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https://www.readbyqxmd.com/read/30557305/pr3-anca-and-panel-diagnostics-in-pediatric-inflammatory-bowel-disease-to-distinguish-ulcerative-colitis-from-crohn-s-disease
#1
Michael P Horn, Anna Maria Peter, Franziska Righini Grunder, Alexander B Leichtle, Johannes Spalinger, Susanne Schibli, Christiane Sokollik
BACKGROUND: Accurate classification of patients with inflammatory bowel disease into the subtypes ulcerative colitis (UC) and Crohn's disease (CD) is still a challenge, but important for therapy and prognosis. OBJECTIVES: To evaluate the diagnostic utility of anti-neutrophil cytoplasmic antibodies specific for proteinase-3 (PR3-ANCA) for ulcerative colitis (UC) and the value of an antibody panel incorporating PR3-ANCA to differentiate between Crohn's disease (CD) and UC...
2018: PloS One
https://www.readbyqxmd.com/read/30556310/prognostic-factors-of-budesonide-therapy-for-the-management-of-crohn-s-disease-a-meta-analysis
#2
Yajun Li, Xiangwei Meng, Xiumei Duan, Tongyu Tang, Chuan He, Yuqin Li
BACKGROUND: This study aimed to identify factors that affect the prognosis of budesonide therapy for Crohn's disease patients. METHOD: Change in Crohn's disease activity index (CDAI) scores at latest follow-up after budesonide therapy reported by individual studies were pooled to gain overall effect size under random effects model and then metaregression analyses were performed to identify factors affecting the change in CDAI scores after budesonide treatment. RESULTS: Fifteen studies (1875 patients; age, 35...
December 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30556095/elicitation-of-health-related-utility-in-perianal-fistula-in-crohn-s-disease
#3
Louise Longworth, Donna Fountain, Jeshika Singh, Ismail Azzabi, Glynn Owen, Ulf Lundstam, Shaji Sebastian
BACKGROUND AND OBJECTIVE: Perianal fistulae are a common complication of Crohn's disease (CD) and pose a substantial burden on quality of life. Data capturing health-related utility associated with perianal fistulae in CD are scarce. The current study aims to value health states related to different stages of the disease to quantitatively evaluate the impact of complex perianal fistulae on CD patients' quality of life. METHODS: Eight health state descriptions associated with complex perianal fistulae in CD were developed following qualitative research with patients and validation by clinicians...
December 17, 2018: Patient
https://www.readbyqxmd.com/read/30555064/polymorphisms-in-toll-like-receptor-tlr-1-4-9-and-slc11a1-genes-and-their-association-with-paratuberculosis-susceptibility-in-holstein-and-indigenous-crossbred-cattle-in-turkey
#4
Mehmet Ulas Cinar, Harun Hizlisoy, B Ilal Akyüz, Korhan Arslan, Esma Gamze Aksel, Kadİr Semİh Gümü Şsoy
Mycobacterium avium subsp. paratuberculosis (MAP) causes major problem in a wide range of animal species. In ruminant livestock including cattle, it causes a chronic disease called Johne's disease, or paratuberculosis (pTB) which is currently considered as potential zoonosis, causing Crohn's disease in humans. MAP infection susceptibility is suspected to be controlled by host genetics. Thus, selecting individuals according to their genetic structure could help to obtain bovine populations that are increasingly resistant to MAP infection...
December 2018: Journal of Genetics
https://www.readbyqxmd.com/read/30554225/the-incidence-and-risk-factors-of-venous-thromboembolism-in-patients-with-inflammatory-bowel-disease-a-prospective-multicenter-cohort-study
#5
Katsuyoshi Ando, Mikihiro Fujiya, Yoshiki Nomura, Yuhei Inaba, Yuya Sugiyama, Yu Kobayashi, Takuya Iwama, Masami Ijiri, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Yusuke Mizukami, Kazumi Akasaka, Satoshi Fujii, Satoshi Yamada, Hiroshi Nakase, Toshikatsu Okumura
BACKGROUND: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than in the general population in Western studies. However, the actual state of VTE in Asian IBD remains poorly understood. AIMS: To reveal the incidence of VTE in IBD patients in Japan. METHODS: Eighty-five patients admitted to 3 gastroenterology centers were registered from 2013 to 2018. The incidence of VTE in patients with IBD (n = 42) was prospectively compared to that among patients with other digestive diseases (n = 43)...
December 14, 2018: Digestion
https://www.readbyqxmd.com/read/30554159/rates-and-characteristics-of-postcolonoscopy-colorectal-cancer-in-the-swedish-ibd-population-what-are-the-differences-from-a-non-ibd-population
#6
Jessica Stjärngrim, Anders Ekbom, Ulf Hammar, Rolf Hultcrantz, Anna M Forsberg
OBJECTIVE: The rate of postcolonoscopy colorectal cancer (PCCRC) is considered a key quality indicator of colonoscopy; little is known about PCCRC in IBD. DESIGN: A population-based cohort study of colonoscopies in Sweden from 2001 to 2010 was conducted. Individuals with a colorectal cancer (CRC) detected within 36 months after a colonoscopy were identified and stratified on UC, Crohn's disease (CD) or non-IBD. The CRCs were classified as detected CRCs (dCRC) (0-6 months) or as PCCRCs (6-36 months)...
December 15, 2018: Gut
https://www.readbyqxmd.com/read/30554149/skin-staining-due-to-intravenous-iron-extravasation-in-a-teenager-with-crohn-s-disease
#7
Rachel Elizabeth Harris, Victoria Garrick, Lee Curtis, Richard K Russell
No abstract text is available yet for this article.
December 15, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/30553051/perineal-prevention-and-protection-in-obstetrics-cngof-clinical-practice-guidelines
#8
G Ducarme, A C Pizzoferrato, R de Tayrac, C Schantz, T Thubert, C Le Ray, D Riethmuller, E Verspyck, B Gachon, F Pierre, F Artzner, B Jacquetin, X Fritel
INTRODUCTION: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms. MATERIAL AND METHODS: These guidelines were developed in accordance with the methods prescribed by the French Health Authority (HAS). RESULTS: A prenatal clinical examination of the perineum is recommended for women with a history of Crohn's disease, OASIS, genital mutilation, or perianal lesions (professional consensus)...
December 12, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/30551218/the-influence-of-antidepressants-on-the-disease-course-among-patients-with-crohn-s-disease-and-ulcerative-colitis-a-danish-nationwide-register-based-cohort-study
#9
Marie Skov Kristensen, Thora Majlund Kjærulff, Annette Kjær Ersbøll, Anders Green, Jesper Hallas, Lau Caspar Thygesen
Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Methods: Patients registered with an incident diagnosis of CD or UC in the Danish National Patient Register (2000-2017) were included...
December 14, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30551185/work-loss-before-and-after-diagnosis-of-crohn-s-disease
#10
Åsa H Everhov, Hamed Khalili, Johan Askling, Pär Myrelid, Jonas F Ludvigsson, Jonas Halfvarson, Caroline Nordenvall, Martin Neovius, Jonas Söderling, Ola Olén
Background: The aim of this study was to examine work loss in patients with Crohn's disease. Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015)...
December 14, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30551150/disease-severity-and-depressive-symptoms-in-adolescents-with-inflammatory-bowel-disease-the-mediating-role-of-parent-and-youth-illness-uncertainty
#11
Marissa N Baudino, Kaitlyn L Gamwell, Caroline M Roberts, John E Grunow, Noel J Jacobs, Stephen R Gillaspy, Clayton S Edwards, Larry L Mullins, John M Chaney
Objective: The objective of this study is to examine parent and youth appraisals of illness uncertainty as potential serial mediators in the relation between disease severity and youth depressive symptoms in adolescents with inflammatory bowel disease (IBD). Methods: Participants were 85 adolescents 13-18 years of age (Mage = 15.75, SD =1.51) with a confirmed diagnosis of IBD (Crohn's disease, 59%; ulcerative colitis, 41%) and a primary caregiver. At a scheduled outpatient visit, caregivers completed a measure of illness uncertainty, while adolescents completed measures of illness uncertainty and depressive symptoms...
December 14, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/30550821/treatment-of-active-crohn-s-disease-with-an-ordinary-food-based-diet-that-replicates-exclusive-enteral-nutrition
#12
V Svolos, R Hansen, B Nichols, C Quince, U Z Ijaz, R T Papadopoulou, C A Edwards, D Watson, A Alghamdi, A Brejnrod, C Ansalone, H Duncan, L Gervais, R Tayler, J Salmond, D Bolognini, R Klopfleisch, D R Gaya, S Milling, R K Russell, K Gerasimidis
BACKGROUND & AIMS: Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn's disease (CD), but its acceptability is limited. There is a need for novel dietary treatments for CD. METHODS: We evaluated the effects of an individualized, food-based diet (CD-TREAT), with similar composition to EEN, on the gut microbiome, inflammation and clinical response in a rat model, healthy adults, and children with relapsing CD. Twenty-five healthy adults randomly received EEN or CD-TREAT for 7 days, followed by a 14-day washout period, followed by the alternate diet...
December 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30550091/-title
#13
O P Gurina, A A Stepanova, E A Dementieva, A E Blinov, O N Varlamova, G A Blinov
The purpose of study is to establish features of autoimmune reaction of children with Crohn's disease. The sampling included 62 patients aged from 2 to 17 years with diagnosis of Crohn's disease. The evaluation was carried out concerning concentration in blood serum of immunoglobulins IgA, IgM, IgG, IgЕ, antibodies to Saccharomyces cerevisiae (ASCA) classes IgA, IgG и IgЕ, antibodies to Candida albicans classes IgA, IgM, IgG и IgЕ, anti-neutrophilic cytoplasmic antibodies (ANCA) to myeloperoxidase (MPO), to proteinase 3 (PR3), anti-nuclear antibodies (ANA), antibodies to DNAds, DNAss (to double-helical and single-stranded DNA), antibodies to antigens of small and large intestines, pancreas, circulating immune complexes...
2018: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/30550051/an-overview-of-inflammatory-bowel-disease
#14
Lisa Younge
Inflammatory bowel disease (IBD) is a term that refers to two main conditions: Crohn's disease and ulcerative colitis. It is a lifelong inflammatory disorder that affects the gastrointestinal tract. Managing IBD requires a multidisciplinary team approach, and specialist IBD nurses have an important role in this, providing education, support and advocacy to patients with IBD. This article provides an overview of the symptoms of Crohn's disease and ulcerative colitis, as well as the medical, nutritional and surgical management strategies that can be used...
December 10, 2018: Nursing Standard
https://www.readbyqxmd.com/read/30548259/vulval-crohn-disease-a-case-series-of-26-patients
#15
Emily Forward, Nianda Reid, Gayle Fischer
Vulval Crohn disease is rare and likely under-reported, leading to difficulty in diagnosis and delay in treatment. In this case series, we report the clinical features and discuss therapy in 26 consecutive patients with vulval Crohn disease, with or without documented gastrointestinal disease, presenting between January 2016 and July 2018. We highlight the need for treatment that is in some cases more aggressive than the requirement to manage the patient's gastrointestinal involvement.
December 11, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/30547661/-micronutrients-in-enteral-nutrition-formulas-is-it-possible-to-innovate
#16
Xavier Mateu de Antonio
The term "micronutrients" include vitamins and trace elements. Their recommended intakes in enteral formulas has been adhered to RDI/RDA and, in addition, their content is regulated in the European Union. However, deficiencies in micronutrients has been reported in specific patient groups under enteral nutrition (EN) in the last years. Even so, the research in micronutrients in EN is scarce. The aim of this review was to assess the literature to establish possible improvements in micronutrients in EN formulas for adult patients...
April 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30547200/ivim-with-fractional-perfusion-as-a-novel-biomarker-for-detecting-and-grading-intestinal-fibrosis-in-crohn-s-disease
#17
Meng-Chen Zhang, Xue-Hua Li, Si-Yun Huang, Ren Mao, Zhuang-Nian Fang, Qing-Hua Cao, Zhong-Wei Zhang, Xu Yan, Min-Hu Chen, Zi-Ping Li, Can-Hui Sun, Shi-Ting Feng
OBJECTIVES: Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its value for detecting and grading intestinal fibrosis in adults with CD compared with contrast-enhanced imaging and traditional diffusion-weighted imaging using surgical histopathology as a reference standard...
December 13, 2018: European Radiology
https://www.readbyqxmd.com/read/30546265/understanding-therapeutic-concepts-in-crohn-s-disease
#18
Gilles Rg Monif
For more than a decade, the therapeutic focus for Crohn's disease has remained fixed at temporary arrestment of symptomology. The Centers for Disease Control and Prevention (CDC) lists Crohn's disease as a disease entity without current cure. Biologics in combination with antibiotics can frequently achieve remissions. Without ongoing drug administration, these remissions tend to be of limited duration. Conceptual advancements in understanding the pathogenesis of Crohn's disease have identified treatment approaches, the focus of which goes beyond temporary remission...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/30545552/fetal-distress-and-urgent-cesarean-delivery-due-to-new-onset-peripartum-crohn-s-disease
#19
Misgav Rottenstreich, Amihai Rottenstreich, Moshe Rottenstreich
No abstract text is available yet for this article.
December 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30545401/a-comparative-study-of-the-gut-microbiota-in-immune-mediated-inflammatory-diseases-does-a-common-dysbiosis-exist
#20
Jessica D Forbes, Chih-Yu Chen, Natalie C Knox, Ruth-Ann Marrie, Hani El-Gabalawy, Teresa de Kievit, Michelle Alfa, Charles N Bernstein, Gary Van Domselaar
BACKGROUND: Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at a higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology is common to all IMIDs, in recent years, considerable knowledge has emerged regarding the plausible role of the gut microbiome in IMIDs. This study used 16S rRNA gene amplicon sequencing to compare the gut microbiota of patients with Crohn's disease (CD; N = 20), ulcerative colitis (UC; N = 19), multiple sclerosis (MS; N = 19), and rheumatoid arthritis (RA; N = 21) versus healthy controls (HC; N = 23)...
December 13, 2018: Microbiome
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