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Photothermal therapy with immune nanoparticles

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https://www.readbyqxmd.com/read/29893126/triple-stimuli-responsive-magnetic-hollow-porous-carbon-based-nanodrug-delivery-system-for-magnetic-resonance-imaging-guided-synergistic-photothermal-chemotherapy-of-cancer
#1
Fan Wu, Ming Zhang, Hanwen Lu, Dong Liang, Yaliang Huang, Yonghong Xia, Yuqing Hu, Shengqiang Hu, Jianxiu Wang, Xinyao Yi, Jun Zhang
The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(γ-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (Fe3 O4 ) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy...
July 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29774068/platelet-camouflaged-nanococktail-simultaneous-inhibition-of-drug-resistant-tumor-growth-and-metastasis-via-a-cancer-cells-and-tumor-vasculature-dual-targeting-strategy
#2
Lijia Jing, Haijing Qu, Dongqi Wu, Chaojian Zhu, Yongbo Yang, Xing Jin, Jian Zheng, Xiangsheng Shi, Xiufeng Yan, Yang Wang
Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult to inhibit the growth of MDR cancer due to its chemoresistance. Furthermore, MDR cancers are more likely to metastasize, causing a high mortality among cancer patients. In this study, a nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) to efficiently inhibit the growth and metastasis of drug-resistant tumors via a cancer cells and tumor vasculature dual-targeting strategy...
2018: Theranostics
https://www.readbyqxmd.com/read/29721075/combining-photothermal-therapy-and-immunotherapy-against-melanoma-by-polydopamine-coated-al-2-o-3-nanoparticles
#3
Wenfei Chen, Ming Qin, Xiaoyan Chen, Qin Wang, Zhirong Zhang, Xun Sun
Photothermal therapy (PTT) can be an effective antitumor therapy, but it may not completely eliminate tumor cells, leading to the risk of recurrence or metastasis. Here we describe nanocarriers that allow combination therapy involving PTT and immunotherapy. Nanocarriers are prepared by coating Al2 O3 nanoparticles with non-toxic, biodegradable polydopamine, which shows high photothermal efficiency. A near-infrared laser irradiation can kill the majority of tumor tissues, resulting in the release of tumor-associated antigens...
2018: Theranostics
https://www.readbyqxmd.com/read/29665282/photothermal-therapy-generates-a-thermal-window-of-immunogenic-cell-death-in-neuroblastoma
#4
Elizabeth E Sweeney, Juliana Cano-Mejia, Rohan Fernandes
A thermal "window" of immunogenic cell death (ICD) elicited by nanoparticle-based photothermal therapy (PTT) in an animal model of neuroblastoma is described. In studies using Prussian blue nanoparticles to administer photothermal therapy (PBNP-PTT) to established localized tumors in the neuroblastoma model, it is observed that PBNP-PTT conforms to the "more is better" paradigm, wherein higher doses of PBNP-PTT generates higher cell/local heating and thereby more cell death, and consequently improved animal survival...
May 2018: Small
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#5
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29540781/chemo-photothermal-therapy-combination-elicits-anti-tumor-immunity-against-advanced-metastatic-cancer
#6
Jutaek Nam, Sejin Son, Lukasz J Ochyl, Rui Kuai, Anna Schwendeman, James J Moon
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma...
March 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29377647/cellular-uptake-and-tissue-biodistribution-of-functionalized-gold-nanoparticles-and-nanoclusters
#7
María A Escudero-Francos, Vanesa Cepas, Pedro González-Menédez, Rosana Badía-Laíño, Marta E Díaz-García, Rosa M Sainz, Juan C Mayo, David Hevia
In this study, the in vitro uptake by fibroblasts and in vivo biodistribution of 15 nm 11-mercaptoundecanoicacid-protected gold nanoparticles (AuNPs-MUA) and 3 nm glutathione- and 3 nm bovine serum albumin-protected gold nanoclusters (AuNCs@GSH and AuNCs@BSA, respectively) were evaluated. In vitro cell viability was examined after gold nanoparticle treatment for 48 h, based on MTT assays and analyses of morphological structure, the cycle cell, cellular doubling time, and the gold concentration in cells. No potential toxicity was observed at any studied concentration (up to 10 ppm) for AuNCs@GSH and AuNCs@BSA, whereas lower cell viability was observed for AuNPs-MUA at 10 ppm than for other treatments...
February 2017: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29344312/an-endogenous-vaccine-based-on-fluorophores-and-multivalent-immunoadjuvants-regulates-tumor-micro-environment-for-synergistic-photothermal-and-immunotherapy
#8
Ling Li, Suleixin Yang, Linjiang Song, Yan Zeng, Tao He, Ning Wang, Chuan Yu, Tao Yin, Li Liu, Xiawei Wei, Qinjie Wu, Yuquan Wei, Li Yang, Changyang Gong
Recently, near-infrared (NIR) light-based photothermal therapy (PTT) has been widely applied in cancer treatment. However, in most cases, the tissue penetration depth of NIR light is not sufficient and thus photothermal therapy is unable to completely eradicate deep, seated tumors inevitably leading to recurrence of the tumor. Due to this significant limitation of NIR, improved therapeutic strategies are urgently needed. Methods: We developed an endogenous vaccine based on a novel nanoparticle platform for combinatorial photothermal ablation and immunotherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29339567/erythrocyte-membrane-coated-gold-nanocages-for-targeted-photothermal-and-chemical-cancer-therapy
#9
Dao-Ming Zhu, Wei Xie, Yu-Sha Xiao, Meng Suo, Ming-Hui Zan, Qing-Quan Liao, Xue-Jia Hu, Li-Ben Chen, Bei Chen, Wen-Tao Wu, Li-Wei Ji, Hui-Ming Huang, Shi-Shang Guo, Xing-Zhong Zhao, Quan-Yan Liu, Wei Liu
Recently, red blood cell (RBC) membrane-coated nanoparticles have attracted much attention because of their excellent immune escapability; meanwhile, gold nanocages (AuNs) have been extensively used for cancer therapy due to their photothermal effect and drug delivery capability. The combination of the RBC membrane coating and AuNs may provide an effective approach for targeted cancer therapy. However, few reports have shown the utilization of combining these two technologies. Here, we design erythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy...
January 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29336463/protein-corona-in-drug-delivery-for-multimodal-cancer-therapy-in-vivo
#10
Eugenia Li Ling Yeo, Patricia Soo Ping Thong, Khee Chee Soo, James Chen Yong Kah
The protein corona is inevitably formed on nanoparticles (NPs) when they are introduced in vivo and has been associated with a reduction in targeting yield, immune recognition and rapid blood clearance, leading to poor tumor accumulation. We have recently shown that it is possible to exploit the protein corona for drug delivery by exploiting it for loading and triggering the release of a photosensitizer Chlorin e6 (Ce6) for simultaneous photodynamic (PDT) and photothermal therapy (PTT) in vitro. Here, we extended our previous in vitro studies to evaluate its effectiveness in vivo...
February 1, 2018: Nanoscale
https://www.readbyqxmd.com/read/29334363/macrophage-membrane-coated-iron-oxide-nanoparticles-for-enhanced-photothermal-tumor-therapy
#11
Qian-Fang Meng, Lang Rao, Minghui Zan, Ming Chen, Guang-Tao Yu, Xiaoyun Wei, Zhuhao Wu, Yue Sun, Shi-Shang Guo, Xing-Zhong Zhao, Fu-Bing Wang, Wei Liu
Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should have long blood circulation times and active cancer targeting. Additionally, they should be harmless and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3 O4 NPs). Inherited from the Fe3 O4 core and the macrophage membrane shell, the resulting Fe3 O4 @MM NPs exhibited good biocompatibility, immune evasion, cancer targeting and light-to-heat conversion capabilities...
April 3, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29285274/lipopolysaccharide-coated-cus-nanoparticles-promoted-anti-cancer-and-anti-metastatic-effect-by-immuno-photothermal-therapy
#12
Bian Jang, Li Xu, Madhappan S Moorthy, Wei Zhang, Ling Zeng, Mingyeong Kang, Minseok Kwak, Junghwan Oh, Jun-O Jin
To meet the ultimate goal of cancer therapy, which is treating not only the primary tumor but also preventing metastatic cancer, the concept of combining immunotherapy with photothermal therapy (PTT) is gaining great interest. Here, we studied the new material, lipopolysaccharide (LPS) coated copper sulfide nanoparticles (LPS-CuS), for the immuno-photothermal therapy. We evaluated the effect of LPS-CuS for induction of apoptosis of CT26 cells and activation of dendritic cells. Moreover, the LPS-CuS and laser irradiation was examined anti-metastasis effect by liver metastasis model mouse in vivo ...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29176077/erythrocyte-membrane-coated-gold-nanocages-for-targeted-cancer-photothermal-and-chemical-therapy
#13
Dao Ming Zhu, Wei Xie, Yu Sha Xiao, Meng Suo, Ming-Hui Zan, Qing-Quan Liao, Xue-Jia Hu, Li Ben Chen, Bei Chen, Wentao Wu, Li Wei Ji, Huiming Huang, Shi Shang Guo, Xing-Zhong Zhao, Quan Yan Liu, Wei Liu
Recently, RBC membrane coated nanoparticles have attracted much attention because of their excellent immune escape ability; meanwhile, Au nanocages (AuNs) have been extensively used for cancer therapy due to its photothermal effect and drug delivery capability. The combination of RBC membrane coating and Au nanocages may provide an effective approach for targeted cancer therapy. However, few reports have shown the utilization of combining these two technologies. Here, we present the development of Erythrocyte membrane-coated Gold nanocages for targeted cancer photothermal and chemical therapy...
November 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28663143/oxygen-self-enriched-nanoparticles-functionalized-with-erythrocyte-membranes-for-long-circulation-and-enhanced-phototherapy
#14
Hao Ren, Jiaqi Liu, Yuqin Li, Haoran Wang, Sizhan Ge, Ahu Yuan, Yiqiao Hu, Jinhui Wu
In recent years, indocyanine green (ICG) encapsulated in different kinds of nano-carriers have been developed to overcome its short lifetime in vivo and non-selectivity in cancer cells. However, these nanoparticles are still easily recognized and captured by the reticuloendothelial system (RES) and the low singlet oxygen quantum (0.08) of ICG inevitably leads to a limited efficacy of phototherapy. To overcome these limitations, a novel oxygen self-enriched biomimetic red blood cell (RBC) was developed by cloaking albumin nanoparticles which contained ICG and perfluorocarbon (PFC) with RBC membranes...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27934074/cancer-cell-membrane-biomimetic-nanoparticles-for-homologous-targeting-dual-modal-imaging-and-photothermal-therapy
#15
Ze Chen, Pengfei Zhao, Zhenyu Luo, Mingbin Zheng, Hao Tian, Ping Gong, Guanhui Gao, Hong Pan, Lanlan Liu, Aiqing Ma, Haodong Cui, Yifan Ma, Lintao Cai
An active cell membrane-camouflaged nanoparticle, owning to membrane antigens and membrane structure, can achieve special properties such as specific recognition, long blood circulation, and immune escaping. Herein, we reported a cancer cell membrane-cloaked nanoparticle system as a theranostic nanoplatform. The biomimetic nanoparticles (indocyanine green (ICG)-loaded and cancer cell membrane-coated nanoparticles, ICNPs) exhibit a core-shell nanostructure consisting of an ICG-polymeric core and cancer cell membrane shell...
November 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27826115/prussian-blue-nanoparticle-based-photothermal-therapy-combined-with-checkpoint-inhibition-for-photothermal-immunotherapy-of-neuroblastoma
#16
Juliana Cano-Mejia, Rachel A Burga, Elizabeth E Sweeney, John P Fisher, Catherine M Bollard, Anthony D Sandler, Conrad Russell Y Cruz, Rohan Fernandes
We describe "photothermal immunotherapy," which combines Prussian blue nanoparticle (PBNP)-based photothermal therapy (PTT) with anti-CTLA-4 checkpoint inhibition for treating neuroblastoma, a common, hard-to-treat pediatric cancer. PBNPs exhibit pH-dependent stability, which makes them suitable for intratumorally-administered PTT. PBNP-based PTT is able to lower tumor burden and prime an immune response, specifically an increased infiltration of lymphocytes and T cells to the tumor area, which is complemented by the antitumor effects of anti-CTLA-4 immunotherapy, providing a more durable treatment against neuroblastoma in an animal model...
February 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27791364/albumin-bioinspired-gd-cus-nanotheranostic-agent-for-in-vivo-photoacoustic-magnetic-resonance-imaging-guided-tumor-targeted-photothermal-therapy
#17
Weitao Yang, Weisheng Guo, Wenjun Le, Guoxian Lv, Fuhe Zhang, Lei Shi, Xiuli Wang, Jun Wang, Sheng Wang, Jin Chang, Bingbo Zhang
Photothermal therapy (PTT) is attracting increasing interest and becoming more widely used for skin cancer therapy in the clinic, as a result of its noninvasiveness and low systemic adverse effects. However, there is an urgent need to develop biocompatible PTT agents, which enable accurate imaging, monitoring, and diagnosis. Herein, a biocompatible Gd-integrated CuS nanotheranostic agent (Gd:CuS@BSA) was synthesized via a facile and environmentally friendly biomimetic strategy, using bovine serum albumin (BSA) as a biotemplate at physiological temperature...
November 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27767031/photothermal-therapy-with-immune-adjuvant-nanoparticles-together-with-checkpoint-blockade-for-effective-cancer-immunotherapy
#18
Qian Chen, Ligeng Xu, Chao Liang, Chao Wang, Rui Peng, Zhuang Liu
A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy. Indocyanine green (ICG), a photothermal agent, and imiquimod (R837), a Toll-like-receptor-7 agonist, are co-encapsulated by poly(lactic-co-glycolic) acid (PLGA). The formed PLGA-ICG-R837 nanoparticles composed purely by three clinically approved components can be used for near-infrared laser-triggered photothermal ablation of primary tumours, generating tumour-associated antigens, which in the presence of R837-containing nanoparticles as the adjuvant can show vaccine-like functions...
October 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27450902/elimination-of-epithelial-like-and-mesenchymal-like-breast-cancer-stem-cells-to-inhibit-metastasis-following-nanoparticle-mediated-photothermal-therapy
#19
Hayley J Paholak, Nicholas O Stevers, Hongwei Chen, Joseph P Burnett, Miao He, Hasan Korkaya, Sean P McDermott, Yadwinder Deol, Shawn G Clouthier, Tahra Luther, Qiao Li, Max S Wicha, Duxin Sun
Increasing evidence suggesting breast cancer stem cells (BCSCs) drive metastasis and evade traditional therapies underscores a critical need to exploit the untapped potential of nanotechnology to develop innovative therapies that will significantly improve patient survival. Photothermal therapy (PTT) to induce localized hyperthermia is one of few nanoparticle-based treatments to enter clinical trials in human cancer patients, and has recently gained attention for its ability to induce a systemic immune response targeting distal cancer cells in mouse models...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/27401941/nanoparticles-for-imaging-and-treatment-of-metastatic-breast-cancer
#20
REVIEW
Qingxin Mu, Hui Wang, Miqin Zhang
Metastatic breast cancer is one of the most devastating cancers that have no cure. Many therapeutic and diagnostic strategies have been extensively studied in the past decade. Among these strategies, cancer nanotechnology has emerged as a promising strategy in preclinical studies by enabling early identification of primary tumors and metastases, and by effective killing of cancer cells. Areas covered: This review covers the recent progress made in targeting and imaging of metastatic breast cancer with nanoparticles, and treatment using nanoparticle-enabled chemo-, gene, photothermal- and radio-therapies...
January 2017: Expert Opinion on Drug Delivery
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