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https://www.readbyqxmd.com/read/30121967/disulfiram-a-re-positioned-aldehyde-dehydrogenase-inhibitor-enhances-radiosensitivity-of-human-glioblastoma-cells-in-vitro
#1
Hyeon Kang Koh, Soo Yeon Seo, Jin Ho Kim, Hak Jae Kim, Eui Kyu Chie, Seung-Ki Kim, Il Han Kim
Purpose: Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on in vitro radiosensitivity of glioblastoma cells with different methylation status of O6-methylguanine-DNA methyltransferase (MGMT) promoter and the underlying mechanism of such effect. Materials and Methods: Five human glioblastoma cells (U138MG, T98G, U251MG, U87MG, and U373MG) and one normal human astrocyte (NHA) cell were cultured and treated with DSF or 6MV x-rays (0, 2, 4, 6, 8 Gy)...
August 13, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/30121802/therapeutic-efficacy-of-rituximab-for-the-management-of-adult-onset-steroid-dependent-nephrotic-syndrome-a-retrospective-study
#2
Takayuki Katsuno, Tomohiro Masuda, Shoji Saito, Noritoshi Kato, Takuji Ishimoto, Sawako Kato, Tomoki Kosugi, Naotake Tsuboi, Hiroshi Kitamura, Toyonori Tsuzuki, Yasuhiko Ito, Shoichi Maruyama
BACKGROUND: Recent reports have described the efficacy of rituximab in treating steroid-dependent nephrotic syndrome (SDNS) in pediatric patients. However, few reports describe data regarding adult-onset SDNS. We investigated the efficacy of rituximab for the management of adult-onset SDNS. METHODS: We performed a retrospective cohort study investigating eight patients with adult-onset SDNS who were treated with rituximab. Clinical data were obtained at the initiation of rituximab therapy...
August 18, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/30121687/knowledge-of-obesity-related-pregnancy-risks-among-expectant-mothers-and-its-associated-factors
#3
M Leelavathi, R S Danasamy
BACKGROUND: Obesity in pregnancy causes both maternal and foetal complications hence adequate knowledge of obesity related pregnancy risks would ensure better outcomes. This study aims to determine the knowledge of obesity related pregnancy risks among pregnant women. METHODS: A cross-sectional study was conducted among pregnant women from four antenatal clinics in Seremban, between February and May 2015. Knowledge on pregnancy risks was assessed using questionnaire...
August 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/30121618/clinical-and-cost-effectiveness-of-one-session-treatment-ost-versus-multisession-cognitive-behavioural-therapy-cbt-for-specific-phobias-in-children-protocol-for-a-non-inferiority-randomised-controlled-trial
#4
Barry D Wright, Cindy Cooper, Alexander J Scott, Lucy Tindall, Shehzad Ali, Penny Bee, Katie Biggs, Trilby Breckman, Thompson E Davis Iii, Lina Gega, Rebecca Julie Hargate, Ellen Lee, Karina Lovell, David Marshall, Dean McMillan, M Dawn Teare, Jonathan Wilson
INTRODUCTION: Specific phobias (intense, enduring fears of an object or situation that lead to avoidance and severe distress) are highly prevalent among children and young people. Cognitive-behavioural therapy (CBT) is a well-established, effective intervention, but it can be time consuming and costly because it is routinely delivered over multiple sessions during several months. Alternative methods of treating severe and debilitating phobias in children are needed, like one-session treatment (OST), to reduce time and cost, and to prevent therapeutic drift and help children recover quickly...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30121611/enhancing-peer-support-experience-for-patients-discharged-from-acute-psychiatric-care-protocol-for-a-randomised-controlled-pilot-trial
#5
Liana Urichuk, Marianne Hrabok, Katherine Hay, Pamela Spurvey, Daniella Sosdjan, Michelle Knox, Allen Fu, Shireen Surood, Robert Brown, Jeff Coulombe, Jill Kelland, Katherine Rittenbach, Mark Snaterse, Adam Abba-Aji, Xin-Min Li, Pierre Chue, Andrew J Greenshaw, Vincent I O Agyapong
INTRODUCTION: This study will evaluate the effectiveness of an innovative peer support programme. The programme incorporates leadership training, mentorship, recognition and reward systems for peer support workers, and supportive/reminder text messaging for patients discharged from acute (hospital) care. We hypothesise that patients enrolled in the peer support system plus daily supportive/reminder text messages condition will achieve superior outcomes in comparison to other groups. METHODS AND ANALYSIS: This is a prospective, rater-blinded, four-arm randomised controlled trial...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30121609/process-evaluation-of-a-randomised-controlled-trial-of-a-pharmacological-strategy-to-improve-hypertension-control-protocol-for-a-qualitative-study
#6
Abdul Salam, Ruth Webster, Anushka Patel, Pavithra Godamunne, Arunasalam Pathmeswaran, H Asita de Silva, Anthony Rogers, Stephen Jan, Tracey-Lea Laba
INTRODUCTION: Globally, the prevalence of uncontrolled hypertension is high, particularly in low- and middle-income countries. There is a critical need for strategies to improve hypertension control. The early use of a fixed low-dose combination of three antihypertensive drugs (triple pill) has the potential to significantly improve hypertension control. The TRI ple Pill vs. U sual care M anagement for P atients with mild-to- moderate H ypertension (TRIUMPH) randomised controlled trial (RCT) is designed to test the effects of this strategy compared with usual care in patients with mild-to-moderate hypertension...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30121589/providing-routine-chronic-disease-preventive-care-in-community-substance-use-services-a-pilot-study-of-a-multistrategic-clinical-practice-change-intervention
#7
Danika Tremain, Megan Freund, Paula Wye, Jenny Bowman, Luke Wolfenden, Adrian Dunlop, Kate Bartlem, Christophe Lecathelinais, John Wiggers
OBJECTIVES: To evaluate the potential effectiveness of a practice change intervention in increasing preventive care provision in community-based substance use treatment services. In addition, client and clinician acceptability of care were examined. DESIGN: A pre-post trial conducted from May 2012 to May 2014. SETTING: Public community-based substance use treatment services (n=15) in one health district in New South Wales (NSW), Australia...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30121514/low-flow-time-is-associated-with-a-favorable-neurological-outcome-in-out-of-hospital-cardiac-arrest-patients-resuscitated-with-extracorporeal-cardiopulmonary-resuscitation
#8
Takayuki Otani, Hirotaka Sawano, Tomoaki Natsukawa, Tetsufumi Nakashima, Hiroshi Oku, Chison Gon, Motonori Takahagi, Yasuyuki Hayashi
PROPOSE: The aim of this retrospective study was to investigate the prognostic factors in extracorporeal cardiopulmonary resuscitation (ECPR) patients and to assess their accuracy as predictors of a favorable neurological outcome. MATERIALS AND METHODS: Between October 2009 and December 2017, we retrospectively analyzed witnessed out-of-hospital cardiac arrest patients who were admitted to our hospital and resuscitated with ECPR. We compared the baseline characteristics, pre-hospital clinical course, arrest causes, and blood samples on admission for the favorable and unfavorable outcome groups...
August 11, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30121406/clinical-outcome-after-mechanical-thrombectomy-in-diabetic-patients-with-major-ischemic-stroke-of-the-anterior-cerebral-circulation
#9
Jan Borggrefe, Berit Glück, Volker Maus, Oezgur Onur, Nuran Abdullayev, Utako Barnikol, Christoph Kabbasch, Gereon Rudolf Fink, Anastasios Mpotsaris
BACKGROUND: Among patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT), diabetic patients (DP) show a poorer outcome compared to non-diabetic patients (NDP). This study aims to provide a comprehensive analysis of factors associated with unfavorable outcome in DP receiving MT for stroke of the anterior circulation. METHODS: This study includes 317 out of 498 consecutive patients who received interventional treatment for AIS in the terminal internal carotid artery and/or middle cerebral artery, including 46 DP...
August 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30121369/somatic-hnf1a-mutations-in-the-malignant-transformation-of-hepatocellular-adenomas-a-retrospective-analysis-of-data-from-msk-impact-and-tcga
#10
Jaclyn F Hechtman, Ghassan K Abou Alfa, Zsofia K Stadler, Diana L Mandelker, Michael H A Roehrl, Ahmet Zehir, Efsevia Vakiani, Sumit Middha, David S Klimstra, Jinru Shia
Mutations of Hepatocyte-Nuclear-Factor-1-Homeobox-A gene and loss of Liver-Fatty-Acid-Binding-Protein are well documented in hepatocellular adenoma. However, the role of Hepatocyte-Nuclear-Factor-1-Homeobox-A mutations in hepatocellular carcinoma remains to be determined. In this study, all hepatocellular neoplasms evaluated by our institutional Memorial Sloan Kettering-Integrated Mutational Profiling of Actionable Clinical Targets assay or the Cancer Genome Atlas sequencing, and cases reported in the literature, were queried for Hepatocyte-Nuclear-Factor-1-Homeobox-A mutations...
August 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/30121324/observed-patterns-of-cervical-radiculopathy-how-often-do-they-differ-from-a-standard-netter-diagram-distribution
#11
Steven J McAnany, John M Rhee, Evan O Baird, Weilong Shi, Jeffrey Konopka, Thomas M Neustein, Rafael Arceo
BACKGROUND: Traditionally, cervical radiculopathy is thought to present with symptoms and signs in a standard, textbook, reproducible pattern as seen in a "Netter diagram." To date, no study has directly examined cervical radicular patterns attributable to single level pathology in patients undergoing ACDF. PURPOSE: The purpose of this study is to examine cervical radiculopathy patterns in a surgical population and determine how often patients present with the standard textbook (i...
August 16, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/30121183/social-vs-non-social-measures-of-learning-potential-for-predicting-community-functioning-across-phase-of-illness-in-schizophrenia
#12
Peter E Clayson, Robert S Kern, Keith H Nuechterlein, Barbara J Knowlton, Carrie E Bearden, Tyrone D Cannon, Alan P Fiske, Livon Ghermezi, Jacqueline N Hayata, Gerhard S Hellemann, William P Horan, Kimmy Kee, Junghee Lee, Kenneth L Subotnik, Catherine A Sugar, Joseph Ventura, Cindy M Yee, Michael F Green
Studies demonstrate that dynamic assessment (i.e., learning potential) improves the prediction of response to rehabilitation over static measures in individuals with schizophrenia. Learning potential is most commonly assessed using neuropsychological tests under a test-train-test paradigm to examine change in performance. Novel learning potential approaches using social cognitive tasks may have added value, particularly for the prediction of social functioning, but this area is unexplored. The present study is the first to investigate whether patients with schizophrenia demonstrate social cognitive learning potential across phase of illness...
August 15, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/30121163/evaluation-of-a-patient-care-planning-intervention-to-improve-appointment-attendance-by-adults-after-bariatric-surgery
#13
Vincent A Santiago, Katie Warwick, Shanthini Ratnakumarasuriyar, Ajibike Oyewumi, Sandra Robinson, Sanjeev Sockalingam
OBJECTIVES: Bariatric surgery is recognized as a durable treatment for severe obesity; however, high rates of nonattendance and patient engagement during the postoperative period remain challenges. This pre/post study evaluates a quality-improvement initiative to improve attendance at bariatric surgery program appointments and to heighten program efficiency, as measured by appointment attendance, cancellations and new assessments. METHODS: Patients and staff were consulted in order to identify causes for patient attrition after surgery...
May 8, 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/30121146/regulatory-t-cell-abundance-and-activation-status-before-and-after-priming-with-hivis-dna-and-boosting-with-mva-hiv-rgp140-gla-af-may-impact-the-magnitude-of-the-vaccine-induced-immune-responses
#14
Raquel Matavele Chissumba, Abílio Luciano, Eduardo Namalango, Asli Bauer, Nilesh Bhatt, Britta Wahren, Charlotta Nilsson, Christof Geldmacher, Gabriella Scarlatti, Ilesh Jani, Luc Kestens
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+ CD45RA+ - rTregs), activated (FoxP3High CD45RA- - aTregs) and memory (FoxP3Low CD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studied how the abundance and phenotypes of Tregs in terms of activation status and expression of HIV-1 binding molecules would have changed during vaccination in healthy volunteers participating in a phase IIa HIV vaccine clinical trial...
August 12, 2018: Immunobiology
https://www.readbyqxmd.com/read/30121072/pleth-variability-index-or-stroke-volume-optimization-during-open-abdominal-surgery-a-randomized-controlled-trial
#15
Hans Bahlmann, Robert G Hahn, Lena Nilsson
BACKGROUND: The impact of Goal Directed Fluid Therapy (GDFT) based on the non-invasive Pleth Variability Index (PVI) on clinical outcome after abdominal surgery has only sparingly been explored. The purpose of this study was to compare the effect of intraoperative GDFT guided by PVI to a control group using esophageal Doppler on the incidence of complications and length of hospital stay after major abdominal surgery. We hypothesized that there would be no difference between the groups...
August 18, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30120831/functional-performance-tests-identify-lateral-ankle-sprain-risk-a-prospective-pilot-study-in-adolescent-soccer-players
#16
Jupil Ko, Adam Rosen, Cathleen N Brown
Determining the clinical utility of functional performance tests (FPTs) and establishing cutoff scores could be useful in identifying those athletes who could benefit from effective injury prevention interventions. Our purpose was to determine the accuracy of FPTs in identifying adolescent athletes who go on to experience lateral ankle sprain(s) and establish specific cutoff scores capable of identifying those who sustain a lateral ankle sprain in the near future. Sixty-four participants (age = 15.5 ± 1.3yrs; height = 161...
August 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/30120800/blastema-formation-and-periosteal-ossification-in-the-regenerating-adult-mouse-digit
#17
Lindsay A Dawson, Paula P Schanes, Patrick Kim, Felisha M Imholt, Osama Qureshi, Connor P Dolan, Ling Yu, Mingquan Yan, Katherine N Zimmel, Alyssa R Falck, Ken Muneoka
While mammals cannot regenerate amputated limbs, mice and humans have regenerative ability restricted to amputations transecting the digit tip, including the terminal phalanx (P3). In mice the regeneration process is epimorphic and mediated by the formation of a blastema comprised of undifferentiated proliferating cells that differentiate to regenerate the amputated structures. Blastema formation distinguishes the regenerative response from a scar-forming healing response. The mouse digit tip serves as a pre-clinical model to investigate mammalian blastema formation and endogenous regenerative capabilities...
August 18, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30120678/docetaxel-rechallenge-in-castration-resistant-prostate-cancer-defining-clinical-factors-for-successful-treatment-response-and-improvement-in-overall-survival
#18
Christian Thomas, Maximilian P Brandt, Stephanie Baldauf, Igor Tsaur, Sebastian Frees, Hendrik Borgmann, Wolfgang Jäger, Georg Bartsch, Meike Schneider, Robert Dotzauer, Andreas Neisius, Axel Haferkamp
PURPOSE: The purpose of the study was to define clinical factors for successful treatment response and re-exposure to docetaxel in metastatic castration-resistant prostate cancer (mCRPC). METHODS: An mCRPC database of patients receiving first-line docetaxel and rechallenge courses was established. Several clinical factors were evaluated for prediction of treatment response. Multivariate cox-regression analysis was used to define pre-treatment and treatment factors for survival...
August 17, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30120584/an-eras-protocol-for-bariatric-surgery-is-it-safe-to-discharge-on-post-operative-day-1
#19
Jenny Lam, Toshiaki Suzuki, David Bernstein, Beiqun Zhao, Carlos Maeda, Thach Pham, Bryan J Sandler, Garth R Jacobsen, Joslin N Cheverie, Santiago Horgan
BACKGROUND: Laparoscopic sleeve gastrectomy is the most commonly performed bariatric surgery in the world. Enhanced recovery after surgery (ERAS) protocols have been shown to reduce complications and decrease length of stay for various types of surgeries. In this study, we propose an ERAS protocol for laparoscopic sleeve gastrectomy and compare the clinical outcomes with patients who received standard care. METHODS: We performed a single-institution retrospective analysis in patients who underwent laparoscopic sleeve gastrectomy from February 2015 to December 2017...
August 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30120546/is-myotomy-plus-diverticulopexy-suitable-for-symptomatic-zenker-s-diverticula
#20
Jacopo Vannucci, Alberto Matricardi, Elisa Scarnecchia, Rosanna Capozzi, Valeria Liparulo, Stefano Santoprete, Lucio Cagini, Francesco Puma
The aim of the study was to prospectively evaluate the outcome of myotomy plus diverticulopexy over short and long-terms. A prospectively collected consecutive series (2007-2017) of 37 patients undergoing myotomy plus diverticulopexy was analyzed for clinical condition, operative information, peri-operative events, and follow-up by means of interview and physical examination. Diverticulopexy was scheduled regardless of the diverticulum's features and patient condition, other than operability. There was no choice or selection between possible treatment options...
August 17, 2018: Dysphagia
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