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https://www.readbyqxmd.com/read/30230909/clinical-significance-of-upper-airway-virus-detection-in-critically-ill-hematology-patients
#1
Jérôme Legoff, Noémie Zucman, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Jérôme Lambert, Achille Kouatchet, Alexandre Demoule, François Vincent, Martine Nyunga, Fabrice Bruneel, Adrien Contejean, Séverine Mercier-Delarue, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Carole Schwebel, Mercé Jourdain, Michael Darmon, Matthieu Resche-Rigon, Elie Azoulay
RATIONALE: Noninvasive diagnostic tests can ensure the early identification and treatment of viral infections in patients with hematological malignancies. OBJECTIVES: To assess the clinical relevance of a positive virus PCR test on nasal swabs in critically ill hematology patients Methods: Post-hoc analysis of a prospective cohort of critically ill hematology patients admitted to 17 ICUs. Nasal swabs sampled and frozen at ICU admission were tested using a multiplex PCR assay...
September 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30181726/intravenous-ribavirin-for-parainfluenza-and-respiratory-syncytial-virus-in-an-infant-receiving-extracorporeal-membrane-oxygenation-and-continuous-renal-replacement-therapy
#2
Cheryl L Sargel, Mohammed Aboud, Aimee Forster, Loralie J Langman, Jessica Tansmore, Bruce A Mueller, William E Smoyer, Jeffery J Auletta
BACKGROUND: Viral bronchiolitis remains a significant cause of hospitalization as well as morbidity and mortality during the first year of life, with treatment options beyond supportive care being limited. In cases of severe illness, ribavirin may offer therapeutic benefit. OBJECTIVE: We report the use of intravenous (IV) ribavirin in an infant requiring concomitant venovenous extracorporeal membrane oxygenation (VV-ECMO) and continuous venovenous hemofiltration (CVVH) for respiratory syncytial virus (RSV) and parainfluenza virus (PIV) coinfection...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30174887/viral-infection-in-community-acquired-pneumonia-patients-with-fever-a-prospective-observational-study
#3
Ru-Jia Tao, Xiao-Li Luo, Wen Xu, Bei Mao, Ruo-Xuan Dai, Cheng-Wei Li, Li Yu, Fen Gu, Shuo Liang, Hai-Wen Lu, Ke-Bin Chen, Jiu-Wu Bai, Xiao-Bin Ji, Shu-Yi Gu, Xiao-Li Sun, Fa-Hui Dai, Ping Jiang, Wei-Jun Cao, Jin-Fu Xu
Background: Patients with community acquired pneumonia (CAP) caused by viruses can develop severe complications, which result in hospitalization and death. The purpose of this study was to analyse the aetiology, incidence, clinical characteristics, and outcomes of CAP patients with fever during non-pandemics, and then to provide theoretical basis for accurate diagnosis and treatment in CAP patients. Methods: An enrolment system was established for monitoring the CAP patients with fever...
July 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30149147/risk-factors-for-parainfluenza-virus-lower-respiratory-tract-disease-after-hematopoietic-cell-transplantation
#4
Sachiko Seo, Hu Xie, Wendy M Leisenring, Jane M Kuypers, Farah T Sahoo, Sonia Goyal, Louise E Kimball, Angela P Campbell, Keith R Jerome, Janet A Englund, Michael Boeckh
Parainfluenza virus (PIV) infection can progress from upper respiratory tract infection (URTI) to lower respiratory tract disease (LRTD) in immunocompromised hosts. Risk factors for progression to LRTD and presentation with LRTD without prior URTI are poorly defined. Hematopoietic cell transplant (HCT) recipients with PIV infection were retrospectively analyzed using standardized definitions of LRTD. PIV was detected in 540 HCT recipients; 343 had URTI alone and 197 (36%) had LRTD (possible, 76; probable, 19; proven, 102)...
August 25, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30143939/new-clinical-and-seasonal-evidence-of-infections-by-human-parainfluenzavirus
#5
Marta E Álvarez-Argüelles, Susana Rojo-Alba, Zulema Pérez Martínez, Álvaro Leal Negredo, José Antonio Boga Riveiro, María Agustina Alonso Álvarez, Julián Rodríguez Súarez, María de Oña Navarro, Santiago Melón García
Human Parainfluenzaviruses (PIVs) account for a significant proportion of viral acute respiratory infections (ARIs) in children, and are also associated with morbidity and mortality in adults, including nosocomial infections. This work aims to describe PIV genotypes and their clinical and epidemiological distribution. Between December 2016 and December 2017, 6121 samples were collected, and submitted to viral culture and genomic quantification, specifically Parainfluenza 1-4 (PIV1-4), Influenza A and B, Respiratory Syncytial Virus (RSV) A and B, Adenovirus, Metapneumovirus, Coronavirus, Rhinovirus, and Enterovirus...
August 24, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30109291/detection-of-non-influenza-viruses-in-acute-respiratory-infections-in-children-under-five-year-old-in-cote-d-ivoire-january-december-2013
#6
Herve A Kadjo, Edgard Adjogoua, Ndongo Dia, Marius Adagba, Ouattara Abdoulaye, Saraka Daniel, Bertin Kouakou, David C Ngolo, Daouda Coulibaly, Talla Nzussouo Ndahwouh, Mireille Dosso
Background: Influenza sentinel surveillance in Cote d'Ivoire showed that 70% of Acute Respiratory Infections (ARI) cases remained without etiology. This work aims to describe the epidemiological, clinical, and virological pattern of ARI that tested negative for influenza virus, in children under five years old. Materials and Methods: one thousand and fifty nine samples of patients presenting influenza Like Illness (ILI) or Severe Acute Respiratory Infections (SARI) symptoms were tested for other respiratory viruses using multiplex RT-PCR assays targeting 10 respiratory viruses...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29961826/parainfluenza-virus-in-hospitalized-adults-a-7-year-retrospective-study
#7
Elliott Russell, Amy Yang, Sydney Tardrew, Michael G Ison
Background: Parainfluenza virus (PIV) is a cause of respiratory tract infection in children and the immunocompromised population, but its clinical manifestations, impact, and outcomes in hospitalized adults are not well studied. Methods: This retrospective study included adults (≥18 years old) admitted to Northwestern Memorial Hospital or Prentice Women's Hospital (both in Chicago, Illinois) between 1 August 2009 and 31 July 2016 with a positive molecular test result for PIV...
May 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29851817/age-related-prevalence-of-common-upper-respiratory-pathogens-based-on-the-application-of-the-filmarray-respiratory-panel-in-a-tertiary-hospital-in-greece
#8
Nikolaos J Tsagarakis, Anthi Sideri, Panagiotis Makridis, Argyro Triantafyllou, Alexandra Stamoulakatou, Eleni Papadogeorgaki
The FilmArray Respiratory Panel (FA-RP) is an FDA certified multiplex PCR that can detect 17 viruses and 3 bacteria responsible for upper respiratory tract infections, thus it is potentially useful to the assessment of the age-related prevalence of these pathogens.In this observational study, we retrospectively analyzed the results of all the respiratory samples, which had been processed during 1 year-period (November 2015 to November 2016) with the FA-RP, in the Central Laboratories of Hygeia & Mitera General Hospitals of Athens, Greece...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29780847/community-acquired-respiratory-paramyxovirus-infection-after-allogeneic-hematopoietic-cell-transplantation-a-single-center-experience
#9
Yasmin Spahr, Sarah Tschudin-Sutter, Veronika Baettig, Francesca Compagno, Michael Tamm, Jörg Halter, Sabine Gerull, Jakob Passweg, Hans H Hirsch, Nina Khanna
Background: Paramyxoviruses include respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (MPV), which may cause significant respiratory tract infectious disease (RTID) and mortality after allogeneic hematopoietic cell transplantation (HCT). However, clinical data regarding frequency and outcome are scarce. Methods: We identified all paramyxovirus RTIDs in allogeneic HCT recipients diagnosed by multiplex polymerase chain reaction between 2010 and 2014...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29777867/antibiotic-exposure-prior-to-respiratory-viral-infection-is-associated-with-progression-to-lower-respiratory-tract-disease-in-allogeneic-hematopoietic-cell-transplant-recipients
#10
Chikara Ogimi, Elizabeth M Krantz, Jonathan L Golob, Alpana Waghmare, Catherine Liu, Wendy M Leisenring, Christopher R Woodard, Sara Marquis, Jane M Kuypers, Keith R Jerome, Steven A Pergam, David N Fredricks, Mohamed L Sorror, Janet A Englund, Michael Boeckh
Recent publications note an association between antibiotic exposure and respiratory viral infections (RVIs). Antibiotics affect microbiota and impair immune response against RVIs in mice, and low microbiome diversity is associated with pulmonary complications including viral lower respiratory tract disease (LRTD) in hematopoietic cell transplantation (HCT) recipients. In this study, we examined whether antibiotic exposure was associated with increased risk of disease progression in RVIs post-transplantation...
May 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29771962/progression-of-the-radiologic-severity-index-predicts-mortality-in-patients-with-parainfluenza-virus-associated-lower-respiratory-infections
#11
Ajay Sheshadri, Dimpy P Shah, Myrna Godoy, Jeremy J Erasmus, Juhee Song, Liang Li, Scott E Evans, Roy F Chemaly, Burton F Dickey, David E Ost
BACKGROUND: Radiologic severity may predict adverse outcomes after lower respiratory tract infection (LRI). However, few studies have quantified radiologic severity of LRIs. We sought to evaluate whether a semi-quantitative scoring tool, the Radiologic Severity Index (RSI), predicted mortality after parainfluenza virus (PIV)-associated LRI. METHODS: We conducted a retrospective review of consecutively-enrolled adult patients with hematologic malignancy or hematopoietic stem cell transplantation and with PIV detected in nasal wash who subsequently developed radiologically-confirmed LRI...
2018: PloS One
https://www.readbyqxmd.com/read/29742628/evaluation-of-dwell-time-for-peripheral-intravenous-catheters-started-in-the-field-for-geriatric-blunt-trauma-patients
#12
Darcy L Day, Francisco Conde
Replacement time for peripheral intravenous (PIV) catheters started in the field is unclear. The purpose of this study was to compare field-start PIV catheter dwell time of 2 days or less versus field-start PIV catheter dwell time of more than 2 days for the development of indicators of infection for geriatric blunt trauma patients. A retrospective case series was conducted at the state-designated trauma referral center. Activated trauma team patients with blunt injury were included if 65 years or older and if admitted from the field for 7 days or more with a PIV catheter placed prehospital...
May 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29720526/-pseudomonas-aeruginosa-protease-iv-exacerbates-pneumococcal-pneumonia-and-systemic-disease
#13
Jessica L Bradshaw, Armando R Caballero, Michael A Bierdeman, Kristen V Adams, Haley R Pipkins, Aihua Tang, Richard J O'Callaghan, Larry S McDaniel
Pneumonia is a pulmonary disease affecting people of all ages and is consistently a leading cause of childhood mortality and adult hospitalizations. Streptococcus pneumoniae and Pseudomonas aeruginosa are major lung pathogens commonly associated with community-acquired and nosocomial pneumonia. Additionally, mixed lung infections involving these bacterial pathogens are increasing in prevalence and are frequently more severe than single infections. The cooperative interactions of these two pathogens that impact pulmonary disease severity are understudied...
May 2018: MSphere
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#14
Adriana Weinberg, Marisa M Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, Donald Robert Harris, Christiana Smith, George Siberry
To identify factors that predispose human immunodeficiency virus (HIV)-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization, and death in the first 6-24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. Nested case-control study of 107 LRTI+ infants enrolled in the International Site Development Initiative (NISDI) Perinatal and Longitudinal Study in Latin American Countries (LILAC) studies with and 140 LRTI- in the first 6 months, matched by date and place of birth...
June 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29518269/viral-etiologies-of-influenza-like-illness-and-severe-acute-respiratory-infections-in-thailand
#15
Malinee Chittaganpitch, Sunthareeya Waicharoen, Thitipong Yingyong, Prabda Praphasiri, Somchai Sangkitporn, Sonja J Olsen, Kim A Lindblade
BACKGROUND: Information on the burden, characteristics and seasonality of non-influenza respiratory viruses is limited in tropical countries. OBJECTIVES: Describe the epidemiology of selected non-influenza respiratory viruses in Thailand between June 2010 and May 2014 using a sentinel surveillance platform established for influenza. METHODS: Patients with influenza-like illness (ILI; history of fever or documented temperature ≥38°C, cough, not requiring hospitalization) or severe acute respiratory infection (SARI; history of fever or documented temperature ≥38°C, cough, onset <10 days, requiring hospitalization) were enrolled from 10 sites...
July 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29489664/risk-factors-for-severe-bronchiolitis-caused-by-respiratory-virus-infections-among-mexican-children-in-an-emergency-department
#16
Mireya Robledo-Aceves, María de Jesús Moreno-Peregrina, Fernando Velarde-Rivera, Elba Ascencio-Esparza, Francisco M Preciado-Figueroa, Miguela A Caniza, Griselda Escobedo-Melendez
Severe bronchiolitis is the most common reason for hospitalization among children younger than 2 years. This study analyzed the prevalence of community-acquired respiratory virus infection and the risk factors for hospitalization of Mexican children with severe bronchiolitis treated in an Emergency department.This retrospective study included 134 children 2 years or younger with severe viral bronchiolitis, and 134 healthy age-matched controls. The study period was September 2012 to January 2015. We determined the viral etiology and coinfections with multiple viruses and compared the risk factors detected in children with severe viral bronchiolitis with those in the control group...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29477066/supercritical-fluid-chromatography-photodiode-array-detection-electrospray-ionization-mass-spectrometry-as-a-framework-for-impurity-fate-mapping-in-the-development-and-manufacture-of-drug-substances
#17
Gregory F Pirrone, Rose M Mathew, Alexey A Makarov, Frank Bernardoni, Artis Klapars, Robert Hartman, John Limanto, Erik L Regalado
Impurity fate and purge studies are critical in order to establish an effective impurity control strategy for approval of the commercial filing application of new medicines. Reversed phase liquid chromatography-diode array-mass spectrometry (RPLC-DAD-MS) has traditionally been the preferred tool for impurity fate mapping. However, separation of some reaction mixtures by LC can be very problematic requiring combination LC-UV for area % analysis and a different LC-MS method for peak identification. In addition, some synthetic intermediates might be chemically susceptible to the aqueous conditions used in RPLC separations...
March 30, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29456976/respiratory-viruses-in-febrile-neutropenic-patients-with-respiratory-symptoms
#18
Mohsen Meidani, Seyed Alireza Mirmohammad Sadeghi
Background: Respiratory infections are a frequent cause of fever in neutropenic patients, whereas respiratory viral infections are not frequently considered as a diagnosis, which causes high morbidity and mortality in these patients. Materials and Methods: This prospective study was performed on 36 patients with neutropenia who admitted to hospital were eligible for inclusion with fever (single temperature of >38.3°C or a sustained temperature of >38°C for more than 1 h), upper and lower respiratory symptoms...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29411555/innate-immune-response-to-viral-infections-in-primary-bronchial-epithelial-cells-is-modified-by-the-atopic-status-of-asthmatic-patients
#19
Sylwia Moskwa, Wojciech Piotrowski, Jerzy Marczak, Małgorzata Pawełczyk, Anna Lewandowska-Polak, Marzanna Jarzębska, Małgorzata Brauncajs, Anna Głobińska, Paweł Górski, Nikolaos G Papadopoulos, Michael R Edwards, Sebastian L Johnston, Marek L Kowalski
PURPOSE: In order to gain an insight into determinants of reported variability in immune responses to respiratory viruses in human bronchial epithelial cells (HBECs) from asthmatics, the responses of HBEC to viral infections were evaluated in HBECs from phenotypically heterogeneous groups of asthmatics and in healthy controls. METHODS: HBECs were obtained during bronchoscopy from 10 patients with asthma (6 atopic and 4 non-atopic) and from healthy controls (n=9) and grown as undifferentiated cultures...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29394367/contribution-to-malaria-transmission-of-symptomatic-and-asymptomatic-parasite-carriers-in-cambodia
#20
Amélie Vantaux, Reingsey Samreth, Eakpor Piv, Nimol Khim, Saorin Kim, Laura Berne, Sophy Chy, Dysoley Lek, Sovannaroth Siv, Walter R Taylor, Didier Ménard
Background: Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers. Methods: Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential...
April 23, 2018: Journal of Infectious Diseases
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