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Giola Santoni, Amaia Calderón-Larañaga, Davide L Vetrano, Anna-Karin Welmer, Nicola Orsini, Laura Fratiglioni
Background: Geriatric health charts that are similar to pediatric growth charts could facilitate monitoring health changes and predicting care needs in older adults. We aimed to validate an existing composite score (Health Assessment Tool [HAT]) and provide provisional age-specific reference curves for the general older population. Methods: Data came from the SNAC-K population study (n=3363 participants 60+ years examined clinically at baseline and 3 years later)...
December 4, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
R Laun, S Tanner, J-P Grassmann, J Schneppendahl, M Wild, M Hakimi, J Windolf, P Jungbluth
BACKGROUND: Radial head arthroplasty represents a widely accepted treatment for elbow injuries with non-reconstructible radial head fractures. The aim of this retrospective multicenter study was to assess mid-term results of patients with clearly defined elbow injuries including type III fractures of the radial head according to Mason's classification type III after primary arthroplasty using a cemented bipolar design. MATERIALS AND METHODS: In 45 cases a primary cemented bipolar arthroplasty of the radial head was implanted for elbow injuries combined with an acute Mason type III radial head fracture...
December 4, 2018: Musculoskeletal Surgery
Lei Yang, Dawei Ge, Xi Chen, Chunzhi Jiang, Shengnai Zheng
BACKGROUND/AIMS: To explore the potential role of miR-544a in spinal cord injury and the possible mechanism involved. METHODS: We established a mouse model with spinal cord injury to examine the changes in grip force recovery of the forelimb or the posterior limb of the mouse. Microarray was performed to achieve differentiated miRNAs in the mice. The expressions of miR-544a, MCP-1, IL36B and IL17B after spinal cord injury were detected by qRT-PCR. Subsequently, miR-544a was overexpressed to observe changes in inflammation and grip strength after spinal cord injury...
December 4, 2018: Cellular Physiology and Biochemistry
James F Nowak, Johnson Samuel
Minimally-assisted tooth repair (MaTR) systems are envisioned to be capable of substituting for the skill of a dentist. If successfully developed, MaTR systems could enable lower-skilled dental technicians to provide dental care at a fraction of the overall medical cost. This paper explores a key initial step towards the development of such systems by quantifying the machining responses of pristine human teeth relevant to dental preparation procedures. The working hypothesis of the study is that such findings will enable the benchmarking of key process planning and control metrics relevant for the future development of MaTR systems...
November 16, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Médéa Locquet, Charlotte Beaudart, Jean-Yves Reginster, Olivier Bruyère
The longitudinal relationship between bone health and muscle health is scarcely explored. We aimed to explore the relationship between bone decline and muscle decline over 1 year in older individuals. We used data from the SarcoPhAge cohort, which aims to identify the consequences of sarcopenia. In this way, this study also highlights the yearly changes in muscle mass (by dual-energy absorptiometry), muscle weakness (by grip strength), and/or physical performance (by the short physical performance battery test)...
December 3, 2018: Calcified Tissue International
A Yu, K L Yick, S P Ng, J Yip
Active and sports fashion in the high-end market focuses on fit, superior comfort and functional performance for various end-uses. However, the engineering design of sports gloves in relation to hand anthropometry measurements remains unclear. In this study, two types of ready-to-wear sport gloves, namely, war-gaming glove and hiking glove were purchased from the market. The glove dimensions, fabrication properties and the effect of glove fit on hand and finger dexterity were investigated. Thirty female individuals (20-29 years old) participated a series of hand performance tests and subjective perception rating assessments towards the gloves...
February 2019: Applied Ergonomics
Tod Clark, Sheila McRae, Jeff Leiter, Yiyang Zhang, Jamie Dubberley, Peter MacDonald
PURPOSE: The purpose of this randomized clinical trial was to determine whether quality of life and function, as measured using subjective questionnaires and clinical assessment, are different after open versus arthroscopic debridement of the pathologic extensor carpi radialis brevis origin in the treatment of lateral epicondylitis at 1 year postoperatively. METHODS: Patients older than 16 years with a minimum of 6 months of nonoperative management for lateral epicondylitis were recruited into this prospective, single-blinded randomized clinical trial...
December 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Jinyu Xu, Jun Shi, Jiaming Zhang, Yun Zhang
The present investigation evaluates the protective effect of vorinostat on neuronal cells in the traumatic brain injury (TBI) and also postulates the possible mechanism of its action. Marmarou's weight-drop model was used to induce the TBI. Further, animals were treated with vorinostat 100 mg/kg intraperitoneally 30 min before the TBI induction. Neurological score and brain water content were determined in all the groups and thereafter oxidative stress parameters and adenosine triphosphate (ATP) content were determined in the neuronal tissues of TBI mice...
2018: Folia Neuropathologica
Yi-Nan Gong, Jeremy Chase Crawford, Bradlee L Heckmann, Douglas R Green
Programmed cell death plays a central role in maintaining homeostasis. Various studies have demonstrated that programmed cell death is not a one-way street; cells can survive even when the core cell death processes are underway. Cell death initiation, prevention, and recovery function in a coordinated fashion to establish and maintain a homeostatic environment. In this review, we discuss how dying cells can be rescued from death's grip and the subsequent physiological consequences. We suggest a fundamental question to be answered-at least at the single cell level is, can we predict if a certain cell is more or less likely to survive or die? And importantly, what physiological and pathological consequences, as well as therapeutic approaches can we delineate from this ability to predict cell death versus survival...
December 1, 2018: FEBS Journal
R Srikanth, Koteswara Rao Rayidi, Subha Kakumanu
Introduction: The main deformity following an adult lower brachial plexus injury is the loss of finger flexion. Distal nerve transfers have been used to restore finger and thumb flexion followed by tendon transfers for intrinsic replacement for opening of the fingers. When patients present beyond 6 months, only tendon transfers are applicable. Since the brachioradialis (BR) is always spared in such injuries, it is the ideal muscle to provide finger flexion. Wrist extensor power may not be normal for the use of the radial wrist extensor to serve as donor...
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Carmen de Keijzer, Cathryn Tonne, Séverine Sabia, Xavier Basagaña, Antònia Valentín, Archana Singh-Manoux, Josep Maria Antó, Jordi Alonso, Mark J Nieuwenhuijsen, Jordi Sunyer, Payam Dadvand
There is increasing evidence of the health benefits of exposure to natural environments, including green and blue spaces. The association with physical functioning and its decline at older age remains to be explored. The aim of the present study was to investigate the longitudinal association between the natural environment and the decline in physical functioning in older adults. We based our analyses on three follow-ups (2002-2013) of the Whitehall II study, including 5759 participants (aged 50 to 74 years at baseline) in the UK...
November 28, 2018: Environment International
Francisco José Amo-Setién, César Leal-Costa, Rebeca Abajas-Bustillo, Domingo González-Lamuño, Carlos Redondo-Figuero
STUDY DESIGN: Cross-sectional. INTRODUCTION: The muscle strength has been studied in different populations in relation with individual and other factors. PURPOSE OF THE STUDY: The purpose of this study was to determine values of grip strength in adolescents and to examine its association with sex, age, weight, height, nutritional status, handedness, and academic performance. METHODS: A total of 452 adolescents (246 men and 206 women) aged 12 to 17 years were included in the study...
November 29, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Ameline Bardo, Laurent Vigouroux, Tracy L Kivell, Emmanuelle Pouydebat
Differences in grip techniques used across primates are usually attributed to variation in thumb-finger proportions and muscular anatomy of the hand. However, this cause-effect relationship is not fully understood because little is known about the biomechanical functioning and mechanical loads (e.g., muscle or joint forces) of the non-human primate hand compared to that of humans during object manipulation. This study aims to understand the importance of hand proportions on the use of different grip strategies used by humans, extant great apes (bonobos, gorillas and orangutans) and, potentially, fossil hominins (Homo naledi and Australopithecus sediba) using a musculoskeletal model of the hand...
December 2018: Journal of Human Evolution
Juha Suuronen, Samu Sjöblom, Marjo Tuppurainen, Risto Honkanen, Toni Rikkonen, Heikki Kröger, Joonas Sirola
OBJECTIVE: The aim of this cross-sectional study was to determine the association of hormonal contraception and other life-style factors and habits affecting body composition (BC) and muscle strength. STUDY DESIGN: We measured the body composition of 400 healthy Finnish women (aged 20-40 years) using total body dual energy x-ray absorptiometry (TB-DXA) as well as grip strength (GS [kPa]) with a hand-held dynamometer and knee extension strength (KES [kg]) between 2011 and 2014...
November 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Junjun Chen, Yaoyao Hao, Shaomin Zhang, Guanghao Sun, Kedi Xu, Weidong Chen, Xiaoxiang Zheng
BACKGROUND: The neural principles underlying reaching and grasping movements have been studied extensively in primates for decades. However, few experimental apparatuses have been developed to enable a flexible combination of reaching and grasping in one task in three-dimensional (3D) space. NEW METHOD: By combining a custom turning table with a 3D translational device, we have developed a highly flexible apparatus that enables the subject to reach multiple positions in 3D space, and grasp differently shaped objects with multiple grip types in each position...
November 28, 2018: Journal of Neuroscience Methods
Helmut Wegmann, Simon Heider, Michael Novak, Matthias Sperl, Tanja Kraus, Georg Singer, Holger Till
BACKGROUND: Only few reports have described the outcome of pediatric patients following radial head resection. Therefore, the aim of the present study was to assess clinical and radiologic outcome of patients with open physes following resection of the radial head. MATERIALS AND METHODS: Skeletally immature patients treated with resection of the radial head were included. Range of motion (ROM) of the elbow joint was compared with preoperative values. Grip strength, pronation and supination strength, and carrier angle were compared with the unaffected side...
November 27, 2018: Journal of Shoulder and Elbow Surgery
Irene Cabrera-Martos, Araceli Ortiz-Rubio, Irene Torres-Sánchez, Janet Rodríguez-Torres, Laura López-López, Marie Carmen Valenza
OBJECTIVE: To evaluate the effects of an intervention based on a specific set of goals on goal attainment, manual dexterity, hand grip strength and finger prehension force compared to a standardized approach in patients with Parkinson's disease. DESIGN: Randomized controlled trial. SETTING: Home-based. PARTICIPANTS: Fifty patients with a clinical diagnosis of Parkinson's disease acknowledging impaired manual ability were randomized into two groups...
December 3, 2018: Clinical Rehabilitation
Magalie Fréchou, Isabelle Margaill, Catherine Marchand-Leroux, Virginie Beray-Berthat
Efforts are still needed regarding the research of therapeutics for ischemic stroke. While in experimental studies the protective effect of pharmacological agents is often highlighted by a reduction of the lesion size evaluated in the short term (days), in clinical studies a functional recovery of patients suffering from stroke is expected on the long-term (months and years). Long-term functional preclinical studies are highly recommended to evaluate potential neuroprotective agents for stroke, rather than an assessment of the infarction size at a short time point...
November 27, 2018: Behavioural Brain Research
N F Miryutova, V A Vorobyev, I M Samoilova, A A Zaitsev, S V Alaitseva, O V Dostovalova, N N Minchenco
BACKGROUND: When choosing the algorithm of rehabilitative measures, the localization of the stroke, brain reserve, and neuroplasticity as well as clinical characteristics (motor, postural, speech, cognitive impairments), etc. are taken into consideration. Monitoring the health status of the patients is an integral component of and an important condition for the successful post-stroke rehabilitation. AIM: The objective of the present study was to evaluate the clinical, functional and psychological status of the patients with stroke during the early and late restorative periods...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
S Kim, C W Won, B S Kim, S Kim, J Yoo, S Byun, H C Jang, B L Cho, S J Son, J H Lee, Y S Park, K M Choi, H J Kim, S G Lee
OBJECTIVES: This study was conducted to determine the cutoff value and efficacy of the EuroQol Visual Analogue Scale (EQ-VAS) for predicting frailty. DESIGN: The EQ-VAS medians (Interquartile Range) were compared and analyzed against the FFI. PARTICIPANTS: The subjects were 1471 older adults aged 70 to 84 years who had completed both EQ-VAS and Fried Frailty index (FFI) in the first baseline year (2016) of the Korean Frailty and Aging Cohort Study...
2018: Journal of Nutrition, Health & Aging
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