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https://www.readbyqxmd.com/read/30098986/do-5%C3%AE-reductase-inhibitors-raise-circulating-serum-testosterone-levels-a-comprehensive-review-and-meta-analysis-to-explaining-paradoxical-results
#1
REVIEW
Abdulmaged M Traish, Yonah Krakowsky, Gheorghe Doros, Abraham Morgentaler
INTRODUCTION: Many studies have reported that 5α-reductase inhibitors (finasteride and dutasteride) raise serum testosterone (T) levels, yet there is lack of consistency among studies on this point. AIM: To review and meta-analyze available studies reporting changes in serum T concentrations in men treated with 5α-reductase inhibitors (5α-RIs). METHODS: A Medline search using PubMed and EMBASE was performed including the following key words: "finasteride," "dutasteride," "testosterone and 5α-reductases...
August 8, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29661690/the-history-of-testosterone-and-the-evolution-of-its-therapeutic-potential
#2
REVIEW
Abraham Morgentaler, Abdulmaged Traish
INTRODUCTION: Testosterone therapy has been controversial since its synthesis in the 1930s to the present day. Testosterone's history provides depth and context for current controversies. AIM: To review the history of testosterone therapy from its initial synthesis in the 1930s to the modern day. METHODS: Expert review of the literature. MAIN OUTCOME MEASURES: Impactful events in the history of testosterone. RESULTS: By the 1940s there was already a fascinating literature that described the many symptomatic benefits of testosterone therapy that are recognized today...
April 13, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29486065/the-state-of-testosterone-therapy-since-the-fda-s-2015-labelling-changes-indications-and-cardiovascular-risk
#3
REVIEW
Martin Miner, Abraham Morgentaler, Mohit Khera, Abdulmaged M Traish
OBJECTIVE: A label change in testosterone (T) products in March 2015 followed a highly publicized FDA advisory committee meeting in September 2014. Changes included a warning of possible increased cardiovascular (CV) risks and restriction of indicated populations to younger men with a limited set of known aetiologies of testosterone deficiency (TD). These changes greatly impacted clinical practice and public perception of T therapy (TTh). Our aim was to review these changes in the light of subsequently published studies...
July 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29067698/double-trouble-co-occurrence-of-testosterone-deficiency-and-body-fatness-associated-with-all-cause-mortality-in-us-men
#4
D S Lopez, X Qiu, S Advani, K K Tsilidis, M Khera, J Kim, A Morgentaler, R Wang, S Canfield
BACKGROUND: Testosterone deficiency (TD, total testosterone ≤350 ng/dL [12.15 nmol L-1 ]) and obesity epidemic are growing in parallel in the United States. Yet, the sequelae of TD and obesity on the risk of mortality remain unclear. OBJECTIVE: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥30 kg/m2 ), and abdominal obesity (waist circumference ≥102 cm), is associated with a risk of all-cause mortality in American men...
January 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/28988938/testosterone-therapy-in-a-man-with-intermediate-risk-prostate-cancer-pro
#5
Abraham Morgentaler
The original prohibition of testosterone therapy for men with prostate cancer was based on outdated concepts developed more than 70 yr ago. Current evidence, although limited, provides consistently reassuring results that testosterone therapy may be reasonably offered to many men with prostate cancer. These men may experience valuable benefits in quality of life if they suffer from symptoms of testosterone deficiency (hypogonadism).
October 2017: European Urology Focus
https://www.readbyqxmd.com/read/28807505/delayed-ejaculation-and-associated-complaints-relationship-to-ejaculation-times-and-serum-testosterone-levels
#6
RANDOMIZED CONTROLLED TRIAL
Abraham Morgentaler, Paula Polzer, Stanley Althof, Alexander Bolyakov, Craig Donatucci, Xiao Ni, Ankur B Patel, Shehzad Basaria
BACKGROUND: Although delayed ejaculation (DE) is typically characterized as a persistently longer than anticipated or desired time to ejaculation (or orgasm) during sexual activity, a timing-based definition of DE and its association with serum testosterone has not been established in a large cohort. AIM: To examine in an observational study estimated intravaginal ejaculatory latency time (IELT) and masturbatory ejaculation latency time (MELT) in men self-reporting DE, assess the association of IELT and MELT with serum testosterone levels, and determine whether correlation with demographic and sexual parameters exist...
September 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28753828/risk-of-testosterone-flare-in-the-era-of-the-saturation-model-one-more-historical-myth
#7
REVIEW
Yonah Krakowsky, Abraham Morgentaler
CONTEXT: When luteinizing hormone-releasing hormone (LHRH) agonists were introduced in the 1980s, it was universally believed that the initial transient rise in serum testosterone (T), termed T flare, caused rapid prostate cancer (PCa) growth and led to disease progression, complications, and death. It became routine to offer antiandrogens (AAs) to prevent these risks. However, over the last decade, it has become recognized that androgens have a finite ability to stimulate PCa growth (the saturation model), providing a theoretical challenge to the risks of T flare...
July 1, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753796/serum-concentrations-of-sex-hormone-binding-globulin-vary-widely-in-younger-and-older-men-clinical-data-from-a-men-s-health-practice
#8
Yonah Krakowsky, William Conners, Abraham Morgentaler
BACKGROUND: The testosterone (T) status of a man is influenced by serum concentrations of sex hormone-binding globulin (SHBG). Specifically, tight binding of T to SHBG is believed to render the SHBG-bound T fraction biologically unavailable, meaning that interpretation of T levels in the clinical setting depends in part on knowledge of SHBG concentrations. Although SHBG levels have been reported in population studies, there is scant information for men presenting with clinical symptoms...
June 3, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28735014/initial-clinical-experience-with-testosterone-undecanoate-therapy-aveed-in-men-with-testosterone-deficiency-in-the-united-states
#9
Yonah Krakowsky, William Conners, Emily Davidson, Alex Rawji, Abraham Morgentaler
OBJECTIVE: To report our initial experiences with testosterone undecanoate (TU 750) mg (AVEED) in men with testosterone deficiency. METHODS: All patients receiving TU 750 mg at our center between July 1, 2014, and August 1, 2016, were identified. Clinical response was assessed through structured interviews and laboratory evaluations. Adverse events were documented, including increase in prostate specific antigen (PSA), increase in hematocrit (Hct), and the development of postinjection cough...
November 2017: Urology
https://www.readbyqxmd.com/read/28434676/meta-analysis-of-results-of-testosterone-therapy-on-sexual-function-based-on-international-index-of-erectile-function-scores
#10
REVIEW
Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci, Mario Maggi
CONTEXT: The interpretation of available clinical evidence related to the effect of testosterone (T) treatment (TTh) on sexual function has been inconsistent, in part due to the use of different and self-reported measures to assess outcomes. The International Index of Erectile Function (IIEF) is the most frequently used validated tool to assess male sexual function. OBJECTIVE: To perform a meta-analysis of available data evaluating the effect of TTh on male sexual function using IIEF as the primary outcome...
December 2017: European Urology
https://www.readbyqxmd.com/read/28266512/andrology-testosterone-reference-ranges-and-diagnosis-of-testosterone-deficiency
#11
Abraham Morgentaler
No abstract text is available yet for this article.
May 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28262100/sexual-rehabilitation-after-treatment-for-prostate-cancer-part-2-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#12
Andrea Salonia, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Mohit Khera
INTRODUCTION: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer. AIM: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction. METHODS: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016...
March 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28262099/sexual-rehabilitation-after-treatment-for-prostate-cancer-part-1-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#13
Andrea Salonia, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Mohit Khera
INTRODUCTION: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer. AIM: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning prevention and management strategies for post-RP erectile function impairment in terms of preoperative patient characteristics and intraoperative factors that could influence erectile function recovery. METHODS: A literature search was performed using Google and PubMed databases for English-language original and review articles published up to August 2016...
March 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27920032/overselling-hysteria-the-role-of-the-media-and-medical-journals-in-promoting-questionable-risks-a-case-study-of-the-testosterone-controversy
#14
Abdulmaged M Traish, Jay C Vance, Abraham Morgentaler
No abstract text is available yet for this article.
January 2017: EMBO Reports
https://www.readbyqxmd.com/read/27914560/diagnosis-and-treatment-of-testosterone-deficiency-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#15
REVIEW
Mohit Khera, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Andrea Salonia
INTRODUCTION: Testosterone deficiency (TD), also known as hypogonadism, is a condition affecting a substantial proportion of men as they age. The diagnosis and management of TD can be challenging and clinicians should be aware of the current literature on this condition. AIM: To review the available literature concerning the diagnosis and management of TD and to provide clinically relevant recommendations from the Fourth International Consultation for Sexual Medicine (ICSM) meeting...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27872026/male-and-female-sexual-dysfunction-in-a-rapidly-changing-cultural-environment-addressing-gender-equality-versus-equivalence-in-the-bedroom
#16
REVIEW
Marianne Brandon, Abraham Morgentaler
INTRODUCTION: The socio-sexual climate in Western cultures is changing at an astounding rate. Never before have societal expectations about gender roles shifted so radically, transforming our understanding of what it means to be a sexual man or woman today. We have observed that confusion regarding masculine and feminine roles within long-term committed relationships can represent challenges for the treatment of sexual dysfunction. Despite the relevance to sexual medicine, sexual medicine specialists have largely avoided this controversial topic...
April 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27449261/testosterone-therapy-can-be-given-to-men-with-no-concern-that-it-will-promote-prostate-cancer-development-or-progression-pro
#17
REVIEW
Abraham Morgentaler
No abstract text is available yet for this article.
October 2016: Journal of Urology
https://www.readbyqxmd.com/read/27313122/fundamental-concepts-regarding-testosterone-deficiency-and-treatment-international-expert-consensus-resolutions
#18
Abraham Morgentaler, Michael Zitzmann, Abdulmaged M Traish, Anthony W Fox, T Hugh Jones, Mario Maggi, Stefan Arver, Antonio Aversa, Juliana C N Chan, Adrian S Dobs, Geoffrey I Hackett, Wayne J Hellstrom, Peter Lim, Bruno Lunenfeld, George Mskhalaya, Claude C Schulman, Luiz O Torres
To address widespread concerns regarding the medical condition of testosterone (T) deficiency (TD) (male hypogonadism) and its treatment with T therapy, an international expert consensus conference was convened in Prague, Czech Republic, on October 1, 2015. Experts included a broad range of medical specialties including urology, endocrinology, diabetology, internal medicine, and basic science research. A representative from the European Medicines Agency participated in a nonvoting capacity. Nine resolutions were debated, with unanimous approval: (1) TD is a well-established, clinically significant medical condition that negatively affects male sexuality, reproduction, general health, and quality of life; (2) symptoms and signs of TD occur as a result of low levels of T and may benefit from treatment regardless of whether there is an identified underlying etiology; (3) TD is a global public health concern; (4) T therapy for men with TD is effective, rational, and evidence based; (5) there is no T concentration threshold that reliably distinguishes those who will respond to treatment from those who will not; (6) there is no scientific basis for any age-specific recommendations against the use of T therapy in men; (7) the evidence does not support increased risks of cardiovascular events with T therapy; (8) the evidence does not support increased risk of prostate cancer with T therapy; and (9) the evidence supports a major research initiative to explore possible benefits of T therapy for cardiometabolic disease, including diabetes...
July 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27132578/testosterone-therapy-and-prostate-cancer
#19
REVIEW
Emily Davidson, Abraham Morgentaler
Changes in understanding regarding the relationship of androgens and prostate cancer have led to changes in the use of testosterone therapy. The evidence supports a finite ability of androgens to stimulate prostate cancer growth, with a maximum achieved at low testosterone concentrations, called the saturation model. The saturation point corresponds with maximal androgenic stimulation at 250 ng/dL. Evidence is reviewed herein regarding the relationship of testosterone to prostate cancer and the relatively new practice of offering testosterone therapy to men with a history of prostate cancer...
May 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/26769391/pavel-ivanovich-karpov-1873-1932-the-russian-prinzhorn-art-of-the-insane-in-russia
#20
Vladimir Lerner, Grigory Podolsky, Eliezer Witztum
The complicated relationship between the discipline of mental health and the arts has barely been studied systematically. Mental hospitals, shelters and prisons--institutions that accommodate the mentally ill--sometimes promote but often discourage and disrupt the patients' artistic creativity and the images created. In psychiatric circles, the recognition of patient art was a long, slow and frustrating process. Among the Western psychiatrists who studied the creative activity of the mentally ill, researchers usually mention such names as C...
March 2016: History of Psychiatry
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