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https://www.readbyqxmd.com/read/29889657/how-visual-cortical-organization-is-altered-by-ophthalmologic-and-neurologic-disorders
#1
Serge O Dumoulin, Tomas Knapen
Receptive fields are a core property of cortical organization. Modern neuroimaging allows routine access to visual population receptive fields (pRFs), enabling investigations of clinical disorders. Yet how the underlying neural circuitry operates is controversial. The controversy surrounds observations that measurements of pRFs can change in healthy adults as well as in patients with a range of ophthalmological and neurological disorders. The debate relates to the balance between plasticity and stability of the underlying neural circuitry...
June 11, 2018: Annual Review of Vision Science
https://www.readbyqxmd.com/read/29889115/the-fatigue-assessment-scale-quality-and-availability-in-sarcoidosis-and-other-diseases
#2
Celine Hendriks, Marjolein Drent, Marjon Elfferich, Jolanda De Vries
PURPOSE OF REVIEW: Fatigue is a problem experienced by many patients suffering from chronic diseases, including sarcoidosis patients. It has a substantial influence on patients' quality of life (QoL). It is, therefore, important to properly assess fatigue with a valid and reliable measure. The Fatigue Assessment Scale (FAS) is the only validated self-reporting instrument classifying fatigue in sarcoidosis. The aim of this review was to examine the psychometric properties of the FAS and the diseases and languages in which it has been used...
September 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29877948/inhibition-of-mir-25-aggravates-diabetic-peripheral-neuropathy
#3
Yanzhuo Zhang, Chunyu Song, Jing Liu, Yonghong Bi, Hao Li
The hyperglycemia-induced enhanced oxidative stress is a key factor of diabetic peripheral neuropathy implicated in the pathogenesis of diabetic neuropathy, and microRNA may be involved, playing promotion or protection roles. In this study, we aimed to investigate the function of miR-25 during the development of oxidative/nitrative stress and in subsequent neurological problems. We detected the oxidative stress effects and expression of miR-25 on sciatic nerves from db/db diabetic model mice and analyzed the expression of related genes by qPCR and Western blotting...
August 1, 2018: Neuroreport
https://www.readbyqxmd.com/read/29871886/risk-factors-and-outcomes-of-rapid-correction-of-severe-hyponatremia
#4
Jason C George, Waleed Zafar, Ion Dan Bucaloiu, Alex R Chang
BACKGROUND AND OBJECTIVES: Rapid correction of severe hyponatremia can result in serious neurologic complications, including osmotic demyelination. Few data exist on incidence and risk factors of rapid correction or osmotic demyelination. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a retrospective cohort of 1490 patients admitted with serum sodium <120 mEq/L to seven hospitals in the Geisinger Health System from 2001 to 2017, we examined the incidence and risk factors of rapid correction and osmotic demyelination...
July 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29804161/dual-therapy-with-clopidogrel-and-aspirin-prevents-early-neurological-deterioration-in-ischemic-stroke-patients-carrying-cyp2c19-2-reduced-function-alleles
#5
Jing Lin, Zhao Han, Chun Wang, Xingyang Yi, Zhenxiao Chai, Qiang Zhou, Ruyue Huang
PURPOSE: To investigate the associations between CYP2C19 genotypes and early neurological deterioration (END), and to carry out a stratified analysis of the effectiveness of clopidogrel alone and dual antiplatelet therapy with clopidogrel and aspirin for prevention of END according to CYP2C19 genotypes in ischemic stroke (IS) patients. METHODS: This was a prospective, observational, two-center study. A total of 375 acute IS patients were enrolled. Platelet aggregation was measured before and after the 7- to 10-day treatment...
May 26, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29793902/the-effects-of-implicit-and-explicit-motor-learning-in-gait-rehabilitation-of-people-after-stroke-protocol-for-a-randomized-controlled-trial
#6
Li-Juan Jie, Melanie Kleynen, Kenneth Meijer, Anna Beurskens, Susy Braun
BACKGROUND: A significant part of neurological rehabilitation focuses on facilitating the learning of motor skills. Training can adopt either (more) explicit or (more) implicit forms of motor learning. Gait is one of the most practiced motor skills within rehabilitation in people after stroke because it is an important criterion for discharge and requirement for functioning at home. OBJECTIVE: The aim of this study was to describe the design of a randomized controlled study assessing the effects of implicit motor learning compared with the explicit motor learning in gait rehabilitation of people suffering from stroke...
May 24, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29772467/yawning-and-cortisol-levels-in-multiple-sclerosis-potential-new-diagnostic-tool
#7
Simon B N Thompson, Alister Coleman, Nicola Williams
Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had been diagnosed with multiple sclerosis. Saliva cortisol samples were collected before and after yawning or after stimuli presentation in the absence of yawning...
July 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29717896/the-importance-of-food-nutrition-and-physical-activity-in-cancer-prevention-an-interview-with-dr-kate-allen
#8
Kate Allen
Kate Allen speaks to Roshaine Wijayatunga, Managing Commissioning Editor. Dr Kate Allen works as an Executive Director in Science and Public Affairs at World Cancer Research Fund International ( http://wcrf.org ), an NGO and leading authority in the field of cancer prevention through diet, weight and physical activity. Kate is responsible for the organization's scientific, policy and conference programs in the areas of food, nutrition, physical activity and weight management. An important aspect of her role is helping to create collaborative relationships and activities across the WCRF national charities (in Europe, America and Asia) in these areas, as well as maintaining and creating external partnerships...
June 2018: Future Oncology
https://www.readbyqxmd.com/read/29670570/mexican-national-institute-of-neurology-and-neurosurgery-stroke-registry-results-of-a-25-year-hospital-based-study
#9
Antonio Arauz, Juan Manuel Marquez-Romero, Miguel A Barboza, Fabiola Serrano, Carol Artigas, Luis Manuel Murillo-Bonilla, Carlos Cantú-Brito, José Luis Ruiz-Sandoval, Fernando Barinagarrementeria
Background and purpose: Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk factors and outcomes. Methods: The demographic data, stroke description, ancillary tests, vascular risk factors, and modified Rankin scale (mRs) were registered...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29650316/seesway-a-free-web-based-system-for-analysing-and-exploring-standing-balance-data
#10
Ross A Clark, Yong-Hao Pua
BACKGROUND AND OBJECTIVES: Computerised posturography can be used to assess standing balance, and can predict poor functional outcomes in many clinical populations. A key limitation is the disparate signal filtering and analysis techniques, with many methods requiring custom computer programs. This paper discusses the creation of a freely available web-based software program, SeeSway (www.rehabtools.org/seesway), which was designed to provide powerful tools for pre-processing, analysing and visualising standing balance data in an easy to use and platform independent website...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29570500/curcumin-mitigates-axonal-injury-and-neuronal-cell-apoptosis-through-the-perk-nrf2-signaling-pathway-following-diffuse-axonal-injury
#11
Tingqin Huang, Junjie Zhao, Dan Guo, Honggang Pang, Yonglin Zhao, Jinning Song
Diffuse axonal injury (DAI) accounts for more than 50% of all traumatic brain injury. In response to the mechanical damage associated with DAI, the abnormal proteins produced in the neurons and axons, namely, β-APP and p-tau, induce endoplasmic reticulum (ER) stress. Curcumin, a major component extracted from the rhizome of Curcuma longa, has shown potent anti-inflammatory, antioxidant, anti-infection, and antitumor activity in previous studies. Moreover, curcumin is an activator of nuclear factor-erythroid 2-related factor 2 (Nrf2) and promotes its nuclear translocation...
May 23, 2018: Neuroreport
https://www.readbyqxmd.com/read/29556872/embolic-strokes-of-undetermined-source-in-a-cohort-of-polish-stroke-patients
#12
Jan Pawel Bembenek, Michal Adam Karlinski, Iwona Kurkowska-Jastrzebska, Anna Czlonkowska
We aimed to provide a descriptive analysis of embolic stroke of undetermined etiology (ESUS) population based on a long-term prospective stroke registry. We retrospectively analyzed data collected in a detailed registry regarding consecutive patients admitted for first-ever ischemic stroke (IS) between January 2001 and December 2015. We used Org 10172 in Acute Stroke Treatment classification supplemented with ESUS criteria proposed by the Cryptogenic Stroke/ESUS International Working Group. Within the ESUS group, we additionally compared patients ≤ 60 and > 60 years of age...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29538685/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guideline-on-subthalamic-nucleus-and-globus-pallidus-internus-deep-brain-stimulation-for-the-treatment-of-patients-with-parkinson-s-disease-executive-summary
#13
Anand Rughani, Jason M Schwalb, Christos Sidiropoulos, Julie Pilitsis, Adolfo Ramirez-Zamora, Jennifer A Sweet, Sandeep Mittal, Alberto J Espay, Jorge Gonzalez Martinez, Aviva Abosch, Emad Eskandar, Robert Gross, Ron Alterman, Clement Hamani
QUESTION 1: Is bilateral subthalamic nucleus deep brain stimulation (STN DBS) more, less, or as effective as bilateral globus pallidus internus deep brain stimulation (GPi DBS) in treating motor symptoms of Parkinson's disease, as measured by improvements in Unified Parkinson's Disease Rating Scale, part III (UPDRS-III) scores? RECOMMENDATION: Given that bilateral STN DBS is at least as effective as bilateral GPi DBS in treating motor symptoms of Parkinson's disease (as measured by improvements in UPDRS-III scores), consideration can be given to the selection of either target in patients undergoing surgery to treat motor symptoms...
June 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29529907/high-serum-uric-acid-levels-are-a-protective-factor-against-unfavourable-neurological-functional-outcome-in-patients-with-ischaemic-stroke
#14
Yu-Fang Wang, Jiao-Xing Li, Xun-Sha Sun, Rong Lai, Wen-Li Sheng
Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke. Methods We retrospectively analysed the outcomes of 1166 patients with ischaemic stroke who were hospitalized in our centre during August 2008 to November 2012. Correlations of serum uric acid levels and prognostic outcomes were analysed. Results Men had higher serum uric acid levels and better neurological functional outcomes compared with women. There was a strong negative correlation between serum uric acid levels and unfavourable neurological functional outcomes...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29506970/treatment-with-creatine-monohydrate-in-spinal-and-bulbar-muscular-atrophy-protocol-for-a-randomized-double-blind-placebo-controlled-trial
#15
Yasuhiro Hijikata, Masahisa Katsuno, Keisuke Suzuki, Atsushi Hashizume, Amane Araki, Shinichiro Yamada, Tomonori Inagaki, Daisuke Ito, Akihiro Hirakawa, Fumie Kinoshita, Masahiko Gosho, Gen Sobue
BACKGROUND: Although spinal and bulbar muscular atrophy (SBMA) has been classified as a motor neuron disease, several reports have indicated the primary involvement of skeletal muscle in the pathogenesis of this devastating disease. Recent studies reported decreased intramuscular creatine levels in skeletal muscles in both patients with SBMA and transgenic mouse models of SBMA, which appears to contribute to muscle weakness. OBJECTIVE: The present study aimed to examine the efficacy and safety of oral creatine supplementation to improve motor function in patients with SBMA...
March 5, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29492558/medical-waveform-format-encoding-rules-representation-of-neurointensive-care-waveform-data
#16
Ian Piper, Martin Shaw, Christopher Hawthorne, John Kinsella, Laura Moss
OBJECTIVE: Technology in neurointensive care units can collect and store vast amounts of complex patient data. The CHART-ADAPT project is aimed at developing technology that will allow for the collection, analysis and use of these big data at the patient's bedside in neurointensive care units. A requirement of this project is to automatically extract and transfer high-frequency waveform data (e.g. ICP) from monitoring equipment to high performance computing infrastructure for analysis...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29490321/moving-towards-a-cure-for-ms-increased-immunosuppression-and-striving-for-no-evidence-of-disease-activity-neda
#17
Brian Wong, Jonathan Cahill, Syed Rizvi
Multiple sclerosis (MS) is a chronic central nervous system demyelinating disease. The cause is unknown, but likely results from a combination of genetic predisposition and environmental exposures leading to autoimmune destruction of the brain and spinal cord. The most common phenotype of MS is relapsing-remitting (RRMS), characterized by episodes of neurological symptoms, typically lasting days to weeks, followed by symptom remission. After years of disease, the majority of RRMS cases transform into secondary progressive MS (SPMS), characterized by slowly worsening symptoms and progressive neurological disability, which may or may not be also accompanied by superimposed relapses...
March 1, 2018: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/29465512/microrna-changes-in-firefighters
#18
Kyoung Sook Jeong, Jin Zhou, Stephanie C Griffin, Elizabeth T Jacobs, Devi Dearmon-Moore, Jing Zhai, Sally R Littau, John Gulotta, Paul Moore, Wayne F Peate, Crystal M Richt, Jefferey L Burgess
OBJECTIVES: Firefighters have elevated cancer incidence and mortality rates. MicroRNAs play prominent roles in carcinogenesis, but have not been previously evaluated in firefighters. METHODS: Blood from 52 incumbent and 45 new recruit nonsmoking firefighters was analyzed for microRNA expression, and the results adjusted for age, obesity, ethnicity, and multiple comparisons. RESULTS: Nine microRNAs were identified with at least a 1.5-fold significant difference between groups...
May 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29442540/management-of-immune-related-adverse-events-in-patients-treated-with-immune-checkpoint-inhibitor-therapy-american-society-of-clinical-oncology-clinical-practice-guideline
#19
Julie R Brahmer, Christina Lacchetti, Bryan J Schneider, Michael B Atkins, Kelly J Brassil, Jeffrey M Caterino, Ian Chau, Marc S Ernstoff, Jennifer M Gardner, Pamela Ginex, Sigrun Hallmeyer, Jennifer Holter Chakrabarty, Natasha B Leighl, Jennifer S Mammen, David F McDermott, Aung Naing, Loretta J Nastoupil, Tanyanika Phillips, Laura D Porter, Igor Puzanov, Cristina A Reichner, Bianca D Santomasso, Carole Seigel, Alexander Spira, Maria E Suarez-Almazor, Yinghong Wang, Jeffrey S Weber, Jedd D Wolchok, John A Thompson
Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process...
June 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29419720/minimally-invasive-surgery-for-neuromuscular-scoliosis-results-and-complications-in-a-series-of-one-hundred-patients
#20
Lotfi Miladi, Mathilde Gaume, Nejib Khouri, Michael Johnson, Vicken Topouchian, Christophe Glorion
STUDY DESIGN: A retrospective review. OBJECTIVE: To report the results of an alternative technique using a minimally invasive fusionless surgery. The originality is based on the progressive correction of the deformities with proximal and distal fixation and on the reliability of the pelvic fixation using iliosacral screws on osteoporotic bones. SUMMARY OF BACKGROUND DATA: Spinal deformities are common in neuromuscular diseases. Conventional treatment involves bracing, followed by spinal instrumented fusion...
August 2018: Spine
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