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JOURNAL ARTICLE
Yuzhi Wang, Samantha Wilder, Mohit Butaney, Mahmoud Hijazi, David Gandham, Monica Van Til, Benjamin Goldman, Ji Qi, Mahin Mirza, Anna Johnson, Michael Rudoff, David Wenzler, Craig G Rogers, Brian R Lane
PURPOSE: Partial nephrectomy is standard-of-care treatment for small renal masses. As utilization of partial nephrectomy increases and includes larger and complex tumors, the risk of conversion to radical nephrectomy likely increases. We evaluated incidence and reason for conversion to radical nephrectomy in patients scheduled for partial nephrectomy by surgeons participating in MUSIC (the Michigan Urologic Surgery Improvement Collaborative). MATERIALS AND METHODS: All patients in whom robotic partial nephrectomy was planned were stratified by completed procedure (robotic partial nephrectomy vs radical nephrectomy)...
May 2024: Journal of Urology
#22
JOURNAL ARTICLE
Jason R McConnery, Jeffrey N Bone, Ran D Goldman, Anne Hicks, Claire Seaton, Padmaja Subbarao, Theo J Moraes
OBJECTIVES: Asthma is a chronic lung condition that can be exacerbated when triggered by viruses. Pandemic public health restrictions aimed to reduce COVID-19 transmission indirectly effected other circulating viruses. This study assessed the impact of the pandemic and associated public health measures on acute paediatric asthma across four tertiary sites in three Canadian provinces. We queried whether pandemic-related changes would impair preventive care and delay presentation to care, increasing asthma exacerbation severity...
May 2024: Paediatrics & Child Health
#23
Brandon J Bhasin, Jennifer L Raymond, Mark S Goldman
UNLABELLED: Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures modeling core features of many memory systems: an early- and late-learning brain region and two sites of plasticity. We show that the synaptic dynamics of the circuit during consolidation of an analog memory can be understood as a temporal integration process, by which transient changes in activity driven by plasticity in the early-learning area are accumulated into persistent synaptic changes at the late-learning site...
March 25, 2024: bioRxiv
#24
JOURNAL ARTICLE
Tanja C Vallée, Jannik S Glasmacher, Hannes Buchner, Peter D Arkwright, Uta Behrends, Anastasia Bondarenko, Michael J Browning, David K Buchbinder, Alessandro Cattoni, Liudmyla Chernyshova, Peter Ciznar, Theresa Cole, Wojciech Czogala, Gregor Dueckers, John David M Edgar, Fatih Erbey, Anders Fasth, Francesca Ferrua, Renata Formankova, Eleonora Gambineri, Andrew R Gennery, Frederick D Goldman, Luis Ignacio Gonzalez-Granado, Carsten Heilmann, Tarja Heiskanen-Kosma, Hanna Juntti, Leena Kainulainen, Hirokazu Kanegane, Neslihan E Karaca, Sara Sebnem Kilic, Christoph Klein, Sylwia Koltan, Irina Kondratenko, Isabelle Meyts, Gulnara M Nasrullayeva, Lucia Dora Notarangelo, Srdjan Pasic, Isabelle Pellier, Claudio Pignata, Siraj Ahmed Misbah, Ansgar S Schulz, Gesmar Rs Segundo, Anna Shcherbina, Mary A Slatter, Robert Sokolic, Pere Soler-Palacin, Polina Stepensky, Joris M van Montfrans, Samppa Ryhänen, Beata Wolska-Kuśnierz, John B Ziegler, Xiaodong Zhao, Alessandro Aiuti, Hans D Ochs, Michael H Albert
WAS is a multifaceted monogenic disorder with a broad disease spectrum and variable disease severity and a variety of treatment options including allogeneic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT). No reliable biomarker exists to predict disease course and outcome for individual patients. A total of 577 patients with a WAS variant from 26 countries and a median follow-up of 8.9 years (0.3-71.1), totaling 6118 patient-years, were included in this international retrospective study...
April 5, 2024: Blood
#25
JOURNAL ARTICLE
Chen Dun, Christi M Walsh, Caitlin W Hicks, Thomas Stasko, Allison T Vidimos, Barry Leshin, Elizabeth M Billingsley, Brett M Coldiron, Richard G Bennett, Victor J Marks, Clark Otley, Howard W Rogers, Glenn D Goldman, John G Albertini, Martin A Makary
BACKGROUND: Mohs micrographic surgery efficiently treats skin cancer through staged resection, but surgeons' varying resection rates may lead to higher medical costs. OBJECTIVE: To evaluate the cost savings associated with a quality improvement. MATERIALS AND METHODS: The authors conducted a retrospective cohort study using 100% Medicare fee-for-service claims data to identify the change of mean stages per case for head/neck (HN) and trunk/extremity (TE) lesions before and after the quality improvement intervention from 2016 to 2021...
April 5, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
#26
JOURNAL ARTICLE
Michael A Goldman
As biologists have long known, the genome is only one piece in the puzzle of life.
April 5, 2024: Science
#27
EDITORIAL
Natalia Pabón-Mora, C Stewart Gillmor, Maria Helena S Goldman, Gabriela C Pagnussat
No abstract text is available yet for this article.
April 3, 2024: Plant Reproduction
#28
JOURNAL ARTICLE
Joshua Guedalia, Michal Lipschuetz, Adva Cahen-Peretz, Sarah M Cohen, Yishai Sompolinsky, Galit Shefer, Eli Melul, Zivanit Ergaz-Shaltiel, Debra Goldman-Wohl, Simcha Yagel, Ronit Calderon-Margalit, Ofer Beharier
Hybrid immunity, acquired through vaccination followed or preceded by a COVID-19 infection, elicits robust antibody augmentation. We hypothesize that maternal hybrid immunity will provide greater infant protection than other forms of COVID-19 immunity in the first 6 months of life. We conducted a case-control study in Israel, enrolling 661 infants up to 6 months of age, hospitalized with COVID-19 (cases) and 59,460 age-matched non-hospitalized infants (controls) between August 24, 2021, and March 15, 2022. Infants were grouped by maternal immunity status at delivery: Naïve (never vaccinated or tested positive, reference group), Hybrid-immunity (vaccinated and tested positive), Natural-immunity (tested positive before or during the study period), Full-vaccination (two-shot regimen plus 1 booster), and Partial-vaccination (less than full three shot regimen)...
April 2, 2024: Nature Communications
#29
JOURNAL ARTICLE
Jonathan Dayan, Noam Goldman, Orna Halevy, Zehava Uni
White Striping (WS), Wooden Breast (WB), and Spaghetti Meat (SM) are documented breast muscle myopathies (BMM) affecting broiler chickens' product quality, profitability and welfare. This study evaluated the efficacy of our newly developed deep learning-based automated image analysis tool for early detection of morphometric parameters related to BMM in broiler chickens. Male chicks were utilized, and muscle samples were collected on d 14 of rearing. Histological procedures, including microscopic scoring, blood vessel count, and collagen quantification, were conducted...
March 20, 2024: Poultry Science
#30
REVIEW
L Taylor Flynn, Nadia N Bouras, Volodar M Migovich, Jacob D Clarin, Wen-Jun Gao
Nearly 25 years ago, Dr. Patricia Goldman-Rakic published her review paper, "The 'Psychic' Neuron of the Cerebral Cortex," outlining the circuit-level dynamics, neurotransmitter systems, and behavioral correlates of pyramidal neurons in the cerebral cortex, particularly as they relate to working memory. In the decades since the release of this paper, the existing literature and our understanding of the pyramidal neuron have increased tremendously, and research is still underway to better characterize the role of the pyramidal neuron in both healthy and psychiatric disease states...
2024: Frontiers in Human Neuroscience
#31
JOURNAL ARTICLE
Charles R Reiter, Vivek M Abraham, Daniel L Riddle, Nirav K Patel, Ashton H Goldman
BACKGROUND: Significant heterogeneity exists regarding patient reported outcome measures (PROMs) used in total hip (THA) and knee (TKA) arthroplasty randomized controlled trials (RCTs). This study investigates the PROMs used as primary and secondary outcomes in contemporary arthroplasty RCTs. METHODS: A literature search identified THA and TKA RCTs that were published in top ten impact factor orthopaedic journals from 2017 to 2021. Screening identified 241 trials: 76 THA, 157 TKA, and eight combined...
April 1, 2024: Archives of Orthopaedic and Trauma Surgery
#32
JOURNAL ARTICLE
Hannah Loughlin, Jacob Jackson, Chloe Looman, Alayna Starll, Jeremy Goldman, Zhiying Shan, Chunxiu Yu
Aerobic exercise has been shown to have established benefits on motor function in Parkinson's disease (PD). However, the impact of exercise on depressive symptoms in PD remains unclear. This study aimed to investigate the effects of regular exercise, specifically using a forced running wheel, on both motor performance and the prevalence of depression in a unilateral 6-OHDA-lesioned rat model of PD. The behavioral outcomes of exercise were assessed through the rotarod test (RT), forelimb adjusting step test (FAST), sucrose consumption test (SCT), and novelty sucrose splash test (NSST)...
June 2024: IBRO neuroscience reports
#33
JOURNAL ARTICLE
Cindy Gombaut, Melanie Bakovic, Hoang-Viet Tran, Jennifer Goldman, Sean Wallace, Bharat Ranganath
BACKGROUND: Simultaneous free flap breast reconstruction combined with contralateral mastopexy or breast reduction can increase patient satisfaction and minimize the need for a second procedure. Surgeon concerns of increases in operative time, postoperative complications, and final breast symmetry may decrease the likelihood of these procedures being done concurrently. This study analyzed postoperative outcomes of simultaneous contralateral mastopexy or breast reduction with free flap breast reconstruction...
April 1, 2024: Annals of Plastic Surgery
#34
JOURNAL ARTICLE
Christine Jade Dilla-Ermita, Polly Goldman, Amy Anchieta, Mitchell J Feldmann, Dominique D A Pincot, Randi A Famula, Mishi Vachev, Glenn S Cole, Steven J Knapp, Steven J Klosterman, Peter M Henry
Fusarium oxysporum f.sp. fragariae ( Fof ) race 1 is avirulent on cultivars with the dominant resistance gene, FW1 , while Fof race 2 is virulent on FW1 -resistant cultivars. We hypothesized there was a gene-for-gene interaction between a gene at the FW1 locus and an avirulence gene ( AvrFW1 ) in Fof race 1. To identify a candidate AvrFW1 , we compared genomes of twenty-four Fof race 1 and three Fof race 2 isolates. We found one candidate gene that was present in race 1, absent in race 2, highly expressed in planta, and homologous to a known effector, secreted in xylem 6 ( SIX6 )...
March 29, 2024: Molecular Plant-microbe Interactions: MPMI
#35
JOURNAL ARTICLE
Darren M Weber, Jueun C Kim, Scott M Goldman, Nigel J Clarke, Michael K Racke
Early detection of Alzheimer's disease (AD) represents an unmet clinical need. Beta-amyloid (Aβ) plays an important role in AD pathology, and the Aβ42/40 peptide ratio is a good indicator for amyloid deposition. In addition, variants of the APOE gene are associated with variable AD risk. Here we describe the development and validation of high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for plasma Aβ40 and Aβ42 quantitation, as well as apolipoprotein E (ApoE) phenotype determination as a surrogate for APOE genotype...
March 28, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
#36
JOURNAL ARTICLE
Rosanne Hoffman, Shelley Kay, Rumour Piepenbrink, Jennifer Goldman, Jennifer Schuster, Lauren Grimes, Dana Keener Mast
We explored the role of school nurses during the COVID-19 pandemic by conducting interviews and focus groups with them in 2022 and 2023 in an urban public school district. Findings indicated that school nurses played an essential public health role in engaging the school community, overseeing COVID-19 testing, and enforcing risk mitigation strategies during the pandemic. Our results contribute to understanding school nurses' experiences during the pandemic and highlight the need for training and support for their vital role...
March 28, 2024: American Journal of Public Health
#37
JOURNAL ARTICLE
Amy R Rappaport, Chrisann Kyi, Monica Lane, Meghan G Hart, Melissa L Johnson, Brian S Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I Spira, Jonathan W Goldman, Ciaran D Scallan, Desiree Schenk, Christine D Palmer, Matthew J Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R Boucher, Milana Egorova, Robert L Veres, J Aaron Espinosa, Jason R Jaroslavsky, Lauren D Kraemer Tardif, Lindsey Acrebuche, Christopher Puccia, Leiliane Sousa, Rita Zhou, Kyounghwa Bae, J Randolph Hecht, David P Carbone, Benny Johnson, Andrew Allen, Andrew R Ferguson, Karin Jooss
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providing long-term clinical benefit to patients with cancer. Here we evaluated safety and tolerability of a therapeutic vaccine encoding 20 shared neoantigens derived from selected common oncogenic driver mutations as primary endpoints in an ongoing phase 1/2 study in patients with advanced/metastatic solid tumors. Secondary endpoints included immunogenicity, overall response rate, progression-free survival and overall survival...
March 27, 2024: Nature Medicine
#38
JOURNAL ARTICLE
A Rovai, V Lolli, N Trotta, S Goldman, X De Tiège
Cerebrovascular Reactivity (CVR) refers to the ability of cerebral blood vessels to dilate or constrict under the effect of vasoactive substances and can be estimated using functional Magnetic Resonance Imaging (fMRI). Computation of CVR maps is relevant in various brain diseases and requires specialized data processing. We introduce CVRmap, an opensource software that automates the computation of CVR map. The toolbox complies with the Brain Imaging Data Structure (BIDS) standards.
March 27, 2024: Scientific Reports
#39
JOURNAL ARTICLE
M L Schwandt, V A Ramchandani, J Upadhyay, C Ramsden, N Diazgranados, D Goldman
The relationship between pain and alcohol use disorder (AUD) is complex and bidirectional. The current study examines risk factors for pain in a large comprehensively phenotyped sample including individuals from across the spectrum of alcohol use and misuse. Participants (n = 1101) were drawn from the National Institute on Alcohol Abuse and Alcoholism Natural History Protocol and included treatment-seeking AUD inpatients (AUD+Tx, n = 369), individuals with AUD not seeking treatment (AUD+, n = 161), and individuals without AUD (AUD-, n = 571)...
March 25, 2024: Alcohol
#40
JOURNAL ARTICLE
Esra Sefik, Ryan M Guest, Katrina Aberizk, Roberto Espana, Katrina Goines, Derek M Novacek, Melissa M Murphy, Adam E Goldman-Yassen, Joseph F Cubells, Opal Ousley, Longchuan Li, Sarah Shultz, Elaine F Walker, Jennifer G Mulle
The 3q29 deletion (3q29Del) is a copy number variant (CNV) with one of the highest effect sizes for psychosis-risk (>40-fold). Systematic research offers avenues for elucidating mechanism; however, compared to CNVs like 22q11.2Del, 3q29Del remains understudied. Emerging findings indicate that posterior fossa abnormalities are common among carriers, but their clinical relevance is unclear. We report the first in-depth evaluation of psychotic symptoms in participants with 3q29Del (N=23), using the Structured Interview for Psychosis-Risk Syndromes, and compare this profile to 22q11...
March 21, 2024: Psychiatry Research
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