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Tio2 photothermal

Liangcan He, Chenchen Mao, Michael Brasino, Albert Harguindey, Wounjhang Park, Andrew P Goodwin, Jennifer N Cha
Near infrared (NIR)-absorbing noble metal nanostructures are being extensively studied as theranostic agents, in particular for photoacoustic imaging and photothermal therapy. Because of the electric field enhancement at the tips of anisotropic metal nanostructures, positioning photoactive species at these sites can lead to increased energy absorption. Herein, we show the site-specific placement of NIR-active photosensitizers at the ends of gold nanorods (AuNRs) by growing porous TiO2 caps. The surface plasmon resonance of the AuNRs was carefully tuned to overlap with the exciton absorption of indocyanine green (ICG), a NIR photosensitizer with low quantum yields and poor photostability...
August 8, 2018: ACS Applied Materials & Interfaces
Leyan Lei, Tiantian Kong, Pingan Zhu, Zhanxiao Kang, Xiaowei Tian, Liqiu Wang
We demonstrate hierarchical nest/crust-like colloidosomes composed of interlocked titanium dioxide (TiO2 ) nanofibers using spontaneously evolved n-butanol/water/ n-butanol (B/W/B) emulsions. We find two mechanisms to produce colloidosomes from B/W/B droplets due to their mutual solubility and dewetting discrepancy. Porous TiO2 colloidal capsules with loosely intertwined nanofibers were obtained after the dewetting of nanofiber-coated B/W/B droplets, while crustlike TiO2 colloidosomes with a thin shell and large hollow interior are developed from amphiphilic polymer-stabilized B/W/B droplets...
July 31, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Siqi Wang, Wenzhi Ren, Jianhua Wang, Zhenqi Jiang, Madiha Saeed, Lili Zhang, Aiguo Li, Aiguo Wu
At present, transmembrane glycoprotein CD133 highly expressed pancreatic cancer stem cells (PCSCs), with the features of chemotherapeutic/radiotherapeutic resistance and exclusive tumorigenic potential, are considered as the primary cause of metastasis and recurrence in pancreatic cancer, and therefore are an effective target in the disease treatment. Furthermore, with the launch of precision medicine, multifunctional nanoprobes have been applied as an efficient strategy for the magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) of pancreatic cancer...
July 24, 2018: Biomaterials Science
Xiaoxia Han, Ju Huang, Xiangxiang Jing, Dayan Yang, Han Lin, Zhigang Wang, Pan Li, Yu Chen
The conventional inorganic semiconductors are not suitable for in vivo therapeutic nanomedicine because of the lack of an adequate and safe irradiation source to activate them. This work reports on the rational design of titania (TiO2 )-based semiconductors for enhanced and synergistic sono-/photoinduced tumor eradication by creating an oxygen-deficient TiO2- x layer onto the surface of TiO2 nanocrystals, which can create a crystalline-disordered core/shell structure (TiO2 @TiO2- x ) with black color. As found in the lessons from traditional photocatalysis, such an oxygen-deficient TiO2- x layer with abundant oxygen defects facilitates and enhances the separation of electrons (e- ) and holes (h+ ) from the energy-band structure upon external ultrasound irradiation, which can significantly improve the efficacy of sono-triggered sonocatalytic tumor therapy...
May 22, 2018: ACS Nano
Hong-Ye Wan, Jian-Li Chen, Xingzhong Zhu, Liang Liu, Jianfang Wang, Xiao-Ming Zhu
Targeting protein degradation is recognized as a valid approach to cancer therapy. The ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway are two major pathways for intracellular protein degradation. Proteasome inhibitors such as bortezomib are clinically approved for treating malignancies, but to date, they are still unsatisfactory for cancer therapy. This study identifies titania-coated gold nano-bipyramid (NBP/TiO2 ) nanostructures as an autophagic flux inhibitor, as the smallest NBP/TiO2 nanostructures induce significant autophagosome accumulation in human glioblastoma U-87 MG cells via blocking the autophagosome-lysosome fusion process and inhibiting lysosomal degradation...
March 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Yunqian Dai, Mingyun Zhu, Xiaotian Wang, Yanan Wu, Chengqian Huang, Wanlin Fu, Xiangyu Meng, Yueming Sun
In this work, the rationally-designed sharp corners on Au nanorods tremendously improved the catalytic activity, particularly in the presence of visible light irradiation, towards the hydrogenation of 4-nitrophenol to 4-aminophenol. A strikingly increased rate constant of 50.6 g-1 s-1 L was achieved in M-Au-3, which was 41.8 times higher than that of parent Au nanorods under dark conditions. The enhanced activities were proportional to the extent of the protruding sharp corners. Furthermore, remarkably enhanced activities were achieved in novel ternary Au/RGO/TiO2 sheets, which were endowed with a 52...
June 15, 2018: Nanotechnology
Zhenyi Zhang, Xiaoyi Jiang, Benkang Liu, Lijiao Guo, Na Lu, Li Wang, Jindou Huang, Kuichao Liu, Bin Dong
The ultrafast transfer of plasmon-induced hot electrons is considered an effective kinetics process to enhance the photoconversion efficiencies of semiconductors through strong localized surface plasmon resonance (LSPR) of plasmonic nanostructures. Although this classical sensitization approach is widely used in noble-metal-semiconductor systems, it remains unclear in nonmetallic plasmonic heterostructures. Here, by combining ultrafast transient absorption spectroscopy with theoretical simulations, IR-driven transfer of plasmon-induced hot electron in a nonmetallic branched heterostructure is demonstrated, which is fabricated through solvothermal growth of plasmonic W18 O49 nanowires (as branches) onto TiO2 electrospun nanofibers (as backbones)...
March 2018: Advanced Materials
Lei Sun, Zhenglin Li, Zhuo Li, Ying Hu, Chong Chen, Chenhui Yang, Baosheng Du, Ye Sun, Flemming Besenbacher, Miao Yu
Photothermal agents (PTAs) with high biocompatibility and therapeutic efficacy have become particularly fascinating, however, knowledge of their photothermal performance is rather limited. Herein, rationally designed core-shell TiO2 nanoparticles have been fabricated using a mild hydrogenation method, where NaBH4 was used as the H2 source. The resultant TiO2 possesses strong optical absorption in the NIR region and remarkable photothermal conversion capability and stability, leading to a high inhibition rate on cancer cells...
November 2, 2017: Nanoscale
Wenzhi Ren, M Zubair Iqbal, Leyong Zeng, Tianxiang Chen, Yuanwei Pan, Jinshun Zhao, Hao Yin, Lili Zhang, Jichao Zhang, Aiguo Li, Aiguo Wu
TiO2 nanomaterials have been widely used for anticancer drug carriers and UV/980 nm NIR triggered cancer synergistic platforms. However, traditional pure TiO2 nanocarriers encounter some serious drawbacks, such as low drug loading ability, limited tissue penetration of UV light, and heating effect of 980 nm NIR on normal tissue, which obstruct their further application in cancer treatment. To overcome those challenges, novel mesoporous silica (mSiO2 ) coated black TiO2 core-shell nanocomposites are designed and constructed as doxorubicin carriers for 808 nm NIR triggered thermal imaging guided photothermal therapy combined chemotherapy of breast cancer...
August 10, 2017: Nanoscale
Nuo Yu, Yong Hu, Xiaoyong Wang, Gang Liu, Zhaojie Wang, Zixiao Liu, Qiwei Tian, Meifang Zhu, Xiangyang Shi, Zhigang Chen
Conventional wide bandgap semiconductors can absorb UV/visible light but have no photoabsorption band in the near-infrared (NIR) region, leading to difficulty in their use as NIR-responsive agents. With TiO2 as an example, we report the tuning from UV-responsive TiO2 nanocrystals to blue TiO2 nanocrystals with newly appeared NIR absorption band through the Nb-doping strategy. A strong NIR band should result from the localized surface plasmon resonances due to the considerable free electrons originating from the efficient incorporation of Nb5+ ions (<15...
July 6, 2017: Nanoscale
Juan Mou, Tianquan Lin, Fuqiang Huang, Jianlin Shi, Hangrong Chen
A new kind of green titania ( G -TiO2- x ) with obvious green color was facilely synthesized from black titania ( B -TiO2- x ) through subsequently strong ultrasonication. Comparatively, this stable G -TiO2- x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2- x lattice order owing to the effect of ultrasonication. This feature enables G -TiO2- x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth...
2017: Theranostics
Yoonsun Jang, Sojin Kim, Seungae Lee, Chang-Min Yoon, Inkyu Lee, Jyongsik Jang
Graphene oxide (GO) enwrapped SiO2 /TiO2 hollow nanoparticles (GO-HNP) are synthesized by the Stöber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibility and high uniformity in diameter (ca. 50 nm). Furthermore, this nanoparticle shows λ=808 nm laser induced PpIX release properties (photoinduced "on-off" drug-release system). GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT)...
March 13, 2017: Chemistry: a European Journal
Yi Yang, Yuanzhi Li, Mingyang Mao, Min Zeng, Xiujian Zhao
Novel ramsdellite MnO2 hollow spheres consisting of closely stacked nanosheets (R-MnO2 -HS) were synthesized by a facile method. The R-MnO2 -HS sample was characterized with SEM, XRD, TEM, BET, XPS, diffusive reflectance UV-vis-IR absorption, etc. Remarkably, R-MnO2 -HS exhibits highly efficient catalytic activity for the purification of benzene (a carcinogenic air pollutant) under the full solar spectrum or visible-infrared irradiation, even under the infrared irradiation. Its catalytic activity (initial CO2 production rate) under the full solar spectrum irradiation is as high as 210...
January 25, 2017: ACS Applied Materials & Interfaces
Neha Arora, M Ibrahim Dar, Mojtaba Abdi-Jalebi, Fabrizio Giordano, Norman Pellet, Gwénolé Jacopin, Richard H Friend, Shaik Mohammed Zakeeruddin, Michael Grätzel
We report on both the intrinsic and the extrinsic stability of a formamidinium lead bromide [CH(NH2)2PbBr3 = FAPbBr3] perovskite solar cell that yields a high photovoltage. The fabrication of FAPbBr3 devices, displaying an outstanding photovoltage of 1.53 V and a power conversion efficiency of over 8%, was realized by modifying the mesoporous TiO2-FAPbBr3 interface using lithium treatment. Reasons for improved photovoltaic performance were revealed by a combination of techniques, including photothermal deflection absorption spectroscopy (PDS), transient-photovoltage and charge-extraction analysis, and time-integrated and time-resolved photoluminescence...
November 9, 2016: Nano Letters
Jeong Hoon Byeon
Ag-TiO2@polyethylene glycol (PEG) nanoparticles were continuously obtained in a single-pass configuration by appropriately reacting freshly flame-synthesized TiO2 with Ag formed in an ultrasonic aqueous medium containing PEG. When the proposed synthesis was kept constant, the production rate for Ag-TiO2@PEG nanoparticles reached approximately 3 g/h while only using a combination of a lab-scale inverse-diffusion flame (16 mm head diameter) and an ultrasonic Ag(I) cell (50 mL). The synthesized nanoparticles were employed as inducers for in vitro photoinduced therapy to kill cancer cells at different light wavelengths...
August 10, 2016: Scientific Reports
Mojtaba Abdi-Jalebi, M Ibrahim Dar, Aditya Sadhanala, Satyaprasad P Senanayak, Fabrizio Giordano, Shaik Mohammed Zakeeruddin, Michael Grätzel, Richard H Friend
We report on the optimization of the interfacial properties of titania in mesoscopic CH3NH3PbI3 solar cells. Modification of the mesoporous TiO2 film by TiCl4 treatment substantially reduced the surface traps, as is evident from the sharpness of the absorption edge with a significant reduction in Urbach energy (from 320 to 140 meV) determined from photothermal deflection spectroscopy, and led to an order of magnitude enhancement in the bulk electron mobility and corresponding decrease in the transport activation energy (from 170 to 90 meV) within a device...
August 18, 2016: Journal of Physical Chemistry Letters
Kil Ju Na, Gye-Choon Park
In present society, the technology in various field has been sharply developed and advanced. In medical technology, especially, photothermal therapy and photodynamic therapy have had limelight for curing cancers and diseases. The study investigates the photothermal therapy that reduces side effects of existing cancer treatment, is applied to only cancer cells, and dose not harm any other normal cells. The photothermal properties of porous silicon for therapy are analyzed in order to destroy cancer cells that are more weak at heat than normal ones...
February 2016: Journal of Nanoscience and Nanotechnology
Huijuan Zhang, Xiaojing Jiao, Qianqian Chen, Yandan Ji, Xiaoge Zhang, Xing Zhu, Zhenzhong Zhang
Phototherapy, which mainly includes photothermal treatment (PTT) and photodynamic treatment (PDT), is a photo-initiated, noninvasive and effective approach for cancer treatment. The high accumulation of photosensitizers (PSs) in a targeted tumor is still a major challenge for efficient light conversion, to generate reactive oxygen species (ROS) and local hyperthermia. In this study, a simple and efficient hyaluronic acid (HA)-modified nanoplatform (HA-TiO2@MWCNTs) with high tumor-targeting ability, excellent phototherapy efficiency, low light-associated side effects and good water solubility was developed...
February 26, 2016: Nanotechnology
Juan Mou, Tianquan Lin, Fuqiang Huang, Hangrong Chen, Jianlin Shi
Substantially different from traditional combinatorial-treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) by using multi-component nanocomposite under excitation of separate wavelength, a novel single near infrared (NIR) laser-induced multifunctional theranostic nanoplatform has been rationally and successfully constructed by a single component black titania (B-TiO2-x) for effective imaging-guided cancer therapy for the first time. This multifunctional PEGylated B-TiO2-x shows high dispersity/stability in aqueous solution, excellent hemo/histocompatibility and broad absorption ranging from NIR to ultraviolet (UV)...
April 2016: Biomaterials
Dorota Korte, Mladen Franko
In this work, complex geometrical optics is, for what we believe is the first time, applied instead of geometrical or wave optics to describe the probe beam interaction with the field of the thermal wave in photothermal beam deflection (photothermal deflection spectroscopy) experiments on thin films. On the basis of this approach the thermal (thermal diffusivity and conductivity), optical (energy band gap), and transport (carrier lifetime) parameters of the semiconductor thin films (pure TiO2, N- and C-doped TiO2, or TiO2/SiO2 composites deposited on a glass or aluminum support) were determined with better accuracy and simultaneously during one measurement...
January 1, 2015: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
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