Zhao Zhang, Zixiang Wei, Jintong Guo, Jinxiao Lyu, Bingzhe Wang, Gang Wang, Chunfei Wang, Liqiang Zhou, Zhen Yuan, Guichuan Xing, Changfeng Wu, Xuanjun Zhang
Practical photodynamic therapy calls for high-performance, less O2 -dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based photosensitizers exhibit excellent photocatalytic performance, but the in vivo applications are hindered by conventional O2 -dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region...
January 2, 2024: Nature Communications