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https://www.readbyqxmd.com/read/30073584/refining-the-benefit-risk-profile-of-anti-epileptic-drugs-in-headache-disorders
#1
REVIEW
Michael J Marmura, Aliza S Kumpinsky
Anti-epileptic drugs are among the most effective drugs for migraine prophylaxis, and will likely continue to have a role even as new therapies emerge. Topiramate and valproate are effective for the preventive treatment of migraine, and other medications such as gabapentin or lamotrigine may have a role in the treatment of those with allodynia or frequent aura, respectively. Oxcarbazepine, carbamazepine, phenytoin, gabapentin, and others may alleviate pain in trigeminal neuralgia. While many anti-epileptic drugs can be effective in those with migraine or other headaches, most of these agents can potentially cause serious side effects...
August 2, 2018: CNS Drugs
https://www.readbyqxmd.com/read/30057825/percutaneous-epidural-hydrogel-sealant-for-the-treatment-of-spontaneous-intracranial-hypotension-a-case-report-of-chronic-thoracic-neuralgia-and-technical-lessons-learned
#2
Michael G Hillegass, Samuel F Luebbert, Maureen F McClenahan
We report a case in which a 34-year-old female with refractory intracranial hypotension headaches due to a spontaneous dural tear was ultimately treated with CT-guided transforaminal epidural placement of a synthetic absorbable sealant (DuraSeal®). The procedure successfully resolved her headaches; however she subsequently developed thoracic neuralgia presumably due to mass effect of the sealant material on the lower thoracic spinal cord and nerve roots. This case report describes the potential for significant spinal cord and nerve root compression as well as the development of chronic neuralgia with the placement of epidural hydrogel and fibrin glue sealants...
2018: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/30055103/reduced-inhibition-in-brainstem-circuits-in-classical-trigeminal-neuralgia
#3
A Gündüz, U Uygunoğlu, D Uluduz, S Saip, A Siva, B Göksan, M E Kızıltan
OBJECTIVE: We hypothesized that prepulse modulation (PPM) would be altered in trigeminal neuralgia (TN) if suprasegmental inhibitory network involvement was present and tested our hypothesis in a group of patients with classical TN. METHODS: The study enrolled nine consecutive patients with classical TN and 14 healthy subjects. Diagnosis and classification followed the International Classification of Headache Disorders-third edition (beta version). The blink reflex (BR) and BR-PPM were recorded...
July 28, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/30054391/long-term-depression-induced-by-optogenetically-driven-nociceptive-inputs-to-trigeminal-nucleus-caudalis-or-headache-triggers
#4
B Pradier, H B Shin, D S Kim, R St Laurent, D Lipscombe, J A Kauer
The peripheral trigeminovascular pathway mediates oro- and craniofacial pain and projects centrally to the brainstem trigeminal nucleus caudalis (TNc). Sensitization of this pathway is involved in many pain conditions, but little is known about synaptic plasticity at its first central synapse. We have taken advantage of optogenetics to investigate plasticity selectively evoked at synapses of nociceptive primary afferents onto TNc neurons. Based on immuno-labeling in the trigeminal ganglia, TRPV1-lineage neurons comprise primarily peptidergic and non-peptidergic nociceptors...
July 27, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29989049/yokukansan-kampo-medicinal-formula-prevents-the-development-of-morphine-tolerance-by-inhibiting-the-secretion-of-orexin-a
#5
Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa
Background: Yokukansan (YKS), a traditional herbal (Kampo) medicine consisting of seven herbs, is effective in the treatment of pain disorders, such as headache, postherpetic neuralgia, fibromyalgia, and trigeminal neuralgia, and we have previously shown it to be effective against morphine analgesic tolerance in rats. It has been reported that orexin receptor antagonists prevent the development of morphine tolerance and that YKS inhibits the secretion of orexin A in the hypothalamus. This study examined whether the inhibition of the secretion of orexin A by YKS is one mechanism underlying its effect against morphine analgesic tolerance...
June 2018: Integrative medicine research
https://www.readbyqxmd.com/read/29909973/-french-guidelines-for-diagnosis-and-treatment-of-classical-trigeminal-neuralgia-french-headache-society-and-french-neurosurgical-society
#6
A Donnet, E Simon, E Cuny, G Demarquay, A Ducros, S De Gaalon, P Giraud, E Guégan Massardier, M Lanteri-Minet, D Leclercq, C Lucas, M Navez, C Roos, D Valade, P Mertens
No abstract text is available yet for this article.
June 14, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29904802/an-update-on-repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-co-morbid-pain-and-depressive-symptoms
#7
REVIEW
Jonathan H Hsu, Zafiris J Daskalakis, Daniel M Blumberger
PURPOSE: Review recent meta-analyses and clinical trials investigating the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) for concurrent pain and depressive symptoms. RECENT FINDINGS: Recent meta-analyses have included both pain and depression outcomes in fibromyalgia and chronic pain. Randomized controlled trials have also been conducted in post-herpetic neuralgia, trauma-related headache, and neuropathic pain with attention to both pain and depressive symptoms...
June 14, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29863583/congenital-unilateral-atlanto-occipital-rotatory-subluxation-rare-cause-of-c1-neuralgia
#8
Mihir R Bapat, Amandeep Gujral, Bharat K Patel
STUDY DESIGN: Case report OBJECTIVE.: We report a rare case of congenital unilateral rotatory atlanto-occipital subluxation that presented with left C1 neuralgia. SUMMARY OF BACKGROUND DATA: Secondary occipital neuralgia is commonly attributed to pathologies of the atlanto-axial joint and C2/C3 nerve involvement. Our case depicts a model of slow creeping atlanto-occipital subluxation due to a rare left C1 superior articular facet dysplasia with C1 foraminal stenosis presenting as C1 neuralgia...
May 31, 2018: Spine
https://www.readbyqxmd.com/read/29862074/sphenopalatine-ganglion-block-for-the-treatment-of-acute-migraine-headache
#9
Mohamed Binfalah, Eman Alghawi, Eslam Shosha, Ali Alhilly, Moiz Bakhiet
Transnasal sphenopalatine ganglion block is emerging as is an attractive and effective treatment modality for acute migraine headaches, cluster headache, trigeminal neuralgia, and several other conditions. We assessed the efficacy and safety of this treatment using the Sphenocath® device. 55 patients with acute migraine headaches underwent this procedure, receiving 2 ml of 2% lidocaine in each nostril. Pain numeric rating scale (baseline, 15 minutes, 2 hours, and 24 hours) and patient global impression of change (2 hours and 24 hours after treatment) were recorded...
2018: Pain Research and Treatment
https://www.readbyqxmd.com/read/29778285/subcutaneous-tissue-metastasis-from-glioblastoma-multiforme-a-case-report-and-review-of-the-literature
#10
Natalia Frade Porto, Juan Delgado Fernández, María de Los Ángeles García Pallero, Juan Ramón Penanes Cuesta, Paloma Pulido Rivas, Ricardo Gil Simoes
Glioblastoma multiforme is the most common primary brain tumor, despite an aggressive clinical course, less than 2% of patients develop extraneural metastasis. We present a 72-year-old male diagnosed with a right temporal glioblastoma due to headache. He underwent total gross resection surgery and after that the patient was treated with adyuvant therapy. Five months after the patient returned with trigeminal neuralgia, and MRI showed an infratemporal cranial mass which infiltrates masticator space, the surrounding bone, the temporal muscle and superior cervical and parotid lymph nodes...
May 16, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29720816/short-lasting-unilateral-neuralgiform-headache-attacks
#11
REVIEW
Andrew Levy, Manjit S Matharu
Short-lasting unilateral neuralgiform headache attacks (SUNHA) is characterized by strictly unilateral trigeminal distribution pain that occurs in association with ipsilateral cranial autonomic features. There are two subtypes: short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). These disorders are rare but highly disabling. The management of SUNHA can be challenging...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29600913/natural-history-of-cavernous-sinus-meningiomas
#12
Aymeric Amelot, Remy van Effenterre, Michel Kalamarides, Philippe Cornu, Anne-Laure Boch
OBJECTIVE Meningiomas confined to the cavernous sinus (MCSs) are benign tumors. Due to the high risk of severe complications, the intracavernous surgical procedure was abandoned in favor of radiotherapy. However, the choice of treatment remains complicated due to the fact that the natural history of this lesion has not yet been described. METHODS The authors studied the natural history of this lesion using a prospective series of 53 consecutive patients suffering from MCSs. The median follow-up duration was 10...
March 30, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29597050/did-fr%C3%A3-d%C3%A3-ric-chopin-die-from-heart-failure
#13
Antonio Perciaccante, Philippe Charlier, Camilla Negri, Alessia Coralli, Otto Appenzeller, Raffaella Bianucci
On October 17, 1849, Poland's greatest composer, Frédéric Chopin (1810-1849) died aged 39. His cause of death remains unknown. An investigation of the documental sources was performed to reconstruct the medical history of the artist. Since his earliest years, his life had been dominated by poor health. Recurrent episodes of cough, fever, headaches, lymphadenopathy- a series of symptoms that may be attributed to viral respiratory infections- manifested in his teens. Later in life, he had chest pain, hemoptysis, hematemesis, neuralgia, and arthralgia...
May 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29574434/herpes-zoster-ophthalmicus-evolving-into-headache-characterised-as-hemicrania-continua
#14
Sanjay Prakash, Ankit Dave, Hemant Joshi
Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster infection. However, a few patients may develop different types of pain after herpetic lesions. We are reporting two patients who developed postherpetic hemicrania continua (HC). Case 1: a 54-year-old woman had a 10-month history of continuous left-sided pain with superimposed exacerbations. The pain started with the onset of herpetic lesions in the ophthalmic division. The lesions subsided in a few weeks. However, the pain persisted and it responded exclusively to indomethacin...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29562973/helmet-induced-occipital-neuralgia-in-a-military-aviator
#15
Julio A Chalela
BACKGROUND: Headaches among military personnel are very common and headgear wear is a frequently identified culprit. Helmet wear may cause migrainous headaches, external compression headache, other primary cranial neuralgias, and occipital neuralgia. The clinical features and the response to treatment allow distinction between the different types of headaches. Headaches among aviators are particularly concerning as they may act as distractors while flying and the treatment options are often incompatible with flying status...
April 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29560635/-treatment-of-occipital-neuralgia-by-electroacupuncture-combined-with-neural-mobilization
#16
Yan Wang, Zi-Nan Guo, Zhen Yang, Shun Wang
OBJECTIVE: To observe the effect of electroacupuncture (EA) combined with neural mobilization (NM) in the treatment of occipital neuralgia. METHODS: A total of 62 occipital neuralgia patients were randomized into EA group (19 cases), NM group (22 cases) and EA+NM group (21 cases). EA was applied at acupoint-pairs as Yuzhen (BL 9)- Tianzhu (BL 10), Fengchi (GB 20)- Wangu (GB 12), etc. NM intervention consisted of occipital muscle group mobilization, C2 spinous process mobilization, cervical joint passive movement management mobilization, etc...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29559871/radiofrequency-ablation-of-pericranial-nerves-for-treating-headache-conditions-a-promising-option-for-patients
#17
Alaa Abd-Elsayed, Laura Kreuger, Shawna Wheeler, Janet Robillard, Susanne Seeger, Douglas Dulli
Background: Chronic daily headache, including chronic migraine, can be challenging to treat. Medications often only provide limited improvement, and surgical interventions can be associated with significant adverse effects. We present our experience with using radiofrequency ablation (RFA) for pericranial nerves to treat chronic headache conditions. Methods: This retrospective analysis included patients who received RFA for pericranial nerves to treat chronic daily headache conditions from January 1, 2015 to June 1, 2016...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/29556851/novel-interventional-nonopioid-therapies-in-headache-management
#18
REVIEW
Omar Viswanath, Roxanna Rasekhi, Rekhaben Suthar, Mark R Jones, Jacquelin Peck, Alan D Kaye
PURPOSE OF REVIEW: Headaches encompass a broad-based category of a symptom of pain in the region of the head or neck. For those patients who unfortunately do not obtain relief from conservative treatment, interventional techniques have been developed and are continuing to be refined in an attempt to treat this subset of patients with the goal of return of daily activities. This investigation reviews various categories of headaches, their pathophysiology, and types of interventional treatments currently available...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29537058/-lacosamide-associated-with-high-degree-block-in-a-patient-with-trigeminal-neuralgia
#19
M Marin-Gracia, D Cantero-Lozano, E Garces-Anton, A Lopez-Bravo, A Garrido-Fernandez, M P Navarro-Perez, S Santos-Lasaosa, M Garces-Redondo
INTRODUCTION: Lacosamide is an antiepileptic drug whose exact mechanism of action remains unknown. It acts by increasing the slow inactivation of the voltage-dependent sodium channels of the cell membranes. It is indicated in the treatment of focal seizures with or without secondary generalisation and is occasionally used as adjunct treatment in neuropathic pain. Although the most frequent side effects are mild (dizziness, diplopia, blurred vision, headache, tremor, etc.), others such as supraventricular tachyarrhythmias, changes in repolarisation, atrioventricular blocks and even cardiac arrest or sudden death have been reported...
March 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29431387/herpes-zoster-and-postherpetic-neuralgia-prevention-and-management
#20
Aaron Saguil, Shawn Kane, Michael Mercado, Rebecca Lauters
Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Patients may present with malaise, headache, low-grade fever, and abnormal skin sensations for two to three days before the classic maculopapular rash appears. The rash is usually unilateral, confined to a single dermatome, and typically progresses to clear vesicles that become cloudy and crust over in seven to 10 days...
November 15, 2017: American Family Physician
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