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https://www.readbyqxmd.com/read/1033706/crdiovascular-effects-of-lidocaine-during-acid-base-imbalance
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R W Yakaitis, J D Thomas, J E Mahaffey
Although lidocaine HCl is often given to critically ill patients with ventricular tachyarrhythmias, it use is not without hazard. To investigate whether acid-base disturbances and their subsequent effects on molecular ioization influence cardiovascular (CV) response to lidocaine, dogs in normal acid-base balance, metabolic acidosis, respiratory acidosis, and respiratory alkalosis were given 2 or 4 mg/kg lidocaine IV. Heart rate (HR), PR and QT intervals, MAP, LVEDP, LV dp/dt, and LV dp/dt divided by CPIP were measured at intervals...
November 1976: Anesthesia and Analgesia
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