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Tromso study

Kristina Sivertsen, Marko Lukic, Agnete E Kristoffersen
BACKGROUND: Alcohol is consumed almost worldwide and is the most widely used recreational drug in the world. Harmful use of alcohol is known to cause a large disease-, social- and economic burden on society. Only a few studies have examined the relationship between CAM use and alcohol consumption. To our knowledge there has been no such research in Norway. The aim of this study is to describe and compare alcohol consumption and injuries related to alcohol across gender and different CAM approaches...
August 13, 2018: BMC Complementary and Alternative Medicine
Mashhood Ahmed Sheikh
BACKGROUND: The aim of this study was to assess the associations between child maltreatment (CM), psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism (i.e., low metabolism), and chronic bronchitis/emphysema/COPD in adulthood. METHODS: The present analysis used cross-sectional data collected in 2007-2008 within the Tromsø Study, Norway (N = 12,981). CM was measured with a single item, and self-reported information on psychopathological symptoms and physical health outcomes was used...
August 1, 2018: Journal of Affective Disorders
A V Hauger, A Bergland, K Holvik, A Ståhle, N Emaus, B H Strand
Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality? BMD consistent with osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. INTRODUCTION: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier...
August 9, 2018: Osteoporosis International
Vegard Skirbekk, Melissa Hardy, Bjørn Heine Strand
Both high grip strength and being married independently relate to better functional capacity and health at older ages, but the combined effect of marital status and strength have not been investigated. Especially at older ages, declining strength can have adverse health and social consequences, where having a spouse could potentially help with everyday support and alleviate some of the negative effects of sarcopenia. We investigate how grip strength relates to being married among two cohorts of 59-71 year olds (born 1923-35 and 1936-48) in the Norwegian city of Tromsø, controlling for a broad set of health variables and sociodemographic characteristics...
August 2018: SSM—Population Health
Maria Carlsson, Tom Wilsgaard, Stein Harald Johnsen, Liv-Hege Johnsen, Maja-Lisa Løchen, Inger Njølstad, Ellisiv Bøgeberg Mathiesen
Background Studies on the relationship between temporal trends in risk factors and incidence rates of intracerebral hemorrhage are scarce. Aims To analyze temporal trends in risk factors and incidence rates of intracerebral hemorrhage using individual data from a population-based study. Methods We included 28,167 participants of the Tromsø Study enrolled between 1994 and 2008. First-ever intracerebral hemorrhages were registered through 31 December 2013. Hazard ratios (HRs) for intracerebral hemorrhage were analyzed by Cox proportional hazards models, risk factor levels over time by generalized estimating equations, and incidence rate ratios (IRR) by Poisson regression...
July 30, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Trygve S Ellingsen, Jostein Lappegård, Tove Skjelbakken, Ellisiv B Mathiesen, Inger Njølstad, Sigrid K Brækkan, John-Bjarne Hansen
<AbstractText Label="Background" NlmCategory="UNASSIGNED">Red cell distribution width (RDW) is a risk marker of venous thromboembolism (VTE), myocardial infarction (MI), stroke, and cancer. Due to interrelations between these diseases, the association between RDW and VTE may be explained by MI, stroke, or cancer. Objective: To investigate whether the effect of RDW on VTE could be explained by intermediate development of MI, stroke, or cancer. Methods: RDW was measured in 24 363 participants of the Tromsø Study in 1994-1995...
April 2018: Research and Practice in Thrombosis and Haemostasis
S B Jensen, K Hindberg, T Solomon, E N Smith, J D Lapek, D J Gonzalez, N Latysheva, K A Frazer, S K Braekkan, J-B Hansen
BACKGROUND: Prophylactic anticoagulant treatment may substantially reduce the incidence of venous thromboembolism (VTE) but entails considerable risk of severe bleeding. Identification of individuals at high risk of VTE through the use of predictive biomarkers is desirable in order to achieve a favorable benefit-to-harm ratio. OBJECTIVE: We aimed to identify predictive protein biomarker candidates of VTE. METHODS: We performed a case-control study of 200 individuals that participated in the Tromsø Study, a population-based cohort, where blood samples were collected before the VTE events occurred...
July 2, 2018: Journal of Thrombosis and Haemostasis: JTH
A Johansen, L Romundstad, C S Nielsen, H Schirmer, A E Eggen, A Stubhaug
Background The prevalence of persistent postoperative pain in the general population is poorly documented, but clinical studies indicate that the problem is common. Aim The aim of this study was (1) to assess the prevalence of persistent postoperative pain among individuals operated during the last 3 years in a general population and (2) to describe factors associated with chronic postoperative pain. Materials and methods As part of a cross-sectional health survey in the municipality of Tromsø, North Norway, all participants answered questions on surgery, persisting pain and sensory abnormalities in the area of surgery...
December 29, 2017: Scandinavian Journal of Pain
Solbjørg Makalani Myrtveit, Jens Christoffer Skogen, Børge Sivertsen, Ólöf Anna Steingrímsdóttir, Audun Stubhaug, Christopher Sivert Nielsen
Aim Among individuals who experience whiplash accidents, around 20% develop chronic pain. We aimed to compare number of painful locations and pain intensity between individuals with chronic whiplash and individuals with other chronic pain, and to investigate whether differences could be explained by pain tolerance. Methods Employing data from the sixth wave of the Tromsø Study, individuals reporting whiplash were compared to individuals with other chronic pain. Number of pain locations was compared using Poisson regression, pain intensity using linear regression...
December 29, 2017: Scandinavian Journal of Pain
Trygve Lofterød, Elin S Mortensen, Hawa Nalwoga, Tom Wilsgaard, Hanne Frydenberg, Terje Risberg, Anne Elise Eggen, Anne McTiernan, Sura Aziz, Erik A Wist, Andreas Stensvold, Jon B Reitan, Lars A Akslen, Inger Thune
BACKGROUND: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear. METHODS: A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Pre-diagnostic triglycerides, total-cholesterol and HDL-cholesterol were measured, and detailed clinical and histopathological data were obtained...
June 15, 2018: BMC Cancer
Mashhood Ahmed Sheikh
OBJECTIVE: Physical inactivity is a major public health problem associated with an increased risk of several psychiatric and physical conditions. This study investigated the association between leisure time physical activity (PA) and incident use of prescription tranquilizers in a regionally representative and prospective cohort. METHODS: A total of 4043 men and women (mean age: 61.3 years; 57% women) from the Tromsø Study were followed for six years. Leisure time PA was captured at baseline...
October 1, 2018: Journal of Affective Disorders
Mashhood Ahmed Sheikh
OBJECTIVE: Many researchers view retrospective reports with skepticism. Indeed, the observed association between retrospectively-reported childhood disadvantage (CD) and morbidity in adulthood has been criticized as an artefactual correlation driven by the psychological state of the respondent at the time of reporting (current psychological state). The aim of this study was to assess the role of current psychological state in the association between childhood disadvantage and morbidity in adulthood...
August 2018: Journal of Psychiatric Research
Bolli Thorsson, Gudny Eiriksdottir, Sigurdur Sigurdsson, Elias Freyr Gudmundsson, Michael L Bots, Thor Aspelund, Kjell Arne Arntzen, Ellisiv B Mathiesen, Vilmundur Gudnason
OBJECTIVES: Population statistics for carotid plaque and cardiovascular risk factors reported in scientific journals are usually presented as averages for the population or age and sex adjusted, rather than sex and age groups. Important population differences about atherosclerosis and cardiovascular risk factors may thus be missed. We compare the distribution of cardiovascular risk factors, carotids plaque and carotid intima-media thickness (CIMT) in two population-based studies. METHODS: Carotid artery atherosclerotic plaque prevalence and risk factors levels for cardiovascular disease by sex in 5-year age groups from the Risk Evaluation For Infarct Estimates Reykjavik study (REFINE-Reykjavik study) were compared with data from the Tromsø 6 study...
May 31, 2018: BMJ Open
Trygve S Ellingsen, Jostein Lappegård, Thor Ueland, Pål Aukrust, Sigrid K Brækkan, John-Bjarne Hansen
Red cell distribution width (RDW) is associated with venous thromboembolism (VTE), but the underlying mechanism(s) is unclear. Iron deficiency is associated with high RDW, and studies suggest an association between iron deficiency and VTE. To assess whether iron deficiency is a risk factor for VTE that explains the association between RDW and VTE, we conducted a nested case-control study of 390 patients with VTE and 802 age- and sex-matched controls selected from the population-based cohort of the Tromsø Study...
June 12, 2018: Blood Advances
Svein Ivar Bekkelund, Stein Harald Johnsen
BACKGROUND: Creatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population. METHODS: CK and hs-CRP were measured in the population-based Tromsø study that included entire birth cohorts and random samples of citizens between 30-87 years of age. The analyses were performed sex-stratified in 5969 men and 6827 women...
2018: PloS One
Petja Lyn Langholz, Bjørn Heine Strand, Sarah Cook, Laila A Hopstock
AIM: There is a lack of studies on the prevalence of frailty, and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of the present study was to investigate the association between the frailty phenotype and all-cause mortality in men and women in a Norwegian cohort study. METHODS: We followed 712 participants (52% women) aged ≥70 years participating in the population-based Tromsø 5 Study in 2001-2002 for all-cause mortality up to 2016...
May 29, 2018: Geriatrics & Gerontology International
Elin Marie Lindstad Løvåsmoen, Mari Nyland Bjørgo, Mirjam Lukasse, Berit Schei, Lena Henriksen
OBJECTIVES: The caesarean (CS) section rate varies among hospitals in Norway, and little is known about whether this is influenced by women's preferences. The aim of this study was to investigate the differences in women's preferred mode of delivery during pregnancy between five hospitals in Norway, and to relate this to the actual mode of delivery. STUDY DESIGN: A prospective cohort study of 2,177 unselected pregnant women in five hospitals in Norway. Women were recruited at their standard ultrasound examinations, and data was collected through questionnaires and electronic patient charts...
June 2018: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
Stein Harald Johnsen, Bjarne K Jacobsen, Sigrid K Brækkan, John-Bjarne Hansen, Ellisiv B Mathiesen
BACKGROUND: Whether long-chain n-3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size. METHODS: We obtained questionnaire-based information on fish consumption and carotid ultrasonography from 3900 persons aged 45-74 years...
May 25, 2018: Nutrition Journal
Solveig Engebretsen, Arnoldo Frigessi, Kenth Engø-Monsen, Anne-Sofie Furberg, Audun Stubhaug, Birgitte Freiesleben de Blasio, Christopher Sivert Nielsen
Background and aims Twin studies have found that approximately half of the variance in pain tolerance can be explained by genetic factors, while shared family environment has a negligible effect. Hence, a large proportion of the variance in pain tolerance is explained by the (non-shared) unique environment. The social environment beyond the family is a potential candidate for explaining some of the variance in pain tolerance. Numerous individual traits have previously shown to be associated with friendship ties...
July 26, 2018: Scandinavian Journal of Pain
M S W Teigmo, T E Gundersen, N Emaus, G Grimnes
BACKGROUND/OBJECTIVES: Sufficient vitamin A levels are important for many functions-and both too little and too much may have detrimental health effects. The aim of the study was to describe the distribution of retinol levels in Norwegian adolescents, the relation between lifestyle factors and retinol levels, and the relation between retinol levels and bone mineral density (BMD). SUBJECTS/METHODS: Serum retinol was measured in 414 girls and 474 boys aged 15-19 years, participating in the Tromsø Study: Fit Futures...
May 23, 2018: European Journal of Clinical Nutrition
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