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https://www.readbyqxmd.com/read/30121590/development-of-a-population-pharmacokinetic-model-of-olanzapine-for-chinese-health-volunteers-and-patients-with-schizophrenia
#1
Anning Li, Shuangmin Ji, Weihua Yue, Hao Yan, Fang Dong, Canjun Ruan, Wenbiao Li, Wei Lu, Dai Zhang, Chuanyue Wang
OBJECTIVE: Olanzapine is an atypical antipsychotic drug commonly used for the treatment of schizophrenia. However, there are still many complications associated with the use of olanzapine, and researchers continually strive to improve the handling of data from regular therapeutic drug monitoring (TDM). The objective of this study is to optimise the individualised treatment of olanzapine by establishing a population pharmacokinetics (PopPK) model in Chinese patients with schizophrenia...
August 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/30120928/correlation-of-spectral-domain-optical-coherence-tomography-with-histology-and-electron-microscopy-in-the-porcine-retina
#2
Wankun Xie, Min Zhao, Shu-Huai Tsai, William L Burkes, Luke B Potts, Wenjuan Xu, H Ross Payne, Travis W Hein, Lih Kuo, Robert H Rosa
Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo. Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling the human retina, is limited. Herein, we correlated the hypo- and hyper-reflective bands on SD-OCT with histology of the lamellar architecture and cellular constituents of the porcine retina. SD-OCT images were acquired with the Heidelberg Spectralis HRA + OCT. Histological analysis was performed using epoxy resin embedded tissue and transmission electron microscopy...
August 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/30120566/a-3d-nanoscale-polyhedral-oligomeric-silsesquioxanes-network-for-microextraction-of-polycyclic-aromatic-hydrocarbons
#3
Habib Bagheri, Gohar Soofi, Hasan Javanmardi, Majid Karimi
Polyhedral oligomeric silsesquioxanes are 3D nanoscaled materials with large potential in solid phase microextraction (SPME). Here, as a case study, an octaglycidyldimethylsilyl modified polyhedral oligomeric silsesquioxane network is described. It was deposited on a stainless steel wire via a sol-gel method and used as a fiber coating for SPME of aromatic compounds. The uniform pore structure, high surface area, and hydrophobicity of the network make it susceptible toward isolation of non-polar and semi-polar chemical compounds...
August 17, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/30120273/porous-sno-2-nanoparticles-based-ion-chromatographic-determination-of-non-fluorescent-antibiotic-chloramphenicol-in-complex-samples
#4
Nadeem Muhammad, Abdul Rahman, Muhammad Adnan Younis, Qamar Subhani, Khurram Shehzad, Hairong Cui, Yan Zhu
Nowadays, there are rising concerns about the extensive use of the antibiotics such as chloramphenicol (CAP), has threatened the human life in the form of various vicious diseases. The limited selectivity and sensitivity of confirmatory techniques (UV and electrochemical) and non-fluorescence property of CAP make its determination a challenging task in the modern pharmaceutical analysis. In order to redeem the selective, sensitive and cost-effective fluorescence methodology, here by the dual role of synthesized porous SnO2 nanoparticles were exploited; (i) a porous sorbent in a µ-QuEChERS based sample preparation and as (ii) a stimulant for the transformation of non-fluorescent analytes namely CAP and p-nitrophenol (p-NP) into their respective fluorescent product...
August 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30120081/bile-acid-metabolites-in-early-pregnancy-and-risk-of-gestational-diabetes-in-chinese-women-a-nested-case-control-study
#5
Jing Li, Xiaoxu Huo, Yun-Feng Cao, Sai-Nan Li, Zuo Du, Ping Shao, Junhong Leng, Cuiping Zhang, Xiao-Yu Sun, Ronald C W Ma, Zhong-Ze Fang, XilinYang
BACKGROUND: Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM). METHODS: We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in China: 243 women with GDM were matched with 243 non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline were used to examine full-range associations of bile acid metabolites with GDM...
August 14, 2018: EBioMedicine
https://www.readbyqxmd.com/read/30119731/a-class-specific-artificial-receptor-based-on-molecularly-imprinted-polymer-coated-quantum-dot-centers-for-the-detection-of-signaling-molecules-n-acyl-homoserine-lactones-present-in-gram-negative-bacteria
#6
Jean de Dieu Habimana, Jian Ji, Fuwei Pi, Eric Karangwa, Jiadi Sun, Wei Guo, Fangchao Cui, Jingdong Shao, Claudine Ntakirutimana, Xiulan Sun
Herein, a novel class-specific artificial receptor-based on molecularly imprinted polymer (MIP)-coated quantum dots (QDs@MIP) was synthesized, characterized, and used for the detection and quantification of the bacterial quorum signaling molecules N-acyl-homoserine lactones (AHLs), a class of autoinducers from Gram-negative bacteria. The QDs@MIP was prepared by surface imprinting technique under controlled conditions using CdSe/ZnS QDs as the signal transducing material. The synthesis of the QDs@MIP was characterized by transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis, and fluorescence spectroscopy...
November 15, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30119682/vitamin-d-receptor-polymorphism-rs2228570-is-significantly-associated-with-risk-of-dyslipidemia-and-serum-ldl-levels-in-chinese-han-population
#7
Jian Jia, Yayu Tang, Chong Shen, Ning Zhang, Haixia Ding, Yiyang Zhan
BACKGROUND: The goal of this study was to determine if vitamin D receptor (VDR) gene polymorphisms underlie susceptibility to dyslipidemia in a Chinese Han population. METHODS: Three tag single nucleotide polymorphisms (SNPs) (rs11574129, rs2228570, and rs739837) were genotyped using TaqMan assays to determine VDR SNP associations with dyslipidemia. We genotyped 877 cases of dyslipidemia from a normotensive, non-diabetes mellitus population and 1822 non-dyslipidemia subjects in a stage I study...
August 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30119482/dark-solitons-manipulation-using-optical-event-horizon
#8
Zhixiang Deng, Jun Liu, Xianwei Huang, Chujun Zhao, Xinlin Wang
We demonstrate that the optical event horizon can provide an effective technique to actively control the propagation properties of a dark soliton with another weak probe wave. Careful power adjustment of the probe wave enables the black soliton converted into a gray one with varying grayness through the nonlinear interaction, corresponding to a nearly adiabatic variation of the soliton's speed. The sign of the phase angle for the newly formed gray soliton at optical event horizon is significantly dependent on the frequency of the launched probe wave...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119480/design-rules-for-optimizing-unipolar-coded-brillouin-optical-time-domain-analyzers
#9
Zhisheng Yang, Zonglei Li, Simon Zaslawski, Luc Thévenaz, Marcelo A Soto
The performance of unipolar unicolor coded Brillouin optical time-domain analysis (BOTDA) is evaluated based on both Simplex and Golay codes. Four major detrimental factors that limit the system performance, including decoded-gain trace distortion, coding pulse power non-uniformity, polarization pulling and higher-order non-local effects, are thoroughly investigated. Through theoretical analysis and an experimental validations, solutions and optimal design conditions for unipolar unicolor coded BOTDA are clearly established...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30118867/neutrophils-and-neutrophil-lymphocyte-ratio-inflammatory-markers-associated-with-intimal-media-thickness-of-atherosclerosis
#10
Ling-Bing Meng, Ze-Mou Yu, Peng Guo, Qing-Qing Wang, Ruo-Mei Qi, Meng-Jie Shan, Jian Lv, Tao Gong
INTRODUCTION: Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L...
August 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30118824/the-interaction-between-the-znf804a-gene-and-cannabis-use-on-the-risk-of-psychosis-in-a-non-clinical-sample
#11
Jordi Soler, Bárbara Arias, Jorge Moya, Manuel Ignacio Ibáñez, Generós Ortet, Lourdes Fañanás, Mar Fatjó-Vilas
The ZNF804A gene and cannabis use are risk factors for psychosis and both have also been associated with schizotypal traits. This study aimed to investigate: i) the association of lifetime cannabis use (and its dose effect) with schizotypal personality traits, and ii) whether the genetic variability at ZNF804A gene modulates that association. Our sample consisted of 385 Spanish non-clinical subjects (43.1% males, mean age = 21.11(2.19)). Schizotypy was evaluated using the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (SPQ-CP), Interpersonal (SPQ-I) and Disorganized (SPQ-D)...
August 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30118564/thylakoids-proteome-modulation-in-pea-plants-grown-at-different-irradiances-a-quantitative-proteomic-profiling-in-a-non-model-organism-aided-by-transcriptomic-data-integration
#12
Pascal Albanese, Marcello Manfredi, Angela Re, Emilio Marengo, Guido Saracco, Cristina Pagliano
Plant thylakoid membranes contain hundreds of proteins closely interplaying to cope with ever-changing environmental conditions. We investigated how Pisum sativum L. (pea) grown at different irradiances optimizes light-use efficiency through the differential accumulation of thylakoid proteins. Thylakoid membranes from plants grown under low (LL), moderate (ML) and high (HL) light intensity were characterized by combining chlorophyll fluorescence measurements with quantitative label-free proteomic analysis. Protein sequences retrieved from available transcriptomic data considerably improved the thylakoid proteome profiling, increasing the quantifiable proteins from 63 to 194...
August 17, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/30117918/label-free-multimodal-coherent-anti-stokes-raman-scattering-analysis-of-microparticles-in-unconstrained-microfluidics
#13
K O'Dwyer, R Mouras, A A Mani, D Rice, M Gleeson, N Liu, S A M Tofail, C Silien
Fast, label-free optical identification and quantification of biomolecules and other relevant biological materials in microfluidic devices and the vascular system will play a major role in liquid biopsy and related diagnoses. An optical microscope probing simultaneously non-linear coherent anti-Stokes Raman scattering (CARS) and linear scattering (LS) was used to probe microparticles in aqueous solutions flowed unconstrained in microfluidic channels. Despite the optical complexity of these systems, where out-of-focus microparticles randomly impede CARS and LS, and where water CARS generates a substantial background, we demonstrate that in-focus microparticles can be individually and unambiguously detected when CARS and LS are co-analyzed...
August 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/30116982/predicting-growth-traits-with-genomic-selection-methods-in-zhikong-scallop-chlamys-farreri
#14
Yangfan Wang, Guidong Sun, Qifan Zeng, Zhihui Chen, Xiaoli Hu, Hengde Li, Shi Wang, Zhenmin Bao
Selective breeding is a common and effective approach for genetic improvement of aquaculture stocks with parental selection as the key factor. Genomic selection (GS) has been proposed as a promising tool to facilitate selective breeding. Here, we evaluated the predictability of four GS methods in Zhikong scallop (Chlamys farreri) through real dataset analyses of four economical traits (e.g., shell length, shell height, shell width, and whole weight). Our analysis revealed that different GS models exhibited variable performance in prediction accuracy depending on genetic and statistical factors, but non-parametric method, including reproducing kernel Hilbert spaces regression (RKHS) and sparse neural networks (SNN), generally outperformed parametric linear method, such as genomic best linear unbiased prediction (GBLUP) and BayesB...
August 16, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/30116540/cardiac-structure-and-function-with-and-without-metabolic-syndrome-the-echocardiographic-study-of-latinos-echo-sol
#15
REVIEW
Melissa Burroughs Peña, Katrina Swett, Neil Schneiderman, Daniel M Spevack, Sonia G Ponce, Gregory A Talavera, Mayank M Kansal, Martha L Daviglus, Jianwen Cai, Barry E Hurwitz, Maria M Llabre, Carlos J Rodriguez
Objective: We assessed the hypothesis that metabolic syndrome is associated with adverse changes in cardiac structure and function in participants of the Echocardiographic Study of Latinos (Echo-SOL). Methods: Non-diabetic Echo-SOL participants were included in this cross-sectional analysis. Metabolic syndrome was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used adjusting for multiple potential confounding variables...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/30116526/a-multi-center-nested-case-control-study-on-hospitalization-costs-and-length-of-stay-due-to-healthcare-associated-infection
#16
Yu Lü, Min Hong Cai, Jian Cheng, Kun Zou, Qian Xiang, Jia Yu Wu, Dao Qiong Wei, Zhong Hua Zhou, Hui Wang, Chen Wang, Jing Chen
Background: In 2018, the Chinese government demanded nationwide implementation of medical insurance payment methods based on Single-Disease Payment (SDP), but during the operation process the medical insurance system did not fully consider the extra economic burden caused by healthcare-associated infection (HAI). HAIs can prolong the length of stay and increase the hospitalization costs, but only a few studies have been conducted in Sichuan province, China. We evaluated the hospitalization costs and length of stay due to HAI in Sichuan province based on the prevalence survey, and provided data reference for China's medical insurance reform...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/30115505/high-density-of-periaortic-adipose-tissue-in-abdominal-aortic-aneurysm
#17
Marina Dias-Neto, Jorn P Meekel, Theodorus G van Schaik, Jacqueline Hoozemans, Fábio Sousa-Nunes, Tiago Henriques-Coelho, Rutger J Lely, Willem Wisselink, Jan D Blankensteijn, Kak K Yeung
OBJECTIVES: Perivascular adipose tissue (PVAT) is currently seen as a paracrine organ that produces vasoactive substances, including inflammatory agents, which may have an impact on the vasculature. In this study PVAT density was quantified in patients with an aortic aneurysm and compared with those with a non-dilated aorta. Since chronic inflammation, as the pathway to medial thinning, is a hallmark of abdominal aortic aneurysms (AAAs), it was hypothesised that PVAT density is higher in AAA patients...
August 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/30115253/population-pharmacokinetic-analysis-of-propofol-in-underweight-patients-under-general-anaesthesia
#18
J H Park, S M Choi, J H Park, K H Lee, H J Yun, E K Lee, B M Choi, G J Noh
BACKGROUND: The modified Marsh and Schnider pharmacokinetic models for propofol consistently produce negatively and positively biased predictions in underweight patients, respectively. We aimed to develop a new pharmacokinetic model of propofol in underweight patients. METHODS: Twenty underweight (BMI<18.5 kg m-2 ) patients aged 20-68 yr were given an i.v. bolus of propofol (2 mg kg-1 ) for induction of anaesthesia. Anaesthesia was maintained with a zero-order infusion (8 mg kg-1 h-1 ) of propofol and target-controlled infusion of remifentanil...
September 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30114470/4-hydroxy-6-7-methylenedioxy-3-methoxyflavone-a-novel-flavonoid-from-dulacia-egleri-with-potential-inhibitory-activity-against-cathepsins-b-and-l
#19
Leice M R de Novais, Cauane C O de Arueira, Luiz F Ferreira, Tereza A N Ribeiro, Paulo T Sousa, Marcos J Jacinto, Mário G de Carvalho, Wagner A S Judice, Larissa O P Jesus, Aline A de Souza, Heron F V Torquato, Edgar J Paredes-Gamero, Virginia C Silva
A new flavone, 4'-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by 1D, 2D-NMR analysis, including HRESIMS data. The results obtained in the biological assays showed that the compound 1 was able to inhibit cathepsins B and L with IC50 of 14.88 ± 0.18 μM and 3.19 ± 0.07 μM, respectively...
August 13, 2018: Fitoterapia
https://www.readbyqxmd.com/read/30114201/strong-correlation-of-lumefantrine-concentrations-in-capillary-and-venous-plasma-from-malaria-patients
#20
Liusheng Huang, Norah Mwebaza, Richard Kajubi, Florence Marzan, Camilla Forsman, Sunil Parikh, Francesca T Aweeka
BACKGROUND: Lumefantrine is a long-acting antimalarial drug with an elimination half-life of over 3 days and protein binding of 99 percent. Correlation of lumefantrine concentrations from capillary plasma via fingerprick (Cc) versus venous plasma (Cv) remains to be defined. METHODS: Venous and capillary plasma samples were collected simultaneously from children, pregnant women, and non-pregnant adults at 2, 24, 120hr post last dose of a standard 3-day artemether-lumefantrine regimen they received for uncomplicated malaria...
2018: PloS One
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