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https://www.readbyqxmd.com/read/29451900/the-arid1a-p53-and-%C3%A3-catenin-statuses-are-strong-prognosticators-in-clear-cell-and-endometrioid-carcinoma-of-the-ovary-and-the-endometrium
#1
Marlene Heckl, Elisa Schmoeckel, Linda Hertlein, Miriam Rottmann, Udo Jeschke, Doris Mayr
AIM: The objective of this study was to evaluate the prognostic value of ARID1A, p53, p21, p16 and ß-Catenin in endometrioid and clear cell ovarian and endometrial carcinomas. MATERIALS AND METHODS: 97 tumors were available for analysis of ARID1A, p53, p21, p16 and ß-Catenin with the techniques of tissue microarray and immunohistochemistry. 32 were ovarian carcinomas and 65 were endometrial carcinomas. RESULTS: Endometrioid ovarian carcinomas showed negative staining for ARID1A (a) and p21 (b), aberrant expression of p53 (c) and p16 (d) and ß-Catenin positive nuclear expression (e) respectively in 19% (a), 100% (b), 28...
2018: PloS One
https://www.readbyqxmd.com/read/29451647/criopreserved-ovarian-tissue-transplantation-and-bone-restoration-metabolism-in-castrated-rats
#2
Lígia Helena Ferreira Melo E Silva, João Marcos DE Meneses E Silva, Mahmoud Salama, Luiz Gonzaga Porto Pinheiro, Franciele Osmarini Lunardi, Paulo Goberlânio Barros DA Silva, Carlos Gustavo Hirth, Igor Freitas DE Lucena, Glauco Jorge DA Costa Gomes, José Alberto Dias Leite
OBJECTIVES: to evaluate estradiol levels and autotransplantation heated ovarian tissue effects, after vitrification, on rats bone metabolism previously oophorectomized bilaterally. METHODS: experimental study with 27 rats aged 11 to 12 weeks and weighing 200g to 300g, submitted to bilateral oophorectomy and ovarian tissue cryopreservation for subsequent reimplantation. Animals were divided into two groups, A and B, with 8 and 19 rats, respectively. Autotransplantation occurred in two periods according to castration time: after one week, in group A, and after one month in group B...
2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29450960/effect-of-flower-orientation-on-the-male-and-female-traits-of-myrtillocactus-geometrizans-cactaceae
#3
Sandra A Aguilar-García, Dulce M Figueroa-Castro, Pedro L Valverde, F Vite
1.Intra-individual variation in the production and size of reproductive traits has been documented in columnar cacti, being higher in Equator-facing flowers. Such variation is attributed to the high amount of photosynthetic active radiation intercepted by stems oriented towards the Equator. Most studies focused on this phenomenon have documented the existence of intra-individual variation on traits associated with the female function; however, its impact on traits associated with the male function has been neglected...
February 16, 2018: Plant Biology
https://www.readbyqxmd.com/read/29450927/histological-and-immunohistochemical-evaluation-of-granulosa-cells-during-different-stages-of-folliculogenesis-in-bovine-ovaries
#4
App Teh, U Z Izzati, K Mori, N Fuke, T Hirai, G Kitahara, R Yamaguchi
Bovine granulosa cells (GC) vary in their morphological aspect during different stages of folliculogenesis. In this study, 10 morphologically normal bovine ovaries were collected to study the structural aspects of different stages of GC using intermediate filament protein antibodies including cytokeratin AE1/AE3 (AE1/AE3), vimentin, nectin-4 and desmin. Hormonal immunolocalization was assessed using the immunomarkers anti-Müllerian hormone (AMH) and inhibin alpha. In addition, tumour markers and proliferation markers using c-erbB-2 oncoprotein and proliferating cell nuclear antigen, respectively, were investigated...
February 15, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29450856/hysterectomy-and-perceived-physical-function-in-middle-aged-australian-women-a-20-year-population-based-prospective-cohort-study
#5
Louise F Wilson, Nirmala Pandeya, Julie Byles, Gita D Mishra
PURPOSE: Hysterectomy is one of the most common gynaecological procedures worldwide. Changes in endocrine function may impact age-associated decline in physical function and these changes may be accelerated by hysterectomy. The aim of this study was to investigate associations between hysterectomy status and self-reported physical function limitations. METHODS: Our study sample (n = 8624) came from the mid-cohort (born 1945-1950) of the Australian Longitudinal Study on Women's Health (ALSWH)...
February 15, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29450608/imaging-findings-of-ovarian-dysgerminoma-with-emphasis-on-multiplicity-and-vascular-architecture-pathogenic-implications
#6
Takahiro Tsuboyama, Yumiko Hori, Masatoshi Hori, Hiromitsu Onishi, Mitsuaki Tatsumi, Makoto Sakane, Takashi Ota, Noriyuki Tomiyama
We report the imaging findings of three ovarian dysgerminomas that coexisted with other germ cell tumors or gonadoblastomas, focusing on the distribution of tumor nests and vascular architecture, which might provide information about the pathogenesis of dysgerminomas. In a 14-year-old female with dysgerminoma and coexisting gonadoblastomas, contrast-enhanced magnetic resonance imaging (MRI) demonstrated a solid mass in the right ovary, which presented as hyperintense lobules on diffusion-weighted imaging separated by fibrovascular septa...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29449730/ovarian-leiomyoma-with-myxoid-stroma
#7
A Moulla, N Magdy, M El-Bahrawy
Ovarian smooth muscle tumours are rare. Notable myxoid change in smooth muscle tumours is uncommon, and raises diagnostic issues that need to be considered on evaluating a spindle cell lesion with notable myxoid change. There is only one case of myxoid leiomyoma of the ovary previously reported. We here report a case of ovarian leiomyoma with areas of myxoid stroma and discuss the relevant differential diagnosis and histological features to be assessed in such a lesion.
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449726/primary-well-differentiated-neuroendocrine-tumor-of-ovary-collides-with-mucinous-borderline-tumor-in-a-postmenopausal-female-a-report-of-case-and-review-of-literature
#8
M Shahid, A Siddiqi
Collision tumors represent a coexistence of two adjacent but histologically distinct tumors without histologic admixture in an organ. Primary well differentiated neuroendocrine tumor of ovary is rare and coexistent borderline mucinous tumor makes this association extremely rare. Although these tumors have been reported in other organs, its occurrence in ovary is rare. Collision tumor comprising primary neuroendocrine tumor of ovary and mucinous borderline tumor is an extremely rare occurrence. Here we report a case of this collision tumor in a postmenopausal female...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449679/tert-promoter-mutation-in-adult-granulosa-cell-tumor-of-the-ovary
#9
Jessica A Pilsworth, Dawn R Cochrane, Zhouchunyang Xia, Geraldine Aubert, Anniina E M Färkkilä, Hugo M Horlings, Satoshi Yanagida, Winnie Yang, Jamie L P Lim, Yi Kan Wang, Ali Bashashati, Jacqueline Keul, Adele Wong, Kevin Norris, Sara Y Brucker, Florin-Andrei Taran, Bernhard Krämer, Annette Staebler, Esther Oliva, Sohrab P Shah, Stefan Kommoss, Friedrich Kommoss, C Blake Gilks, Duncan M Baird, David G Huntsman
The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by activating TERT to maintain telomere length and telomerase activity, which is a crucial step of tumorigenesis. Two somatic mutations in the TERT promoter (C228T; C250T) have been identified as gain-of-function mutations that promote transcriptional activation of TERT in multiple cancers, such as melanoma and glioblastoma. A recent study investigating TERT promoter mutations in ovarian carcinomas found C228T and C250T mutations in 15...
February 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29449314/vitamin-d-pcos-and-androgens-in-men-a-systematic-review
#10
Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara R Obermayer-Pietsch, Elisabeth Lerchbaum
BACKGROUND: Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. AIM: The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men. METHODS: We performed a systematic literature search in Pubmed for relevant English language publications published from January 2012 until July 2017...
February 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29449022/expression-patterns-of-claudin-5-and-its-related-signals-during-luteal-regression-in-pseudopregnant-rats-the-enhanced-effect-of-additional-pgf-treatment
#11
Lina Qi, Jingle Jiang, Pengjin Jin, Meiqian Kuang, Quanwei Wei, Fangxiong Shi, Dagan Mao
To study the expression patterns of claudin-5 and its related signals during luteal regression in rats, a sequential PMSG/hCG treatment paradigm was used to obtain a single, well-defined generation of corpus luteum (CL). A total of 35 rats were treated with one PGF or two PGF at an interval of 24 h from day 7 of pseudopregnancy to induce CL regression. Serum and ovaries were collected at 0, 2, 4, 8 or 24 h after one PGF injection (1 PGF), 2 or 24 h after two PGF injections (2 PGF). The serum progesterone level was detected by RIA; the ovarian expression of claudin-5, the phosphorylations of STAT3 (p-STAT3), Akt (p-Akt), ERK1/2 (p-ERK) and p38 MAPK (p-p38) were detected by western blot, real-time PCR and IHC...
February 12, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29447630/metformin-as-an-adjunct-therapy-for-the-treatment-of-moderate-to-severe-acne-vulgaris
#12
John K Lee, Andrew D Smith
The purpose of this literature review is to evaluate the use of metformin as an adjunct therapy in the treatment of moderate-to-severe acne in those not diagnosed with polycystic ovary syndrome (PCOS) or androgen excess. The authors conducted independent literature searches. Results were limited to clinical trials and randomized controlled trials. Studies with participants diagnosed with moderateto-severe acne vulgaris taking metformin versus placebo or other active treatment were included;studies with participants diagnosed with PCOS or androgen excess were excluded...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447491/association-between-th1-th2-immune-imbalance-and-obesity-in-women-with-or-without-polycystic-ovary-syndrome
#13
Ping Gong, Bingwei Shi, Juan Wang, Peixia Cao, Zhenyu Diao, Yuji Wang, Yali Hu, Shuping Li
OBJECTIVES: This study aimed to investigate the Th1/Th2 cells in peripheral blood of PCOS patients, and assess the potential correlation between Th1/Th2 imbalance and obesity. METHODS: Thirty-nine PCOS patients and 23 age-matched controls were enrolled. The PBMCs were obtained before pharmacological intervention in women with or without PCOS. The profiles of Th1 (IFN-γ) and Th2 (IL-4) cytokines of CD3 + CD - T lymphocyte subsets were analyzed by flow cytometry...
February 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29447380/sirtuins-in-gamete-biology-and-reproductive-physiology-emerging-roles-and-therapeutic-potential-in-female-and-male-infertility
#14
Carla Tatone, Giovanna Di Emidio, Arcangelo Barbonetti, Gaspare Carta, Alberto M Luciano, Stefano Falone, Fernanda Amicarelli
BACKGROUND: Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of fertility emerged in 2003 when a defective reproductive phenotype was observed in SIRT1-null mice. Although studies on Sirtuins in reproductive biology have been increasing in the last years, a recent comprehensive update on this issue is still lacking...
February 13, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29447022/correction-to-seyyed-abootorabi-et-al-the-effect-of-vitamin-d-supplementation-on-insulin-resistance-visceral-fat-and-adiponectin-in-vitamin-d-deficient-women-with-polycystic-ovary-syndrome-a-randomized-placebo-controlled-trial
#15
https://www.readbyqxmd.com/read/29445121/tomato-auxin-response-factor-5-regulates-fruit-set-and-development-via-the-mediation-of-auxin-and-gibberellin-signaling
#16
Songyu Liu, Youwei Zhang, Qiushuo Feng, Li Qin, Changtian Pan, Anthony Tumbeh Lamin-Samu, Gang Lu
Auxin response factors (ARFs) encode transcriptional factors that function in the regulation of plant development processes. A tomato ARF gene, SlARF5, was observed to be expressed at high levels in emasculated ovaries but maintained low expression levels in pollinated ovaries. The amiRNA SlARF5 lines exhibited ovary growth and formed seedless fruits following emasculation. These parthenocarpic fruits developed fewer locular tissues, and the fruit size and weight were decreased in transgenic lines compared to those of wild-type fruits...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445069/expression-and-distribution-of-the-zinc-finger-protein-snai3-in-mouse-ovaries-and-pre-implantation-embryos
#17
Shujuan Guo, Xing-Yu Yan, Feifei Shi, Ke Ma, Zi-Jiang Chen, Cong Zhang
The Snail gene family includes Snai1, Snai2, and Snai3 that encode zinc finger-containing transcriptional repressors in mammals. The expression and localization of SNAI1 and SNAI2 have been studied extensively during folliculogenesis, ovulation, luteinization, and embryogenesis in mice. However, the role of SNAI3 is unknown. In this study, we investigated the expression of SNAI3 during these processes. Our immunohistochemistry data showed that SNAI3 first appeared in oocytes by postnatal day (PD) 9. Following this, SNAI3 was found to be expressed consistently in theca and interstitial cells, along with oocytes...
February 15, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29444704/hpmsc-transplantation-restoring-ovarian-function-in-premature-ovarian-failure-mice-is-associated-with-change-of-th17-tc17-and-th17-treg-cell-ratios-through-the-pi3k-akt-signal-pathway
#18
Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan, Hongqin Zhang
BACKGROUND: Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF). But the exact mechanism remains unclear. The goal of the present study is to investigate the role of immune factors (T-helper 17 (Th17), cytotoxic T (Tc17) and regulatory T (Treg) cells) in the recovery of ovarian function and whether the phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway is involved in the regulation...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29444667/in-vitro-antileishmanial-and-cytotoxicity-activities-of-essential-oils-from-haplophyllum-tuberculatum-a-juss-leaves-stems-and-aerial-parts
#19
Assia Hamdi, Joanne Bero, Claire Beaufay, Guido Flamini, Zohra Marzouk, Yvan Vander Heyden, Joelle Quetin-Leclercq
BACKGROUND: Plants used for traditional medicine produce diverse and complex secondary metabolites exhibiting various medicinal properties. The medicinal plant Haplophyllum tuberculatum is used by native people against malaria and parasitic infections. METHODS: In this study and in order to contribute for the search of new natural drugs for leishmaniasis, the essential oils of H. tuberculatum leaves, stems and aerial parts (leaves+stems) collected in two different periods, 2013 and 2015, and their components by GC/FID and GC/MS analyses were investigated...
February 14, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29443823/aerobic-training-improves-quality-of-life-in-women-with-polycystic-ovary-syndrome
#20
Eduardo Caldas Costa, Joceline Cássia Ferezini de Sá, Nigel Keith Stepto, Ingrid Bezerra Barbosa Costa, Luiz Fernando Farias-Junior, Simone da Nóbrega Tomaz Moreira, Elvira Maria Mafaldo Soares, Telma Maria Araújo Moura Lemos, Rodrigo Alberto Vieira Browne, George Dantas Azevedo
PURPOSE: To investigate the effects of a supervised aerobic exercise training intervention on health-related quality of life (HRQL), cardiorespiratory fitness, cardiometabolic profile, and affective response in overweight/obese women with polycystic ovary syndrome (PCOS). METHODS: Twenty-seven overweight/obese inactive women with PCOS (body mass index, BMI ≥ 25 kg/m; aged from 18 to 34 years) were allocated into an exercise group (n = 14) and a control group (n = 13)...
February 13, 2018: Medicine and Science in Sports and Exercise
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