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Osseointegration

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https://www.readbyqxmd.com/read/28820570/engineering-of-micro-to-nano-structured-3d-printed-drug-releasing-titanium-implants-for-enhanced-osseointegration-and-localized-delivery-of-anticancer-drugs
#1
Shaheer Maher, Gagandeep Kaur, Luis Lima-Marques, Andreas Evdokiou, Dusan Losic
Primary and secondary bone cancers are major causes of pathological bone fractures and their treatment through implant fixation and conventional chemotherapy has many limitations. These implants may suffer from poor osseointegration and their rejection is causing repeated surgery, patient's suffering and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics administrated using conventional drug delivery. In this paper to address these two problems we present new type of localized drug-releasing titanium implants with enhanced implants' bio-integration and drug release capabilities that could provide high concentration of toxic anticancer drugs locally to treat bone cancers...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28819908/the-effect-of-cationically-modified-phosphorylcholine-polymers-on-human-osteoblasts-in-vitro-and-their-effect-on-bone-formation-in-vivo
#2
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
The effect of introducing cationic charge into phosphorylcholine (PC)-based polymers has been investigated in this study with a view to using these materials as coatings to improve bone formation and osseointegration at the bone-implant interface. PC-based polymers, which have been used in a variety of medical devices to improve biocompatibility, are associated with low protein adsorption resulting in reduced complement activation, inflammatory response and cell adhesion. However, in some applications, such as orthopaedics, good integration between the implant and bone is needed to allow the distribution of loading stresses and a bioactive response is required...
August 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28819613/aseptic-loosening-after-total-hip-arthroplasty-in-an-acromegalic-patient-a-case-report
#3
Simon Koulischer, Bilal Kapanci, Nicolas Bloemers, Tatiana Charles, Marc Jayankura
INTRODUCTION: Acromegaly is a rare disorder characterized by excess secretion of growth hormone and its principle mediator, insulin-like growth factor-1. Although acromegaly is frequently associated with osteoarthritis, the outcome of arthroplasty in this population is not documented. CASE REPORT: We report here a case of aseptic loosening of an uncemented total hip arthroplasty acetabulum in an acromegalic patient that was revised with a cemented cup. It has been suggested that the incidence of this complication is increased in other pathology with a similarly high bone-turnover (e...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28818783/development-of-a-porous-3d-graphene-pdms-scaffold-for-improved-osseointegration
#4
Jianfeng Li, Xiao Liu, Jeremy M Crook, Gordon G Wallace
Osseointegration in orthopedic surgery plays an important role for bone implantation success. Traditional treatment of implant surface aimed at improved osseointegration has limited capability for its poor performance in supporting cell growth and proliferation. Polydimethylsiloxane (PDMS) is a widely used silicon-based organic polymer material with properties that are useful in cosmetics, domestic applications and mechanical engineering. In addition, the biocompatibility of PDMS, in part due to the high solubility of oxygen, makes it an ideal material for cell-based implants...
August 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28817740/influence-of-microtextured-implant-surfaces-on-peri-implantitis-and-its-treatment-a-preclinical-trial
#5
Juan C Rodriguez, Tapan Koticha, Diana L Eubanks, Ivan Rudek, Fred J Molz, Ludovica Chiavaccini, Andrew Claude, Steven Elder, Hom-Lay Wang
PURPOSE: The prevalence of peri-implantitis has increased significantly, forcing clinicians to search for ways to prevent it. Laser-microtextured surfaces promote soft tissue attachment and provide a tight seal around implants. Hence, the aim of this study was to examine the clinical, radiographic, and histologic features of ligature-induced peri-implantitis, as well as the effect of surgical treatment of these induced peri-implantitis lesions on laser-microtextured implants in a controlled animal model...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28817668/titanium-biomaterials-with-complex-surfaces-induced-aberrant-peripheral-circadian-rhythms-in-bone-marrow-mesenchymal-stromal-cells
#6
Nathaniel Hassan, Kirstin McCarville, Kenzo Morinaga, Cristiane M Mengatto, Peter Langfelder, Akishige Hokugo, Yu Tahara, Christopher S Colwell, Ichiro Nishimura
Circadian rhythms maintain a high level of homeostasis through internal feed-forward and -backward regulation by core molecules. In this study, we report the highly unusual peripheral circadian rhythm of bone marrow mesenchymal stromal cells (BMSCs) induced by titanium-based biomaterials with complex surface modifications (Ti biomaterial) commonly used for dental and orthopedic implants. When cultured on Ti biomaterials, human BMSCs suppressed circadian PER1 expression patterns, while NPAS2 was uniquely upregulated...
2017: PloS One
https://www.readbyqxmd.com/read/28814861/the-influence-of-direct-laser-metal-sintering-implants-on-the-early-stages-of-osseointegration-in-diabetic-mini-pigs
#7
Naiwen Tan, Xiangwei Liu, Yanhui Cai, Sijia Zhang, Bo Jian, Yuchao Zhou, Xiaoru Xu, Shuai Ren, Hongbo Wei, Yingliang Song
BACKGROUND: High failure rates of oral implants have been reported in diabetic patients due to the disruption of osseointegration. The aim of this study was to investigate whether direct laser metal sintering (DLMS) could improve osseointegration in diabetic animal models. METHODS: Surface characterizations were carried out on two types of implants. Cell morphology and the osteogenic-related gene expression of MG63 cells were observed under conditions of DLMS and microarc oxidation (MAO)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28812941/self-retaining-magnetic-implant-a-novel-design-of-orbital-prosthesis-for-the-exenterated-orbit
#8
Shiu Ting Mak, Timmy K C Chan, Kenneth K W Li
Orbital exenteration can lead to significant disfigurement causing considerable functional, cosmetic and psychological disturbances to the patient. Orbital prosthesis is important for the patient's cosmetic and psychological rehabilitation. A 49-year-old man received orbital exenteration and postoperative radiotherapy for malignant orbital carcinoma. In view of uncertain suitability and survival of osseointegrated implant in his case, a novel design of ocular implant consisting of a self-retaining magnetic spring retainer and a coupling silicone prosthesis was used...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28805275/participation-of-extracellular-signal-regulated-kinases-1-2-in-osteoblast-and-adipocyte-differentiation-of-mesenchymal-stem-cells-grown-on-titanium-surfaces
#9
Heitor F Silva, Rodrigo P F Abuna, Helena B Lopes, Marcelo S Francischini, Paulo T de Oliveira, Adalberto L Rosa, Marcio M Beloti
Osteoblasts and adipocytes coexist in the implantation site and affect the process of titanium (Ti) osseointegration. As extracellular signal-regulated kinases 1/2 (ERK1/2) are involved in osteogenesis and adipogenesis, the aim of our study was to investigate if the effects of Ti surface topography on osteoblast and adipocyte differentiation are modulated by ERK1/2. The experiments were conducted based on the effect of the ERK1/2 inhibitor, PD98059, on mesenchymal stem cells (MSCs) grown under osteogenic and adipogenic conditions on Ti with nanotopography (Ti-Nano) or on machined Ti (Ti-Machined)...
August 14, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28803814/revision-total-hip-arthroplasty-with-a-monoblock-splined-tapered-grit-blasted-titanium-stem
#10
Michael D Hellman, Sean M Kearns, Daniel D Bohl, Bryan D Haughom, Brett R Levine
BACKGROUND: In revision total hip arthroplasty (THA), proximal femoral bone loss creates a challenge of achieving adequate stem fixation. The purpose of this study was to examine the outcomes of a monoblock, splined, tapered femoral stem in revision THA. METHODS: Outcomes of revision THA using a nonmodular, splined, tapered femoral stem from a single surgeon were reviewed. With a minimum of 2-year follow-up, there were 68 cases (67 patients). Paprosky classification was 3A or greater in 85% of the cases...
July 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28803735/previously-successful-dental-implants-can-fail-when-patients-commence-anti-resorptive-therapy-a-case-series
#11
M A Pogrel, S L Ruggiero
This article reports a type of localized osteonecrosis that can occur in patients who have had successful osseointegrated implants for many years and then commence anti-resorptive therapy. Eleven female patients were identified who had successful implant insertion, but who were placed on anti-resorptive therapy (bisphosphonates or denosumab) several years later and developed osteonecrosis around the implants. In each case, the osteonecrosis occurred only around the implants and not around the patient's remaining teeth...
August 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28803411/electro-chemical-deposition-of-nano-hydroxyapatite-zinc-coating-on-titanium-metal-substrate
#12
N A El-Wassefy, F M Reicha, N S Aref
BACKGROUND: Titanium is an inert metal that does not induce osteogenesis and has no antibacterial properties; it is proposed that hydroxyapatite coating can enhance its bioactivity, while zinc can contribute to antibacterial properties and improve osseointegration. AIMS: A nano-sized hydroxyapatite-zinc coating was deposited on commercially pure titanium using an electro-chemical process, in order to increase its surface roughness and enhance adhesion properties...
August 13, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28793839/roughness-and-hydrophilicity-as-osteogenic-biomimetic-surface-properties
#13
Barbara Boyan, Ethan Major Lotz, Zvi Schwartz
Successful dental and orthopaedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics like bone morphogenetic proteins. An understanding of the interaction between cells and how cells interact with the physical features characteristics of their environments have has led to the development ofse bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and hydrophilicity wettability of native bone have been shown to provide cells in the osteoblast lineage cells with the structural cues to promote tissue regeneration and net new bone formation...
August 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28791830/zirconium-the-material-of-the-future-in-modern-implantology
#14
REVIEW
Paweł Kubasiewicz-Ross, Marzena Dominiak, Tomasz Gedrange, Ute U Botzenhart
The authors present the contemporary state of knowledge concerning alternative materials for dental implantology. First of all, factors influencing osseointegration are stated. The most important factors seem to be the type of implant surface. Among the numerous parameters describing them, the most important are: average roughness and porous density. Some studies proved that materials with comparable surface roughness provide similar osseointegration. In modern implantology titanium is the material still considered as a "gold standard"...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791077/bone-morphogenetic-protein-coating-on-titanium-implant-surface-a-systematic-review
#15
REVIEW
Haim Haimov, Natali Yosupov, Ginnady Pinchasov, Gintaras Juodzbalys
OBJECTIVES: The purpose of the study is to systematically review the osseointegration process improvement by bone morphogenetic protein coating on titanium implant surface. MATERIAL AND METHODS: An electronic literature search was conducted through the MEDLINE (PubMed) and EMBASE databases. The search was restricted for articles published during the last 10 years from October 2006 to September 2016 and articles were limited to English language. RESULTS: A total of 41 articles were reviewed, and 8 of the most relevant articles that are suitable to the criteria were selected...
April 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/28783082/incorporation-of-collagen-in-calcium-phosphate-cements-for-controlling-osseointegration
#16
Ming-Hsien Hu, Pei-Yuan Lee, Wen-Cheng Chen, Jin-Jia Hu
In this study, we investigated the effect of supplementing a non-dispersive dicalcium phosphate-rich calcium phosphate bone cement (DCP-rich CPC) with type I collagen on in vitro cellular activities and its performance as a bone graft material. Varying amounts of type I collagen were added during the preparation of the DCP-rich CPC. In vitro cell adhesion, morphology, viability, and alkaline phosphatase (ALP) activity were evaluated using progenitor bone cells. Bone graft performance was evaluated via a rat posterolateral lumbar fusion model and osteointegration of the implant...
August 6, 2017: Materials
https://www.readbyqxmd.com/read/28773005/implant-stability-of-biological-hydroxyapatites-used-in-dentistry
#17
Maria Piedad Ramírez Fernández, Sergio A Gehrke, Patricia Mazón, Jose L Calvo-Guirado, Piedad N De Aza
The aim of the present study was to monitor implant stability after sinus floor elevation with two biomaterials during the first six months of healing by resonance frequency analysis (RFA), and how physico-chemical properties affect the implant stability quotient (ISQ) at the placement and healing sites. Bilateral maxillary sinus augmentation was performed in 10 patients in a split-mouth design using a bobine HA (BBM) as a control and porcine HA (PBM). Six months after sinus lifting, 60 implants were placed in the posterior maxilla...
June 12, 2017: Materials
https://www.readbyqxmd.com/read/28772697/calcium-phosphate-bioceramics-a-review-of-their-history-structure-properties-coating-technologies-and-biomedical-applications
#18
REVIEW
Noam Eliaz, Noah Metoki
Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials...
March 24, 2017: Materials
https://www.readbyqxmd.com/read/28771196/preparation-and-evaluation-of-dexamethasone-dex-growth-and-differentiation-factor-5-gdf-5-surface-modified-titanium-using-%C3%AE-cyclodextrin-conjugated-heparin-cd-hep-for-enhanced-osteogenic-activity-in-vitro-and-in-vivo
#19
Dae Hyeok Yang, Sun-Jung Yoon, Deok-Won Lee
The most ideal implant models in the dental and orthopedic fields to minimize the failure rate of implantation involve the improvement of osseointegration with host bone. Therefore, a focus of this study is the preparation of surface-modified titanium (Ti) samples of disc and screw types using dexamethasone (DEX) and/or growth and differentiation factor-5 (GDF-5), as well as the evaluation of their efficacies on bone formation in vitro and in vivo. X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and contact angle measurement were used to evaluate the surface chemical composition, surface morphology and wettability, respectively...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28767464/role-of-osteogenic-coatings-on-implant-surfaces-in-promoting-bone-to-implant-contact-in-experimental-osteoporosis-a-systematic-review-and-meta-analysis
#20
Alexis Ghanem, Sergio Varela Kellesarian, Tariq Abduljabbar, Nawwaf Al-Hamoudi, Fahim Vohra, Fawad Javed
OBJECTIVE: The aim of this systematic review and meta-analysis was to evaluate the role of osteogenic coatings (placement of a thin film of organic and inorganic osteoinductive and osteoproliferative materials) on implant surfaces in augmenting bone-to-implant contact (BIC) in osteoporotic bone. DATA SOURCES: To answer the focused question "Do osteogenic coatings on implant surfaces increase BIC in osteoporotic bone?" PubMed/MEDLINE, EMBASE, ISI Web of Knowledge, Scopus, and Google-Scholar databases were searched till June 2017 using different combinations of the following key words: bone-to-implant contact, coating, implant surface, osseointegration, and osteoporosis...
July 31, 2017: Implant Dentistry
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