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Tromso study

Mashhood Ahmed Sheikh
Several researchers have raised the concern that the cross-sectional association of retrospectively reported childhood adversity with self-reported onset of asthma and chronic bronchitis in adulthood may be confounded, as well as mediated by an individual's mental health. The aim of this study was to assess the effect of retrospectively reported childhood adversity on self-reported onset of asthma and chronic bronchitis in adulthood, independent of potential confounding and mediating variables (including respondent's mental health)...
November 2018: Journal of Psychosomatic Research
Bjørn Heine Strand, Astrid Bergland, Lone Jørgensen, Henrik Schirmer, Nina Emaus, Rachel Cooper
Background: Evidence pertaining to whether more recent born generations of adults reaching old age have better physical capability than previous generations is scarce and inconclusive. We aimed to investigate birth cohort differences in grip strength. Methods: The study comprised 5,595 individuals from the Tromsø study waves in 1994/1995, 2007/2008, and 2015/2016. Grip strength (bar) was measured using a Martin vigorimeter, and compared across three birth cohorts of 66- to 84-year-olds (born in: 1910-1929, 1923-1942, 1931-1949), as well as within narrower age bands to ensure nonoverlapping cohorts...
October 11, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Elin Evensen, Guri Skeie, Tom Wilsgaard, Tore Christoffersen, Elaine Dennison, Anne-Sofie Furberg, Guri Grimnes, Anne Winther, Nina Emaus
The effect of birth weight and childhood body mass index (BMI) on adolescents' bone parameters is not established. The aim of this longitudinal, population-based study was to investigate the association of birth weight, childhood BMI, and growth, with adolescent bone mass and bone density in a sample of 633 adolescents (48% girls) from The Tromsø Study: Fit Futures. This population-based cohort study was conducted in 2010-2011 and 2012-2013 in Tromsø, Norway. Bone mineral content (BMC) and areal BMD (aBMD) were measured at total hip (TH) and total body (TB) by dual-energy X-ray absorptiometry (DXA) and converted to internal Z -scores...
September 2018: JBMR Plus
Marit D Solbu, Svein O Kolset, Trond G Jenssen, Tom Wilsgaard, Maja-Lisa Løchen, Ellisiv B Mathiesen, Toralf Melsom, Bjørn O Eriksen, Trine M Reine
BACKGROUND AND AIMS: Cardiovascular disease is a common cause of morbidity and mortality, with gender differences in pathophysiology. The endothelial glycocalyx maintains vascular integrity, and glycocalyx shedding reflects endothelial dysfunction and early atherosclerosis. Syndecan-1 and -4 are components of the glycocalyx, and increased serum levels indicate glycocalyx damage. We hypothesised that increased serum syndecan-1 and -4 were independently associated with myocardial infarction (MI), ischaemic stroke and all-cause mortality in men and women from a general population...
September 15, 2018: Atherosclerosis
Erlend Bugge, Rolf Wynn, Tom Eirik Mollnes, Solveig Klæbo Reitan, Ole Kristian Grønli
BACKGROUND: There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. METHODS: Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 years, consecutively admitted to a psychiatric hospital in Tromsø, Norway (69°N). RESULTS: The most common diagnosis was Recurrent depressive disorder (26...
September 27, 2018: BMC Psychiatry
Marius Renninger, Maja-Lisa Løchen, Ulf Ekelund, Laila A Hopstock, Lone Jørgensen, Ellisiv B Mathiesen, Inger Njølstad, Henrik Schirmer, Tom Wilsgaard, Bente Morseth
Physical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisure-time physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20-54 years who took part in the second Tromsø Study. At baseline in 1979-80 LTPA was assessed by questionnaire. Data on MI was collected and adjudicated through hospital and causes of death registries between 1979 and 2013...
September 13, 2018: Preventive Medicine
Line H Evensen, Trond Isaksen, Kristian Hindberg, Sigrid K Braekkan, John-Bjarne Hansen
BACKGROUND: Whether physical activity influences the risk of incident venous thromboembolism (VTE) remains controversial, potentially due to methodological challenges, such as regression dilution bias. OBJECTIVES: To investigate whether physical activity was associated with VTE risk, and explore the role of body mass index (BMI) as a mediator in a population-based cohort with repeated assessments of physical activity. METHODS: Participants (n=30 002) attending one or more surveys of the Tromsø Study 4-6 (1994-95, 2001-02, 2007-08) were included and categorized based on weekly physical activity...
September 6, 2018: Journal of Thrombosis and Haemostasis: JTH
Agnethe Eltoft, Kjell Arne Arntzen, Tom Wilsgaard, Ellisiv B Mathiesen, Stein Harald Johnsen
No abstract text is available yet for this article.
August 24, 2018: Atherosclerosis
Kristina Sivertsen, Marko Lukic, Agnete E Kristoffersen
BACKGROUND: Alcohol is consumed almost worldwide and is the most widely used recreational drug in the world. Harmful use of alcohol is known to cause a large disease-, social- and economic burden on society. Only a few studies have examined the relationship between CAM use and alcohol consumption. To our knowledge there has been no such research in Norway. The aim of this study is to describe and compare alcohol consumption and injuries related to alcohol across gender and different CAM approaches...
August 13, 2018: BMC Complementary and Alternative Medicine
Mashhood Ahmed Sheikh
BACKGROUND: The aim of this study was to assess the associations between child maltreatment (CM), psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism (i.e., low metabolism), and chronic bronchitis/emphysema/COPD in adulthood. METHODS: The present analysis used cross-sectional data collected in 2007-2008 within the Tromsø Study, Norway (N = 12,981). CM was measured with a single item, and self-reported information on psychopathological symptoms and physical health outcomes was used...
December 1, 2018: Journal of Affective Disorders
A V Hauger, A Bergland, K Holvik, A Ståhle, N Emaus, B H Strand
Low bone mineral density (BMD) gives an increased risk of fractures, which can lead to premature death. Can BMD of the wrist predict mortality? BMD consistent with osteopenia and osteoporosis gave a significantly increased risk of death for both men and women in a general population in Tromsø, Norway. INTRODUCTION: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier...
August 9, 2018: Osteoporosis International
Vegard Skirbekk, Melissa Hardy, Bjørn Heine Strand
Both high grip strength and being married independently relate to better functional capacity and health at older ages, but the combined effect of marital status and strength have not been investigated. Especially at older ages, declining strength can have adverse health and social consequences, where having a spouse could potentially help with everyday support and alleviate some of the negative effects of sarcopenia. We investigate how grip strength relates to being married among two cohorts of 59-71 year olds (born 1923-35 and 1936-48) in the Norwegian city of Tromsø, controlling for a broad set of health variables and sociodemographic characteristics...
August 2018: SSM—Population Health
Maria Carlsson, Tom Wilsgaard, Stein Harald Johnsen, Liv-Hege Johnsen, Maja-Lisa Løchen, Inger Njølstad, Ellisiv Bøgeberg Mathiesen
Background Studies on the relationship between temporal trends in risk factors and incidence rates of intracerebral hemorrhage are scarce. Aims To analyze temporal trends in risk factors and incidence rates of intracerebral hemorrhage using individual data from a population-based study. Methods We included 28,167 participants of the Tromsø Study enrolled between 1994 and 2008. First-ever intracerebral hemorrhages were registered through 31 December 2013. Hazard ratios (HRs) for intracerebral hemorrhage were analyzed by Cox proportional hazards models, risk factor levels over time by generalized estimating equations, and incidence rate ratios (IRR) by Poisson regression...
July 30, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Trygve S Ellingsen, Jostein Lappegård, Tove Skjelbakken, Ellisiv B Mathiesen, Inger Njølstad, Sigrid K Brækkan, John-Bjarne Hansen
<AbstractText Label="Background" NlmCategory="UNASSIGNED">Red cell distribution width (RDW) is a risk marker of venous thromboembolism (VTE), myocardial infarction (MI), stroke, and cancer. Due to interrelations between these diseases, the association between RDW and VTE may be explained by MI, stroke, or cancer. Objective: To investigate whether the effect of RDW on VTE could be explained by intermediate development of MI, stroke, or cancer. Methods: RDW was measured in 24 363 participants of the Tromsø Study in 1994-1995...
April 2018: Research and Practice in Thrombosis and Haemostasis
S B Jensen, K Hindberg, T Solomon, E N Smith, J D Lapek, D J Gonzalez, N Latysheva, K A Frazer, S K Braekkan, J-B Hansen
Essentials Discovery of predictive biomarkers of venous thromboembolism (VTE) may aid risk stratification. A case-control study where plasma was sampled before the occurrence of VTE was established. We generated untargeted plasma proteomic profiles of 200 individuals by use of mass spectrometry. Assessment of the biomarker potential of 501 proteins yielded 46 biomarker candidates. ABSTRACT: Background Prophylactic anticoagulant treatment may substantially reduce the incidence of venous thromboembolism (VTE) but entails considerable risk of severe bleeding...
September 2018: Journal of Thrombosis and Haemostasis: JTH
A Johansen, L Romundstad, C S Nielsen, H Schirmer, A E Eggen, A Stubhaug
Background The prevalence of persistent postoperative pain in the general population is poorly documented, but clinical studies indicate that the problem is common. Aim The aim of this study was (1) to assess the prevalence of persistent postoperative pain among individuals operated during the last 3 years in a general population and (2) to describe factors associated with chronic postoperative pain. Materials and methods As part of a cross-sectional health survey in the municipality of Tromsø, North Norway, all participants answered questions on surgery, persisting pain and sensory abnormalities in the area of surgery...
December 29, 2017: Scandinavian Journal of Pain
Solbjørg Makalani Myrtveit, Jens Christoffer Skogen, Børge Sivertsen, Ólöf Anna Steingrímsdóttir, Audun Stubhaug, Christopher Sivert Nielsen
Aim Among individuals who experience whiplash accidents, around 20% develop chronic pain. We aimed to compare number of painful locations and pain intensity between individuals with chronic whiplash and individuals with other chronic pain, and to investigate whether differences could be explained by pain tolerance. Methods Employing data from the sixth wave of the Tromsø Study, individuals reporting whiplash were compared to individuals with other chronic pain. Number of pain locations was compared using Poisson regression, pain intensity using linear regression...
December 29, 2017: Scandinavian Journal of Pain
Trygve Lofterød, Elin S Mortensen, Hawa Nalwoga, Tom Wilsgaard, Hanne Frydenberg, Terje Risberg, Anne Elise Eggen, Anne McTiernan, Sura Aziz, Erik A Wist, Andreas Stensvold, Jon B Reitan, Lars A Akslen, Inger Thune
BACKGROUND: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear. METHODS: A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Pre-diagnostic triglycerides, total-cholesterol and HDL-cholesterol were measured, and detailed clinical and histopathological data were obtained...
June 15, 2018: BMC Cancer
Mashhood Ahmed Sheikh
OBJECTIVE: Physical inactivity is a major public health problem associated with an increased risk of several psychiatric and physical conditions. This study investigated the association between leisure time physical activity (PA) and incident use of prescription tranquilizers in a regionally representative and prospective cohort. METHODS: A total of 4043 men and women (mean age: 61.3 years; 57% women) from the Tromsø Study were followed for six years. Leisure time PA was captured at baseline...
October 1, 2018: Journal of Affective Disorders
Mashhood Ahmed Sheikh
OBJECTIVE: Many researchers view retrospective reports with skepticism. Indeed, the observed association between retrospectively-reported childhood disadvantage (CD) and morbidity in adulthood has been criticized as an artefactual correlation driven by the psychological state of the respondent at the time of reporting (current psychological state). The aim of this study was to assess the role of current psychological state in the association between childhood disadvantage and morbidity in adulthood...
August 2018: Journal of Psychiatric Research
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