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https://www.readbyqxmd.com/read/29679350/alleviation-mechanisms-of-selenium-on-cadmium-spiked-in-chicken-ovarian-tissue-perspectives-from-autophagy-and-energy-metabolism
#1
Shuang Wang, Zhe Xu, Hang Yin, Yahong Min, Shu Li
Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Administration of Cd for 12 weeks led to energy metabolism disorder of the chicken ovarian tissues, which resulted in autophagy. In addition, the mRNA expression of glucose-related genes including hexokinase II (HK2), pyruvate kinase (PK), pyruvate dehydrogenase complex (PDHX), and succinate dehydrogenase (SDH) and the activities of ATPase, including Na+ -K+ -ATPase, Ca2+ -ATPase, Mg2+ -ATPase, were all downregulated remarkably compared with the control...
April 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29679326/synthetic-peg-hydrogel-for-engineering-the-environment-of-ovarian-follicles
#2
Uziel Mendez, Hong Zhou, Ariella Shikanov
The functional unit within the ovary is the ovarian follicle, which is also a morphological unit composed of three basic cell types: the oocyte, granulosa, and theca cells. Similar to human ovarian follicles, mouse follicles can be isolated from their ovarian environment and cultured in vitro to study folliculogenesis, or follicle development for days or weeks. Over the course of the last decade, follicle culture in a three-dimensional (3D) environment exponentially improved the outcomes of in vitro folliculogenesis...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29679322/three-dimensional-hydrogel-based-culture-to-study-the-effects-of-toxicants-on-ovarian-follicles
#3
Hong Zhou, Ariella Shikanov
Various toxicants, such as drugs and their metabolites, can cause potential ovarian toxicity. As the functional units of the ovary, ovarian follicles are susceptible to this type of damage at all developmental stages. Studying the effects of toxicants on ovarian follicles is an important task. Three-dimensional (3D) hydrogels, such as fibrin alginate interpenetrating networks (FA-IPNs), can support ovarian follicle culture in vitro for extended periods of time and serve as a suitable tool for studying ovotoxicity...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29678671/the-development-of-oocytes-in-the-ovary-of-a-parthenogenetic-tick-haemaphysalis-longicornis
#4
Ryo Mihara, Rika Umemiya-Shirafuji, Yasuyuki Abe, Tomohide Matsuo, Noriyuki Horiuchi, Suguru Kawano, Kozo Fujisaki, Hiroshi Suzuki
Haemaphysalis longicornis is an important vector of various pathogens in domestic animals and humans. The tick is a unique species with bisexual and parthenogenetic races. Although mating induces oocyte development, it is possible in the parthenogenetic race to complete oogenesis without copulation. Here we examined the developmental process of oocytes from unfed to the oviposition period in parthenogenetic H. longicornis. We classified the developmental stages of oocytes into five stages: stage I, germinal vesicle occupies more than half of the cytoplasm; stage II, germinal vesicle occupies less than half of the cytoplasm; stage III, germinal vesicle migrates from the center in the oocyte to the vicinity of the pedicel cells; stage IV, the cytoplasm is filled with yolk granules of various sizes; stage V, the cytoplasm is occupied by large yolk granules...
April 17, 2018: Parasitology International
https://www.readbyqxmd.com/read/29678491/polycystic-ovary-syndrome-pcos-an-inflammatory-systemic-lifestyle-endocrinopathy
#5
REVIEW
Seema Patel
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29678103/ouantitative-proteomic-analysis-of-cellular-responses-to-a-designed-amino-acid-feed-in-a-monoclonal-antibody-producing-chinese-hamster-ovary-cell-line
#6
Fatemeh Torkashvand, Fereidoun Mahboudi, Manouchehr Vossoughi, Elnaz Fatemi, Seyed Masoud Moosavi Basri, Amir Heydari, Behrouz Vaziri
Background: Chinese hamster ovary (CHO) cell line is considered as the most common cell line in the biopharmaceutical industry because of its capability in performing efficient post-translational modifications and producing the recombinant proteins, which are similar to natural human proteins. The optimization of the upstream process via different feed strategies has a great impact on the target molecule expression and yield. Methods: To determine and understand the molecular events beneath the feed effects on the CHO cell, a label-free quantitative proteomic analysis was applied...
April 21, 2018: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29676714/-does-ovarian-cancer-start-in-the-fallopian-tubes-possible-implications-for-preventive-adnexal-removal
#7
M P Steenbeek, J Bulten, N Hoogerbrugge, L F A G Massuger, J M A Pijnenborg, J A de Hullu
BACKGROUND: Recent insights in high-grade serous ovarian cancer development are pointing to the fallopian tubes as likely place of origin and not the ovaries themselves. This may have consequences for patients with increased risk of ovarian cancer. Adnexal removal is currently recommended for this patient group at an age of 35-45, which leads to premature menopause. CASE DESCRIPTION: In a 55-year-old woman with a BRCA1 germ line mutation, a high-grade serous carcinoma was unexpectedly diagnosed in both fallopian tubes during preventive adnexal removal...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676471/vitamin-d3-regulates-steroidogenesis-in-granulosa-cells-through-amp-activated-protein-kinase-ampk-activation-in-a-mouse-model-of-polycystic-ovary-syndrome
#8
Shabnam Bakhshalizadeh, Fardin Amidi, Reza Shirazi, Maryam Shabani Nashtaei
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in reproductive-aged women. Hormonal abnormality caused by steroidogenesis disturbances appears to be the main culprit of the clinical picture in PCOS. Vitamin D3 could regulate steroidogenesis in granulosa cells, but the mechanism of action of vitamin D3 on steroidogenesis remains unknown. AMP-activated protein kinase (AMPK) has a modulating role in steroid hormone production. We investigated the effect of vitamin D3 on steroidogenesis in cultured granulosa cells of dehydroepiandrosterone-induced PCOS mice and studied the involvement of AMPK signalling pathway in the current process...
April 20, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29676013/insemination-intrafollicular-fertilization-and-development-of-the-fertilization-plug-during-gestation-in-heterandria-formosa-poeciliidae
#9
Mari Carmen Uribe, Harry J Grier
The viviparous teleost Heterandria formosa is a remarkable species for its reproductive characters including: (a) the smallest oocyte in viviparous fish species; (b) a high level of matrotrophy with a complex placenta; and (c) the highest level of superfetation. Superfetation involves (d) the continuous development of oocytes and fertilization at the same time with embryos in gestation. The sequential fertilization of oocytes requires (e) storage of spermatozoa in the ovary. Among these characteristics, fertilization is of fundamental interest, specifically the intrafollicular fertilization of poeciliids, species that do not present micropyle, and the consequent formation of the fertilization plug, a structure developed at the periphery of the follicle where the entrance of spermatozoa occurs...
April 20, 2018: Journal of Morphology
https://www.readbyqxmd.com/read/29675930/relationship-between-ultrasonographic-and-biochemical-markers-of-tubal-ectopic-pregnancy-and-success-of-subsequent-management
#10
Batool Nadim, Chuan Lu, Fernando Infante, Shannon Reid, George Condous
OBJECTIVES: To determine whether there is an association between morphologic types of tubal ectopic pregnancy (EP), 0-hour human chorionic gonadotropin (hCG) levels, and subsequent management success. METHODS: We conducted a prospective study (November 2006-December 2015). Women had a diagnosis of EP by transvaginal ultrasonography if they had an inhomogeneous mass adjacent to the ovary and moving separately from it ("blob" sign), a mass with a hyperechoic ring around the gestational sac ("bagel" sign), or a gestational sac with an embryonic pole with or without a yolk sac with or without cardiac activity...
April 20, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29675735/xanthogranulomatosis-of-the-spleen-a-case-report
#11
Goshi Fujimoto, Ken Hayashi, Shigetoshi Yamada, Hiroshi Kusanagi, Koichi Honma
BACKGROUND: Xanthogranulomatous inflammation is recognized as a subtype of cholecystitis; however, it can also occur in other organs. Xanthogranulomatosis of the kidney, bone, ovary, endometrium, vagina, prostate, lymph nodes and pancreas was reported. Herein, we report a case of laparoscopic splenectomy in a patient with xanthogranulomatosis of the spleen that was difficult to diagnose preoperatively. CASE PRESENTATION: A 63-year-old man with a past medical history of hyperlipidemia had gradually growing multiple splenic masses, which were revealed on abdominal ultrasonography...
April 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29675484/resveratrol-supplementation-rescues-pool-of-growing-follicles-and-ovarian-stroma-from-cisplatin-induced-toxicity-on-the-ovary-in-sprague-dawley-rats-an-experimental-study
#12
Gbotolorun Stella Chinwe, Okafor Izuchukwu Azuka, Ndoeche Chidinma Adaeze
Background: Cisplatin is a potent antineoplastic agent for many cancers but causes several levels of gonadal damage. Ovarian toxicity is a major concern of young cancer patients undergoing chemotherapy. Objective: This study sought to examine the effect of Cisplatin and Resveratrol supplementation on ovarian function in Sprague-Dawley rats. Materials and Methods: In this experimental study, 45 cyclic Sprague-Dawley rats with an average weight of 160 gr were divided into 9 groups (n=5/group)...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675469/noninvasive-ovarian-cancer-biomarker-detection-via-an-optical-nanosensor-implant
#13
Ryan M Williams, Christopher Lee, Thomas V Galassi, Jackson D Harvey, Rachel Leicher, Maria Sirenko, Madeline A Dorso, Janki Shah, Narciso Olvera, Fanny Dao, Douglas A Levine, Daniel A Heller
Patients with high-grade serous ovarian carcinoma (HGSC) exhibit poor 5-year survival rates, which may be significantly improved by early-stage detection. The U.S. Food and Drug Administration-approved biomarkers for HGSC-CA-125 (cancer antigen 125) and HE4 (human epididymis protein 4)-do not generally appear at detectable levels in the serum until advanced stages of the disease. An implantable device placed proximal to disease sites, such as in or near the fallopian tube, ovary, uterine cavity, or peritoneal cavity, may constitute a feasible strategy to improve detection of HGSC...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29675034/relationship-between-the-estimated-breeding-values-for-litter-traits-at-birth-and-ovarian-and-embryonic-traits-and-their-additive-genetic-variance-in-gilts-at-35-days-of-pregnancy
#14
Carolina L A Da Silva, Han A Mulder, Marleen L W J Broekhuijse, Bas Kemp, Nicoline M Soede, Egbert F Knol
We investigated (1) the relationship between the estimated breeding values (EBVs) for litter traits at birth and ovulation rate (OR), average corpora luteal weight, uterine length and embryonic survival and development traits in gilts at 35 days of pregnancy by linear regression, (2) the genetic variance of OR, average corpora lutea (CL) weight, uterine length and embryonic survival and development traits at 35 days of pregnancy, and (3) the genetic correlations between these traits. Landrace ( n = 86) and Yorkshire × Landrace ( n = 304) gilts were inseminated and slaughtered at 35 days of pregnancy...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29674607/up-regulation-of-long-noncoding-rna-sra-promotes-cell-growth-inhibits-cell-apoptosis-and-induces-secretion-of-estradiol-and-progesterone-in-ovarian-granular-cells-of-mice
#15
Yan Li, Haixu Wang, Dangxia Zhou, Ting Shuang, Haibo Zhao, Biliang Chen
BACKGROUND Increasing evidence indicates that long noncoding RNAs (LncRNAs) play a key role in multiple pathological processes. It has been shown that LncRNA steroid receptor RNA activator (SRA) is elevated in peripheral blood of patients with polycystic ovary syndrome (PCOS). The aim of this study was to assess the effect of elevated LncRNA SRA on ovarian granular cells of mice in vitro. MATERIAL AND METHODS We firstly isolated granular cells from mouse ovaries and over-expressed the LncRNA SRA by means of lentiviral transfection in this cell line...
April 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29674245/effects-of-multiple-life-stage-exposure-to-the-fungicide-prochloraz-in-xenopus-laevis-manifestations-of-antiandrogenic-and-other-modes-of-toxicity
#16
Jonathan T Haselman, Patricia A Kosian, Joseph J Korte, Allen W Olmstead, Sigmund J Degitz
The Larval Amphibian Growth and Development Assay (LAGDA) is an internationally harmonized testing guideline for evaluating effects of chronic chemical exposure in amphibians. In order to evaluate the effects of chronic exposure to an antiandrogenic chemical in an amphibian model, prochloraz was tested using a variation of the LAGDA design. Exposure was initiated with <1d post-fertilization embryos at nominal concentrations of 0, 6.7, 20, 60 and 180 μg/L (0, 18, 53, 159, 478 nM) and continued in flow-through conditions until two months following the median time that controls completed metamorphosis...
April 3, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29674165/identification-expression-and-function-of-myosin-heavy-chain-family-genes-in-tribolium-castaneum
#17
Chengjun Li, Juanjuan Liu, Peng Lü, Shangshang Ma, Keming Zhu, Lu Gao, Bin Li, Keping Chen
Functions of myosin heavy chain (myosin) family genes are poorly understood in some insects. To address this, we determined the expression and function of myosin family genes in Tribolium castaneum. TcMyo15 is predominantly expressed in early embryos, late larvae and early adults, but TcMyo7B transcripts significantly increased in late larvae. TcMyo20 transcripts are abundant in pre-adults, whereas TcMhc1 is highly expressed in post-embryonic stages. TcMhc2 shows peak expression in late pupae. TcMyo9 transcripts reached their highest levels in late pupae...
April 16, 2018: Genomics
https://www.readbyqxmd.com/read/29673681/a-rare-krukenberg-tumor-arising-from-a-primary-adenocarcinoma-of-the-small-intestine
#18
Angel An-Chieh Liu, Chi-Huang Chen, Wei-Min Liu, Ching-Wen Chang
OBJECTIVE: A Krukenberg tumor is a malignancy in the ovary that metastasizes from a primary site. Here, we report a very rare case of bilateral Krukenberg tumors of the ovaries arising from a primary adenocarcinoma of the small intestine in a 53-year-old Taiwanese woman. CASE REPORT: The patient presented with a 3-month history of abdominal distension and acid regurgitation. Gastroscopy and colonoscopy findings were negative. According to the preoperative image, we highly suspected that the small bowel mass was the primary tumor with metastatic tumors to bilateral ovarian masses...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673624/an-efficient-method-to-control-high-mannose-and-core-fucose-levels-in-glycosylated-antibody-production-using-deoxymannojirimycin
#19
Sagit Shalel Levanon, Orit Aharonovitz, Ayelet Maor-Shoshani, Gita Abraham, Dan Kenett, Yehoshua Aloni
Glycosylation on the Fc region of recombinant Immunoglobulin G (IgG) therapeutic antibodies is a critical protein quality attribute which may affect the efficacy and safety of the molecule. During the development of biosimilar therapeutics, adjustment of the glycosylation profile is required in order to match the reference innovator profile. Deoxymannojirimycin (DMJ), a known inhibitor of mannosidase, was used in this study to modulate the glycosylation pattern of antibodies. The effect of DMJ, at concentrations of 5 μM - 500 μM, on non-fucosylated glycoform levels was tested in the biosynthesis processes of two different IgG1 (IgG1 #A and IgG1 #B) using two Chinese hamster ovary (CHO) cell lines (CHO-DXB-11 and CHOK1SV, respectively) in Erlenmeyer flasks and in lab scale bioreactors...
April 16, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29673382/risk-of-synchronous-endometrial-disorders-in-women-with-endometrioid-borderline-tumors-of-the-ovary
#20
Shuang-Zheng Jia, Jun-Ji Zhang, Jun-Jun Yang, Yang Xiang, Zhiyong Liang, Jin-Hua Leng
BACKGROUND: Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women with EBOT and associated factors, as well as their oncological and fertility outcomes. RESULTS: This retrospective study included 33 women with EBOT. Their mean age was 41.9 years, and endometria were evaluated in 25 of these patients. The prevalence of synchronous endometrial disorders was 52...
April 19, 2018: Journal of Ovarian Research
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