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Osseointegration

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https://www.readbyqxmd.com/read/28930925/conical-modification-of-forearm-free-flaps-for-single-stage-reconstruction-after-total-orbital-exenteration
#1
Chad A Purnell, Elbert E Vaca, Marco F Ellis
BACKGROUND: Orbital exenteration is a significant reconstructive challenge for plastic surgeons. Options described for these defects range from healing by secondary intention to free tissue transfer. The authors present our preferred reconstruction of orbital defects with free forearm-based flaps, which provides quality soft tissue and orbital contouring in 1 stage to consistently allow placement of bone-anchored implants for eventual orbital prosthesis. METHODS: This conical shape of the orbit is deconstructed into a "Pac-Man" type shaped flap that leaves adequate depth for a prosthesis...
September 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28929117/histological-evidence-of-the-osseointegration-of-fractured-direct-metal-laser-sintering-implants-retrieved-after-5-years-of-function
#2
Francesco Mangano, Carlo Mangano, Adriano Piattelli, Giovanna Iezzi
BACKGROUND: Direct metal laser sintering (DMLS) is an additive manufacturing technique that allows the fabrication of dental implants layer by layer through the laser fusion of titanium microparticles. The surface of DMLS implants is characterized by a high open porosity with interconnected pores of different sizes; therefore, it has the potential to enhance and accelerate bone healing. To date, however, there are no histologic/histomorphometric studies in the literature evaluating the interface between bone and DMLS implants in the long-term...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28926380/osseointegrated-transtibial-implants-in-patients-with-peripheral-vascular-disease-a-multicenter-case-series-of-5-patients-with-1-year-follow-up
#3
Robin Atallah, Jiao Jiao Li, William Lu, Ruud Leijendekkers, Jan Paul Frölke, Munjed Al Muderis
BACKGROUND: Osseointegration is an alternative treatment for amputees who are unable to wear or have difficulty wearing a socket prosthesis. Although the majority of limb amputations are due to vascular disease, such amputations have been perceived as a contraindication to osseointegration surgery. We report the outcomes of osseointegrated reconstruction in a series of 5 patients with limb amputation due to peripheral vascular disease. METHODS: Five patients with transtibial amputation and a history of peripheral vascular disease who received an osseointegration implant from 2014 to 2015 were followed for 12 months...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28925678/dual-functionalized-graphene-oxide-based-sirna-delivery-system-for-implant-surface-bio-modification-with-enhanced-osteogenesis
#4
Li Zhang, Qing Zhou, Wen Song, Kaimin Wu, Yumei Zhang, Yimin Zhao
Surface functionalization by siRNA is a novel strategy for improved implant osseointegration. Gene delivery system with safety and high transfection activity is a crucial factor for siRNA-functionalized implant to exert its biological function. To this end, polyethylene glycol (PEG) and polyethylenimine (PEI) dual-functionalized graphene oxide (GO) (nGO-PEG-PEI) may present a promising siRNA vector. In this study, nano-sized nGO-PEG-PEI was prepared and optimized for siRNA delivery. Titania nanotubes (NT) fabricated by anodic oxidation were bio-modified with nGO-PEG-PEI/siRNA by cathodic electrodeposition, designated as NT-GPP/siRNA...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28922615/the-impact-of-incorporating-antimicrobials-into-implant-surfaces
#5
N J Hickok, I M Shapiro, A F Chen
With the increase in numbers of joint replacements, spinal surgeries, and dental implantations, there is an urgent need to combat implant-associated infection. In addition to stringent sterile techniques, an efficacious way to prevent this destructive complication is to create new implants with antimicrobial properties. Specifically, these implants must be active in the dental implant environment where the implant is bathed in the glycoprotein-rich salivary fluids that enhance bacterial adhesion, and propagation, and biofilm formation...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28922244/fibular-graft-effective-panorama-for-prosthetic-rehabilitation-of-resected-mandible
#6
Pankaj Kharade, Saidul Islam, Mahesh Verma, Swati Sharma, Ranjeet Bodh
Surgical management of extensive tumors in the mandibular region leads to massive disfigurement of the face. Also the prosthetic outcome of such patients rehabilitated with free soft tissue flaps is very poor. Reconstruction of extensive defects to overcome the disfigurement is a challenging procedure and can be achieved with free fibula flap. Free fibula graft provides sufficient length of bone for the reconstruction of the postsurgical defects. Excellent vascularity of fibula flap allows for easy uptake of the graft and osseointegration of the dental implants...
September 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28922242/long-term-follow-up-of-osseointegrated-orbital-prosthetic-reconstruction
#7
Joshua J DeSerres, Curtis R Budden, Johan F Wolfaardt, Gordon H Wilkes
BACKGROUND: Osseointegrated implants have been used for craniofacial prosthetic reconstruction since 1979. The authors sought to review long-term outcomes of osseointegrated orbital reconstruction at the Institute for Reconstructive Sciences in Medicine (iRSM). METHODS: Twenty-six patients have undergone osseointegrated orbital prosthetic (OOP) reconstruction at iRSM since 1991. A retrospective chart review was performed and patient satisfaction assessed through a questionnaire used in previous osseointegration studies...
September 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28921659/ligature-induced-peri-implantitis-and-periodontitis-in-mice
#8
Sarah Hiyari, Ryan Wong, Aline Yaghsezian, Azadi Naghibi, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih
AIM: Peri-implantitis (PI), inflammation around dental implants, shares characteristics with periodontitis (PD). However, PI is more difficult to control, treat, and detailed pathophysiology is unclear. We aimed to compare PI and PD progression utilizing a murine model. MATERIALS AND METHODS: Four-week-old male C57BL/6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets and osseointegrated. Ligatures were tied around the implant and second molar...
September 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28918187/surface-modification-of-titanium-substrates-for-enhanced-osteogenetic-and-antibacterial-properties
#9
Peng Liu, Yansha Hao, Yongchun Zhao, Zhang Yuan, Yao Ding, Kaiyong Cai
The insufficient osseointegration and bacterial infection of titanium and its alloys remain the key challenges in their clinic applications, which may result in failure implantation. To improve osteogenetic and antibacterial properties, TiO2 nanotube arrays were fabricated on titanium substrates for loading of antibacterial drug. Then, TiO2 nanotube arrays were covered with chitosan/sodium alginate multilayer films. The successful construction of this system was verified via scanning electron microscopy and contact angle measurement...
August 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28915955/implications-of-bisphosphonate-calcium-ion-depletion-interfering-with-desmosome-epithelial-seal-in-osseointegrated-implants-and-pressure-ulcers
#10
Louis Z G Touyz, Kelvin I Afrashtehfar
Osteoporosis (OP) is a global bone disease prevalent in aging in humans, especially in older women. Bisphosphonates (BPs) are commonly used as therapy for OP as it influences hard and soft tissues calcium metabolism. Mucosal and dermal ulceration with exposure of underlying bone arises from incomplete epithelial recovery due to reduced desmosome formation deriving from lack of available calcium. Pathological situations such as bisphosphonate-related osteonecrosis of the jaw have been described. This hypothesis states other situations which demand intact functional desmosomes such as healing skin over chronic pressure points leading to pressure ulcers (as well-known as bedsores, pressure sores, pressure injuries, decubitus ulcers), and hemidesmosomes such as epithelial seals in contact with titanium surfaces will have a higher prevalence of breakdown among patients being treated with BPs...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28914397/influence-of-acid-treatment-on-surface-properties-and-in-vivo-performance-of-ti6al4v-alloy-for-biomedical-applications
#11
Daniel J Fernandes, Ruy G Marques, Carlos N Elias
The purpose of this work was to investigate the influence of acid treatment on the surface properties and in vivo performance of titanium grade 5 (Ti6Al4V) alloy. Mini-implants with surface treatment were inserted into New Zealand rabbit tibia for 1, 4 and 8 weeks. SEM analysis showed intercommunicated micropores in acid treated samples. AFM showed micron and sub-micron roughness. The thickness of the titanium oxide layer increased with surface treatment, with a significant reduction of Al and V concentration...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28911958/application-of-real-time-surgical-navigation-for-zygomatic-implant-insertion-in-patients-with-severely-atrophic-maxilla
#12
Feng Wang, Michael M Bornstein, Kuofeng Hung, Shengchi Fan, Xiaojun Chen, Wei Huang, Yiqun Wu
PURPOSE: Computer-aided treatment technology has extended its applications to oral implantology. This report describes the authors' initial clinical experience on the application of a commercially available navigation system (VectorVision) in zygomatic implant (ZI) insertion in the severely atrophic maxilla. MATERIALS AND METHODS: This was a retrospective longitudinal study. Eligible patients with maxillary edentulism who were treated with ZI placement were enrolled...
August 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28895441/successful-placement-of-a-baha-implant-in-a-patient-with-epidermolysis-bullosa-a-case-report-and-review-of-the-literature
#13
Jason R Brown, D Micah Milgraum, Farhaad R Riyaz, Marla N Jahnke, Prasad John Thottam
INTRODUCTION: Epidermolysis bullosa (EB) is a spectrum of mechanobullous disorders characterized by blistering following minor trauma or traction to the skin. Hearing loss in this population is poorly described in the otolaryngology literature, and its treatment oftentimes results in external auditory canal skin irritation. CASE PRESENTATION: We present the case of a 26-year-old female with EB and mixed hearing loss unable to wear conventional hearing aids due to sequelae of the external auditory canals...
September 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28888015/functionalization-of-titanium-dioxide-nanotubes-with-biomolecules-for-biomedical-applications
#14
REVIEW
Weslley F Oliveira, Isabel R S Arruda, Germana M M Silva, Giovanna Machado, Luana C B B Coelho, Maria T S Correia
Titanium (Ti) and its alloys are extensively used in the manufacture of implants because they have biocompatibility. The production of a nanostructured surface can be achieved by means of titanium dioxide nanotubes (TNTs) which can have dimensions equivalent to the nanometric components of human bone, in addition to increasing the efficiency of such implants. The search is ongoing for ways to improve the performance of these TNTs in terms of their functionalization through coating these nanotubular matrices with biomolecules...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28885666/double-acid-etching-treatment-of-dental-implants-for-enhanced-biological-properties
#15
Lluís Giner, Montse Mercadé, Sergi Torrent, Miquel Punset, Román A Pérez, Luis M Delgado, Francisco Javier Gil
BACKGROUND: The topographical features on the surface of dental implants have been considered as a critical parameter for enhancing the osseointegration of implants. In this work, we proposed a surface obtained by a combination of shot blasting and double acid etching. The double acid etching was hypothesized to increase the submicron topography and hence further stimulate the biological properties of the titanium implant. METHODS: The topographical features (surface roughness and real surface area), wettability and surface chemical composition were analyzed...
September 8, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28885574/release-of-vegf-from-dental-implant-improves-osteogenetic-process-preliminary-in-vitro-tests
#16
Barbara Zavan, Letizia Ferroni, Chiara Gardin, Stefano Sivolella, Adriano Piattelli, Eitan Mijiritsky
INTRODUCTION: During osseointegration process, the presence of an inflammatory event could negatively influence the proper osteogenetic ability of the implant surface. In order to reduce this possibility, an implementation of angiogenetic event through the release of Vascular Endothelial Growth Factor (VEGF) can be a tool as co-factor for osteoblastic differentiation. In this paper, novel dental implant surfaces enriched with VEGF have been tested. MATERIAL AND METHODS: The ability of VEGF-enriched titanium implants to improve the osteogenetic properties of Mesenchymal stem cells (MSC), also in the presence of an inflammatory environment, have been in vitro tested...
September 8, 2017: Materials
https://www.readbyqxmd.com/read/28882950/cytocompatibility-of-direct-laser-interference-patterned-titanium-surfaces-for-implants
#17
Philip Hartjen, Ola Nada, Thiago Gundelwein Silva, Clarissa Precht, Anders Henningsen, Marzellus GROßE Holthaus, Nikolai Gulow, Reinhard E Friedrich, Henning Hanken, Max Heiland, Christoph Zwahr, Ralf Smeets, Ole Jung
In an effort to generate titanium surfaces for implants with improved osseointegration, we used direct laser interference patterning (DLIP) to modify the surface of pure titanium grade 4 of four different structures. We assessed in vitro cytoxicity and cell attachment, as well as the viability and proliferation of cells cultured directly on the surfaces. Attachment of the cells to the modified surfaces was comparably good compared to that of cells on grit-blasted and acid-etched reference titanium surfaces...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28880245/evaluation-of-the-healing-potential-of-demineralized-dentin-matrix-fixed-with-recombinant-human-bone-morphogenetic-protein-2-in-bone-grafts
#18
Sang-Yun Kim, Young-Kyun Kim, Yeoung-Hyun Park, Joo-Cheol Park, Jeong-Kui Ku, In-Woong Um, Ji-Yun Kim
We aimed to evaluate the efficacy of demineralized dentin matrix (DDM) fixed with recombinant human bone morphogenetic protein-2 (rhBMP-2) through an experimental and a clinical study. Unilateral upper second and third premolars of eight beagles were extracted. A mucoperiosteal flap was elevated around the extraction socket, and a bone defect was made using a surgical drill. Each DDM was fixed with rhBMP-2, and autogenous bone was grafted at the bone defect area with a collagenous membrane. The beagles were euthanized at two, four, eight, and 12 weeks after receiving the bone graft...
September 7, 2017: Materials
https://www.readbyqxmd.com/read/28879758/light-controlled-bmsc-sheet-implant-complexes-with-improved-osteogenesis-via-an-lrp5-%C3%AE-catenin-runx2-regulatory-loop
#19
Zhiwei Jiang, Huiming Wang, Ke Yu, Yuting Feng, Ying Wang, Tingben Huang, Kaichen Lai, Yue Xi, Guoli Yang
The combination of bone marrow mesenchymal stem cell (BMSC) sheets and titanium implants (BMSC sheet-implant complexes) can accelerate osseointegration. However, methods of fabricating BMSC sheet-implant complexes are quite limited, and the survival of BMSC sheet-implant complexes is one of the key barriers. Here, we show that a light-controlled fabricating system can generate less injured BMSC sheet-implant complexes with improved viability and osteogenesis, and non-invasive monitoring of viability of BMSC sheet-implant complexes using lentiviral delivery system is feasible...
September 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28879673/response-of-preosteoblasts-to-titanium-with-periodic-micro-nanometer-scale-grooves-produced-by-femtosecond-laser-irradiation
#20
Peng Chen, Masayoshi Miyake, Masahiro Tsukamoto, Yusuke Tsutsumi, Takao Hanawa
To investigate the cellular response to designed topography in vitro, we studied the adhesion, proliferation, osteogenic differentiation, and calcification of mouse preosteoblasts (MC3T3-E1) cultured on titanium (Ti) surfaces with periodic micrometer scale grooves containing nanometer scale ripples in the vertical direction fabricated by single-shot, femtosecond laser irradiation (fsTi). The surface composition and chemical state of fsTi were almost the same as those of mirror-polished Ti without femtosecond laser irradiation (mTi)...
September 6, 2017: Journal of Biomedical Materials Research. Part A
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