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“Erick Turner”

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https://www.readbyqxmd.com/read/30271944/small-sample-sizes-reduce-the-replicability-of-task-based-fmri-studies
#1
Benjamin O Turner, Erick J Paul, Michael B Miller, Aron K Barbey
Despite a growing body of research suggesting that task-based functional magnetic resonance imaging (fMRI) studies often suffer from a lack of statistical power due to too-small samples, the proliferation of such underpowered studies continues unabated. Using large independent samples across eleven tasks, we demonstrate the impact of sample size on replicability, assessed at different levels of analysis relevant to fMRI researchers. We find that the degree of replicability for typical sample sizes is modest and that sample sizes much larger than typical (e...
2018: Communications biology
https://www.readbyqxmd.com/read/30261934/hiding-negative-trials-by-pooling-them-a-secondary-analysis-of-pooled-trials-publication-bias-in-fda-registered-antidepressant-trials
#2
Ymkje Anna de Vries, Annelieke M Roest, Erick H Turner, Peter de Jonge
BACKGROUND: Previous studies on reporting bias generally examined whether trials were published in stand-alone publications. In this study, we investigated whether pooled-trials publications constitute a specific form of reporting bias. We assessed whether negative trials were more likely to be exclusively published in pooled-trials publications than positive trials and examined the research questions, individual trial results, and conclusions presented in these articles. METHODS: Data from a cohort of 105 randomized controlled trials of 16 antidepressants were extracted from earlier publications and the corresponding Food and Drug Administration (FDA) reviews...
September 28, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/30178024/financial-conflicts-of-interest-among-oncologist-authors-of-reports-of-clinical-drug-trials
#3
Cole Wayant, Erick Turner, Chase Meyer, Philip Sinnett, Matt Vassar
No abstract text is available yet for this article.
October 1, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30035274/machine-learning-for-large-scale-quality-control-of-3d-shape-models-in-neuroimaging
#4
Dmitry Petrov, Boris A Gutman, Shih-Hua Julie Yu, Theo G M van Erp, Jessica A Turner, Lianne Schmaal, Dick Veltman, Lei Wang, Kathryn Alpert, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Christopher R K Ching, Vince Calhoun, David Glahn, Theodore D Satterthwaite, Ole Andreas Andreasen, Stefan Borgwardt, Fleur Howells, Nynke Groenewold, Aristotle Voineskos, Joaquim Radua, Steven G Potkin, Benedicto Crespo-Facorro, Diana Tordesillas-Gutiérrez, Li Shen, Irina Lebedeva, Gianfranco Spalletta, Gary Donohoe, Peter Kochunov, Pedro G P Rosa, Anthony James, Udo Dannlowski, Bernhard T Baune, André Aleman, Ian H Gotlib, Henrik Walter, Martin Walter, Jair C Soares, Stefan Ehrlich, Ruben C Gur, N Trung Doan, Ingrid Agartz, Lars T Westlye, Fabienne Harrisberger, Anita Riecher-Rössler, Anne Uhlmann, Dan J Stein, Erin W Dickie, Edith Pomarol-Clotet, Paola Fuentes-Claramonte, Erick Jorge Canales-Rodríguez, Raymond Salvador, Alexander J Huang, Roberto Roiz-Santiañez, Shan Cong, Alexander Tomyshev, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Valentina Ciullo, Elliot Hong, Geraldo Busatto, Marcus V Zanetti, Mauricio H Serpa, Simon Cervenka, Sinead Kelly, Dominik Grotegerd, Matthew D Sacchet, Ilya M Veer, Meng Li, Mon-Ju Wu, Benson Irungu, Esther Walton, Paul M Thompson
As very large studies of complex neuroimaging phenotypes become more common, human quality assessment of MRI-derived data remains one of the last major bottlenecks. Few attempts have so far been made to address this issue with machine learning. In this work, we optimize predictive models of quality for meshes representing deep brain structure shapes. We use standard vertex-wise and global shape features computed homologously across 19 cohorts and over 7500 human-rated subjects, training kernelized Support Vector Machine and Gradient Boosted Decision Trees classifiers to detect meshes of failing quality...
September 2017: Machine Learning in Medical Imaging
https://www.readbyqxmd.com/read/29628364/antidepressants-might-work-for-people-with-major-depression-where-do-we-go-from-here
#5
Andrea Cipriani, Georgia Salanti, Toshi A Furukawa, Matthias Egger, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Lauren Z Atkinson, Anna Chaimani, Julian P T Higgins, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
No abstract text is available yet for this article.
June 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29477251/comparative-efficacy-and-acceptability-of-21-antidepressant-drugs-for-the-acute-treatment-of-adults-with-major-depressive-disorder-a-systematic-review-and-network-meta-analysis
#6
REVIEW
Andrea Cipriani, Toshi A Furukawa, Georgia Salanti, Anna Chaimani, Lauren Z Atkinson, Yusuke Ogawa, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Julian P T Higgins, Matthias Egger, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
BACKGROUND: Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder...
April 7, 2018: Lancet
https://www.readbyqxmd.com/read/29073958/status-of-early-career-academic-cardiology-a-global-perspective
#7
REVIEW
Carl W Tong, Meena S Madhur, Anne K Rzeszut, Marwah Abdalla, Islam Abudayyeh, Erick Alexanderson, Jonathan Buber, Dmitriy N Feldman, Rakesh Gopinathannair, Ravi S Hira, Andrew M Kates, Thorsten Kessler, Steve Leung, Satish R Raj, Erica S Spatz, Melanie B Turner, Anne Marie Valente, Kristin West, Chittur A Sivaram, Joseph A Hill, Douglas L Mann, Andrew M Freeman
Early-career academic cardiologists, who many believe are an important component of the future of cardiovascular care, face myriad challenges. The Early Career Section Academic Working Group of the American College of Cardiology, with senior leadership support, assessed the progress of this cohort from 2013 to 2016 with a global perspective. Data consisted of accessing National Heart, Lung, and Blood Institute public information, data from the American Heart Association and international organizations, and a membership-wide survey...
October 31, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28692793/rare-x-chromosome-abnormalities-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome
#8
Rohan Sharma, Valerie M Harris, Joshua Cavett, Biji T Kurien, Ke Liu, Kristi A Koelsch, Anum Fayaaz, Kaustubh S Chaudhari, Lida Radfar, David Lewis, Donald U Stone, C Erick Kaufman, Shibo Li, Barbara Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Jennifer A Kelly, Bernardo Pons-Estel, Roland Jonsson, Xianglan Lu, Jacques-Eric Gottenberg, Juan-Manuel Anaya, Deborah S Cunninghame-Graham, Andrew J W Huang, Michael T Brennan, Pamela Hughes, Ilias Alevizos, Corinne Miceli-Richard, Edward C Keystone, Vivian P Bykerk, Gideon Hirschfield, Gunnel Nordmark, Sara Magnusson Bucher, Per Eriksson, Roald Omdal, Nelson L Rhodus, Maureen Rischmueller, Michael Rohrer, Marie Wahren-Herlenius, Torsten Witte, Marta Alarcón-Riquelme, Xavier Mariette, Christopher J Lessard, John B Harley, Wan-Fai Ng, Astrid Rasmussen, Kathy L Sivils, R Hal Scofield
OBJECTIVE: Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both diseases are more commonly found in women than in men, at a ratio of ~10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease, suggesting a dose effect on the X chromosome. METHODS: We examined cohorts of SS and SLE patients by constructing intensity plots of X chromosome single-nucleotide polymorphism alleles, along with determining the karyotype of selected patients...
November 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28639505/rationale-and-design-of-the-multiethnic-pharmacogenomics-in-childhood-asthma-consortium
#9
Niloufar Farzan, Susanne J Vijverberg, Anand K Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus Bønnelykke, Esteban G Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M Cloutier, Denis Daley, Herman T Den Dekker, F Nicole Dijk, Liesbeth Duijts, Carlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnik, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme, Anke H Maitland-van der Zee
AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium...
July 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28407390/enantioselective-chemo-and-biocatalysis-partners-in-retrosynthesis
#10
REVIEW
Moritz Hönig, Philipp Sondermann, Nicholas J Turner, Erick M Carreira
Recent developments of stereoselective biocatalytic and chemocatalytic methods are discussed. The review provides a guide to the use of biocatalytic methods in the area of chemical synthesis with focused attention on retrosynthetic considerations and analysis. The transformations presented are organized according to bond disconnections and attendant synthetic methods. The review is expected to lead to better understanding of the characteristics and distinctions of the two complementary approaches. It depicts for researchers in bio- and chemocatalysis a road map of challenges and opportunities for the evolution (and at times revolution) in chemical synthesis...
April 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28360236/spin-in-rcts-of-anxiety-medication-with-a-positive-primary-outcome-a-comparison-of-concerns-expressed-by-the-us-fda-and-in-the-published-literature
#11
Lian Beijers, Bertus F Jeronimus, Erick H Turner, Peter de Jonge, Annelieke M Roest
OBJECTIVES: This study aimed to determine the presence of spin in papers on positive randomised clinical trials (RCTs) of antidepressant medication for anxiety disorders by comparing concerns expressed in the Food and Drug Administration (FDA) reviews with those expressed in the published paper. METHODS: For every positive anxiety medication trial with a matching publication (n=41), two independent reviewers identified the concerns raised in the US FDA reviews and those in the published literature...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/27659240/bias-in-the-reporting-of-harms-in-clinical-trials-of-second-generation-antidepressants-for-depression-and-anxiety-a-meta-analysis
#12
REVIEW
Ymkje Anna de Vries, Annelieke M Roest, Lian Beijers, Erick H Turner, Peter de Jonge
Previous research has shown that reporting bias has inflated the apparent efficacy of antidepressants. We investigated whether apparent safety was also affected. We included 133 trials, involving 31,296 patients, of second-generation antidepressants for the treatment of major depressive disorder (MDD) or anxiety disorders, obtained from Food and Drug Administration (FDA) reviews. We extracted data on overall discontinuation, discontinuation due to adverse events, and serious adverse events (SAEs). Meta-analysis was used to compare discontinuation rates between FDA reviews and matching journal articles, while SAEs were compared qualitatively...
November 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27401359/comparative-efficacy-and-acceptability-of-first-generation-and-second-generation-antidepressants-in-the-acute-treatment-of-major-depression-protocol-for-a-network-meta-analysis
#13
COMPARATIVE STUDY
Toshi A Furukawa, Georgia Salanti, Lauren Z Atkinson, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Anna Chaimani, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aya Suganuma, Norio Watanabe, Sarah Stockton, John R Geddes, Andrea Cipriani
INTRODUCTION: Many antidepressants are indicated for the treatment of major depression. Two network meta-analyses have provided the most comprehensive assessments to date, accounting for both direct and indirect comparisons; however, these reported conflicting interpretation of results. Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression...
July 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27058355/reporting-of-positive-results-in-randomized-controlled-trials-of-mindfulness-based-mental-health-interventions
#14
Stephanie Coronado-Montoya, Alexander W Levis, Linda Kwakkenbos, Russell J Steele, Erick H Turner, Brett D Thombs
BACKGROUND: A large proportion of mindfulness-based therapy trials report statistically significant results, even in the context of very low statistical power. The objective of the present study was to characterize the reporting of "positive" results in randomized controlled trials of mindfulness-based therapy. We also assessed mindfulness-based therapy trial registrations for indications of possible reporting bias and reviewed recent systematic reviews and meta-analyses to determine whether reporting biases were identified...
2016: PloS One
https://www.readbyqxmd.com/read/26989093/influence-of-baseline-severity-on-antidepressant-efficacy-for-anxiety-disorders-meta-analysis-and-meta-regression
#15
REVIEW
Ymkje Anna de Vries, Peter de Jonge, Edwin van den Heuvel, Erick H Turner, Annelieke M Roest
BACKGROUND: Antidepressants are established first-line treatments for anxiety disorders, but it is not clear whether they are equally effective across the severity range. AIMS: To examine the influence of baseline severity of anxiety on antidepressant efficacy for generalised anxiety disorder (GAD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) and panic disorder. METHOD: Fifty-six trials of second-generation antidepressants for the short-term treatment of an anxiety disorder were included...
June 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/26825750/single-locus-enrichment-without-amplification-for-sequencing-and-direct-detection-of-epigenetic-modifications
#16
Thang T Pham, Jun Yin, John S Eid, Evan Adams, Regina Lam, Stephen W Turner, Erick W Loomis, Jun Yi Wang, Paul J Hagerman, Jeremiah W Hanes
A gene-level targeted enrichment method for direct detection of epigenetic modifications is described. The approach is demonstrated on the CGG-repeat region of the FMR1 gene, for which large repeat expansions, hitherto refractory to sequencing, are known to cause fragile X syndrome. In addition to achieving a single-locus enrichment of nearly 700,000-fold, the elimination of all amplification steps removes PCR-induced bias in the repeat count and preserves the native epigenetic modifications of the DNA. In conjunction with the single-molecule real-time sequencing approach, this enrichment method enables direct readout of the methylation status and the CGG repeat number of the FMR1 allele(s) for a clonally derived cell line...
June 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/26422604/does-publication-bias-inflate-the-apparent-efficacy-of-psychological-treatment-for-major-depressive-disorder-a-systematic-review-and-meta-analysis-of-us-national-institutes-of-health-funded-trials
#17
Ellen Driessen, Steven D Hollon, Claudi L H Bockting, Pim Cuijpers, Erick H Turner
BACKGROUND: The efficacy of antidepressant medication has been shown empirically to be overestimated due to publication bias, but this has only been inferred statistically with regard to psychological treatment for depression. We assessed directly the extent of study publication bias in trials examining the efficacy of psychological treatment for depression. METHODS AND FINDINGS: We identified US National Institutes of Health grants awarded to fund randomized clinical trials comparing psychological treatment to control conditions or other treatments in patients diagnosed with major depressive disorder for the period 1972-2008, and we determined whether those grants led to publications...
2015: PloS One
https://www.readbyqxmd.com/read/26291663/neural-networks-underlying-the-metacognitive-uncertainty-response
#18
Erick J Paul, J David Smith, Vivian V Valentin, Benjamin O Turner, Aron K Barbey, F Gregory Ashby
Humans monitor states of uncertainty that can guide decision-making. These uncertain states are evident behaviorally when humans decline to make a categorization response. Such behavioral uncertainty responses (URs) have also defined the search for metacognition in animals. While a plethora of neuroimaging studies have focused on uncertainty, the brain systems supporting a volitional strategy shift under uncertainty have not been distinguished from those observed in making introspective post-hoc reports of categorization uncertainty...
October 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/25806940/reporting-bias-in-clinical-trials-investigating-the-efficacy-of-second-generation-antidepressants-in-the-treatment-of-anxiety-disorders-a-report-of-2-meta-analyses
#19
COMPARATIVE STUDY
Annelieke M Roest, Peter de Jonge, Craig D Williams, Ymkje Anna de Vries, Robert A Schoevers, Erick H Turner
IMPORTANCE: Studies have shown that the scientific literature has overestimated the efficacy of antidepressants for depression, but other indications for these drugs have not been considered. OBJECTIVE: To examine reporting biases in double-blind, placebo-controlled trials on the pharmacologic treatment of anxiety disorders and quantify the extent to which these biases inflate estimates of drug efficacy. DATA SOURCES AND STUDY SELECTION: We included reviews obtained from the US Food and Drug Administration (FDA) for premarketing trials of 9 second-generation antidepressants in the treatment of anxiety disorders...
May 2015: JAMA Psychiatry
https://www.readbyqxmd.com/read/25176275/distribution-and-recovery-trajectory-of-macondo-mississippi-canyon-252-oil-in-louisiana-coastal-wetlands
#20
R Eugene Turner, Edward B Overton, Buffy M Meyer, M Scott Miles, Giovanna McClenachan, Linda Hooper-Bui, Annette Summers Engel, Erick M Swenson, James M Lee, Charles S Milan, Heng Gao
We measured the concentration of petroleum hydrocarbons in 405 wetland sediment samples immediately before the April 2010 Deepwater Horizon disaster led to their broad-scale oiling, and on nine trips afterwards. The average concentrations of alkanes and PAHs were 604 and 186 times the pre-spill baseline values, respectively. Oil was distributed with some attenuation up to 100m inland from the shoreline for alkanes, but increased for aromatics, and was not well-circumscribed by the rapid shoreline assessments (a...
October 15, 2014: Marine Pollution Bulletin
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