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Jinny L Liu, Lisa C Shriver-Lake, Dan Zabetakis, George P Anderson, Ellen R Goldman
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes an arthralgia febrile illness that has affected millions of people on three continents. Previously, neutralizing monoclonal antibodies that have prophylactic and therapeutic activity were found to remove virus in joint tissues, thereby reducing the severity of symptoms in mice and non-human primates. In this study, we sought to develop thermostable small recombinant antibodies against CHIKV for future diagnostic, prophylactic and therapeutic applications...
December 11, 2018: Molecular Immunology
Sharon Siegel, Linlin Fan, Amanda Goldman, Joseph Higgins, Scott Goates, Jamie Partridge
BACKGROUND: Despite its high prevalence, malnutrition in hospitalized patients often goes unrecognized and undertreated. LOCAL PROBLEM: A hospital system sought to improve nutrition care by implementing a quality improvement initiative. Nurses screened patients upon admission using the Malnutrition Screening Tool and initiated oral nutrition supplements for patients at risk. METHODS: We retrospectively reviewed the medical records of 20 697 adult patients to determine whether early initiation of nutrition therapy had reduced hospital length of stay and 30-day readmission rates...
December 12, 2018: Journal of Nursing Care Quality
Tomasz Górski, Romain Veltz, Mathieu Galtier, Hélissande Fragnaud, Jennifer S Goldman, Bartosz Teleńczuk, Alain Destexhe
Many neurons possess dendrites enriched with sodium channels and are capable of generating action potentials. However, the role of dendritic sodium spikes remain unclear. Here, we study computational models of neurons to investigate the functional effects of dendritic spikes. In agreement with previous studies, we found that point neurons or neurons with passive dendrites increase their somatic firing rate in response to the correlation of synaptic bombardment for a wide range of input conditions, i.e. input firing rates, synaptic conductances, or refractory periods...
December 13, 2018: Journal of Computational Neuroscience
Roger D Dias, Leon J Osterweil, Giuseppe Riccardi, Heather M Conboy, George S Avrunin, Steven J Yule, Jennifer M Gabany, David Arney, Marco A Zenati, Lori A Clarke, Julian M Goldman
In the surgical setting, team members constantly deal with a high-demand operative environment that requires simultaneously processing a large amount of information. In certain situations, high demands imposed by surgical tasks and other sources may exceed team member's cognitive capacity, leading to cognitive overload which may place patient safety at risk. In the present study, we describe a novel approach to integrate an objective measure of team member's cognitive load with procedural, behavioral and contextual data from real-life cardiac surgeries...
June 2018: ... IEEE International Inter-Disciplinary Conference on Cognitive Methods in Situation Awareness and Decision Support
Yaya Chu, Sanghoon Lee, Tishi Shah, Changhong Yin, Matthew Barth, Rodney R Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella Van de Ven, Paul Galardy, Stanton C Goldman, Megan S Lim, Michelle Hermiston, Linda M McAllister-Lucas, Lisa Giulino-Roth, Sherrie L Perkins, Mitchell S Cairo
Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in part regulates normal B-cell development. Ibrutinib, a selective and irreversible BTK inhibitor, has been efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia, and marginal zone lymphoma. In this study, we investigated the efficacy of ibrutinib alone and in selective adjuvant combinations against BL in-vitro and in a human BL xenografted immune-deficient NOD...
2019: Oncoimmunology
Aaron Goldman
No abstract text is available yet for this article.
November 13, 2018: Oncotarget
Marco Arieli Herrera-Valdez
A generic formulation for both passive and active transmembrane transport is derived from basic thermodynamical principles. The derivation takes into account the energy required for the motion of molecules across membranes, and includes the possibility of modeling asymmetric flow. Transmembrane currents can then be described by the generic model in the case of electrogenic flow. As it is desirable in new models, it is possible to derive other well known expressions for transmembrane currents as particular cases of the generic formulation...
2018: F1000Research
Clare Lambert, Ran D Goldman
No abstract text is available yet for this article.
December 2018: Canadian Family Physician Médecin de Famille Canadien
Clare Lambert, Ran D Goldman
Question An 8-year-old child who lives in a small town has presented to my practice with a 3-inch laceration on the calf that has been assessed and needs repair with sutures. The family lives 4 hours from the nearest emergency department and I was planning to repair the wound in the office. What is the best way to manage pain in young patients needing sutures for laceration repair? Answer Children are particularly susceptible to experiencing high levels of pain and anxiety during routine emergency procedures such as laceration repair...
December 2018: Canadian Family Physician Médecin de Famille Canadien
Leandro José de Assis, Adriana Manfiolli, Eliciane Mattos, João H T Marilhano Fabri, Iran Malavazi, Ilse D Jacobsen, Matthias Brock, Robert A Cramer, Arsa Thammahong, Daisuke Hagiwara, Laure Nicolas Annick Ries, Gustavo Henrique Goldman
Aspergillus fumigatus mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents. Upon cell wall stress, cell wall-related sugars need to be synthesized from carbohydrate storage compounds. Here we show that this process is dependent on cAMP-dependent protein kinase A (PKA) activity and regulated by the high-osmolarity glycerol response (HOG) MAPKs SakA and MpkC. These protein kinases are necessary for normal accumulation/degradation of trehalose and glycogen, and the lack of these genes reduces glucose uptake and glycogen synthesis...
December 11, 2018: MBio
Marij Gielen, Geja J Hageman, Evangelia E Antoniou, Katarina Nordfjall, Massimo Mangino, Muthuswamy Balasubramanyam, Tim de Meyer, Audrey E Hendricks, Erik J Giltay, Steven C Hunt, Jennifer A Nettleton, Klelia D Salpea, Vanessa A Diaz, Ramin Farzaneh-Far, Gil Atzmon, Sarah E Harris, Lifang Hou, David Gilley, Iiris Hovatta, Jeremy D Kark, Hisham Nassar, David J Kurz, Karen A Mather, Peter Willeit, Yun-Ling Zheng, Sofia Pavanello, Ellen W Demerath, Line Rode, Daniel Bunout, Andrew Steptoe, Lisa Boardman, Amelia Marti, Belinda Needham, Wei Zheng, Rosalind Ramsey-Goldman, Andrew J Pellatt, Jaakko Kaprio, Jonathan N Hofmann, Christian Gieger, Giuseppe Paolisso, Jacob B H Hjelmborg, Lisa Mirabello, Teresa Seeman, Jason Wong, Pim van der Harst, Linda Broer, Florian Kronenberg, Barbara Kollerits, Timo Strandberg, Dan T A Eisenberg, Catherine Duggan, Josine E Verhoeven, Roxanne Schaakxs, Raffaela Zannolli, Rosana M R Dos Reis, Fadi J Charchar, Maciej Tomaszewski, Ute Mons, Ilja Demuth, Andrea Elena Iglesias Molli, Guo Cheng, Dmytro Krasnienkov, Bianca D'Antono, Marek Kasielski, Barry J McDonnell, Richard Paul Ebstein, Kristina Sundquist, Guillaume Pare, Michael Chong, Maurice P Zeegers
Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes...
September 1, 2018: American Journal of Clinical Nutrition
Alberto Goldman, Uwe Wollina
Background: Mondor's disease of the subcutaneous veins of the breast is an uncommon disorder. The etiology of Mondor's disease remains unclear. Usually, it is a self-limited disease. This condition has been associated with trauma, surgical biopsies, breast surgery (including silicone breast implant), physical activity, and a manifestation of breast cancer. Materials and Methods: This is a retrospective analysis of 652 female patients who underwent aesthetic breast surgery in the last 10 years...
July 2018: Journal of Cutaneous and Aesthetic Surgery
Marwan Alhaddad, Douglas C Wu, Joanna Bolton, Monique J Wilson, Isabela T Jones, Monica Boen, Mitchel P Goldman
BACKGROUND: Over the past decade, 2 major modalities for noninvasive skin tightening have emerged: monopolar capacitive-coupled radiofrequency (MRF) and microfocused ultrasound with visualization (MFU-V). Up to date, no comparative clinical trials have been performed. OBJECTIVE: To compare the efficacy and safety of MRF versus MFU-V for the lifting and tightening of the face and neck. MATERIALS AND METHODS: Twenty subjects with mild to moderate skin laxity received MFU-V over one-side of the face and MRF over the other side of the face at the same time...
December 6, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Armond S Goldman
No abstract text is available yet for this article.
December 6, 2018: Journal of Pediatrics
Scott Goldman
No abstract text is available yet for this article.
October 26, 2018: Journal of Thoracic and Cardiovascular Surgery
David F Butler, Brian R Lee, Sarah Suppes, Tracy Sandritter, Jason G Newland, Lory Harte, Jennifer L Goldman
We retrospectively evaluated the effect of penicillin adverse drug reaction (ADR) labeling on surgical antibiotic prophylaxis. Cefazolin was administered in 86% of penicillin ADR-negative (-) and 28% penicillin ADR-positive (+) cases. Broad-spectrum antibiotic use was more common in ADR(+) cases and was more commonly associated with perioperative adverse drug events.
December 2018: Infection Control and Hospital Epidemiology
Alyssa W Goldman, Benjamin Cornwell
Objective: We examine whether racial and socioeconomic factors influence older adults' likelihood of experiencing instability in their social network ties with their adult children. Background: Recent work shows that socially disadvantaged older adults' social networks are more unstable and exhibit higher rates of turnover, perhaps due to greater exposure to broader social-environmental instability. We consider whether this network instability applies to older adults' ties with their adult children, which are often the closest and most reliable social ties in later life...
October 2018: Journal of Marriage and the Family
Rafael Fávero Peixoto-Junior, Larissa Mara de Andrade, Michael Dos Santos Brito, Paula Macedo Nobile, Alexandre Palma Boer Martins, Samira Domingues Carlin, Rafael Vasconcelos Ribeiro, Maria Helena de Souza Goldman, João Felipe Nebó Carlos de Oliveira, Antonio Vargas de Oliveira Figueira, Silvana Creste
Drought is the most significant environmental stress for agricultural production worldwide, and tremendous efforts have been made to improve crop yield under the increasing water scarcity. Transcription factors are major players in the regulation of water stress-related genes in plants. Recently, different MYB transcription factors were characterized for their involvement in drought response. A sugarcane R2R3-MYB gene (ScMYBAS1) and its four alternative forms of transcript (ScMYAS1-2, ScMYBAS1-3, ScMYBAS1-4 and ScMYBAS1-5) were identified in this study...
2018: PloS One
Jack Wright, Stephen P Muench, Adrian Goldman, Alison Baker
Transport of molecules and ions across biological membranes is an essential process in all organisms. It is carried out by a range of evolutionarily conserved primary and secondary transporters. A significant portion of the primary transporters belong to the ATP-binding cassette (ABC) superfamily, which utilise the free-energy from ATP hydrolysis to shuttle many different substrates across various biological membranes, and consequently, are involved in both normal and abnormal physiology. In humans, ABC transporter-associated pathologies are perhaps best exemplified by multidrug-resistance transporters that efflux many xenobiotic compounds due to their remarkable substrate polyspecificity...
December 4, 2018: Biochemical Society Transactions
Daniel J Oh, Alexander L Pleet, Judy L Chen, Julie B Goldman, Amy Lin, Maria S Cortina
Purpose: We describe a rare case of a complex choristoma appearing as a salmon-patch lesion in the nasal conjunctiva. While benign, complex choristomas are grossly indistinguishable from malignant lesions, and an excisional biopsy is warranted to confirm the diagnosis. Observations: A 31-year-old man presented with an elevated glistening pink mass on the conjunctiva. An excisional biopsy with a "no-touch" technique was performed, followed by placement of an amniotic membrane graft without postoperative complications...
March 2019: American Journal of Ophthalmology Case Reports
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