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Osseointegration

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https://www.readbyqxmd.com/read/29144982/bone-mesenchymal-stem-cell-secretion-of-srankl-opg-m-csf-in-response-to-macrophage-mediated-inflammatory-response-influences-osteogenesis-on-nanostructured-ti-surfaces
#1
Qian-Li Ma, Liang Fang, Nan Jiang, Liang Zhang, Ying Wang, Yu-Mei Zhang, Li-Hua Chen
Although it has been well established that osteogenic differentiation of bone mesenchymal stem cells (bMSCs) as well as osteoclastic differentiation of macrophages can be manipulated by the nanostructure of biomaterial surfaces, the interactions among the effects of the surface on immune cells and bMSCs remained unknown. Therefore, in this study, the osteogenic behaviors and secretion of osteoclastogenesis-related cytokines of human bMSCs on TiO2 nanotubular (NT) surfaces in conditioned medium (CM) generated by macrophages cultured on the respective NT surfaces (NT-CM) were analyzed...
November 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29143065/-complex-joint-reconstruction-and-joint-transplantation-with-the-flocsat-concept-planning-and-surgical-implementation
#2
REVIEW
C Krettek, J-D Clausen, C Neunaber
Cartilage defects in adult patients are so far incurable. Fresh osteochondral allograft (OCA) transplantation is based on the insertion of mature, living, mechanically sound hyaline cartilage into an osteochondral defect where it undergoes osseointegration. Intact hyaline cartilage of OCA does not cause immune reactions in the recipient. Many reports show that small OCA have good osseointegration and show good long-term results. These observations have been incorporated into the development of the fresh large (> 10 cm(2)) osteochondral shell allograft transplantation (FLOCSAT) concept, which is based on the following principles: 1) the thickness of the osseous layer should be kept as thin as possible (target < 6-8 mm) so that the transplant remains stable and fixable...
November 15, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29142653/oral-cancer-around-dental-implants-appearing-in-patients-with-without-a-history-of-oral-or-systemic-malignancy-a-systematic-review
#3
REVIEW
Ginnady Pinchasov, Haim Haimov, Monika Druseikaite, Daniel Pinchasov, Inesa Astramskaite, Rafael Sarikov, Gintaras Juodzbalys
Objectives: The purpose of this article is to systematically review the circumstance of oral cancer around osseointegrated dental implants. Material and Methods: An electronic literature search was conducted through the MEDLINE (PubMed) and EMBASE databases. The search was restricted for articles published during the last 21 years from January 1996 to April 2017 and articles were limited to English language. Results: A total of 35 articles were reviewed, and 19 of the most relevant articles that are suitable to the criteria were selected...
July 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/29142645/effect-of-implant-and-occlusal-load-location-on-stress-distribution-in-locator-attachments-of-mandibular-overdenture-a-finite-element-study
#4
Angel Alvarez-Arenal, Ignacio Gonzalez-Gonzalez, Hector deLlanos-Lanchares, Elena Martin-Fernandez, Aritza Brizuela-Velasco, Joseba Ellacuria-Echebarria
PURPOSE: The aim of this study is to evaluate and compare the stress distribution in Locator attachments in mandibular two-implant overdentures according to implant locations and different loading conditions. MATERIALS AND METHODS: Four three-dimensional finite element models were created, simulating two osseointegrated implants in the mandible to support two Locator attachments and an overdenture. The models simulated an overdenture with implants located in the position of the level of lateral incisors, canines, second premolars, and crossed implant...
October 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29140389/influence-of-rhbmp-2-on-guided-bone-regeneration-for-placement-and-functional-loading-of-dental-implants-a-radiographic-and-histologic-study-in-dogs
#5
Heithem Ben Amara, Jung-Won Lee, Jung-Ju Kim, Yun-Mi Kang, Eun-Jung Kang, Ki-Tae Koo
PURPOSE: Evidence on the outcomes of functional loading placed in recombinant human bone morphogenetic protein 2 (rhBMP-2)/acellular collagen sponge (ACS)-induced bone is lacking. The aim of this study was to verify whether guided bone regeneration (GBR) with rhBMP-2/ACS enhances regeneration of missing bone and osseointegration of dental implants subject to functional loading. MATERIALS AND METHODS: Two bilateral standardized large saddle-type defects (≈10 × 10 × 6 mm) were surgically created in each mandible of seven beagle dogs 2 months after tooth extraction...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140385/virtual-treatment-planning-for-implant-retained-nasal-prosthesis-a-clinical-report
#6
Muaiyed Mahmoud Buzayan, Norsiah Binti Yunu, Ha Kien Oon, Omar Tawfiq
Osseointegrated craniofacial implants have improved retention and patients' perceptions of implant-retained nasal prostheses; however, the determination of the available bone sites for implant placement post-rhinectomy is difficult. This case report describes the use of cone beam computed tomography scanning and computer-assisted virtual planning in conjunction with digital photographs for rehabilitation of a facial defect with an implant-retained silicon nasal prosthesis. Two implants were planned in the anatomical area with adequate bone volume to achieve favorable cosmetic outcomes and accessibility for hygiene maintenance...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140378/perception-by-osseointegrated-dental-implants-supporting-a-fixed-prosthesis-a-prospective-study
#7
Purva V Bakshi, Srinath Thakur, Sudhindra Kulkarni
PURPOSE: Osseointegrated implants have been shown to transmit a certain sensibility termed as osseoperception. The purpose of this study was to determine the perception by implants over a period of 6 months after loading in comparison to the natural dentition. MATERIALS AND METHODS: Twenty subjects (ages 40 to 50 years) were included in this split-mouth clinical trial. The subjects were divided into two groups (n = 10) as follows: group 1-subjects with recently cemented implant-supported fixed prosthesis opposing natural teeth; group 2-subjects with recently cemented implant-supported fixed prosthesis in both arches...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140371/biofunctionalization-of-titanium-granules-with-simvastatin-for-improving-osteogenic-activity-and-antibacterial-properties-ex-vivo-study
#8
Zahra Gorgin Karaji, Behzad Houshmand, Shahsanam Abbasi, Sara Shafiei, Shahab Faghihi
PURPOSE: Titanium-based biomaterials present good biocompatibility, while their osseointegration and antibacterial properties need to be improved. This study aimed to enhance the bone-bonding ability of titanium-based granules, which are intended to be used as bone graft. MATERIALS AND METHODS: The titanium granules were anodized in ethylene glycol-based electrolyte and subsequently annealed to be loaded separately with simvastatin. The samples were then inspected with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) for drug loading...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140074/facile-and-versatile-strategy-for-construction-of-anti-inflammatory-and-antibacterial-surfaces-with-polydopamine-mediated-liposomes-releasing-dexamethasone-and-minocycline-for-potential-implants-applications
#9
Xiao Xu, Lixin Wang, Zuyuan Luo, Yaofeng Ni, Haitao Sun, Xiang Gao, Yongliang Li, Siqi Zhang, Yan Li, Shicheng Wei
Reducing early nonbacterial inflammation induced by implanted materials and infection resulting from bacterial contamination around the implant-abutment interface could greatly accelerate implant osseointegration and reduce implant failure, which would be of clinical significance. In this study, we developed a facile and versatile strategy for the construction of anti-inflammatory and antibacterial surfaces on implants, such as orthopedic/dental implants. Briefly, the surfaces of polystyrene (PS) culture plates were first coated with polydopamine and then decorated with dexamethasone plus minocycline-loaded liposomes (Dex/Mino liposomes), which was confirmed by contact angle goniometry, X-ray photoelectron spectroscopy, and fluorescence microscopy...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29138892/-partial-and-complete-joint-transplantation-with-fresh-osteochondral-allografts-the-flocsat-concept
#10
REVIEW
C Krettek, J-D Clausen, N Bruns, C Neunaber
Cartilage defects in adult patients do not heal well. Fresh osteochondral allograft (OCA) transplantation is based on mature, living, mechanically sound hyaline cartilage attached to a bone interface, which is brought into an osteochondral defect, where it becomes osseointegrated. According to current knowledge, intact hyaline cartilage tissue is immune privileged and does not, in contrast to bone, meniscus or ligaments, cause an immune reaction. The technique has the unique advantage of transplanting viable, mature and mechanically stable hyaline cartilage into the affected area...
November 14, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29138601/zinc-phosphate-as-a-definitive-cement-for-implant-supported-crowns-and-fixed-dentures
#11
Dennis Flanagan
Implant-supported dental prostheses can be retained by a screw or cement. Implant-supported fixed partial dentures have a passive fit. A passive fit means there is an internal gap between the abutment surface and the intaglio of the retainer to insure that there is no lateral pressure on the supporting implants or friction upon seating of the prosthesis. This gap is filled with cement for retention of the prosthesis. Any lateral pressure may cause marginal bone loss or periimplantitis. Also, there is usually a microscopic gap at the margin of a crown retainer that exposes the cement to oral fluids...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/29138499/effect-of-titanium-implants-with-strontium-incorporation-on-bone-apposition-in-animal-models-a-systematic-review-and-meta-analysis
#12
Junyu Shi, Yuan Li, Yingxin Gu, Shichong Qiao, Xiaomeng Zhang, Hongchang Lai
This systematic review aims to assess the efficacy of titanium (Ti) implant surfaces with or without strontium (Sr) incorporation on osseointegration in animal experimental studies. An electronic search was conducted using databases of PubMed and EMBASE up to November 2016 to identify studies focusing on osseointegration of strontium-modified titanium implants following PRISMA criteria. The primary outcome was the percentage of bone-to-implant contact (BIC) around the implants with or without strontium-modified surface...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137166/antimicrobial-and-osseointegration-properties-of-nanostructured-titanium-orthopaedic-implants
#13
REVIEW
Marcus Jäger, Herbert P Jennissen, Florian Dittrich, Alfons Fischer, Hedda Luise Köhling
The surface design of titanium implants influences not only the local biological reactions but also affects at least the clinical result in orthopaedic application. During the last decades, strong efforts have been made to improve osteointegration and prevent bacterial adhesion to these surfaces. Following the rule of "smaller, faster, cheaper", nanotechnology has encountered clinical application. It is evident that the hierarchical implant surface micro- and nanotopography orchestrate the biological cascades of early peri-implant endosseous healing or implant loosening...
November 13, 2017: Materials
https://www.readbyqxmd.com/read/29136258/ultra-short-versus-conventional-uncemented-stems-for-hip-replacement-in-octogenarians
#14
Young-Hoo Kim, Jang-Won Park, Jun-Shik Kim
The aim of this study was to determine how an ultra-short anatomic uncemented stem vs a diaphyseal filling five-eighths porous coated uncemented femoral stem (conventional stem) affects the survival of primary total hip arthroplasties in octogenarians. The current study consisted of 52 patients (55 hips) in the ultra-short stem group (mean age, 85.5±5.3 years) and 61 patients (72 hips) in the diaphyseal (conventional) stem group (mean age, 84.1±4.8 years). The predominant diagnosis was osteoarthritis, followed by osteonecrosis of the femoral head, in both groups...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29135387/effect-on-bone-architecture-of-marginal-grooves-in-dental-implants-under-occlusal-loaded-conditions-in-beagle-dogs
#15
Hatsumi Kato, Shinichiro Kuroshima, Nao Inaba, Yusuke Uto, Takashi Sawase
The aim was to clarify whether marginal grooves on dental implants affect osseointegration, bone structure and the alignment of collagen fibers determining bone quality under loaded condition. Anodized Ti-6Al-4V alloy dental implants with and without marginal grooves were used (3.7 × 8.0 mm; test and control implants, respectively). Fourth premolars and first molars of six beagle mandibles were extracted. Two control and test implants were placed in randomly selected healed sites at 12 weeks after tooth extraction...
November 14, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29130804/is-metal-particle-release-associated-with-peri-implant-bone-destruction-an-emerging-concept
#16
T Fretwurst, K Nelson, D P Tarnow, H-L Wang, W V Giannobile
Peri-implant diseases affecting the surrounding structures of endosseous dental implants include peri-implant mucositis and peri-implantitis. The prevalence of peri-implantitis ranges between 15% and 20% after 10 y, highlighting the major challenge in clinical practice in the rehabilitation of dental implant patients. The widespread nature of peri-implant bone loss poses difficulties in the management of biological complications affecting the long-term success of osseointegrated implant reconstructions. Metal and titanium particles have been detected in peri-implant supporting tissues...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29127065/fatigue-performance-of-additively-manufactured-meta-biomaterials-the-effects-of-topology-and-material-type
#17
S M Ahmadi, R Hedayati, Y Li, K Lietaert, N Tümer, A Fatemi, C D Rans, B Pouran, H Weinans, A A Zadpoor
Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is, however, not clear to what extent the material type is important in determining the fatigue behavior of such biomaterials. We therefore aimed to determine the isolated and modulated effects of topological design and material type on the fatigue response of metallic meta-biomaterials fabricated with selective laser melting...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29122983/restricted-cell-functions-on-micropillars-are-alleviated-by-surface-nanocoating-with-amino-groups
#18
Caroline Moerke, Susanne Staehlke, Henrike Rebl, Birgit Finke, J Barbara Nebe
The topographical and chemical surface features of biomaterials are sensed by the cells, affecting their physiology at the interface. On titanium we recently discovered an attempted caveolae-mediated phagocytosis of the sharp-edged microstructures by osteoblasts. This active, energy-consuming process resulted in decreased osteoblastic cell functions, e.g. extracellular matrix proteins. However, chemical modification with plasma polymerized allylamine (PPAAm) was able to amplify osteoblast adhesion and spreading, resulting in better implant osseointegration in vivo In the present in vitro study we analyzed whether this plasma polymer nanocoating is able to attenuate the microtopography-induced changes of osteoblast physiology...
November 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29122237/osseointegration-of-zirconia-dental-implants-in-animal-investigations-a-systematic-review-and-meta-analysis
#19
REVIEW
Stefano Pieralli, Ralf-Joachim Kohal, Emilia Lopez Hernandez, Sam Doerken, Benedikt Christopher Spies
OBJECTIVE: To determine the osseointegration rate of zirconium dioxide (ZrO2) dental implants in preclinical investigations. DATA: Data on the osseointegration rate was extracted considering the bone to implant contact (BIC), removal torque analysis (RTQ) and push-in tests. Meta analyses were conducted using multilevel multivariable mixed-effects linear regression models. The Šidák method was used in case of multiple testing. SOURCES: An electronic screening of the literature (MEDLINE/Pubmed, Cochrane Library and Embase) and a supplementary manual search were performed...
November 6, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29119860/cost-effectiveness-of-bone-anchored-prostheses-using-osseointegrated-fixation-myth-or-reality
#20
Laurent Alain Frossard, Gregory Merlo, Brendan Burkett, Tanya Quincey, Debra Berg
BACKGROUND: In principle, lower limb bone-anchored prostheses could alleviate expenditure associated with typical socket manufacturing and residuum treatments due to socket-suspended prostheses. OBJECTIVE: This study reports (a) the incremental costs and (b) heath gain as well as (c) cost-effectiveness of bone-anchored prostheses compared to socket-suspended prostheses. STUDY DESIGN: Retrospective individual case-controlled observations and systematic review...
November 1, 2017: Prosthetics and Orthotics International
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