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https://www.readbyqxmd.com/read/30540347/association-of-antipsychotic-treatment-with-risk-of-unexpected-death-among-children-and-youths
#1
Wayne A Ray, C Michael Stein, Katherine T Murray, D Catherine Fuchs, Stephen W Patrick, James Daugherty, Kathi Hall, William O Cooper
Importance: Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown. Objective: To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications. Design, Setting, and Participants: This retrospective cohort study was conducted from 1999 through 2014 and included Medicaid enrollees aged 5 to 24 years in Tennessee who had no diagnosis of severe somatic illness, schizophrenia or related psychoses, or Tourette syndrome or chronic tic disorder...
December 12, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/30504763/a-retrospective-observational-study-of-uveitis-in-a-single-center-in-poland-with-a-review-of-findings-in-europe
#2
Joanna Brydak-Godowska, Katarzyna Moskal, Piotr K Borkowski, Mariusz Przybyś, Monika Turczyńska, Dariusz Kęcik
BACKGROUND This study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries. MATERIAL AND METHODS Review of local patient records between 2005-2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. A literature review identified 24 publications from 1976-2017 that reported observational data from patients with uveitis in Europe...
December 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30389078/anti-n-methyl-d-aspartate-receptor-encephalitis-and-electroconvulsive-therapy-literature-review-and-future-directions
#3
REVIEW
Yasas Chandra Tanguturi, Allyson Witters Cundiff, Catherine Fuchs
Despite the majority of patients with anti-N-methyl d-aspartate receptor (NMDAR) antibody encephalitis presenting with catatonic symptoms, the literature has not focused on well-known treatments for catatonia, such as electroconvulsive therapy (ECT). The authors review the literature identifying case reports that document the effective use of ECT for anti-NMDAR encephalitis. They also identify gaps in the literature regarding use and documentation of ECT and review possible mechanisms of action for ECT. The authors propose identifying catatonia as a syndrome with multiple potential causes (including anti-NMDAR encephalitis) and suggest a standardized treatment approach using evidence-based catatonia treatments such as ECT and benzodiazepines...
January 2019: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/30345620/demystifying-viral-anterior-uveitis-a-review
#4
REVIEW
Nicole Shu-Wen Chan, Soon-Phaik Chee
A viral aetiology should be suspected when anterior uveitis is accompanied by ocular hypertension, diffuse stellate keratic precipitates or the presence of iris atrophy. The most common viruses associated with anterior uveitis include herpes simplex virus, varicella-zoster virus, cytomegalovirus and rubella virus. They may present as the following: Firstly, granulomatous cluster of small and medium-sized keratic preciptates in Arlt's triangle, with or without corneal scars, suggestive of herpes simplex or varicella-zoster virus infection...
October 21, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/30338117/association-of-plasma-nitrite-levels-with-obesity-and-metabolic-syndrome-in-the-old-order-amish
#5
F Akram, D Fuchs, M Daue, G Nijjar, A Ryan, M E Benros, O Okusaga, E Baca-Garcia, L A Brenner, C A Lowry, K A Ryan, M Pavlovich, B D Mitchell, S Snitker, T T Postolache
Objectives: Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS. Methods: Fasting nitrite levels were measured in 116 Old Order Amish (78% women)...
October 2018: Obesity Science & Practice
https://www.readbyqxmd.com/read/30325406/relationship-between-patient-presentation-and-morphology-of-coronary-atherosclerosis-by-quantitative-multidetector-computed-tomography
#6
Martina C de Knegt, Jesper J Linde, Andreas Fuchs, Michael H C Pham, Andreas K Jensen, Børge G Nordestgaard, Henning Kelbæk, Lars V Køber, Merete Heitmann, Gitte Fornitz, Jens D Hove, Klaus F Kofoed
Aims: Quantitative computed tomography (QCT) allows assessment of morphological features of coronary atherosclerosis. We aimed to test the hypothesis that clinical patient presentation is associated with distinct morphological features of coronary atherosclerosis. Methods and results: A total of 1652 participants, representing a spectrum of clinical risk profiles [787 asymptomatic individuals from the general population, 468 patients with acute chest pain without acute coronary syndrome (ACS), and 397 patients with acute chest pain and ACS], underwent multidetector computed tomography...
October 15, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/30289352/galleria-mellonella-experimental-model-for-bat-fungal-pathogen-pseudogymnoascus-destructans-and-human-fungal-pathogen-pseudogymnoascus-pannorum
#7
Beth Burgwyn Fuchs, Sudha Chaturvedi, Rodnei Dennis Rossoni, Patricia P de Barros, Fernando Torres-Velez, Eleftherios Mylonakis, Vishnu Chaturvedi
Laboratory investigations of the pathogenesis of Pseudogymnoascus destructans, the fungal causal agent of bat White Nose Syndrome (WNS), presents unique challenges due to its growth requirements (4°-15°C) and a lack of infectivity in the current disease models. Pseudogymnoascus pannorum is the nearest fungal relative of P. destructans with wider psychrophilic - physiological growth range, and ability to cause rare skin infections in humans. Our broad objectives are to create the molecular toolkit for comparative study of P...
2018: Virulence
https://www.readbyqxmd.com/read/30281031/ocular-manifestations-of-cytomegalovirus-in-immunocompetent-hosts
#8
Ashlin Joye, John A Gonzales
PURPOSE OF REVIEW: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts. RECENT FINDINGS: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium...
November 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/30263146/the-effect-of-disease-modifying-therapies-on-cd62l-expression-in-multiple-sclerosis
#9
Margarete Maria Voortman, Paul Greiner, Daniel Moser, Martin Helmut Stradner, Winfried Graninger, Adrian Moser, Bernd Haditsch, Christian Enzinger, Siegrid Fuchs, Franz Fazekas, Johannes Fessler, Michael Khalil
Background: The increasing armamentarium of disease-modifying therapies in multiple sclerosis is accompanied by potentially severe adverse effects. The cell-adhesion molecule CD62L, which facilitates leukocyte extravasation, has been proposed as a predictive marker for treatment tolerability. However, pre-analytical procedures might impact test results, thereby limiting its clinical usability. Whether the immediate analysis of CD62L expression of peripheral blood mononuclear cells can aid treatment decision making is yet unclear...
July 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/30181091/glim-criteria-for-the-diagnosis-of-malnutrition-a-consensus-report-from-the-global-clinical-nutrition-community
#10
T Cederholm, G L Jensen, M I T D Correia, M C Gonzalez, R Fukushima, T Higashiguchi, G Baptista, R Barazzoni, R Blaauw, A Coats, A Crivelli, D C Evans, L Gramlich, V Fuchs-Tarlovsky, H Keller, L Llido, A Malone, K M Mogensen, J E Morley, M Muscaritoli, I Nyulasi, M Pirlich, V Pisprasert, M A E de van der Schueren, S Siltharm, P Singer, K Tappenden, N Velasco, D Waitzberg, P Yamwong, J Yu, A Van Gossum, C Compher
RATIONALE: This initiative is focused on building a global consensus around core diagnostic criteria for malnutrition in adults in clinical settings. METHODS: In January 2016, the Global Leadership Initiative on Malnutrition (GLIM) was convened by several of the major global clinical nutrition societies. GLIM appointed a core leadership committee and a supporting working group with representatives bringing additional global diversity and expertise. Empirical consensus was reached through a series of face-to-face meetings, telephone conferences, and e-mail communications...
September 3, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/30178139/an-investigation-on-optic-nerve-head-involvement-in-fuchs-uveitis-syndrome-using-optical-coherence-tomography-and-fluorescein-angiography
#11
Mohammad Zarei, Ali Abdollahi, Sahel Darabeigi, Nazanin Ebrahimiadib, Ramak Roohipoor, Hamed Ghassemi, Reza Soltani Moghaddam, Masoud Aghsaei Fard
PURPOSE: To investigate optic nerve head involvement in patients with Fuchs uveitis syndrome (FUS). METHODS: Optic nerve head of 43 FUS eyes without clinical optic disc edema and 37 unaffected fellow eyes were evaluated using optical coherence tomography (OCT) of peripapillary retina and retinal nerve fiber layer (RNFL) and fundus fluorescein angiography. RESULTS: Seventy-one percent of FUS eyes showed optic nerve head hyperfluorescence. The mean average RNFL thickness in FUS eyes was 115...
December 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30175461/glim-criteria-for-the-diagnosis-of-malnutrition-a-consensus-report-from-the-global-clinical-nutrition-community
#12
Gordon L Jensen, Tommy Cederholm, M Isabel T D Correia, M Christina Gonzalez, Ryoji Fukushima, Takashi Higashiguchi, Gertrudis Adrianza de Baptista, Rocco Barazzoni, Renée Blaauw, Andrew J S Coats, Adriana Crivelli, David C Evans, Leah Gramlich, Vanessa Fuchs-Tarlovsky, Heather Keller, Luisito Llido, Ainsley Malone, Kris M Mogensen, John E Morley, Maurizio Muscaritoli, Ibolya Nyulasi, Matthias Pirlich, Veeradej Pisprasert, Marian de van der Schueren, Soranit Siltharm, Pierre Singer, Kelly A Tappenden, Nicolas Velasco, Dan L Waitzberg, Preyanuj Yamwong, Jianchun Yu, Charlene Compher, Andre Van Gossum
BACKGROUND: This initiative aims to build a global consensus around core diagnostic criteria for malnutrition in adults in clinical settings. METHODS: The Global Leadership Initiative on Malnutrition (GLIM) was convened by several of the major global clinical nutrition societies. Empirical consensus was reached through a series of face-to-face meetings, telephone conferences, and e-mail communications. RESULTS: A 2-step approach for the malnutrition diagnosis was selected, that is, first screening to identify at risk status by the use of any validated screening tool, and second, assessment for diagnosis and grading the severity of malnutrition...
September 2, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/30170123/hypomorphic-caspase-activation-and-recruitment-domain-11-card11-mutations-associated-with-diverse-immunologic-phenotypes-with-or-without-atopic-disease
#13
Batsukh Dorjbal, Jeffrey R Stinson, Chi A Ma, Michael A Weinreich, Bahar Miraghazadeh, Julia M Hartberger, Stefanie Frey-Jakobs, Stephan Weidinger, Lena Moebus, Andre Franke, Alejandro A Schäffer, Alla Bulashevska, Sebastian Fuchs, Stephan Ehl, Sandhya Limaye, Peter D Arkwright, Tracy A Briggs, Claire Langley, Claire Bethune, Andrew F Whyte, Hana Alachkar, Sergey Nejentsev, Thomas DiMaggio, Celeste G Nelson, Kelly D Stone, Martha Nason, Erica H Brittain, Andrew J Oler, Daniel P Veltri, T Ronan Leahy, Niall Conlon, Maria C Poli, Arturo Borzutzky, Jeffrey I Cohen, Joie Davis, Michele P Lambert, Neil Romberg, Kathleen E Sullivan, Kenneth Paris, Alexandra F Freeman, Laura Lucas, Shanmuganathan Chandrakasan, Sinisa Savic, Sophie Hambleton, Smita Y Patel, Michael B Jordan, Amy Theos, Jeffrey Lebensburger, T Prescott Atkinson, Troy R Torgerson, Ivan K Chinn, Joshua D Milner, Bodo Grimbacher, Matthew C Cook, Andrew L Snow
BACKGROUND: Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold protein in lymphocytes that links antigen receptor engagement with downstream signaling to nuclear factor κB, c-Jun N-terminal kinase, and mechanistic target of rapamycin complex 1. Germline CARD11 mutations cause several distinct primary immune disorders in human subjects, including severe combined immune deficiency (biallelic null mutations), B-cell expansion with nuclear factor κB and T-cell anergy (heterozygous, gain-of-function mutations), and severe atopic disease (loss-of-function, heterozygous, dominant interfering mutations), which has focused attention on CARD11 mutations discovered by using whole-exome sequencing...
August 28, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29961768/germline-cancer-susceptibility-gene-variants-somatic-second-hits-and-survival-outcomes-in-patients-with-resected-pancreatic-cancer
#14
Matthew B Yurgelun, Anu B Chittenden, Vicente Morales-Oyarvide, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Zhi Rong Qian, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Justin L Bui, Chen Yuan, Tingting Li, Wanwan Li, Atsuhiro Masuda, Mancang Gu, Andrea J Bullock, Daniel T Chang, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew D Ducar, Bruce M Wollison, Natalia Khalaf, Kimberly Perez, Sapna Syngal, Andrew J Aguirre, William C Hahn, Matthew L Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Jonathan A Nowak, Brian M Wolpin
PURPOSE: Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors. We sought to determine the prevalence and significance of germline cancer susceptibility gene variants in PDAC with paired somatic and survival analyses. METHODS: Using a customized next-generation sequencing panel, germline/somatic DNA was analyzed from 289 patients with resected PDAC ascertained without preselection for high-risk features (e...
July 2, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29959762/-the-big-five-cataract-surgery-under-multiple-ocular-comorbidity-customised-approach-to-prevent-complications
#15
Andreas F Borkenstein, Eva-Maria Borkenstein
The co-occurence of 5 diseases (cataract, Fuchs dystrophy, pseudoexfoliation syndrome, age-related macular degeneration and dry eye syndrome) can lead to massive impairment of visual acuity. Our case series show that cataract surgery can lead to an enormous profit in visual rehabilitation and therefore in daily routine.
August 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29944680/different-composition-of-intraocular-immune-mediators-in-posner-schlossman-syndrome-and-fuchs-uveitis
#16
Dominika Pohlmann, Stephan Schlickeiser, Sylvia Metzner, Matthias Lenglinger, Sibylle Winterhalter, Uwe Pleyer
Posner-Schlossman-Syndrome (PSS) is clinically characterized by acute, recurrent, mild, unilateral uveitis anterior accompanied by elevated intraocular pressure (IOP). Fuchs´ Uveitis (FU) is a chronic, low-grade-inflammatory disorder, involving anterior uvea and vitreous. The clinical findings show remarkable similarities as well as differences. In our study, we determine the composition of immune mediators in aqueous humor of patients with PSS and FU and evaluate if immune mediators play a crucial role in specific viral intraocular inflammation and IOP rises...
2018: PloS One
https://www.readbyqxmd.com/read/29924204/descemet-membrane-endothelial-keratoplasty-in-multifocal-pseudophakic-eyes
#17
Nicolas Cesário Pereira, Evandro Ribeiro Diniz, Ramon Coral Ghanem, Ruy Cunha Filho, Tatiana Moura Prazeres, Walton Nose, Adriana Dos Santos Forseto
PURPOSE: This report describes the use of Descemet membrane endothelial keratoplasty for the management of endothelial decompensation after multifocal intraocular lens implantation. METHODS: In this retrospective study, we reviewed and assessed the surgical outcomes of 9 patients (9 eyes) who underwent Descemet membrane endothelial keratoplasty after multifocal intraocular lens implantation. RESULTS: Corneal edema occurred due to Fuchs endothelial corneal dystrophy (n=3), pseudophakic bullous keratopathy (n=3), Descemet's membrane detachment (n=2), and toxic anterior segment syndrome (n=1)...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29912095/combined-biomarkers-predict-acute-mortality-among-critically-ill-patients-with-suspected-sepsis
#18
Brendan J Kelly, Ebbing Lautenbach, Irving Nachamkin, Susan E Coffin, Jeffrey S Gerber, Barry D Fuchs, Charles Garrigan, Xiaoyan Han, Warren B Bilker, Jacqueleen Wise, Pam Tolomeo, Jennifer H Han
OBJECTIVES: Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. We compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis. DESIGN: Cohort study. SETTING: The medical and surgical ICUs at an academic medical center...
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29909603/urinary-outcomes-in-patients-with-down-s-syndrome-and-hirschsprung-s-disease
#19
Alexander Johannes Martinus Dingemans, Carlos Albert Reck-Burneo, Molly Fuchs, Alejandra Vilanova Sanchez, Victoria Alison Lane, Erin Hoover, Tassiana Maloof, Laura Weaver, Marc A Levitt, Richard J Wood
INTRODUCTION:  Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group. METHODS:  The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome. RESULTS:  A total of 104 patients with HD were included in this study...
June 17, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29909152/early-fever-after-haploidentical-bone-marrow-transplantation-correlates-with-class-ii-hla-mismatching-and-myeloablation-but-not-outcomes
#20
Shannon R McCurdy, Stephen T Muth, Hua-Ling Tsai, Heather J Symons, Carol Ann Huff, William H Matsui, Ivan Borrello, Douglas E Gladstone, Lode J Swinnen, Kenneth R Cooke, Robert A Brodsky, Javier Bolaños-Meade, Richard F Ambinder, Ravi Varadhan, Leo Luznik, Richard J Jones, Maria P Bettinot, Ephraim J Fuchs
Noninfectious fevers are common early after T cell-replete HLA haploidentical (haplo) peripheral blood transplants and have been associated with cytokine release syndrome and overall mortality. However, less is known regarding the incidence and associations of early fever after bone marrow transplantation (BMT) with post-transplant cyclophosphamide (PTCy). We hypothesized that early fever would be associated with myeloablative conditioning (MAC), because of its relative increase in tissue damage augmenting antigen presentation and class II HLA-mismatching because of recognition of antigen-presenting cells by CD4+ T cells...
June 15, 2018: Biology of Blood and Marrow Transplantation
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