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intra-arterial chemotherapy

Bruno Bartolini, Francesco Puccinelli, Steven D Hajdu, Christina Stathopoulos, Maja Beck-Popovic, Francis L Munier, Guillaume Saliou
We report the intentional occlusion of the middle meningeal artery arising from the lacrimal artery, a novel technique to improve drug delivery in a 14-month-old boy with a history of right sporadic unilateral cavitary retinoblastoma group D. The patient was referred to our institution for intra-arterial chemotherapy after two systemic chemotherapy treatments. The digital subtraction angiography showed a large middle meningeal artery arising from the right lacrimal artery and decrease choroidal enhancement thus decreased flow to the tumor...
November 28, 2018: Interventional Neuroradiology
Kaname Sakuma, Toshiyuki Koizumi, Kenji Mitsudo, Jun Ueda, Yuichiro Hayashi, Toshinori Iwai, Makoto Hirota, Mitomu Kioi, Haruka Yoshii, Hisashi Kaizu, Masaharu Hata, Akira Tanaka, Iwai Tohnai
We herein report a case of squamous cell carcinoma of the buccal mucosa with N3 cervical lymph node metastasis in a 63-year-old man. The patient was treated with combination therapy comprising radiotherapy (2 Gy/day, total of 70 Gy), superselective intra-arterial chemotherapy via a superficial temporal artery (docetaxel, total of 70 mg/m2 and cisplatin, total of 175 mg/m2 ), cetuximab (initial dose of 400 mg/m2 with subsequent weekly doses of 250 mg/m2 intravenously), and four sessions of hyperthermia for cervical lymph node metastases...
February 5, 2018: Oral Radiology
Yasushi Fukuoka, Toshihiro Tanaka, Hideyuki Nishiofuku, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Hiroshi Sakaguchi, Kimihiko Kichikawa
PURPOSE: To develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer. MATERIALS AND METHODS: The design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port...
November 2, 2018: Cardiovascular and Interventional Radiology
Karl R Aigner, Emir Selak, Kornelia Aigner
PURPOSE: Head and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The evaluation of a technique for short-term intra-arterial infusion chemotherapy is described herein. METHODS: In a retrospective study, we reviewed the medical records of 97 patients with head and neck cancers who received short-term intra-arterial infusion chemotherapy (62 patients previously untreated, 35 patients with prior radiotherapy)...
October 31, 2018: Journal of Cancer Research and Clinical Oncology
Masanari Umemura, Md Rafikul Islam, Hidenobu Fukumura, Itaru Sato, Yusuke Kawabata, Kousuke Matsuo, Rina Nakakaji, Akane Nagasako, Makoto Ohtake, Takayuki Fujita, Utako Yokoyama, Tomohiro Nakayama, Haruki Eguchi, Yoshihiro Ishikawa
We previously identified a novel nanomagnetic particle, N,N'-bis(salicylidene)ethylenediamineiron [Fe(Salen)]. Fe(Salen) exhibits not only anti-tumor effects but also magnetic properties. We found that Fe(Salen) can be used for magnet-guided drug delivery and visualization of accumulated drug by magnetic resonance imaging (MRI) because of its magnetism. In addition, Fe(Salen) can generate heat by itself when exposed to an alternating current magnetic field (AMF), resulting in a hyperthermia effect. Here, we partly elucidated the anti-tumor mechanism of Fe(Salen) and performed an intravenous repeated dose toxicity study to decide the therapeutic amount...
October 29, 2018: Cancer Science
Christina Eder-Czembirek, Sascha Rechinger, Gabriela Kornek, Edgar Selzer, Rudolf Seemann
OBJECTIVES: This retrospective study performed a comprehensive analysis of the usage of intra-arterial chemotherapy (iaCh) for locally recurrent UICC stage IV oral squamous cell carcinoma (OSCC) over two decades at the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Vienna to assess the utility of its future use. METHODS: Between 1994 and 2014, iaCh was indicated in 48 OSCC cases. In these, the two most frequent iaCh schemes, cisplatin/5-fluorouracil (Cis/5-FU) and methotrexate/bleomycin (MTX/Bleo), were chosen for further analysis...
October 18, 2018: Clinics
Yuichiro Hayashi, Shuhei Minamiyama, Takashi Ohya, Masaki Iida, Toshinori Iwai, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Masaharu Hata, Masataka Taguri, Kenji Mitsudo
Background and objectives: The aim of present study was to compare the treatment results of daily cisplatin (CDDP), weekly docetaxel (DOC) intra-arterial infusion chemotherapy combined with radiotherapy (DIACRT) regimen and weekly CDDP intra-arterial infusion chemotherapy combined with radiotherapy (WIACRT) for patients with tongue cancer. Materials and Methods: Between January 2007 and December 2016, a total of 11 patients treated with WIACRT and 45 patients treated with DIACRT were enrolled in the present study...
July 30, 2018: Medicina
Liang Wang, Minglei Han, Junyang Zhao, Changhua Wu, Zhongqi Wang, Jing Li, Dan Song, Changfeng Wang, Yang Yang, Lei Guo
Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital.We retrospectively analyzed patients with newly diagnosed unilateral advanced intraocular (group D or E) RB undergoing IAC from October 2016 to December 2017 in our hospital. We recorded the data including age, gender, cycles of IAC, pathway of arteries approached (ophthalmic artery or middle meningeal artery), ocular and systematic complications, globe salvage...
October 2018: Medicine (Baltimore)
Mary E Aronow
No abstract text is available yet for this article.
November 2018: Ophthalmology
Su Ho Kim, Jung Suk Oh, Ho Jong Chun, Byung Gil Choi, Hae Giu Lee
PURPOSE: To compare the feasibility and safety of mono-port catheter system and dual-port catheter system for advanced hepatocellular carcinoma (HCC) in patients with anatomic hepatic artery variation and portal vein tumor thrombosis. MATERIALS AND METHODS: This retrospective study consisted of 22 patients with infiltrative or multiple HCC with unilateral or bilateral portal vein thrombosis who had hepatic artery variation. A mono-port or dual-port catheter system was determined according to the degree of blood supply to the entire tumor through the common hepatic and variant hepatic arteries...
October 5, 2018: Journal of Vascular and Interventional Radiology: JVIR
Hiromasa Endo, Kanako Takayama, Kenji Mitsudo, Tatsuya Nakamura, Ichiro Seto, Hisashi Yamaguchi, Takashi Ono, Motohisa Suzuki, Yusuke Azami, Hitoshi Wada, Masao Murakami, Iwai Tohnai
This study aimed to evaluate the therapeutic effect and toxicity of proton beam therapy in combination with intra-arterial infusion chemotherapy in patients with squamous cell carcinoma of the maxillary gingiva. Between December 2010 and March 2016, 30 patients with T4 squamous cell carcinoma of the maxillary gingiva were treated with radiotherapy and retrograde intra-arterial infusion chemotherapy using cisplatin (20⁻40 mg/m², 4⁻6 times). Radiotherapy was basically administered using boost proton beam therapy for primary tumor and neck lymph node tumors, following 36⁻40 Gy photon radiation therapy delivered to the prophylactic area, to a total dose of 70...
September 15, 2018: Cancers
Zachary K Goldsmith, William Coppess, Andrew S Irvine, Kelley Yuan, Samuel R Barsh, Madison K Ritter, Matthew W McEwen, Jacqueline Flores-Otero, Aileen Garcia-Vargas, Magaly Martinez-Ferrer, Rachel C Brennan, Vanessa M Morales-Tirado, Matthew W Wilson
Purpose: Vitreous seeding remains the primary reason for treatment failure in eyes with retinoblastoma (Rb). Systemic and intra-arterial chemotherapy, each with its own inherent set of complications, have improved salvage rates for eyes with advanced disease, but the location and biology of vitreous seeds present a fundamental challenge in developing treatments with minimal toxicity and risk. The aim of this study was to target the platelet-derived growth factor (PDGF)- PDGF-receptor β (PDGFRβ) signaling pathway and investigate its role in the growth of Rb seeds, apoptotic activity, and invasive potential...
September 4, 2018: Investigative Ophthalmology & Visual Science
Bin Huang, Jiabo Zheng, Zhijun Yao, Wenzhe Fan, Shaopeng Qiu, Lingwu Chen, Junxing Chen
PURPOSE: To assess the efficacy of intra-arterial chemotherapy (IAC) combined with intravesical chemotherapy (IVC) in T1G3 bladder cancer (Bca) after transurethral resection of bladder tumor (TURBT). METHODS: Our study retrospectively reviewed 200 patients with T1G3 BCa who had all undergone TURBT. The patients' medical records were divided into two groups, one group only had IVC with pirarubicin after surgery, and the other group had IAC (cisplatin and epirubicin) combined with IVC after surgery...
September 6, 2018: World Journal of Urology
Roberto Iezzi, Maurizio Pompili, Emanuele Rinninella, Eleonora Annicchiarico, Matteo Garcovich, Lucia Cerrito, Francesca Ponziani, AnnaMaria De Gaetano, Massimo Siciliano, Michele Basso, Maria Assunta Zocco, GianLodovico Rapaccini, Alessandro Posa, Francesca Carchesio, Marco Biolato, Felice Giuliante, Antonio Gasbarrini, Riccardo Manfredi
OBJECTIVES: To date, there is no approved second-line treatment for patients dismissing sorafenib or ineligible for this treatment, so it would be useful to find an effective alternative treatment option. The aim of our study was to evaluate safety, feasibility and effectiveness of transarterial chemoembolisation with degradable starch microspheres (DSM-TACE) in the treatment of patients with advanced hepatocellular carcinoma (HCC) dismissing or ineligible for multikinase-inhibitor chemotherapy administration (sorafenib) due to unbearable side effects or clinical contraindications...
August 31, 2018: European Radiology
Hyung-Il Seo, Dong-Il Kim, Youngsoo Chung, Chang In Choi, Minjoo Kim, Sungpil Yun, Suk Kim, Do Youn Park
Leiomyosarcoma of an artery is very rare, and cases with hepatic metastasis are even rarer. We describe a case of a 70-year-old man who after follow up due to rectal cancer, presented with an intra-abdominal hypervascular mass and a hepatic mass. After surgical resection, it was diagnosed as a leiomyosarcoma of the right gastroepiploic artery with hepatic metastasis. Multiple metastases had recurred at the liver. He has survived more than 53 mo through multimodal treatments (three surgical resections, radiofrequency ablation, transarterial chemoembolization, chemotherapies, and targeted therapy)...
August 16, 2018: World Journal of Clinical Cases
Miwako Nomura, Nobukazu Fuwa, Yutaka Toyomasu, Akinori Takada, Noriko Ii, Jouji Nomura, Hiroyuki Yamada
PURPOSE: We developed an external carotid arterial sheath (ECAS) for performing intra-arterial chemotherapy (IACT) via the superficial temporal artery for head and neck cancer. This study aimed to assess the potential of a novel microcatheter with a steerable tip inserted through the ECAS in comparison to an existing hook-type microcatheter. MATERIALS AND METHODS: The same operator used two types of microcatheters alternately for each weekly IACT session with the same patient, and the fluoroscopy time required for catheterization and the arterial selectivity of each microcatheter were compared...
October 2018: Japanese Journal of Radiology
Anabel Rodriguez, Santiago Zugbi, Flavio Requejo, Alejandra Deu, Claudia Sampor, Mariana Sgroi, Andrea Bosaleh, Adriana Fandiño, Paula Schaiquevich, Guillermo Chantada
Patients with retinoblastoma and central nervous system (CNS) involvement are rarely curable with available treatments. We designed a high-dose intra-arterial regimen targeting the ophthalmic artery and chiasm combined with intrathecal chemotherapy to treat a 4-year-old patient with retinoblastoma metastasized to the CNS. After three cycles of this regimen, including carboplatin, melphalan, and intrathecal topotecan, a partial response of the orbital tumor mass and chiasmatic lesion, and complete response in the cerebrospinal fluid and bone marrow were achieved...
December 2018: Pediatric Blood & Cancer
Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai
Background: Prognosis of patients with hepatocellular carcinoma (HCC) who undergo transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcatheter arterial infusion chemotherapy, is affected by many clinical factors including liver function and tumor progression. However, the effect of body composition such as skeletal muscle and visceral and subcutaneous adipose tissues (VAT and SAT, respectively) on the prognosis of these patients remains unclear...
2018: Cancer Management and Research
Nazanin Maani, Steven W Hetts, Vitaliy L Rayz
Two-scale CFD modeling is used to design and optimize a novel endovascular filtration device for removing toxins from flowing blood. The Chemofilter is temporarily deployed in the venous side of a tumor during the intra-arterial chemotherapy in order to filter excessive chemotherapy drugs such as Doxorubicin from the blood stream. The device chemically binds selective drugs to its surface thus filtering them from blood, after they have had the effect on the tumor and before they reach the heart and other organs...
July 31, 2018: Biomechanics and Modeling in Mechanobiology
Christina Stathopoulos, Alexandre Moulin, Marie-Claire Gaillard, Maja Beck-Popovic, Francesco Puccinelli, Francis L Munier
BACKGROUND/AIMS: To report conservative therapy in diffuse infiltrating retinoblastoma (DIR) and describe specific optic coherence tomography (OCT) features of the tumour. METHODS: Retrospective review of all DIR cases treated conservatively between 1998 and 2012. RESULTS: Three patients (three eyes) were included, cases 1 and 3 with previous enucleation of the contralateral eye and case 2 with unilateral retinoblastoma referred after prior pars plana vitrectomy with silicone oil...
July 26, 2018: British Journal of Ophthalmology
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