body mass index <20 kg/m2 or appendicular skeletal muscle mass index ≤7...
August 10, 2018: American Journal of Respiratory and Critical Care Medicine
Wasim Ahmad Wani, Mudasir Nazir, Javeed Iqbal Bhat, Ehsan-Ul-Haq Malik, Qazi Iqbal Ahmad, Bashir Ahmad Charoo, Syed Wajid Ali
BACKGROUND: The prevalence of Vitamin D deficiency remains high in cystic fibrosis despite daily supplementation. Vitamin D as an immunomodulator has been related to lower respiratory tract infections in children. The present study was undertaken to examine the association between vitamin D status and markers of cystic fibrosis-related pulmonary disease including exacerbations, bacterial colonization and pulmonary function. METHODS: The study includes review of records of 51 cystic fibrosis patients...
July 19, 2018: Pediatrics and Neonatology
Yewande E Odeyemi, O'Dene Lewis, Julius Ngwa, Kristen Dodd, Richard F Gillum, Alem Mehari
PURPOSE: There is presently an ongoing debate on the relative merits of suggested criteria for spirometric airway obstruction. This study tests the null hypothesis that no superiority exists with the use of fixed ratio (FR) of forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) < 0.7 versus less than lower limit predicted (LLN) criteria with or without FEV1 <80% predicted in regards to future mortality. METHODS: In 1988-1994 the Third National Health and Nutrition Examination Survey (NHANES III) measured FEV1 and FVC with mortality follow-up data through December 31, 2011...
July 28, 2018: Journal of the National Medical Association
Catherine H Miele, Matthew R Grigsby, Trishul Siddharthan, Robert H Gilman, J Jaime Miranda, Antonio Bernabe-Ortiz, Robert A Wise, William Checkley
BACKGROUND: Chronic lung disease is a leading contributor to the global disease burden; however, beyond tobacco smoke, we do not fully understand what risk factors contribute to lung function decline in low-income and middle-income countries. METHODS: We collected sociodemographic and clinical data in a randomly selected, age-stratified, sex-stratified and site-stratified population-based sample of 3048 adults aged ≥35 years from four resource-poor settings in Peru...
July 30, 2018: Thorax
Vanessa K S Lage, Ana Cristina R Lacerda, Camila D C Neves, Maria Gabriela A Chaves, Aline A Soares, Liliana P Lima, Jeanne B Martins, Mariana A Matos, Érica L M Vieira, Antônio L Teixeira, Hércules R Leite, Vinicius Cunha Oliveira, Vanessa A Mendonça
Whole-body vibration (WBV) has gained prominence in the rehabilitation of individuals with chronic obstructive pulmonary disease (COPD) because it is a safe and low intensity exercise that promises beneficial effects on physical performance and quality of life. However, its effects on plasma cytokine levels in COPD are still unclear. The aim of the current study was to investigate the acute effects of WBV on inflammatory biomarkers in people with COPD. Twenty-six participants, COPD people (n=13) and healthy controls (n=13), were included...
2018: Rehabilitation Research and Practice
Y Hashimoto, T Okamura, M Hamaguchi, A Obora, T Kojima, M Fukui
BACKGROUND AND AIMS: Recent studies identified that metabolically abnormal non-overweight phenotype is a risk factor for cardiovascular diseases. However, only little is known about risk factors for the progression from metabolically healthy non-overweight (MHNO) to metabolically abnormal phenotype. In this study, we investigated the impact of respiratory function on the progression from MHNO to metabolically abnormal phenotype. METHODS AND RESULTS: In this retrospective cohort study, 8949 (3872 men and 5077 women) individuals with MHNO, who participated in a health-checkup program from 2004 to 2015, were enrolled...
June 7, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Stanislawa Bazan-Socha, Pawel Kuczia, Daniel P Potaczek, Lucyna Mastalerz, Agnieszka Cybulska, Lech Zareba, Romy Kremers, Coenraad Hemker, Anetta Undas
BACKGROUND: Recently, we have reported that asthma is characterized by prothrombotic blood alterations, which were related to the low-grade inflammatory state. Inflammation, however, may also lead to vascular dysfunction. The aim of this study was to evaluate plasma levels of cellular fibronectin (cFN), a marker of vascular injury in asthmatics, and to analyze their impact on described previously prothrombotic blood alterations. METHODS: In a cross-sectional study, we investigated 164 adult stable asthmatics and 72 matched controls...
August 2018: Respiratory Medicine
Konstantina Kontogianni, Kanoe Russell, Ralf Eberhardt, Maren Schuhmann, Claus Peter Heussel, Susan Wood, Felix Jf Herth, Daniela Gompelmann
Objectives: Bronchoscopic lung volume reduction using coils (LVRC) is a well-known treatment option for severe emphysema. The purpose of this study was to identify quantitative computed tomography (QCT) and clinical parameters associated with positive treatment outcome. Patients and methods: The CT scans, pulmonary function tests (PFT), and 6-minute walk test (6-MWT) data were collected from 72 patients with advanced emphysema prior to and at 3 months after LVRC treatment...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jonghoo Lee, Hye Kyeong Park, Min-Jung Kwon, Jae-Uk Song
BACKGROUND AND OBJECTIVE: Reduced lung function and high lipoprotein (a) (Lp(a)) levels are both recognized risk factors for cardiovascular disease. Few studies have investigated the association between serum Lp(a) and lung function in the general population. We evaluated the association between reduced lung function and high Lp(a) levels in healthy individuals without known medical disease diagnoses. METHODS: We performed a cross-sectional study on 64 082 Korean health screening examinees (33 049 males, 38 ± 7 years) who underwent a health examination in 2015...
July 23, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Siyang Zeng, Andrea Tham, Bruce Bos, Joan Jin, Brian Giang, Mehrdad Arjomandi
BACKGROUND: Abnormal lung volumes that reflect air trapping are common in COPD. However, their significance in smokers with preserved spirometry (normal FEV1 to FVC ratio) is unclear. METHODS: Using the Veterans Administration Informatics and Computing Infrastructure database, we identified 7479 patients at risk for COPD (ever smokers >40 years of age without restrictive lung disease) who had preserved spirometry and concomitant lung volume measurements, and examined their subsequent health records for clinical diagnoses of COPD, healthcare utilisation, follow-up spirometry and mortality...
July 20, 2018: Thorax
Daphna Vilozni, Adi Dagan, Moran Lavie, Ifat Sarouk, Bat-El Bar-Aluma, Moshe Ashkenazi, Sarina Levy Mendelovich, Yael Betzalel, Ori Efrati
BACKGROUND: Inspiratory capacity (IC) is often overlooked as an important measured index of spirometry in patients with cystic fibrosis (CF). Abnormally low IC may indicate the onset of static/dynamic hyperinflation, which may be accompanied by dyspnea and an increase in the work of breathing. This cross-sectional study sought to determine whether measuring IC during spirometry, may add clinical value to FEV1 measurements in CF subjects. METHODS: Anthropometric, clinical, spirometry, and static lung volume data were gathered retrospectively from 98 of 165 subjects with CF (mean ± SD age 26...
August 2018: Respiratory Care
Sun Hye Shin, Hye Yun Park, Danbee Kang, Juhee Cho, Sung Ok Kwon, Joo Hun Park, Jae Seung Lee, Yeon-Mok Oh, Don D Sin, Woo Jin Kim, Sang-Do Lee
BACKGROUND: Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association between the stability of blood eosinophils and long-term clinical outcomes in COPD patients has yet to be fully elucidated. This study aimed to evaluate the stability of blood eosinophils and its association with clinical outcomes in COPD patients. METHODS: In total, 299 COPD patients from the Korean Obstructive Lung Disease cohort with at least two blood eosinophil measurements were included...
July 13, 2018: Respiratory Research
Ana E Fernández-Lorenzo, Ana Moreno-Álvarez, Cristóbal Colon-Mejeras, Francisco Barros-Angueira, Alfonso Solar-Boga, Josep Sirvent-Gómez, María L Couce, Rosaura Leis
The frequency of some Cystic Fibrosis (CF) Transmembrane Conductance Regulator gene (CFTR) mutations varies between populations. Genetic testing during newborn screening (NBS) for CF can identify less common mutations with low clinical expression in childhood and previously considered mild but not fully characterized, such as the mutation p.Val232Asp (c.695T > A). The aim of this study was to describe CF patients with the V232D mutation. We identify CF children with the V232D mutation detected by NBS and compare them with CF adults with this mutation whose diagnosis was prompted by clinical symptoms in the same period...
July 2018: Medicine (Baltimore)
Ayse Senay Sasihuseyinoglu, Derya Ufuk Altıntaş, Sureyya Soyupak, Dilek Dogruel, Mustafa Yılmaz, Mahir Serbes, Gulsah Duyuler
Background/Aims: Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators. Methods: Medical records of 28 children with CF who underwent chest CT in Department of Pediatric Allergy and Immunology, Cukurova University Balcali Hospital between March 2011 and January 2016 were retrospectively reviewed...
July 6, 2018: Korean Journal of Internal Medicine
Jian Hou, Huizhen Sun, Yanjun Guo, Yun Zhou, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Previous studies have reported an association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function decline or cardiovascular diseases, or reduced lung function with 10-year cardiovascular (CV) risk. We analyzed risk factors for the 10-year Framingham CV risk using multiple logistic regression, and examined the mediational effect of reduced lung function on the association between exposure to PAHs and FRS using the post-exploratory structural equation modeling. Participants (n = 2268) were drawn from the Wuhan residents at baseline from the Wuhan-Zhuhai Cohort Study...
January 2018: Ecotoxicology and Environmental Safety
Wenhan Jiang, Zifeng Ma, Huiyong Zhang, Henry S Lynn, Beiqi Xu, Xiao Zhang, Rongrong Bi, Jiyou Fu, Yue Chen, Zhen Xiao, Zhijie Zhang, Zhenhui Lu
BACKGROUND: Over the past two or three decades, the prevalence of asthma has significantly increased worldwide; therefore, effective treatment without side effects is of utmost importance. Traditional Chinese medicine (TCM) plays a vital role in reducing symptoms and improving the quality of life in persistent-asthma patients. The aim of this study is to evaluate the efficacy of the Jia Wei Yang He (JWYH) formula in the treatment of asthma and to explore the relationship between the airway microbiome and TCM treatment in asthma patients...
July 4, 2018: Trials
Airi Amemiya, Takeo Fujiwara
BACKGROUND: The respiratory tract of children in low-income families is more likely to be exposed to toxins, which may lead to poor lung function. The purpose of this study was to elucidate the impact of low household income on lung function among children and adolescents in Japan. METHODS: We analyzed a population-based sample of 1,224 children aged 5 to 17 years old from the Japanese Study on Stratification, Health, Income, and Neighborhood (J-SHINE). Forced expiratory volume in 1 s (FEV1) and in 6 s (FEV6) was measured...
June 30, 2018: Journal of Epidemiology
Brittany B Dennis, Giulia Rinaldi, Georgie Housley, Anand Shah, Owais A Shah, Michael R Loebinger
BACKGROUND: Current guidelines recommend a Drug Reaction Assessment (DRA) before beginning inhaled therapies to assess for bronchoconstriction and tolerability. There is limited evidence to support this recommendation. METHODS: In this study we aimed to establish the predictors of successful DRAs in different patient groups using a cohort of all DRAs performed in adults between 2011 and 2016 at the Royal Brompton Hospital. Spirometry, age, gender, height, and underlying lung disease were recorded...
July 2018: Respiratory Medicine
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