Jia Nong, Patrick M Glassman, Vladimir V Shuvaev, Sahily Reyes-Esteves, Helene C Descamps, Raisa Y Kiseleva, Tyler E Papp, Mohamad-Gabriel Alameh, Ying K Tam, Barbara L Mui, Serena Omo-Lamai, Marco E Zamora, Tea Shuvaeva, Evguenia Arguiri, Xijing Gong, Taylor V Brysgel, Ai Wen Tan, Ashley G Woolfork, Aalim Weljie, Christoph A Thaiss, Jacob W Myerson, Drew Weissman, Scott E Kasner, Hamideh Parhiz, Vladimir R Muzykantov, Jacob S Brenner, Oscar A Marcos-Contreras
Effective delivery of mRNA or small molecule drugs to the brain is a significant challenge in developing treatment for acute ischemic stroke. To address the problem, we have developed targeted nanomedicine to increase drug concentrations in endothelial cells of the blood-brain barrier (BBB) of the injured brain. Inflammation during ischemic stroke causes continuous neuronal death and increase of the infarct volume. To enable targeted delivery to the inflamed BBB, we conjugated lipid nanocarriers with antibodies that bind cell adhesion molecules expressed at the BBB...
March 6, 2024: Molecular Therapy