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JOURNAL ARTICLE
Esra Yuca, Ebru Şahin Kehribar, Urartu Özgür Şafak Şeker
HYPOTHESIS: Self-assembling protein subunits hold great potential as biomaterials with improved functions. Among the self-assembled protein structures functional amyloids are promising unique properties such as resistance to harsh physical and chemical conditions their mechanical strength, and ease of functionalization. Curli proteins, which are functional amyloids of bacterial biofilms can be programmed as intelligent biomaterials. EXPERIMENTS: In order to obtain controllable curli based biomaterials for biomedical applications, and to understand role of each of the curli forming monomeric proteins (namely CsgA and CsgB from Escherichia coli) we characterized their binding kinetics to gold, hydroxyapatite, and silica surfaces...
December 29, 2020: Colloids and Surfaces. B, Biointerfaces
#22
REVIEW
Rizacan Sarikaya, Linyong Song, Esra Yuca, Sheng-Xue Xie, Kyle Boone, Anil Misra, Paulette Spencer, Candan Tamerler
Resin-based composite has overtaken dental amalgam as the most popular material for the repair of lost or damaged tooth structure. In spite of the popularity, the average composite lifetime is about half that of amalgam restorations. The leading cause of composite-restoration failure is decay at the margin where the adhesive is applied. The adhesive is intended to seal the composite/tooth interface, but the adhesive seal to dentin is fragile and readily degraded by acids, enzymes and other oral fluids. The inherent weakness of this material system is attributable to several factors including the lack of antimicrobial properties, remineralization capabilities and durable mechanical performance - elements that are central to the integrity of the adhesive/dentin (a/d) interfacial seal...
October 10, 2020: Journal of the Mechanical Behavior of Biomedical Materials
#23
JOURNAL ARTICLE
R Michael E Parkhouse, Glenda Rojas R, Cruz Manuel Aguilar, Claudio Medina, Elizabeth Ferrer, Maria M Cortez Alcovedes
The objective of this study was to identify and treat carriers of adult Taenia solium present in two rural Venezuelan communities through examination of faecal samples by coproscopical analysis, and by the application of a polyclonal and a monoclonal (VP-1) coproantigen ELISA. Both the polyclonal and monoclonal ELISA's were negative when tested with soluble extracts of adults of Ascaris lumbricoides, Hymenolepis nana and Trichuris trichura. The polyclonal ELISA was positive for soluble extracts adults of T...
March 26, 2020: Acta Tropica
#24
JOURNAL ARTICLE
Nicci Owusu-Brackett, Ming Zhao, Argun Akcakanat, Kurt W Evans, Erkan Yuca, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam
Background: PTEN-deficient tumors are dependent on PI3Kβ activity, making PI3Kβ a compelling target. We evaluated the efficacy of PI3Kβ inhibitor AZD8186 on tumors with PTEN loss. Results: In vitro cell viability assay and immunoblotting demonstrated that PTEN loss was significantly correlated with AZD8186 sensitivity in triple negative breast cancer (TNBC) cell lines. Colony formation assay confirmed sensitivity of PTEN-deficient cell lines to AZD8186. AZD8186 inhibited PI3K signaling in PTEN loss TNBC cells...
March 17, 2020: Oncotarget
#25
JOURNAL ARTICLE
Yusuf Yuca, Turker Yucesoy, Olgu Enis Tok, Alper Alkan
PURPOSE: Comparison of low-level laser therapy (LLLT) and ozone therapy (OT) methods for the treatment of facial nerve injury (FNI) in rats, evaluated by histomorphometric measurement analysis. MATERIALS AND METHODS: Thirty rats were randomly divided into control (C), LLLT, and OT groups. The left facial nerves (FNs) of all rats (n = 30) were used in this study. These were held in a surgical clamp for 30 s to create neuropathic damage. The non-injured right FNs of the rats in the control group formed the fourth, sham (S) group in this study (n = 10)...
March 2020: Journal of Cranio-maxillo-facial Surgery
#26
JOURNAL ARTICLE
Randall M Chesnut, Nancy Temkin, Walter Videtta, Gustavo Petroni, Silvia Lujan, Jim Pridgeon, Sureyya Dikmen, Kelley Chaddock, Jason Barber, Joan Machamer, Nahuel Guadagnoli, Peter Hendrickson, Sergio Aguilera, Victor Alanis, Manuel Enrique Bello Quezada, Ermitaño Bautista Coronel, Luis Alberto Bustamante, Armando C Cacciatori, Carlos Javier Carricondo, Felipe Carvajal, Rafael Davila, Mario Dominguez, Jairo Antonio Figueroa Melgarejo, Maria Martha Fillipi, Daniel A Godoy, Delia Cristina Gomez, Angel J Lacerda Gallardo, Juan Antonio Guerra Garcia, Gustavo la Fuente Zerain, Luis Arturo Lavadenz Cuientas, Cecilio Lequipe, Gerardo Vicente Grajales Yuca, Manuel Jibaja Vega, Michael Eduardo Kessler, Hubiel J López Delgado, Freddy Sandi Lora, Ana Maria Mazzola, Roberto Merida Maldonado, Natascha Mezquia de Pedro, J Ricardo Martínez Zubieta, Julio C Mijangos Méndez, Jacobo Mora, Johnny Marcelo Ochoa Parra, Perla B Pahnke, Jorge Paranhos, Gustavo R Piñero, Francisco A Rivadeneira Pilacuán, Mario Napoleon Mendez Rivera, Ricardo Luis Romero Figueroa, Andres M Rubiano, Alexandra Matilde Saraguro Orozco, Juan Ignacio Silesky Jiménez, Luis Silva Naranjo, Caridad Soler Morejon, Zulma Urbina
Globally, intracranial pressure (ICP) monitoring use in severe traumatic brain injury (sTBI) is inconsistent and susceptible to resource limitations and clinical philosophies. For situations without monitoring, there is no published comprehensive management algorithm specific to identifying and treating suspected intracranial hypertension (SICH) outside of the one ad hoc Imaging and Clinical Examination (ICE) protocol in the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST:TRIP) trial...
June 1, 2020: Journal of Neurotrauma
#27
JOURNAL ARTICLE
Nicci Owusu-Brackett, Kurt W Evans, Argun Akcakanat, Erkan Yuca, Coya Tapia, Yasmeen Qamar Rizvi, Ecaterina Ileana Dumbrava, Filip Janku, Funda Meric-Bernstam
Background: Phosphatase and tensin homologue deleted from chromosome 10 (PTEN) negatively regulates the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway. Triple negative breast cancers (TNBC) are often PTEN-deficient, making mTOR a compelling target. We evaluated the efficacy of catalytic mTOR inhibitor TAK228 alone and in combination with eribulin in TNBC. Results: Five of eight triple negative breast cell lines were sensitive to TAK228, independent of PIK3CA/PTEN status. Western blotting demonstrated inhibition of mTORC1/2 signaling as demonstrated by decreased phospho-AKT, phospho-S6 and phospho-4EBP1...
August 20, 2019: Oncotarget
#28
JOURNAL ARTICLE
Bilal Yuca, İbrahim Topçu, Hatice Yağcılar-Aydemir, Cem Okan Özer, Birol Kılıç, Gülden Başyiğit-Kılıç
The objective of this study was to investigate the effects of added beta-glucan (β-glucan) levels on the lipid oxidation, physicochemical, microbiological, textural and sensorial properties of fermented sausage produced with various amounts of beef fat during fermentation and storage periods. To determine the effects of β-glucan, twelve sausage treatments included four controls (no β-glucan) with or without beef fat and starter culture addition and eight β-glucan incorporated groups produced with addition of starter culture, various levels of β-glucan (0, 1, 2%) and different levels (0, 10, 15, 20%) of beef fat were manufactured...
July 2019: Journal of Food Science and Technology
#29
JOURNAL ARTICLE
Tugce Yuca Ozturk, Mehmet Burak Guneser, Silvio Taschieri, Marcello Maddalone, Asiye Nur Dincer, Pier Matteo Venino, Massimo Del Fabbro
Background/purpose: In order to prevent reinfection of the pulp canal space and dressing for regenerative purpose, the coronal seal should have a perfect marginal adaptation. Mineral trioxide aggregate (MTA) and Biodentine are among the most popular sealing materials. These are commonly used in combination with antibiotic medicaments, to ensure disinfection. Aim of the present study was to evaluate the effect of 3 different medicaments on the marginal adaptation of MTA and Biodentine to the dentin...
June 2019: Journal of Dental Sciences
#30
JOURNAL ARTICLE
Cate Wisdom, Casey Chen, Esra Yuca, Yan Zhou, Candan Tamerler, Malcolm L Snead
The rising use of titanium dental implants has increased the prevalence of peri-implant disease that shortens their useful life. A growing view of peri-implant disease suggests that plaque accumulation and microbiome dysbiogenesis trigger a host immune inflammatory response that destroys soft and hard tissues supporting the implant. The incidence of peri-implant disease is difficult to estimate, but with over 3 million implants placed in the USA alone, and the market growing by 500,000 implants/year, such extensive use demands additional interceptive approaches...
April 2019: JOM: the Journal of the Minerals, Metals & Materials Society
#31
JOURNAL ARTICLE
Tolga T Olmez, Esra Yuca, Erol Eyupoglu, Hazal B Catalak, Ozgur Sahin, Urartu Ozgur Safak Seker
Formation of biological materials is a well-controlled process that is orchestrated by biomolecules such as proteins. Proteins can control the nucleation and mineralization of biomaterials, thereby forming the hard tissues of biological organisms, such as bones, teeth, and shells. In this study, the design and implementation of multifunctional designer proteins are demonstrated for fluorescent silica micro/nanoparticle synthesis. The R5 motif of silaffin polypeptide, which is known for its silicification capability, was fused genetically into three spectrally distinct fluorescent proteins with the intention of forming modified fluorescent proteins...
January 31, 2018: ACS Omega
#32
JOURNAL ARTICLE
Fernanda Barbosa Piló, Enrique Javier Carvajal-Barriga, Maria Cristina Guamán-Burneo, Patricia Portero-Barahona, Arthur Matoso Morato Dias, Larissa Falabella Daher de Freitas, Fátima de Cássia Oliveira Gomes, Carlos Augusto Rosa
Chicha, a type of beer made mainly with maize or cassava, is a traditional fermented beverage of the Andean region. There have only been a few studies on yeasts associated with chicha fermentation, and the species diversity occurring during the production of this beverage is not known. The objective of this study was to determine the biodiversity of yeasts in chicha, and to characterize the Saccharomyces cerevisiae populations associated with the production of chicha de jora, seven-grain chicha, chicha de yuca, and chicha de morocho in Ecuador...
October 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#33
JOURNAL ARTICLE
Tugce Onur, Esra Yuca, Tolga Tarkan Olmez, Urartu Ozgur Safak Seker
HYPOTHESIS: Amyloid-forming biofilm proteins of Escherichia coli, namely CsgA and CsgB, can form self-assembled nanofibers on solid surfaces. These proteins can be programmed to form bio-nanomaterials for functional applications. EXPERIMENTS: In this study, the assembly of the CsgA and CsgB protein on solid surfaces was investigated in real time using a quartz crystal microbalance instrument with dissipation monitoring. The assembly kinetics of the CsgA and CsgB proteins in various settings on solid surfaces were investigated...
June 15, 2018: Journal of Colloid and Interface Science
#34
JOURNAL ARTICLE
Songül Karakaya, Sefa Gözcü, Zühal Güvenalp, Hilal Özbek, Hafize Yuca, Benan Dursunoğlu, Cavit Kazaz, Ceyda Sibel Kılıç
CONTEXT: Ferulago (Apiaceae) species have been used since ancient times for the treatment of intestinal worms, hemorrhoids, and as a tonic, digestive, aphrodisiac, or sedative, as well as in salads or as a spice due to their special odors. OBJECTIVES: This study reports the α-amylase and α-glucosidase inhibitory activities of dichloromethane extract and bioactive compounds isolated from Ferulago bracteata Boiss. & Hausskn. roots. MATERIALS AND METHODS: The isolated compounds obtained from dichloromethane extract of Ferulago bracteata roots through bioassay-guided fractionation and isolation process were evaluated for their in vitro α-amylase and α-glucosidase inhibitory activities at 5000-400 µg/mL concentrations...
December 2018: Pharmaceutical Biology
#35
JOURNAL ARTICLE
Kurt W Evans, Erkan Yuca, Argun Akcakanat, Stephen M Scott, Natalia Paez Arango, Xiaofeng Zheng, Ken Chen, Coya Tapia, Emily Tarco, Agda K Eterovic, Dalliah M Black, Jennifer K Litton, Timothy A Yap, Debu Tripathy, Gordon B Mills, Funda Meric-Bernstam
Background: Breast cancer patients who do not respond to neoadjuvant therapy have a poor prognosis. There is a pressing need for novel targets and models for preclinical testing. Here we report characterization of breast cancer patient-derived xenografts (PDX) largely generated from residual tumors following neoadjuvant chemotherapy. Experimental Design: PDXs were derived from surgical samples of primary or locally recurrent tumors. Normal and tumor DNA sequencing, RNASeq, and reverse phase protein arrays (RPPA) were performed...
November 1, 2017: Clinical Cancer Research
#36
JOURNAL ARTICLE
Sarah Kay VanOosten, Esra Yuca, Banu Taktak Karaca, Kyle Boone, Malcolm L Snead, Paulette Spencer, Candan Tamerler
Silver nanoparticles (AgNP) are promising candidates for fighting drug-resistant infections because of their intrinsic antimicrobial effect. The design of high-yield antimicrobial molecules may inadvertently cause variation in host cells' biological responses. While many factors affect AgNPs' efficacy, their surface is exposed to the biological environment and thus plays a critical role in both the preservation of antimicrobial efficacy against pathogens and the modulation of host cells cytotoxicity. This work investigated an engineered biomimetic interface approach to controlling AgNP surface properties to provide them a competitive advantage in a biological environment...
September 2016: Surface Innovations
#37
JOURNAL ARTICLE
Qiang Ye, Paulette Spencer, Esra Yuca, Candan Tamerler
Failure of dental composite restorations is primarily due to recurrent decay at the tooth-composite interface. At this interface, the adhesive and its bond with dentin is the barrier between the restored tooth and the oral environment. In vivo degradation of the bond formed at the adhesive/dentin (a/d) interface follows a cascade of events leading to weakening of the composite restoration. Here, a peptide-based approach is developed to mineralize deficient dentin matrices at the a/d interface. Peptides that have an inherent capacity to self-assemble on dentin and to induce calcium-phosphate remineralization are anchored at the interface...
May 2017: Macromolecular Materials and Engineering
#38
JOURNAL ARTICLE
Natalia Paez Arango, Erkan Yuca, Ming Zhao, Kurt W Evans, Stephen Scott, Charissa Kim, Ana Maria Gonzalez-Angulo, Filip Janku, Naoto T Ueno, Debu Tripathy, Argun Akcakanat, Aung Naing, Funda Meric-Bernstam
BACKGROUND: Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the antitumor effects of selinexor in vitro and in vivo. METHODS: Twenty-six breast cancer cell lines of different breast cancer subtypes were treated with selinexor in vitro. Cell proliferation assays were used to measure the half-maximal inhibitory concentration (IC50 ) and to test the effects in combination with chemotherapy...
August 15, 2017: Breast Cancer Research: BCR
#39
JOURNAL ARTICLE
Fatma Hilal Yılmaz, Sevil Arı Yuca, Hüsamettin Vatansev, Emine Ayça Cimbek, Yaşar Şen, İsa Yılmaz, Fikret Akyürek, Derya Arslan, Derya Çimen, Alaaddin Yorulmaz
OBJECTIVE: This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia. METHODS: This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group...
June 1, 2017: Journal of Clinical Research in Pediatric Endocrinology
#40
JOURNAL ARTICLE
The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children.
S A Yuca, E A Cimbek, Y Şen, O Güvenç, H Vatansev, F Buğrul, F Gün, B Oran
Objective: Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor- β super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15. MIC-1/GDF15 is associated with cardio metabolic risk in adults...
February 2017: Experimental and Clinical Endocrinology & Diabetes
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