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https://www.readbyqxmd.com/read/28430646/immunotherapeutic-target-expression-on-breast-tumors-can-be-amplified-by-hormone-receptor-antagonism-a-novel-strategy-for-enhancing-efficacy-of-targeted-immunotherapy
#1
Ritika Jaini, Matthew G Loya, Charis Eng
Immunotherapy has historically been successful in highly antigenic tumors but has shown limited therapeutic efficacy in non-antigenic tumors such as breast cancers. Our previous studies in autoimmunity have demonstrated that increased antigen load within a tissue enhances immune reactivity against it. We therefore hypothesized that enhancing expression of target proteins on breast tumors can increase efficacy of targeted immunotherapy. We hypothesized that antagonism of the estrogen receptor (ER) can increase expression of targets that are hormonally regulated and facilitate enhanced tumor recognition by targeted immunotherapy...
March 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429443/a-paradigm-shift-in-the-origin-of-ovarian-cancer-the-ovary-is-no-longer-to-blame
#2
Ashleigh Meyn, Boon Lim
No abstract text is available yet for this article.
May 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28429172/a-new-species-of-haematoloechus-looss-1899-digenea-plagiorchioidea-haematoloechidae-a-parasite-of-rana-psilonota-webb-and-r-zweifeli-hillis-frost-webb-anura-ranidae-in-mexico
#3
Virginia León-Règagnon, Ángeles R Romero-Mayén
During an inventory of the helminths of amphibians in Mexico, specimens of an undescribed species of Haematoloechus Looss, 1899 (Digenea: Haematoloechidae) were collected from the lungs of frogs of the "tarahumarae" group in western México. Haematoloechus longicollum n. sp. differs from other known species of Haematoloechus by the combination of the following characters: body elongate and slender in the preovarian region and broad and blunt in the postovarian region, ovary separated from the ventral sucker more than twice the ovary length, oral sucker to pharynx length ratio 1:0...
April 20, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28428942/follicular-fluid-cerebellin-and-betatrophin-regulate-the-metabolic-functions-of-growing-follicles-in-polycystic-ovary-syndrome
#4
Aynur Adeviye Ersahin, Mustafa Acet, Suat Suphan Ersahin, Tuba Acet, Meltem Yardim, Omer Kenanoglu, Suleyman Aydin
OBJECTIVE: The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol. METHODS: Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28428938/effects-of-supplementation-with-antifreeze-proteins-on-the-follicular-integrity-of-vitrified-warmed-mouse-ovaries-comparison-of-two-types-of-antifreeze-proteins-alone-and-in-combination
#5
Min Kyung Kim, Hyun Sun Kong, Hye Won Youm, Byung Chul Jee
OBJECTIVE: The aim of this study was to analyze the effect of supplementing vitrification and warming solutions with two types of antifreeze proteins (AFPs) and the combination thereof on the follicular integrity of vitrified-warmed mouse ovaries. METHODS: Ovaries (n=154) were obtained from 5-week-old BDF1 female mice (n=77) and vitrified using ethylene glycol and dimethyl sulfoxide with the supplementation of 10 mg/mL of Flavobacterium frigoris ice-binding protein (FfIBP), 10 mg/mL of type III AFP, or the combination thereof...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28428692/the-appraisement-of-antioxidant-and-oxidant-status-in-women-undergoing-surgical-menopause
#6
Avneet Kaur, Pooja Negi, Veena Sarna, Rajendra Prasad, Bir S Chavan, Anita Malhotra, Gurjit Kaur
The present study was undertaken to study the impact of surgical menopause on oxidant and antioxidant status in relation to estrogen levels after 3 months of surgery. Total 130 women who had undergone total hysterectomy (TH) with or without bilateral salpingo-oophorectomy (BSO) were included in this study. The oxidant status was assessed by measuring plasma levels of malondialdehyde and antioxidant status was assessed by measuring superoxide dismutase, catalase, glutathione, glutathione peroxidase, estrogen, and Vitamin A, E and C levels...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428125/ovarian-metastasis-of-a-malignant-melanoma-a-case-report
#7
A Mendel, J J Terzibachian, F Aubin, L Malicenco, R Ramanah, D Riethmuller
Malignant melanoma represents 3% of cancers at the woman. The metastatic gynecological localization are rare and ovary is an exceptional site. Prognosis of metastatic ovary malignant melanoma is pejorative (5% 5 years survival). We report a case observed in a 65-year-old patient, who developed 2 melanomas of the left leg and presented a right ovarian tumor during a supervision tomodensitometric 7 years after diagnostic initial. The immunohistochemical assays after annexectomy confirmed the diagnostic of ovarian metastasis...
April 17, 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28428058/the-pseudomonas-aeruginosa-lectin-leca-triggers-host-cell-signalling-by-glycosphingolipid-dependent-phosphorylation-of-the-adaptor-protein-crkii
#8
Shuangshuang Zheng, Thorsten Eierhoff, Sahaja Aigal, Annette Brandel, Roland Thuenauer, Sophie de Bentzmann, Anne Imberty, Winfried Römer
The human pathogen Pseudomonas aeruginosa induces phosphorylation of the adaptor protein CrkII by activating the non-receptor tyrosine kinase Abl to promote its uptake into host cells. So far, specific factors of P. aeruginosa, which induce Abl/CrkII signalling, are entirely unknown. In this research, we employed human lung epithelial cells H1299, Chinese hamster ovary cells and P. aeruginosa wild type strain PAO1 to study the invasion process of P. aeruginosa into host cells by using microbiological, biochemical and cell biological approaches such as Western Blot, immunofluorescence microscopy and flow cytometry...
April 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28427900/molecular-cloning-and-characterization-of-kiss1-in-brandt-s-voles-lasiopodomys-brandtii
#9
Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
Kisspeptin, encoded by kiss1, has been regarded as a major modulator of mammalian puberty and fertility due to its stimulation on GnRH. Brandt's vole is one of the main pest species on the Inner Mongolian steppes for its striking reproductive capacity and kiss1 is a key candidate gene related to reproductive regulatory cascades. In this study, kiss1 cDNA was cloned from the hypothalamus of Brandt's voles and kiss1 mRNA levels were investigated in different tissues, and at different developmental stages, using high-throughput real-time PCR...
April 18, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28427326/no-evidence-for-strong-cytonuclear-conflict-over-sex-allocation-in-a-simultaneously-hermaphroditic-flatworm
#10
Nikolas Vellnow, Dita B Vizoso, Gudrun Viktorin, Lukas Schärer
BACKGROUND: Cytoplasmic sex allocation distorters, which arise from cytonuclear conflict over the optimal investment into male versus female reproductive function, are some of the best-researched examples for genomic conflict. Among hermaphrodites, many such distorters have been found in plants, while, to our knowledge, none have been clearly documented in animals. METHODS: Here we provide a quantitative test for cytonuclear conflict over sex allocation in the simultaneously hermaphroditic flatworm Macrostomum lignano...
April 20, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28426879/acute-exposure-to-dehp-metabolite-mehp-cause-genotoxicity-mutagenesis-and-carcinogenicity-in-mammalian-chinese-hamster-ovary-cells
#11
Yu-Jung Chang, Chia-Yi Tseng, Pei-Ying Lin, Yu-Chen Chuang, Ming-Wei Chao
Di-(2-ethylhexyl) phthalate (DEHP), the common plasticizer used in the production of polyvinyl chloride, can be converted to the more potent metabolite mono-ethylhexyl phthalate (MEHP). Epidemiological studies have shown an association with elevated induction of rat hepatic cancer and reproductive toxicity in response to MEHP exposure. However, the mechanism of genotoxicity and carcinogenicity induced by MEHP treatment remains unclear. As a means to elucidate the mechanisms of action, lethality and mutagenicity in the adenine phosphoribosyltransferase (aprt+/-) gene induced in several CHO cell types by MEHP were assessed...
March 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28426816/ex-vivo-cultures-combined-with-vivo-morpholino-induced-gene-knockdown-provide-a-system-to-assess-the-role-of-wt1-and-gata4-during-gonad-differentiation
#12
Lucas J Rudigier, Christof Dame, Holger Scholz, Karin M Kirschner
Gonad morphogenesis relies on the correct spatiotemporal expression of a number of genes that together fulfill the differentiation of the bipotential gonad into testes or ovaries. As such, the transcription factors WT1 and GATA4 are pivotal for proper gonadal development. Here we address the contributions of GATA4 and WT1 to the sex differentiation phase in testes and ovaries. We applied an ex vivo technique for cultivating gonads in hanging droplets of media that were supplemented with vivo-morpholinos to knockdown WT1 and GATA4 either alone or in combination at the same developmental stage...
2017: PloS One
https://www.readbyqxmd.com/read/28426427/three-new-species-of-pharygodonidae-nematoda-oxyuridea-in-laudakia-tuberculata-squamata-agamidae-from-dehradun-uttarakhand-india
#13
Anjum N Rizvi, Pallab Maity, Charles R Bursey
Parapharyngodon tuberculata sp. nov., Thelandros tuberculata sp. nov. and Thelandros dehradunensis sp. nov. (Nematoda: Pharyngodonidae) from the large intestine of a rock lizard, Laudakia tuberculata Gray, 1827), are described and illustrated. Parapharyngodon tuberculata sp. nov. is the 8th Oriental species and 59th species assigned to the genus Parapharyngodon and differs from other species of the genus by possessing 3 pairs of caudal papillae, an echinate cloacal lip, 112-115 µm spicule length and postbulbar ovary...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426426/pseudopecoelus-mccauleyi-n-sp-and-podocotyle-sp-digenea-opecoelidae-from-the-deep-waters-off-oregon-and-british-columbia-with-an-updated-key-to-the-species-of-pseudopecoelus-von-wicklen-1946-and-checklist-of-parasites-from-lycodes-cortezianus-perciformes-zoarcidae
#14
REVIEW
Charles K Blend, Norman O Dronen, Gabor R Racz, Scott L Gardner
Pseudopecoelus mccauleyi n. sp. (Opecoelidae: Opecoelinae) is described from the intestine of the bigfin eelpout, Lycodes cortezianus (Gilbert, 1890) (Perciformes: Zoarcidae), collected at 200-800 m depths in the Northeastern Pacific Ocean off Oregon and Vancouver Island, British Columbia. The new species is distinguished by possessing a unique combination of the following diagnostic characters: vitelline fields that extend to the posterior margin of the ventral sucker; a slender, tubular and sinuous seminal vesicle that extends some distance into the hindbody; an unspecialized, protuberant ventral sucker; a genital pore at pharynx level; lobed to deeply multilobed testes; a lobed ovary; and an egg size of 68-80 μm × 30-46 μm...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426420/disruption-of-egg-production-by-triclabendazole-resistant-fasciola-hepatica-following-treatment-with-a-commercial-preparation-of-myrrh-mirazid
#15
Mohamed M O Abdelaal, Gerard P Brennan, Robert E B Hanna, Ahmed Abdel-Aziz, Ian Fairweather
An in vitro study has been carried out to monitor changes to the female reproductive system in adult triclabendazole (TCBZ)-resistant Fasciola hepatica following treatment with a commercial preparation of myrrh ("Mirazid"). Flukes were immersed for 6 h and 24 h in myrrh extract at a concentration of 200 µg/ml, then processed for histological and transmission electron microscope (TEM) examination of the uterus, Mehlis' gland, ovary and vitellaria. Egg production had become abnormal at 6 h post-treatment (pt), with the uterine lumen being filled with free vitelline cells and masses of shell protein material; few eggs were present...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28425428/innate-immune-response-of-channel-catfish-ictalurus-punctatus-mannose-binding-lectin-to-channel-catfish-virus-ccv
#16
Donald D Ourth, Emily Marecaux, Deepthi Raghu, Brian C Peterson
The channel catfish virus (CCV) is a pathogenic herpesvirus that infects channel catfish Ictalurus punctatus in pond aquaculture in the southeastern USA. Mannose-binding lectin (MBL), an innate immune protein, could play an important role in the innate response of channel catfish by binding to CCV. Cell cultures of CCV were grown in channel catfish ovary cells (CCOC). A dot-immunoblot enzyme-linked immunosorbent assay was done to determine the binding ability of 5 mo old channel catfish serum MBL (26.2 µg ml-1) to CCOC infected with CCV...
April 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28424461/a-lack-of-coordination-between-sister-chromatids-segregation-and-cytokinesis-in-the-oocytes-of-b6-y-tir-xy-sex-reversed-female-mice
#17
Jia-Qiao Zhu, Seang Lin Tan, Teruko Taketo
The B6.Y(TIR) (XY) mouse develops bilateral ovaries despite the expression of the testis-determining gene Sry during gonadal differentiation. We reported that the oocytes of the XY female are defective in their cytoplasm, resulting in a failure in the second meiotic division after activation or fertilization in vitro. However, the mechanism of meiotic failure or the cause of infertility remained to be clarified. In the present study, we obtained mature oocytes from XY females by superovulation and confirmed that these oocytes also fail in zygotic development...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424321/the-drosophila-zo-1-protein-polychaetoid-suppresses-deltex-regulated-notch-activity-to-modulate-germline-stem-cell-niche-formation
#18
Hideyuki Shimizu, Marian B Wilkin, Simon A Woodcock, Alessandro Bonfini, Yvonne Hung, Sabine Mazaleyrat, Martin Baron
The developmental signalling protein Notch can be proteolytically activated following ligand-interaction at the cell surface, or can be activated independently of its ligands, following Deltex (Dx)-induced Notch endocytosis and trafficking to the lysosomal membrane. The means by which different pools of Notch are directed towards these alternative outcomes remains poorly understood. We found that the Drosophila ZO-1 protein Polychaetoid (Pyd) suppresses specifically the Dx-induced form of Notch activation both in vivo and in cell culture assays...
April 2017: Open Biology
https://www.readbyqxmd.com/read/28423988/tumor-collision-of-uterine-adenocarcinoma-and-leiomyosarcoma-in-a-goat
#19
Jenna C Dockweiler, Brieuc Cossic, Sean P McDonough, Susan L Fubini, Kayla M Le, Callum G Donnelly, Robert O Gilbert, Soon Hon Cheong
An aged mixed-breed goat doe was presented with a 9-mo history of serosanguineous vaginal discharge. Vaginal speculum examination revealed serosanguineous discharge but otherwise no abnormalities. Transrectal ultrasonography showed normal ovaries and multifocal cystic lesions within the uterus. Ovariohysterectomy was recommended because of a strong suspicion of neoplasia. Multiple, non-resectable masses were noted in and around the uterus intraoperatively, and euthanasia was elected. Autopsy revealed multiple masses within the uterus, cervix, and lung parenchyma...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28423889/polymorphism-of-bola-drb3-gene-and-its-association-with-embryo-development-after-in-vitro-fertilization-in-slovak-spotted-x-holstein-fresian-crossbred-cattle
#20
Dominika Kułaj, Joanna Pokorska, Alexander Makarevič, Lucia Olexikova, Joanna Makulska, Peter Chrenek
Objective: The aim of the present research was to verify hypothesis about the association between polymorphism of Bola-DRB3 gene and embryo cleavage after in vitro fertilization in Slovak Spotted x Holstein-Fresian crossbred cattle. Methods: Bovine oocytes recovered from bovine ovaries at slaughtering were matured in E199 medium with 10% FCS and 1IU FSH and LH and fertilized in vitro with sperm of Holstein-Fresian bull during 20h. Presumptive zygotes were cultured in ISM1 culture medium for three days, afterwards the embryos were evaluated and selected into two groups: 1) cleavage (2-, 4-, 6- or 8- cell stage) and 2) undeveloped embryos (no cell cleavage)...
March 25, 2017: Asian-Australasian Journal of Animal Sciences
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