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https://www.readbyqxmd.com/read/30550621/a-facile-on-bead-method-for-fully-symmetric-tetra-substituted-dota-derivatizations-using-peptoid-moieties
#1
Vineeta Rustagi, D Gomika Udugamasooriya
The metal-chelated 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) has made a significant impact on the field of diagnostic imaging. This imaging mechanism is largely dependent on the four side arm functionalities around the DOTA scaffold. We previously demonstrated the effect of peptoid residue modification on these DOTA side arms, thereby conferring diverse physiochemical properties to the imaging mechanism. We generated two on-bead Eu(III)-DOTA libraries with three side arm modifications, where the remaining arm was used to attach DOTA onto the resin...
December 14, 2018: Biopolymers
https://www.readbyqxmd.com/read/30515698/significant-association-of-tox3-loc643714-locus-rs3803662-and-breast-cancer-risk-in-a-cohort-of-iranian-population
#2
Amir Tajbakhsh, Fahimeh Afzal Javan, Mahdi Rivandi, Atefeh Moezzi, Soheila Abedini, Mahla Asghari, Zahra Farjami, Hosein Soltanian, Fatemeh Homaei Shandiz, Mohammad Mahdi Kooshyar, Alireza Pasdar
Genome-wide association studies normally focus on low penetrance and moderate to high-frequency single nucleotide polymorphisms (SNPs), which lead to genetic susceptibility to breast cancer. In this regard, the T allele of rs3803662 has been associated with breast cancer risk and with lower expression level of TOX3. We aimed to assess the risk of breast cancer associated with this polymorphism in an Iranian population. Using Tetra Primer ARMS PCR, rs3803662 was analyzed in a total of 943 individuals (430 cases and 513 healthy controls form North East of Iran)...
December 4, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30513588/the-er-stress-inducer-l-azetidine-2-carboxylic-acid-elevates-the-levels-of-phospho-eif2%C3%AE-and-of-lc3-ii-in-a-ca-2-dependent-manner
#3
Gemma Roest, Evelien Hesemans, Kirsten Welkenhuyzen, Tomas Luyten, Nikolai Engedal, Geert Bultynck, Jan B Parys
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to reduce protein load and restore homeostasis, including via induction of autophagy. We used the proline analogue l-azetidine-2-carboxylic acid (AZC) to induce ER stress, and assessed its effect on autophagy and Ca2+ homeostasis. Treatment with 5 mM AZC did not induce poly adenosine diphosphate ribose polymerase (PARP) cleavage while levels of binding immunoglobulin protein (BiP) and phosphorylated eukaryotic translation initiation factor 2α (eIF2α) increased and those of activating transcription factor 6 (ATF6) decreased, indicating activation of the protein kinase RNA-like ER kinase (PERK) and the ATF6 arms of the UPR but not of apoptosis...
November 30, 2018: Cells
https://www.readbyqxmd.com/read/30478747/development-and-application-of-low-cost-t-arms-pcr-assay-for-agt-and-cyp11b1-gene-polymorphisms
#4
Misbah Hussain, Haq Nawaz Khan, Fazli Rabbi Awan
Angiotensin II (Ang II: a truncated octapeptide of angiotensinogen, AGT) and 11-β-hydroxylase influence regulation of blood pressure. Dysregulation of Ang II and 11-β-hydroxylase can lead to hypertension and elevate aldosterone levels. Polymorphisms in AGT (encodes AGT) and CYP11B1 (encodes 11-β-hydroxylase) shift the paradigm from physiological to pathological. Currently, various high-throughput techniques are used to genotype these polymorphisms. These techniques require expensive infrastructure and reagents...
November 26, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30474684/strategic-synthesis-of-cu-2-cu-4-and-cu-5-complexes-inhibition-and-triggering-of-ligand-arm-hydrolysis-and-self-aggregation-by-chosen-ancillary-bridges
#5
Manisha Das, Angelos B Canaj, Valerio Bertolasi, Mark Murrie, Debashis Ray
The Schiff base ligand HL1 ({2,6-bis(allylimino)methyl}-4-methylphenol) having no coordinating donor arm has been examined for its reaction medium and ancillary bridge dependent reactivity for a hierarchical family of CuII complexes. The ligand showed a unique reactivity pattern toward CuII in solution. The bridging nature of in situ generated HO- ions in the absence and presence of externally added carboxylates (RCOO-; R = CF3, C6H5 and CH3) has been utilized to produce complexes {[Cu2(μ-L2)2(H2O)]2[Cu2(μ-L2)2(H2O)2](ClO4)6} (1) (HL2 = 3-{(allylimino)methyl}-2-hydroxy-5-methylbenzaldehyde), [Cu4(μ4-O)(μ-L1)2(μ1,3-O2CCF3)4] (2), [Cu4(μ4-O)(μ-L1)2(μ1,3-O2CC6H5)4]·H2O (3), and [Cu5(μ3-OH)2(μ-L1)2(μ1,3-OAc)2(OAc)2(H2O)4][Cu5(μ3-OH)2(μ-L1)2(μ1,3-OAc)2(OAc)3(H2O)](ClO4)3·2C2H5OH (4)...
November 26, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30456721/association-of-shmt1-maz-erg-and-l3mbtl3-gene-polymorphisms-with-susceptibility-to-multiple-sclerosis
#6
Seyede Zahra Nazari Mehrabani, Mohammad Hossein Shushizadeh, Mohammad Foad Abazari, Maryam Nouri Aleagha, Abbas Ardalan, Rasoul Abdollahzadeh, Asaad Azarnezhad
Multiple sclerosis (MS) is the most common inflammatory and chronic disease of the central nervous system (CNS). A complex interaction between genetic, environmental, and epigenetic factors is involved in the pathogenesis of MS. With the advancement of GWAS, various variants associated with MS have been identified. This study aimed to evaluate the association of single-nucleotide polymorphisms (SNPs) rs4925166 and rs1979277 in the SHMT1, MAZ rs34286592, ERG rs2836425, and L3MBTL3 rs4364506 with MS. In this case-control study, the association of five SNPs in SHMT1, MAZ, ERG, and L3MBTL3 genes with relapsing-remitting MS (RR-MS) was investigated in 190 patients and 200 healthy individuals...
November 19, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/30447310/interleukin-33-gene-expression-and-rs1342326-polymorphism-in-beh%C3%A3-et-s-disease
#7
Mahsa Talei, Ali Abdi, Dariush Shanebandi, Farhad Jadidi-Niaragh, Alireza Khabazi, Farhad Babaie, Shahriar Alipour, Babak Afkari, Ebrahim Sakhinia, Zohreh Babaloo
OBJECTIVE: Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the current study, we investigated the association of IL-33 gene rs1342326 polymorphism and expression levels of this gene in peripheral blood mononuclear cells (PBMCs) with the susceptibility to BD in Azari population of Iran...
November 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30430339/breast-cancer-risk-associated-with-brca1-2-variants-in-the-pakistani-population
#8
Saba Abbas, Ayesha Siddique, Naeem Shahid, Rabbia Tariq Khan, Warda Fatima
BACKGROUND: Majority of the BRCA1 and BRCA2 mutations are associated with the risk of sporadic and familial breast cancer. Since these genes are significant in DNA repair mechanisms, we focused homology-directed DNA repair (HDDR) and BRCA complex. METHODS: We selected BRCA1 variant (rs80356932, 4491C/T) and BRCA2 variant (rs80359182, 319T/C) from the interaction region of BRCA complex and studied in 100 breast cancer patients and 100 controls using tetra-ARMS-PCR...
November 14, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/30410168/association-of-vaspin-levels-and-its-snp-rs2236242-with-gestational-diabetes-at-a-tertiary-care-setting-research-article
#9
Karishma Kanhya Lal, Rabail Jarwar, Sabah Farhat, Seyda Sadia Fatima
OBJECTIVE: To evaluate and correlate vaspin levels and genotype frequency in gestational diabetes mellitus. METHODS: The case-control study was conducted at Aga Khan University, Karachi, from November 2015 to December 2016, and comprised pregnant women in their second trimester with gestational diabetes mellitus. Healthy pregnant women with similar characteristics were enrolled as the control group. Tetra arms amplification system for vaspin gene was performed. SPSS 21 was used for data analysis...
November 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30390221/efficacy-and-safety-of-cannabidiol-in-epilepsy-a-systematic-review-and-meta-analysis
#10
REVIEW
Simona Lattanzi, Francesco Brigo, Eugen Trinka, Gaetano Zaccara, Claudia Cagnetti, Cinzia Del Giovane, Mauro Silvestrini
BACKGROUND: Approximately one-third of patients with epilepsy presents seizures despite adequate treatment. Hence, there is the need to search for new therapeutic options. Cannabidiol (CBD) is a major chemical component of the resin of Cannabis sativa plant, most commonly known as marijuana. The anti-seizure properties of CBD do not relate to the direct action on cannabinoid receptors, but are mediated by a multitude of mechanisms that include the agonist and antagonist effects on ionic channels, neurotransmitter transporters, and multiple 7-transmembrane receptors...
November 3, 2018: Drugs
https://www.readbyqxmd.com/read/30384759/small-angle-scattering-study-of-tetra-poly-acrylic-acid-gels
#11
Ken Morishima, Xiang Li, Kazuyuki Oshima, Yoshiro Mitsukami, Mitsuhiro Shibayama
Tetra-poly(acrylic acid) (tetra-PAA) gels were fabricated by cross-end coupling of azide (-N3 ) and alkyne (-C≡CH) terminated tetra-arm poly( tert -butyl acrylate)s. The structures of the tetra-PAA gels and their sols (tetra-PAA sols, i.e., tetra-PAA macromer solutions obtained by deprotection of tert -butyl groups) were investigated by small-angle X-ray and small-angle neutron scattering experiments in methanol, salt-free aqueous media, and salt solutions. The scattering functions, I ( q ), of the tetra-PAA sols in methanol were described by the Ornstein-Zernike (OZ) function, <mml:math xmlns:mml="http://www...
October 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/30345492/il-6-genomic-variants-and-risk-of-prostate-cancer
#12
Mohammad Taheri, Rezvan Noroozi, Azadeh Rakhshan, Molud Ghanbari, Mir Davood Omrani, Soudeh Ghafouri-Fard
PURPOSE: To evaluate the role of Interleukin-6 (IL-6) single nucleotide polymorphisms in prostate cancer (PCa) and benign prostate hyperplasia (BPH)Material and Methods: We genotyped two IL-6 intronic variants (rs1800795 and rs2069845) in PCa cases, BPH cases and healthy men referred to Labbafinejad and Shohadaye Tajrish Medical Centers using tetra ARMS-PCR method. RESULTS: The study included 130 PCa cases, 200 BPH cases and 200 healthy men. The C allele of rs1800795 was associated with PCa risk in the assessed population (OR (95% CI) = 1...
October 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/30335238/classical-hla-alleles-tag-snp-in-families-from-antioquia-with-type-1-diabetes-mellitus
#13
Diana Clobeth Sarrazola, Alejandra Marcela Rodríguez, Martín Toro, Alejandra Vélez, Jorge García-Ramírez, María Victoria Lopera, Cristiam M Álvarez, Vital Balthazar González, Juan Manuel Alfaro, Nicolás Pineda-Trujillo
Introduction: The HLA region strongly associates with autoimmune diseases, such as type 1 diabetes. An alternative way to test classical HLA alleles is by using tag SNP. A set of tag SNP for several classical HLA alleles has been reported as associated with susceptibility or resistance to this disease in Europeans. Objective: We aimed at validating the methodology based on tag SNP focused on the inference of classical HLA alleles, and at evaluating their association with type 1 diabetes mellitus in a sample of 200 families from Antioquia...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/30317347/determination-of-reference-intervals-of-thyroid-markers-during-pregnancy-in-urban-area-of-district-rawalpindi-pakistan
#14
Mehwish Gilani, Naveed Asif, Ammad Akram, Mehreen Gilani, Aamir Ijaz, Saima Shakil Malik
OBJECTIVE: To determine the reference values for thyroid stimulating hormone, free tetra-iodothyronine and total tri-iodothyronine for healthy pregnant women. METHODS: This cross sectional study was conducted at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January 2016 to June 2017. Pregnant women with normal, single intrauterine, uncomplicated pregnancy were recruited from the local population. Blood sample was taken to analyse thyroid stimulating hormone, free tetra-iodothyronine and total tri-iodothyronine using chemiluminescence immunoassay...
October 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30262699/detection-of-c-139g-a-d47n-mutation-in-gja8-gene-in-an-extended-family-with-inheritance-of-autosomal-dominant-zonular-cataract-without-pulverulent-opacities-by-exome-sequencing
#15
Padma Gunda, Mamata Manne, Syed Saifuddin Adeel, Ravi Kumar Reddy Kondareddy, Padma Tirunilai
The aim of this studywas to identify the gene causing bilateral autosomal dominant zonular congenital cataract (ADZCC) without pulverulent opacities in an extended Muslim family by exome sequencing and subsequent analysis. An extended family of 37 members (14 affected and 23 unaffected) who belong to different nuclear families was screened for causative gene. Proband and her unaffected son were screened for causative variant by exome sequencing followed by Sanger sequencing of the proband's entire nuclear family...
September 2018: Journal of Genetics
https://www.readbyqxmd.com/read/30252014/biosurfactant-functionalized-porphyrin-chromophore-that-forms-j-aggregates
#16
Shekar Mekala, Kyle C Peters, Kenneth D Singer, Richard A Gross
Structurally complex biosynthesized building blocks whose structures can be systematically varied are of great interest for the synthesis of manipulable self-organizing supramolecular systems. Sophorolipids (SLs) are an important class of glycolipid biosurfactants that consists of a sophorose (glucose disaccharide) polar head group that allows structural diversification by full or selective acetylation at the 6'- and 6''-positions. Porphyrins are a group of naturally-occurring heterocyclic macromolecular organic compounds that have efficient charge transfer properties...
October 10, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/30222353/ion-gel-network-formation-in-an-ionic-liquid-studied-by-time-resolved-small-angle-neutron-scattering
#17
Kei Hashimoto, Kenta Fujii, Kengo Nishi, Mitsuhiro Shibayama
We report the time-resolved small-angle neutron scattering (SANS) study of tetra-arm poly(ethylene glycol) (TetraPEG) polymer network formation in a typical ionic liquid (IL), 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide ([C2 mim][TFSA]). To observe time-dependent SANS profiles, the reaction rate for the AB-type cross-end coupling reaction of TetraPEG macromers was controlled by adding an analogous protic IL, 1-ethylimidazolium TFSA ([C2 imH][TFSA]). At polymer concentrations higher than the overlap concentration ( c*), the SANS profile remained unchanged during the gelation reaction, indicating that the network structure was independent of macromer connectivity in a semidiluted solution...
September 27, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/30192416/the-association-between-st18-gene-polymorphism-and-severe-pemphigus-disease-among-iranian-population
#18
Ifa Etesami, Hassan Seirafi, Narges Ghandi, Hamzeh Salmani, Maedeh Arabpour, Ali Nasrollahzadeh, Amir Teimourpour, Maryam Daneshpazhooh, Mohammad Keramatipour
Recently, ST18 polymorphism has played a role in increasing the risk of pemphigus among some populations such as Egyptian and Jewish. In addition, a variant within the ST18 promoter gene was shown to induce ST18 upregulation and cytokine secretion leading to keratinocyte susceptibility to anti-desmoglein antibodies. Thus, the present study aimed to assess the ST18 single nucleotide polymorphisms (SNP) relationship with pemphigus, disease severity and family history among Iranian population. A total of 111 pemphigus patients and 201 healthy controls were genotyped for three ST18 SNPs rs2304365, rs10504140 and rs4074067 by using TETRA-ARMS PCR method...
September 7, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/30192358/a-rapidly-recoverable-shape-memory-polymer-with-a-topologically-well-controlled-poly-ethyl-methacrylate-structure
#19
Jingjuan Lai, Xingjian Li, Ruiqing Wu, Jinni Deng, Yi Pan, Zhaohui Zheng, Xiaobin Ding
Many of the unique properties of a conventionally crosslinked shape memory network are not found at the same time, and this is a large challenge for the development of advanced shape memory functional materials. In this work, a topologically well-controlled network shape memory poly(ethyl methacrylate) (CN-SMPEMA) is designed and fabricated by introducing two tetra-armed functional structures simultaneously as well-defined structure units to promote switch segment and net-point uniform distribution via the combined technology of the unique controllable atom transfer radical polymerization (ATRP) and copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC)...
September 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/30149365/the-role-of-epidermal-growth-factor-receptor-egfr-common-gene-mutations-in-iranian-women-with-uterine-fibroids
#20
Paria Nikpey, Tahereh Nazari, Shadi Khalili, Ahmad Ebrahimi
OBJECTIVE: Uterine myomas are benign uterine tumors that originate from smooth muscle cells of the myometrium. This common complication can be associated with irreversible complications, including infertility and malignancy. Better understanding of the genetic characteristics of myoma may effect on treatment. Epidermal growth factor receptor gene (EGFR) is one of the most important genes that has the major role in the pathogenesis of myoma, cell growth, differentiation, proliferation and mutagenesis...
August 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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