Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S Antonopoulos, George Lazaros, Anastasios Theofilis, Charalambos Papastamos, Spyridon Papaioannou, Gerasimos Siasos, Kostas Tsioufis, Dimitris Tousoulis
Atherosclerosis and one of its most serious consequences, coronary artery disease, are important sources of morbidity and mortality globally, necessitating early detection and treatment. Considering their complex pathophysiology, including several harmful processes, a comprehensive approach to diagnosis, prognosis, and therapy is very desirable. Extracellular matrix remodeling is a major component of this dangerous cascade, including the cleavage of constituents (collagen, elastin, proteoglycans) and the propagation or exacerbation of the inflammatory response...
October 24, 2022: Current Topics in Medicinal Chemistry