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JOURNAL ARTICLE
Ryan Storgard, Kai Rejeski, Miguel-Angel Perales, Adam Goldman, Roni Shouval
No abstract text is available yet for this article.
April 18, 2024: JAMA Oncology
#2
JOURNAL ARTICLE
Matthias Eibauer, Miriam S Weber, Rafael Kronenberg-Tenga, Charlie T Beales, Rajaa Boujemaa-Paterski, Yagmur Turgay, Suganya Sivagurunathan, Julia Kraxner, Sarah Köster, Robert D Goldman, Ohad Medalia
Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells with tissue-specific mechanical properties and are involved in numerous cellular processes. Due to their intricate architecture, a 3D structure of IFs has remained elusive. Here we use cryo-focused ion-beam milling, cryo-electron microscopy and tomography to obtain a 3D structure of vimentin IFs (VIFs). VIFs assemble into a modular, intertwined and flexible helical structure of 40 α-helices in cross-section, organized into five protofibrils...
April 17, 2024: Nature Structural & Molecular Biology
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JOURNAL ARTICLE
Dylan Kneale, Claire Stansfield, Rebecca Goldman, Sarah Lester, Rachael C Edwards, James Thomas
BACKGROUND: Embedding researchers into policy and other settings may enhance research capacity within organisations to enable them to become more research active. We aimed to generate an evidence map on evaluations of embedded researcher interventions to (i) identify where systematic reviews and primary research are needed and (ii) develop conceptual understandings of 'embedded researchers'. We define 'embedded researchers' through a set of principles that incorporate elements such as the aim of activities, the types of relationships and learning involved, and the affiliations and identities adopted...
April 16, 2024: Implementation science communications
#4
JOURNAL ARTICLE
Xiangqian Liu, Wenfei Huang, Muhammed Bishir, Colin Hodgkinson, David Goldman, Sulie L Chang
BACKGROUND: We previously reported that binge ethanol induces atrophy of the spleen, a key immune organ, in adolescent male F344 rats. Because there are significant sex effects in immune function, we investigated whether binge ethanol exerts sex-dependent effects on the spleen, including producing splenic atrophy. METHODS: We gave F344 rats ethanol (4.8 g/kg/day; 52% w/v; i.g.) on postnatal days [PND] 36 ~ 38 and sacrificed them on PND 39 for spleen collection...
April 16, 2024: Alcohol Clin Exp Res (Hoboken)
#5
JOURNAL ARTICLE
Osama Al-Dalahmah, Matti Lam, Julie J McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A Jakubiak, Rebekka Kühn, Yoon A Kim, Maria Caterina De Rosa, Claudia A Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A DeTure, Jean Paul Vonsattel, Zbigniew K Wszolek, Dennis W Dickson, Tanja Kuhlmann, Holm Zaehres, Hans R Schöler, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, James E Goldman, Vilas Menon, Peter Canoll, Gunnar Hargus
Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by the deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying the MAPT-N279K mutation, which were related to oxidative stress, oxidative phosphorylation, and neuroinflammation with an upregulation of the inflammation-associated protein osteopontin (OPN)...
April 10, 2024: Cell Stem Cell
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JOURNAL ARTICLE
Sana' Muhsen, Alexander Rabadi, Mahmoud Alqudah, Abdelrahman Obiedat, Liyana Owies, Ibrahim Alhawaniah, Sufian Abdel Hafez, Abdallah Al-Ani
AIMS/OBJECTIVES: Tonometry is a fundamental procedure in the diagnosis and management of glaucoma. Different tonometers have been proposed but none are as accurate as the Goldman applanation tonometry (GAT). Nonetheless, due to the limitations of GAT, mobile tonometry methods became prevalent. This study aims to examine the reliability of the Tono-Pen AVIA® (TPA) in measuring intraocular pressure (IOP) across different postures. METHODS: A total of 196 eyes were prospectively examined for IOP changes using GAT and TPA...
April 16, 2024: European Journal of Ophthalmology
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JOURNAL ARTICLE
Hanna L Blaney, Mian B Khalid, Alexander H Yang, Bilal A Asif, Anusha Vittal, Natasha Kamal, Elizabeth C Wright, Tomilowo Abijo, Chris Koh, David George, David Goldman, Yvonne Horneffer, Nancy Diazgranados, Theo Heller
BACKGROUND: Alcohol cessation is the only intervention that both prevents and halts the progressions of alcohol-associated liver disease. The aim of this study was to assess the relationship between a return to alcohol use and consultation with hepatology in treatment-seeking patients with alcohol use disorder (AUD). METHODS: Two hundred forty-two patients with AUD were enrolled in an inpatient treatment program, with hepatology consultation provided for 143 (59%) patients at the request of the primary team...
May 1, 2024: Hepatology Communications
#8
JOURNAL ARTICLE
Stanley Curtis Takagishi, Amy S Grinberg, Hayley Lindsey, Roberta E Goldman, Sean A Baird, Laura Burrone, Jason J Sico, Teresa M Damush
Background Since headache specialists cannot treat all the patients with headache disorders, multidisciplinary teams that include health psychologists are becoming more prevalent. Health psychologists mainly use a form of cognitive-behavioral therapy (CBT), along with biofeedback on occasion, to effectively address patients' pain and headache disorders. The Veterans Health Administration (VHA) is one setting that routinely includes a health psychologist with advanced training in pain disorders in their pain care to its veterans...
March 2024: Curēus
#9
Thaila Fernanda Dos Reis, Camila Diehl, Camila Figueiredo Pinzan, Patrícia Alves de Castro, Gustavo H Goldman
Aspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that the host defense peptide mimetic, brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates of A. fumigatus . CAS-resistant strains with mutations in fks1 that encodes the 1,3-β-D-glucan synthase are not IBX-resistant and BRI+IBX can inhibit their growth. The combination of BRI+IBX plays a fungicidal role, increases the fungal cell permeability and decreases the fungal survival in the presence of A549 epithelial cells...
April 5, 2024: bioRxiv
#10
Dilan Gokyer, Sophia Akinboro, Luhan T Zhou, Anna Kleinhans, Monica M Laronda, Francesca E Duncan, Joan K Riley, Kara N Goldman, Elnur Babayev
STUDY QUESTION: Are the molecular signatures of cumulus cells (CCs) and follicular fluid (FF) of adolescents undergoing fertility preservation differ from that of reproductively adult oocyte donors? SUMMARY ANSWER: The microenvironment immediately surrounding the oocyte, including the CCs and FF, is altered in adolescents undergoing fertility preservation compared to oocyte donors. WHAT IS KNOWN ALREADY: Adolescents experience a period of subfecundity following menarche...
April 6, 2024: bioRxiv
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JOURNAL ARTICLE
Kunal S Patel, Kaleab K Tessema, Riki Kawaguchi, Lindsey Dudley, Alvaro G Alvarado, Sree Deepthi Muthukrishnan, Travis Perryman, Akifumi Hagiwara, Vivek Swarup, Linda M Liau, Anthony C Wang, William Yong, Daniel H Geschwind, Ichiro Nakano, Steven A Goldman, Richard G Everson, Benjamin M Ellingson, Harley I Kornblum
BACKGROUND: Non-enhancing (NE) infiltrating tumor cells beyond the contrast-enhancing (CE) bulk of tumor are potential propagators of recurrence after gross total resection of high-grade glioma. METHODS: We leveraged single-nucleus RNA sequencing on 15 specimens from recurrent high-grade gliomas ( n = 5) to compare prospectively identified biopsy specimens acquired from CE and NE regions. Additionally, 24 CE and 22 NE biopsies had immunohistochemical staining to validate RNA findings...
2024: Neuro-oncology advances
#12
JOURNAL ARTICLE
Najeeb U Siddiqui, Angelo Karaiskakis, Aaron L Goldman, Whitby V I Eagle, Timothy C H Low, Hua Luo, Craig A Smibert, Elizabeth R Gavis, Howard D Lipshitz
During Drosophila oogenesis, the Oskar (OSK) RNA binding protein (RBP) determines the amount of germ plasm that assembles at the posterior pole of the oocyte. Here, we identify mechanisms that subsequently regulate germ plasm assembly in the early embryo. We show that the Smaug (SMG) RBP is transported into the germ plasm of the early embryo where it accumulates in the germ granules. SMG binds to and represses translation of the osk messenger RNA (mRNA) as well as the bruno 1 ( bru1 ) mRNA, which encodes an RBP that we show promotes germ plasm production...
April 12, 2024: Science Advances
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JOURNAL ARTICLE
Shouwei Zhang, Jinfeng Wang, Andriy Yaroshchuk, Qiujiao Du, Pengyang Xin, Merlin L Bruening, Fan Xia
Ion selectivity is the basis for designing smart nanopore/channel-based devices, e.g., ion separators and biosensors. Quantitative characterization of ion selectivities in nanopores often employs the Nernst or Goldman-Hodgkin-Katz (GHK) equation to interpret transmembrane potentials. However, the direction of the measured transmembrane potential drop is not specified in these equations, and selectivity values calculated using absolute values of transmembrane potentials do not directly reveal the ion for which the membrane is selective...
April 12, 2024: Journal of the American Chemical Society
#14
JOURNAL ARTICLE
Raizl G Sussman, Joy Mburu, MacGregor Steele, Annie Bang, Jeremy Friedman, Ran Goldman, Melanie Kirby, Margaret L Rand, Victor S Blanchette, Fred G Pluthero, Suzan Williams, Walter H A Kahr
BACKGROUND: Constitutive inflammation and hemostatic activation have been identified as key contributors to the pathophysiology of sickle cell disease (SCD), leading to clinical consequences such as vaso-occlusive crises and stroke. Patients with hemoglobin SS (HbSS) and hemoglobin SC (HbSC) genotypes are reported to have different symptoms, as do patients in steady-state and crisis situations. Differences among these groups remain unclear in pediatric patients. OBJECTIVES: To compare hemostatic activity in HbSS and HbSC pediatric patients during steady state, in crisis, and in clinical follow-up and compare HbSS and HbSC patients with normal healthy children...
March 2024: Research and Practice in Thrombosis and Haemostasis
#15
JOURNAL ARTICLE
Yuki Bao, Amelia C Frisbee, Jefferson C Frisbee, Daniel Goldman
Blood flow regulation within the microvasculature reflects a complex interaction of regulatory mechanisms and varies spatially and temporally according to conditions such as metabolism, growth, injury, and disease. Understanding the role of microvascular flow distributions across conditions is of interest to investigators spanning multiple disciplines; however, data collection within networks can be labour-intensive and challenging due to limited resolution. To overcome these experimental challenges, computational network models which can accurately simulate vascular behavior are highly beneficial...
April 11, 2024: Journal of Applied Physiology
#16
JOURNAL ARTICLE
Eugene Krustev, John G Hanly, Ricky Chin, Katherine A Buhler, Murray B Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sánchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David Isenberg, Anisur Rahman, Joan T Merrill, Paul R Fortin, Dafna D Gladman, Ian N Bruce, Michelle A Petri, Ellen M Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Graciela S Alarcón, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth C Kalunian, Søren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askenase, Jill Buyon, Marvin J Fritzler, Ann E Clarke, May Y Choi
BACKGROUND: Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort. METHODS: Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort...
April 9, 2024: Lupus Science & Medicine
#17
JOURNAL ARTICLE
Darren M Weber, Steven W Taylor, Robert J Lagier, Jueun C Kim, Scott M Goldman, Nigel J Clarke, David E Vaillancourt, Ranjan Duara, Karen N McFarland, Wei-En Wang, Todd E Golde, Michael K Racke
INTRODUCTION: Plasma Aβ42/40 ratio can help predict amyloid PET status, but its clinical utility in Alzheimer's disease (AD) assessment is unclear. METHODS: Aβ42/40 ratio was measured by LC-MS/MS for 250 specimens with associated amyloid PET imaging, diagnosis, and demographic data, and for 6,192 consecutive clinical specimens submitted for Aβ42/40 testing. RESULTS: High diagnostic sensitivity and negative predictive value (NPV) for Aβ-PET positivity were observed, consistent with the clinical performance of other plasma LC-MS/MS assays, but with greater separation between Aβ42/40 values for individuals with positive vs...
2024: Frontiers in Neurology
#18
JOURNAL ARTICLE
James R Tucker, Ana Badea, Barbara A Blackwell, Dan MacEachern, Aaron Mills
Fusarium head blight (FHB), caused by Fusarium graminearum , is currently the most devastating disease for barley ( Hordeum vulgare ) in Canada. Associated mycotoxins can compromise grain quality, where deoxynivalenol (DON) is considered particularly damaging due to its frequency of detection. Breeding barley with a lower DON content is difficult, due to the poor adaptation and malt quality of resistance sources. A set of European-derived heritage varieties were screened in an FHB nursery in Charlottetown, PE, with selections tested at Brandon, MB, between 2018-2022...
March 11, 2024: Plants (Basel, Switzerland)
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JOURNAL ARTICLE
Yuzhi Wang, Samantha Wilder, Mohit Butaney, Mahmoud Hijazi, David Gandham, Monica Van Til, Benjamin Goldman, Ji Qi, Mahin Mirza, Anna Johnson, Michael Rudoff, David Wenzler, Craig G Rogers, Brian R Lane
PURPOSE: Partial nephrectomy is standard-of-care treatment for small renal masses. As utilization of partial nephrectomy increases and includes larger and complex tumors, the risk of conversion to radical nephrectomy likely increases. We evaluated incidence and reason for conversion to radical nephrectomy in patients scheduled for partial nephrectomy by surgeons participating in MUSIC (the Michigan Urologic Surgery Improvement Collaborative). MATERIALS AND METHODS: All patients in whom robotic partial nephrectomy was planned were stratified by completed procedure (robotic partial nephrectomy vs radical nephrectomy)...
May 2024: Journal of Urology
#20
JOURNAL ARTICLE
Jason R McConnery, Jeffrey N Bone, Ran D Goldman, Anne Hicks, Claire Seaton, Padmaja Subbarao, Theo J Moraes
OBJECTIVES: Asthma is a chronic lung condition that can be exacerbated when triggered by viruses. Pandemic public health restrictions aimed to reduce COVID-19 transmission indirectly effected other circulating viruses. This study assessed the impact of the pandemic and associated public health measures on acute paediatric asthma across four tertiary sites in three Canadian provinces. We queried whether pandemic-related changes would impair preventive care and delay presentation to care, increasing asthma exacerbation severity...
May 2024: Paediatrics & Child Health
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