keyword
MENU ▼
Read by QxMD icon Read
search

fuchs syndrome

keyword
https://www.readbyqxmd.com/read/29961768/germline-cancer-susceptibility-gene-variants-somatic-second-hits-and-survival-outcomes-in-patients-with-resected-pancreatic-cancer
#1
Matthew B Yurgelun, Anu B Chittenden, Vicente Morales-Oyarvide, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Zhi Rong Qian, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Justin L Bui, Chen Yuan, Tingting Li, Wanwan Li, Atsuhiro Masuda, Mancang Gu, Andrea J Bullock, Daniel T Chang, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew D Ducar, Bruce M Wollison, Natalia Khalaf, Kimberly Perez, Sapna Syngal, Andrew J Aguirre, William C Hahn, Matthew L Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Jonathan A Nowak, Brian M Wolpin
PURPOSE: Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors. We sought to determine the prevalence and significance of germline cancer susceptibility gene variants in PDAC with paired somatic and survival analyses. METHODS: Using a customized next-generation sequencing panel, germline/somatic DNA was analyzed from 289 patients with resected PDAC ascertained without preselection for high-risk features (e...
July 2, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29959762/-the-big-five-cataract-surgery-under-multiple-ocular-comorbidity-customised-approach-to-prevent-complications
#2
Andreas F Borkenstein, Eva-Maria Borkenstein
The co-occurence of 5 diseases (cataract, Fuchs dystrophy, pseudoexfoliation syndrome, age-related macular degeneration and dry eye syndrome) can lead to massive impairment of visual acuity. Our case series show that cataract surgery can lead to an enormous profit in visual rehabilitation and therefore in daily routine.
June 29, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29944680/different-composition-of-intraocular-immune-mediators-in-posner-schlossman-syndrome-and-fuchs-uveitis
#3
Dominika Pohlmann, Stephan Schlickeiser, Sylvia Metzner, Matthias Lenglinger, Sibylle Winterhalter, Uwe Pleyer
Posner-Schlossman-Syndrome (PSS) is clinically characterized by acute, recurrent, mild, unilateral uveitis anterior accompanied by elevated intraocular pressure (IOP). Fuchs´ Uveitis (FU) is a chronic, low-grade-inflammatory disorder, involving anterior uvea and vitreous. The clinical findings show remarkable similarities as well as differences. In our study, we determine the composition of immune mediators in aqueous humor of patients with PSS and FU and evaluate if immune mediators play a crucial role in specific viral intraocular inflammation and IOP rises...
2018: PloS One
https://www.readbyqxmd.com/read/29924204/descemet-membrane-endothelial-keratoplasty-in-multifocal-pseudophakic-eyes
#4
Nicolas Cesário Pereira, Evandro Ribeiro Diniz, Ramon Coral Ghanem, Ruy Cunha Filho, Tatiana Moura Prazeres, Walton Nose, Adriana Dos Santos Forseto
PURPOSE: This report describes the use of Descemet membrane endothelial keratoplasty for the management of endothelial decompensation after multifocal intraocular lens implantation. METHODS: In this retrospective study, we reviewed and assessed the surgical outcomes of 9 patients (9 eyes) who underwent Descemet membrane endothelial keratoplasty after multifocal intraocular lens implantation. RESULTS: Corneal edema occurred due to Fuchs endothelial corneal dystrophy (n=3), pseudophakic bullous keratopathy (n=3), Descemet's membrane detachment (n=2), and toxic anterior segment syndrome (n=1)...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29912095/combined-biomarkers-predict-acute-mortality-among-critically-ill-patients-with-suspected-sepsis
#5
Brendan J Kelly, Ebbing Lautenbach, Irving Nachamkin, Susan E Coffin, Jeffrey S Gerber, Barry D Fuchs, Charles Garrigan, Xiaoyan Han, Warren B Bilker, Jacqueleen Wise, Pam Tolomeo, Jennifer H Han
OBJECTIVES: Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. We compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis. DESIGN: Cohort study. SETTING: The medical and surgical ICUs at an academic medical center...
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29909603/urinary-outcomes-in-patients-with-down-s-syndrome-and-hirschsprung-s-disease
#6
Alexander Johannes Martinus Dingemans, Carlos Albert Reck-Burneo, Molly Fuchs, Alejandra Vilanova Sanchez, Victoria Alison Lane, Erin Hoover, Tassiana Maloof, Laura Weaver, Marc A Levitt, Richard J Wood
INTRODUCTION:  Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group. METHODS:  The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome. RESULTS:  A total of 104 patients with HD were included in this study...
June 17, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29909152/early-fever-after-haploidentical-bone-marrow-transplantation-correlates-with-class-ii-hla-mismatching-and-myeloablation-but-not-outcomes
#7
Shannon R McCurdy, Stephen T Muth, Hua-Ling Tsai, Heather J Symons, Carol Ann Huff, William H Matsui, Ivan Borrello, Douglas E Gladstone, Lode J Swinnen, Kenneth R Cooke, Robert A Brodksy, Javier Bolaños-Meade, Richard F Ambinder, Ravi Varadhan, Leo Luznik, Rick J Jones, Maria P Bettinotti, Ephraim J Fuchs
Noninfectious fevers are common early after T cell-replete HLA haploidentical (haplo) peripheral blood transplants and have been associated with cytokine release syndrome and overall mortality. However, less is known regarding the incidence and associations of early fever after bone marrow transplantation (BMT) with post-transplant cyclophosphamide (PTCy). We hypothesized that early fever would be associated with myeloablative conditioning (MAC), because of its relative increase in tissue damage augmenting antigen presentation and class II HLA-mismatching because of recognition of antigen-presenting cells by CD4+ T cells...
June 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29868017/frailty-in-older-adults-is-associated-with-plasma-concentrations-of-inflammatory-mediators-but-not-with-lymphocyte-subpopulations
#8
Diego Marcos-Pérez, María Sánchez-Flores, Ana Maseda, Laura Lorenzo-López, José C Millán-Calenti, Johanna M Gostner, Dietmar Fuchs, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related alterations of the immune system may compromise its competence culminating in a chronic low-grade inflammation state. Thus, it has been proposed that frailty is associated with alterations in the concentration of pro-inflammatory molecules and in different lymphocyte subpopulations. To provide further support to the validity of that hypothesis, we conducted a cross-sectional study in a population of Spanish older adults ( N  = 259, aged 65 and over) classified according to their frailty status...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29851695/hip-instability-in-patients-with-down-syndrome
#9
Daniel Maranho, Kathryn Fuchs, Young-Jo Kim, Eduardo N Novais
The incidence of hip instability in children with Down syndrome is 1% to 7%. The natural history is often progressive, with the typical onset of hypermobility of the hip evolving to habitual dislocation, persistent subluxation, and fixed dislocation, and eventually leading to the loss of independent mobility. Treatment focuses on stabilizing the hip joint and depends on the patient's age and the severity of the disease. Typically, surgical intervention is recommended for the treatment of patients with habitual dislocation, subluxation, and complete dislocation of the hip...
July 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29790605/cd57-identifies-t-cells-with-functional-senescence-before-terminal-differentiation-and-relative-telomere-shortening-in-patients-with-activated-pi3-kinase-delta-syndrome
#10
Paola Cura Daball, Monica Sofia Ventura Ferreira, Sandra Ammann, Christian Klemann, Myriam R Lorenz, Ursula Warthorst, Timothy Ronan Leahy, Niall Conlon, Justin Roche, Pere Soler-Palacín, Marina Garcia-Prat, Ilka Fuchs, Sebastian Fuchs, Fabian Beier, Tim H Brümmendorf, Carsten Speckmann, Peter Olbrich, Olaf Neth, Klaus Schwarz, Stephan Ehl, Anne Rensing-Ehl
Premature T-cell immunosenescence with CD57+ CD8+ T-cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical senescent T-cell population seen in adult individuals or identifies a distinct population in APDS, we compared CD57+ CD8+ T cells from mostly pediatric APDS patients to those of healthy adults with similarly prominent senescent T cells. CD57+ CD8+ T cells from APDS patients were less differentiated with more CD27+ CD28+ effector memory T cells showing increased PD1 and Eomesodermin expression...
May 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29740835/factors-associated-to-early-intrauterine-fetal-demise-after-laser-for-ttts-by-preoperative-fetal-heart-and-doppler-ultrasound
#11
Amélie Delabaere, France Leduc, Quentin Reboul, Florent Fuchs, Sandrine Wavrant, Johanne Dubé, Jean-Claude Fouron, François Audibert
OBJECTIVE: To determine the prognostic value of fetal Doppler and echocardiographic parameters for intrauterine fetal demise (IUFD) within 24 hours and within 1 week after laser coagulation in monochorionic pregnancies complicated by twin-twin transfusion syndrome. METHOD: This retrospective study correlated the preoperative hemodynamic and echocardiography parameters to the outcome in fetuses with twin-twin transfusion syndrome undergoing laser therapy. RESULTS: One hundred and twelve laser coagulations were performed between February 2006 and June 2015...
June 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29697274/effect-of-eicosapentaenoic-acid-on-body-composition-and-inflammation-markers-in-patients-with-head-and-neck-squamous-cell-cancer-from-a-public-hospital-in-mexico
#12
Obed Solís-Martínez, Valentina Plasa-Carvalho, Geraldine Phillips-Sixtos, Yanelly Trujillo-Cabrera, Arturo Hernández-Cuellar, Gloria E Queipo-García, Eduardo Meaney-Mendiolea, Guillermo M Ceballos-Reyes, Vanessa Fuchs-Tarlovsky
INTRODUCTION: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer. MATERIALS AND METHODS: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29662492/rnase-h2-loss-in-murine-astrocytes-results-in-cellular-defects-reminiscent-of-nucleic-acid-mediated-autoinflammation
#13
Kareen Bartsch, Markus Damme, Tommy Regen, Lore Becker, Lillian Garrett, Sabine M Hölter, Katharina Knittler, Christopher Borowski, Ari Waisman, Markus Glatzel, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Björn Rabe
Aicardi-Goutières syndrome (AGS) is a rare early onset childhood encephalopathy caused by persistent neuroinflammation of autoimmune origin. AGS is a genetic disorder and >50% of affected individuals bear hypomorphic mutations in ribonuclease H2 (RNase H2). All available RNase H2 mouse models so far fail to mimic the prominent CNS involvement seen in AGS. To establish a mouse model recapitulating the human disease, we deleted RNase H2 specifically in the brain, the most severely affected organ in AGS. Although RNase H2ΔGFAP mice lacked the nuclease in astrocytes and a majority of neurons, no disease signs were apparent in these animals...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29642561/%C3%AE-nicotinamide-adenine-dinucleotide-%C3%AE-nad-inhibits-atp-dependent-il-1%C3%AE-release-from-human-monocytic-cells
#14
Sebastian Daniel Hiller, Sarah Heldmann, Katrin Richter, Innokentij Jurastow, Mira Küllmar, Andreas Hecker, Sigrid Wilker, Gabriele Fuchs-Moll, Ivan Manzini, Günther Schmalzing, Wolfgang Kummer, Winfried Padberg, J Michael McIntosh, Jelena Damm, Anna Zakrzewicz, Veronika Grau
While interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine essential for host defense, high systemic levels cause life-threatening inflammatory syndromes. ATP, a stimulus of IL-1β maturation, is released from damaged cells along with β-nicotinamide adenine dinucleotide (β-NAD). Here, we tested the hypothesis that β-NAD controls ATP-signaling and, hence, IL-1β release. Lipopolysaccharide-primed monocytic U937 cells and primary human mononuclear leukocytes were stimulated with 2'(3')- O -(4-benzoyl-benzoyl)ATP trieethylammonium salt (BzATP), a P2X7 receptor agonist, in the presence or absence of β-NAD...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29614393/lenalidomide-treatment-in-lower-risk-myelodysplastic-syndromes-the-experience-of-a-czech-hematology-center-positive-effect-of-erythropoietin-%C3%A2-prednisone-addition-to-lenalidomide-in-refractory-or-relapsed-patients
#15
Anna Jonasova, Radana Neuwirtova, Helena Polackova, Magda Siskova, Tomas Stopka, Eduard Cmunt, Monika Belickova, Alena Moudra, Lubomir Minarik, Ota Fuchs, Kyra Michalova, Zuzana Zemanova
Lenalidomide therapy represents meaningful progress in the treatment of anemic patients with myelodysplastic syndromes with del(5q). We present our initial lenalidomide experience and the positive effect of combining erythropoietin and steroids with lenalidomide in refractory and relapsed patients. We treated by lenalidomide 55 (42 female; 13 male; median age 69) chronically transfused lower risk MDS patients with del(5q) (45) and non-del(5q) (10). Response, meaning transfusion independence (TI) lasting ≥ eight weeks, was achieved in 38 (90%) of analyzed patients with del(5q), of whom three achieved TI only by adding erythropoietin ± prednisone...
June 2018: Leukemia Research
https://www.readbyqxmd.com/read/29489429/nut-consumption-and-survival-in-patients-with-stage-iii-colon-cancer-results-from-calgb-89803-alliance
#16
Temidayo Fadelu, Sui Zhang, Donna Niedzwiecki, Xing Ye, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al B Benson, Daniel M Atienza, Michael Messino, Hedy L Kindler, Alan Venook, Shuji Ogino, Kimmie Ng, Kana Wu, Walter Willett, Edward Giovannucci, Jeffrey Meyerhardt, Ying Bao, Charles S Fuchs
Purpose Observational studies have reported increased colon cancer recurrence and mortality in patients with states of hyperinsulinemia, including type 2 diabetes, obesity, sedentary lifestyle, and high glycemic load diet. Nut intake has been associated with a lower risk of type 2 diabetes, metabolic syndrome, and insulin resistance. However, the effect of nut intake on colon cancer recurrence and survival is not known. Patients and Methods We conducted a prospective, observational study of 826 eligible patients with stage III colon cancer who reported dietary intake on food frequency questionnaires while enrolled onto a randomized adjuvant chemotherapy trial...
April 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29446073/ccr2-dependent-gr1-high-monocytes-promote-kidney-injury-in-shiga-toxin-induced-hemolytic-uremic-syndrome-in-mice
#17
Judith-Mira Pohl, Julia K Volke, Stephanie Thiebes, Alexandra Brenzel, Kerstin Fuchs, Nicolas Beziere, Walter Ehrlichmann, Bernd J Pichler, Anthony Squire, Faikah Gueler, Daniel R Engel
The hemolytic uremic syndrome (HUS) is a life-threatening disease of the kidney that is induced by shiga toxin-producing E.coli. Major changes in the monocytic compartment and in CCR2-binding chemokines have been observed. However, the specific contribution of CCR2-dependent Gr1high monocytes is unknown. To investigate the impact of these monocytes during HUS, we injected a combination of LPS and shiga toxin into mice. We observed an impaired kidney function and elevated levels of the CCR2-binding chemokine CCL2 after shiga toxin/LPS- injection, thus suggesting Gr1high monocyte infiltration into the kidney...
June 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29445492/mycoplasma-pneumoniae-associated-fuchs-syndrome
#18
Babikir Kheiri, Nour Aljariri Alhesan, Seetharamprasad Madala, Omar Assasa, Meng Shen, Thair Dawood
Fuchs syndrome is a milder form of the Stevens-Johnson syndrome (SJS) spectrum with only mucosal involvement which can be triggered by Mycoplasma pneumonia (MP) infection. Treatment should be directed toward supportive care including ocular and mucous membrane care, fluids and nutritional support, and pain control. In addition, antibiotic and immunomodulatory treatments are discussed for this entity.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29378740/fuchs-syndrome-a-case-of-fever-mucositis-and-conjunctivitis
#19
Chun Yi Ting, Raveen Shahdadpuri
No abstract text is available yet for this article.
January 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29377783/diagnosis-of-cytomegalovirus-anterior-uveitis-in-two-european-referral-centers
#20
Lia Judice M Relvas, Joelle Antoun, Jolanda D F de Groot-Mijnes, Elie Motulsky, Ninette H Ten Dam-Van Loon, Dorine Makhoul, François Willermain, Laure Caspers
PURPOSE: To evaluate diagnostic methods and clinical signs of CMV anterior uveitis (AU), a rarely described entity in Europe. METHODS: We included patients with clinical characteristics of CMV AU and positive PCR and/or Goldmann-Witmer coefficient (GWc) for CMV. RESULTS: We report 21 patients with unilateral uveitis (100%) and signs of Posner-Schlossman syndrome (PSS) (n = 20, 95.2%), Fuchs uveitis syndrome (FUS) (n = 1, 4.7%), and endotheliitis (n = 4, 19,04%)...
2018: Ocular Immunology and Inflammation
keyword
keyword
167500
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"