Read by QxMD icon Read


Hiran Thabrew, Karolina Stasiak, Sarah E Hetrick, Stephen Wong, Jessica H Huss, Sally N Merry
BACKGROUND: Long-term physical conditions affect 10% to 12% of children and adolescents worldwide; these individuals are at greater risk of developing psychological problems, particularly anxiety and depression. Access to face-to-face treatment for such problems is often limited, and available interventions usually have not been tested with this population. As technology improves, e-health interventions (delivered via digital means, such as computers and smart phones and ranging from simple text-based programmes through to multimedia and interactive programmes, serious games, virtual reality and biofeedback programmes) offer a potential solution to address the psychological needs of this group of young people...
August 16, 2018: Cochrane Database of Systematic Reviews
Nitzan Kutnowski, Hagay Shmuely, Idit Dahan, Fania Shmulevich, Geula Davidov, Anat Shahar, Jerry Eichler, Raz Zarivach, Boaz Shaanan
Protein-DNA interactions are highly dependent on salt concentration. To gain insight into how such interactions are maintained in the highly saline cytoplasm of halophilic archaea, we determined the 3-D structure of VNG0258H/RosR, the first haloarchaeal DNA-binding protein from the extreme halophilic archaeon Halobactrium salinarum. It is a dimeric winged-helix-turn-helix (wHTH) protein with unique features due to adaptation to the halophilic environment. As ions are major players in DNA binding processes, particularly in the halophilic environments, we investigated the solution structure of the ionic envelope and located anions in the first shell around the protein in the crystal using anomalous scattering...
August 12, 2018: Journal of Structural Biology
A R Tellegen, I Rudnik-Jansen, M Beukers, A Miranda-Bedate, F C Bach, W de Jong, N Woike, G Mihov, J Thies, B P Meij, L B Creemers, M A Tryfonidou
Low back pain, related to degeneration of the intervertebral disc (IVD), affects millions of people worldwide. Clinical studies using oral cyclooxygenase-2 (COX-2) inhibitors have shown beneficial effects, although side-effects were reported. Therefore, intradiscal delivery of nonsteroidal anti-inflammatory drugs can be an alternative treatment strategy to halt degeneration and address IVD-related pain. In the present study, the controlled release and biologic potency of celecoxib, a selective COX-2 inhibitor, from polyesteramide microspheres was investigated in vitro...
August 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Rejitha John Raji, Roschen Sasikumar, Elizabeth Jacob
The Adenomatous Polyposis Coli (APC) gene is a multifunctional gene that plays a major role in regulating the Wnt signalling pathway. The Wnt pathway, when activated by Wnt signalling molecules, initiates cell division. Mutation of APC disrupts the regulation and causes continuous activation of the Wnt pathway even in the absence of Wnt signals, thus causing uncontrolled cell proliferation. APC regulates the Wnt pathway by controlling the formation of the nuclear complex β-catenin/TCF that initiates the transcription of the Wnt target genes...
August 12, 2018: Bio Systems
Gourhari Jana, Sudip Pan, Gabriel Merino, Pratim Kumar Chattaraj
Metal acetylides (MCCH, M = Cu, Ag, Au) were already reported to be experimentally detected in molecular form. Herein, we investigate the possibility of noble gas (Ng) insertion within C-H bond of MCCH and their stability is compared with those of the reported MNgCCH and HCCNgH molecules. Our coupled-cluster computations show that MCCNgH (Ng = Kr, Xe, Rn) systems corresponds to minima on the potential energy surfaces, whereas their lighter analogues do not remain in the chemically bound form. Further, their stability is analyzed with respect to all possible dissociation channels...
August 15, 2018: Journal of Physical Chemistry. A
Ka Wing Chan, Erwin Lam, Vincenza D'Anna, Florian Allouche, Carine Michel, Olga Safonova, Philippe Sautet, Christophe Copéret
In alkene metathesis, while group 6 (Mo or W) high-oxidation state alkylidenes are accepted to be key reaction intermediates for both homogeneous and heterogeneous catalysts, it has been proposed that low valent species in their +4 oxidation state can serve as pre-catalysts. However, the activation mechanism for these latter species - generating alkylidenes - is still an open question. Here, we report the syntheses of tungsten (IV)-oxo bisalkoxide molecular complexes stabilized by pyridine ligands, WO(OR)2py3 (R = CMe(CF3)2 (2a), R = Si(OtBu)3 (2b) and R = C(CF3)3 (2c); py = pyridine) and show that upon activation with B(C6F5)3, they display comparable alkene metathesis activities as W(VI)-oxo alkylidenes...
August 15, 2018: Journal of the American Chemical Society
Xing Liu, Hui-Qing Fan
The electron structure, elastic constant, Debye temperature and anisotropy of elastic wave velocity for cubic WO3 are studied using CASTEP based on density functional theory. The optimized structure is consistent with previous work and the band gap is obtained by computing the electronic structure; the top of the valence band is not at the same point as the bottom of the conduction band, which is an indirect band-gap oxide. Electronic properties are studied from the calculation of band structure, densities of states and charge densities...
June 2018: Royal Society Open Science
Muffy Calder, Claire Craig, Dave Culley, Richard de Cani, Christl A Donnelly, Rowan Douglas, Bruce Edmonds, Jonathon Gascoigne, Nigel Gilbert, Caroline Hargrove, Derwen Hinds, David C Lane, Dervilla Mitchell, Giles Pavey, David Robertson, Bridget Rosewell, Spencer Sherwin, Mark Walport, Alan Wilson
In order to deal with an increasingly complex world, we need ever more sophisticated computational models that can help us make decisions wisely and understand the potential consequences of choices. But creating a model requires far more than just raw data and technical skills: it requires a close collaboration between model commissioners, developers, users and reviewers. Good modelling requires its users and commissioners to understand more about the whole process, including the different kinds of purpose a model can have and the different technical bases...
June 2018: Royal Society Open Science
I Stewart, D Ilie, A Zamyatin, S Werner, M F Torshizi, W J Knottenbelt
Quantum computers are expected to have a dramatic impact on numerous fields due to their anticipated ability to solve classes of mathematical problems much more efficiently than their classical counterparts. This particularly applies to domains involving integer factorization and discrete logarithms, such as public key cryptography. In this paper, we consider the threats a quantum-capable adversary could impose on Bitcoin, which currently uses the Elliptic Curve Digital Signature Algorithm (ECDSA) to sign transactions...
June 2018: Royal Society Open Science
Shuo Zhang, Dongqing Wang, Feng Liu
Different from the output-input representation-based identification methods of two-block Hammerstein systems, this paper concerns a separate block-based parameter estimation method for each block of a two-block Hammerstein CARMA system, without combining the parameters of two parts together. The idea is to consider each block as a subsystem and to estimate the parameters of the nonlinear block and the linear block separately (interactively), by using two least-squares algorithms in one recursive step. The internal variable between the two blocks (the output of the nonlinear block, and also the input of the linear block) is replaced by different estimates: when estimating the parameters of the nonlinear part, the internal variable between the two blocks is computed by the linear function; when estimating the parameters of the linear part, the internal variable is computed by the nonlinear function...
June 2018: Royal Society Open Science
Xiaowei Li, Lei Li, Qiong-Hua Wang
We propose a new computational integral imaging (CII) method via the iterative perfect reconstruction technique to improve the visual quality of reconstructed 3D scenes. As is well known, images reconstructed by CII suffer from artifacts and, as a result, degradation of visual quality. As solutions to this problem, the regularization and iterative back-projection (IBP)-based super-resolution (SR) reconstruction algorithms have been shown to be effective for high-visual-quality reconstruction. However, computation of the regularization algorithm is very expensive, and the IBP algorithm is very sensitive to noise in the deblurring process...
July 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Lionel Simonot, Mathieu Hébert, Morgane Gérardin, Cyrielle Monpeurt, Thierry Fournel
Strongly scattering supports coated with thick transparent medium display a bright halo with a characteristic ring shape when illuminated in one point by a thin pencil of light. The halo, whose size is related to the coating thickness, is due to the Fresnel internal reflections of the light scattered by the diffusing support at the coating-air interface. The angular distribution of the reflected light strongly varies over the halo according to the distance from the point initially illuminated, a fact that cannot be observed when a large area of the surface is illuminated as in usual reflectance and bidirectional reflectance distribution function measurements...
July 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Wang Wan-Jun, Wu Zhen-Sen
The propagation characteristics of annular cos-Gaussian beams and Bessel-Gaussian beams in turbulence have been widely investigated. However, the expression of the average intensity of Bessel-Gaussian beams involves a complex double integral, which requires large computational resources and does not easily ensure accuracy. Under this background, through the general cos-Gaussian beam rotation, a new annular cos-Gaussian beam is proposed which not only has some properties of the general cos-Gaussian beam, but also properties similar to those of the Bessel-Gaussian beam...
July 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Yoshito H Ono, Carlos Correia, Rodolphe Conan, Leonardo Blanco, Benoit Neichel, Thierry Fusco
Tomographic wavefront reconstruction is the main computational bottleneck to realize real-time correction for turbulence-induced wavefront aberrations in future laser-assisted tomographic adaptive-optics (AO) systems for ground-based giant segmented mirror telescopes because of its unprecedented number of degrees of freedom, N, i.e., the number of measurements from wavefront sensors. In this paper, we provide an efficient implementation of the minimum-mean-square error (MMSE) tomographic wavefront reconstruction, which is mainly useful for some classes of AO systems not requiring multi-conjugation, such as laser-tomographic AO, multi-object AO, and ground-layer AO systems, but is also applicable to multi-conjugate AO systems...
August 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Konstantin N Pichugin, Dmitrii N Maksimov, Almas F Sadreev
We consider reflection of the Laguerre-Gaussian light beams by a dielectric slab. In view of the unified operator approach, the higher-order Laguerre-Gaussian beams represent a parametric family with the transverse beam profile given by an arbitrary generating parameter. Relying on the Fourier expansion in the focal plane of the beam, we compute the Goos-Hänchen and the Imbert-Fedorov shifts for light beams with non-zero order and azimuthal index. It is demonstrated that both shifts exhibit resonant behavior as functions of the angle of incidence due to the interference between the waves reflected from the upper and lower interfaces...
August 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
D Zola, C Circi, G Vulpetti, S Scaglione
The solar photon sail (SPS) allows space missions without propellant that would otherwise not be feasible. Thrust models frequently used in the literature for the calculation of trajectories often underestimate the effect that the surface roughness has on SPS dynamics. A small variation of the thrust vector can induce a large modification of sail flight. In this work, the variation of the photon momentum vector (PMV) is computed as resulting from the incident Sun radiation, taking into account the absorbed and reflected photons...
August 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Jeffrey J Field, Keith A Wernsing, Jeff A Squier, Randy A Bartels
We derive analytic expressions for the three-dimensional coherent transfer function (CTF) and coherent spread function (CSF) for coherent holographic image reconstruction by phase transfer (CHIRPT) microscopy with monochromatic and broadband illumination sources. The 3D CSF and CTF were used to simulate CHIRPT images, and the results show excellent agreement with experimental data. Finally, we show that the formalism presented here for computing the CSF/CTF pair in CHIRPT microscopy can be readily extended to other forms of single-pixel imaging, such as spatial-frequency-modulated imaging...
August 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Reinier Doelman, Nguyen H Thao, Michel Verhaegen
We present a convex relaxation-based algorithm for large-scale general phase retrieval problems. General phase retrieval problems include, e.g., the estimation of the phase of the optical field in the pupil plane based on intensity measurements of a point source recorded in the image (focal) plane. The non-convex problem of finding the complex field that generates the correct intensity is reformulated into a rank constraint problem. The nuclear norm is used to obtain the convex relaxation of the phase retrieval problem...
August 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Arif Jetha, Nels Thorsteinson, Yazen Jmeian, Ajitha Jeganathan, Patricia Giblin, Johan Fransson
Monoclonal antibody (mAb) candidates from high-throughput screening or binding affinity optimization often contain mutations leading to liabilities for further development of the antibody, such as aggregation-prone regions and lack of solubility. In this work, we optimized a candidate integrin α11-binding mAb for developability using molecular modeling, rational design, and hydrophobic interaction chromatography (HIC). A homology model of the parental mAb Fv region was built, and this revealed hydrophobic patches on the surface of the complementarity-determining region loops...
August 15, 2018: MAbs
Megan T Cray, Daniel I Spector, Chadwick L West
CASE DESCRIPTION A5.5-year-old sexually intact male Bull Terrier was referred for evaluation because of sudden facial swelling and an inability to close its mouth. CLINICAL FINDINGS Physical examination revealed bilaterally elevated nictitating membranes, an inability to adduct the mandible without assistance, and severe, diffuse, firm masticatory muscle swelling. Computed tomographic examination of the head revealed symmetric bilateral enlargement of the temporalis, masseter, and pterygoid muscles with heterogeneous contrast enhancement...
September 1, 2018: Journal of the American Veterinary Medical Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"