keyword
MENU ▼
Read by QxMD icon Read
search

Logan

keyword
https://www.readbyqxmd.com/read/28535442/mining-for-osteogenic-surface-topographies-in-silico-design-to-in%C3%A2-vivo-osseo-integration
#1
Frits F B Hulshof, Bernke Papenburg, Aliaksei Vasilevich, Marc Hulsman, Yiping Zhao, Marloes Levers, Natalie Fekete, Meint de Boer, Huipin Yuan, Shantanu Singh, Nick Beijer, Mark-Anthony Bray, David J Logan, Marcel Reinders, Anne E Carpenter, Clemens van Blitterswijk, Dimitrios Stamatialis, Jan de Boer
Stem cells respond to the physicochemical parameters of the substrate on which they grow. Quantitative material activity relationships - the relationships between substrate parameters and the phenotypes they induce - have so far poorly predicted the success of bioactive implant surfaces. In this report, we screened a library of randomly selected designed surface topographies for those inducing osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Cell shape features, surface design parameters, and osteogenic marker expression were strongly correlated in vitro...
May 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28529711/we-can-shift-academic-culture-through-publishing-choices
#2
Corina J Logan
Researchers give papers for free (and often actually pay) to exploitative publishers who make millions off of our articles by locking them behind paywalls. This discriminates not only against the public (who are usually the ones that paid for the research in the first place), but also against the academics from institutions that cannot afford to pay for journal subscriptions and the 'scholarly poor'. I explain exploitative and ethical publishing practices, highlighting choices researchers can make right now to stop exploiting ourselves and discriminating against others...
2017: F1000Research
https://www.readbyqxmd.com/read/28522581/conformational-dynamics-of-the-frameshift-stimulatory-structure-in-hiv-1
#3
Dustin B Ritchie, Tonia R Cappellano, Collin Tittle, Negar Rezajooei, Logan Rouleau, William Ka Sikkema, Michael T Woodside
Programmed ribosomal frameshifting (PRF) in HIV-1 is thought to be stimulated by a hairpin in the mRNA, although a pseudoknot-like triplex has also been proposed. Because the conformational dynamics of the stimulatory structure under tension applied by the ribosomal helicase during translation may play an important role in PRF, we used optical tweezers to apply tension to the HIV stimulatory structure and monitor its unfolding and refolding dynamics. The folding and unfolding kinetics and energy landscape of the hairpin were measured by ramping the force on the hairpin up and down, providing a detailed biophysical characterisation...
May 18, 2017: RNA
https://www.readbyqxmd.com/read/28522569/brain-derived-neurotrophic-factor-and-airway-fibrosis-in-asthma
#4
Michelle R Freeman, Venkatachalem Sathish, Logan J Manlove, Shengyu Wang, Rodney D Britt, Michael A Thompson, Christina M Pabelick, Y S Prakash
Airway remodeling in asthma driven by inflammation involves proliferation of epithelial cells and airway smooth muscle (ASM), as well as enhanced extracellular matrix (ECM) generation and deposition, i.e. fibrosis. Accordingly, understanding pro-fibrotic mechanisms is important for developing novel therapeutic strategies in asthma. Recent studies, including our own, have suggested a role for locally-produced growth factors such as brain-derived neurotrophic factor (BDNF) in mediating and modulating inflammation effects...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28521089/nanoporous-block-polymer-thin-films-functionalized-with-bio-inspired-ligands-for-the-efficient-capture-of-heavy-metal-ions-from-water
#5
Jacob Logan Weidman, Ryan A Mulvenna, Bryan W Boudouris, William A Phillip
Heavy metal contamination of water supplies poses a serious threat to public health, prompting the development of novel and sustainable treatment technologies. One promising approach is to molecularly engineer the chemical affinity of a material for the targeted removal of specific molecules from solution. In this work, nanoporous polymer thin films generated from tailor-made block polymers were functionalized with the bio-inspired moieties glutathione and cysteamine for the removal of heavy metal ions, including lead and cadmium, from aqueous solutions...
May 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28516830/childhood-victimization-attachment-coping-and-substance-use-among-victimized-women-on-probation-and-parole
#6
Amanda Dishon-Brown, Seana Golder, Tanya Renn, Katherine Winham, George E Higgins, T K Logan
Justice-involved women report high rates of victimization across their life span, and these experiences contribute to their involvement in the criminal justice (CJ) system. Within this population, research has identified an overlap among victimization and substance use, a high-risk coping mechanism. Furthermore, research indicates attachment style is related to coping and high-risk behaviors. Research is needed to understand the relationship among these mechanisms as they relate to intimate partner violence (IPV)...
May 17, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28516426/characterization-of-medication-use-in-a-multicenter-sample-of-pediatric-inpatients-with-autism-spectrum-disorder
#7
Logan K Wink, Ernest V Pedapati, Ryan Adams, Craig A Erickson, Kahsi A Pedersen, Eric M Morrow, Desmond Kaplan, Matthew Siegel
Nearly 11% of youth with Autism Spectrum Disorder (ASD) undergo psychiatric hospitalization, and 65% are treated with psychotropic medication. Here we characterize psychotropic medication usage in subjects enrolled in the Autism Inpatient Collection. Participant psychotropic medication usage rates topped 90% at admission and discharge, though there was a decline at 2-month follow-up. Antipsychotics, ADHD medications, and sleep aids were the most commonly reported classes of medications. The impact of age, gender, and non-verbal IQ on medication usage rates was minimal, though age and IQ may play a role in prescribing practices...
May 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28513579/electricity-from-methane-by-reversing-methanogenesis
#8
Michael J McAnulty, Venkata G Poosarla, Kyoung-Yeol Kim, Ricardo Jasso-Chávez, Bruce E Logan, Thomas K Wood
Given our vast methane reserves and the difficulty in transporting methane without substantial leaks, the conversion of methane directly into electricity would be beneficial. Microbial fuel cells harness electrical power from a wide variety of substrates through biological means; however, the greenhouse gas methane has not been used with much success previously as a substrate in microbial fuel cells to generate electrical current. Here we construct a synthetic consortium consisting of: (i) an engineered archaeal strain to produce methyl-coenzyme M reductase from unculturable anaerobic methanotrophs for capturing methane and secreting acetate; (ii) micro-organisms from methane-acclimated sludge (including Paracoccus denitrificans) to facilitate electron transfer by providing electron shuttles (confirmed by replacing the sludge with humic acids), and (iii) Geobacter sulfurreducens to produce electrons from acetate, to create a microbial fuel cell that converts methane directly into significant electrical current...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28512688/perceptions-of-exercise-during-medical-school
#9
Drew J Bunker, David B Newsome, Logan M Petit, William S Richardson, Ashley L Weiss
No abstract text is available yet for this article.
May 16, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28511931/water-compatible-micron-sized-monodisperse-molecularly-imprinted-beads-for-selective-extraction-of-five-iridoid-glycosides-from-cornus-officinalis-fructus
#10
Wenhua Ji, Tao Wang, Wei Liu, Feng Liu, Lanping Guo, Yanling Geng, Xiao Wang
An efficient, accurate and sensitive method for the determination of five iridoid glycosides (IGs) in Cornus officinalis fructus using molecularly imprinted solid phase extraction (MISPE) coupled with high performance liquid chromatography (HPLC) has been developed. Water-compatible molecularly imprinted beads (MIBs) were synthesized by precipitation polymerization, using alkenyl glycosides glucose as the hydrophilic functional monomer. Scanning electron microscopy showed that the MIBs had a narrow particle size distribution, with diameters in the range 7...
May 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28511053/opioid-analgesics-and-heroin-examining-drug-misuse-trends-among-a-sample-of-drug-treatment-clients-in-kentucky
#11
Grant A Victor, Robert Walker, Jennifer Cole, T K Logan
BACKGROUND: In an effort to mitigate Kentucky's prescription drug misuse, legislative intervention efforts were introduced in 2012 and 2013 to better regulate pain clinics, prescribed use of opioid analgesics, and to expand the monitoring of opioid prescriptions. The focus of this paper is primarily on opioid analgesics and heroin and the relationship of use/misuse patterns of these drugs to state drug policy initiatives. METHODS: A secondary data analysis of drug treatment clients (N=52,360) was conducted to project illicit drug use trends in Kentucky...
May 13, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28507064/tumor-necrosis-factor-receptor-associated-factor-6-traf6-mediates-ubiquitination-dependent-stat3-activation-upon-salmonella-typhimurium-infection
#12
Hai-Hua Ruan, Zhen Zhang, Su-Ying Wang, Logan M Nickels, Li Tian, Jian-Jun Qiao, Jun Zhu
Salmonella enterica serovar Typhimurium (S Typhimurium) can inject effector proteins into host cells via Type III secretion systems (T3SSs). These effector proteins modulate a variety of host transcriptional responses to facilitate bacterial growth and survival. Here, we show that S Typhimurium infection of host cells specifically induces ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6). This TRAF6 ubiquitination is triggered by the Salmonella pathogenicity island-1 (SPI-I) T3SS effectors SopB and SopE2...
May 15, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28504408/kv1-3-channels-facilitate-the-connection-between-metabolism-and-blood-flow-in-the-heart
#13
REVIEW
Vahagn Ohanyan, Liya Yin, Raffi Bardakjian, Christopher Kolz, Molly Enrick, Tatevik Hakobyan, Jordan Luli, Kathleen Graham, Mohamed Khayata, Suzanna Logan, John Kmetz, William M Chilian
The connection between metabolism and flow in the heart, metabolic dilation, is essential for cardiac function. We recently found redox-sensitive Kv1.5 channels play a role in coronary metabolic dilation; however, more than one ion channel likely plays a role in this process as animals null for these channels still showed limited coronary metabolic dilation. Accordingly, we examined the role of another Kv1 family channel, the energetically linked Kv1.3 channel, in coronary metabolic dilation. We measured myocardial blood flow (contrast echocardiography) during norepinephrine-induced increases in cardiac work (heart rate x mean arterial pressure) in WT, WT mice given correolide (preferential Kv1...
May 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28500892/enrichment-of-extremophilic-exoelectrogens-in-microbial-electrolysis-cells-using-red-sea-brine-pools-as-inocula
#14
Noura A Shehab, Juan F Ortiz-Medina, Krishna P Katuri, Ananda Rao Hari, Gary Amy, Bruce E Logan, Pascal E Saikaly
Applying microbial electrochemical technologies for the treatment of highly saline or thermophilic solutions is challenging due to the lack of proper inocula to enrich for efficient exoelectrogens. Brine pools from three different locations (Valdivia, Atlantis II and Kebrit) in the Red Sea were investigated as potential inocula sources for enriching exoelectrogens in microbial electrolysis cells (MECs) under thermophilic (70°C) and hypersaline (25% salinity) conditions. Of these, only the Valdivia brine pool produced high and consistent current 6...
May 3, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28500272/probing-the-lithium-response-pathway-in-hipscs-implicates-the-phosphoregulatory-set-point-for-a-cytoskeletal-modulator-in-bipolar-pathogenesis
#15
Brian T D Tobe, Andrew M Crain, Alicia M Winquist, Barbara Calabrese, Hiroko Makihara, Wen-Ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D Sheridan, Ryan W Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C B Basa, Michael J McCarthy, Namrata D Udeshi, Philipp Mertins, Steven A Carr, Guy A Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J Gutierrez, Laurence M Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S Nye, Husseini Manji, Jeffrey H Price, Colleen A McClung, Hagop S Akiskal, Martin Alda, De-Maw M Chuang, Joseph T Coyle, Yang Liu, Yang D Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L Sidman, Shelley Halpain, Stephen J Haggarty, Yoshio Goshima, Evan Y Snyder
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling the proteomics of BDP-hiPSC-derived neurons, we found that lithium alters the phosphorylation state of collapsin response mediator protein-2 (CRMP2)...
May 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28497097/a-randomized-controlled-pilot-study-of-educational-techniques-in-teaching-basic-arthroscopic-skills-in-a-low-income-country
#16
Abhiram R Bhashyam, Catherine Logan, Heather J Roberts, Rameez A Qudsi, Jacky Fils, George S M Dyer
BACKGROUND: Little is known about how to introduce complex technologies like arthroscopy into low-income countries. Thus, we compared low- versus high-resource intensive methods of teaching basic arthroscopic skills in a randomized controlled trial in Haiti. METHODS: Forty-eight Haitian orthopaedic surgeons and residents attending an orthopaedic conference in Haiti were block randomized to receive instruction through a composite video (Control) or a composite video plus hands-on teaching with an expert visiting surgeon (Intervention)...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28496126/fabrication-constrained-nanophotonic-inverse-design
#17
Alexander Y Piggott, Jan Petykiewicz, Logan Su, Jelena Vučković
A major difficulty in applying computational design methods to nanophotonic devices is ensuring that the resulting designs are fabricable. Here, we describe a general inverse design algorithm for nanophotonic devices that directly incorporates fabrication constraints. To demonstrate the capabilities of our method, we designed a spatial-mode demultiplexer, wavelength demultiplexer, and directional coupler. We also designed and experimentally demonstrated a compact, broadband 1 × 3 power splitter on a silicon photonics platform...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495878/local-amplifiers-of-il-4r%C3%AE-mediated-macrophage-activation-promote-repair-in-lung-and-liver
#18
Carlos M Minutti, Lucy H Jackson-Jones, Belén García-Fojeda, Johanna A Knipper, Tara E Sutherland, Nicola Logan, Emma Rinqvist, Raquel Guillamat-Prats, David A Ferenbach, Antonio Artigas, Cordula Stamme, Zissis C Chroneos, Dietmar M Zaiss, Cristina Casals, Judith E Allen
The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type-2 mediated-macrophage activation. In the lung, surfactant protein A (SP-A) enhanced IL-4-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury following infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair following bacterial infection, but resulted in fibrosis following peritoneal dialysis...
May 11, 2017: Science
https://www.readbyqxmd.com/read/28495086/cell-line-studies-and-analytical-measurements-of-three-paclitaxel-complex-variations
#19
Thomas Manning, Sydney Plummer, Rechelle Woods, Greg Wylie, Dennis Phillips, Logan Krajewski
The copper(II) cation, sucrose, and hydroxychloroquine were complexed with the chemotherapy agent paclitaxel and studied for medicinal activity. Data (GI50, LD50) from single dose and five dose National Cancer Institute sixty cell line panels are presented. Analytical measurements of different complexes were made using Nuclear Magnetic Resonance ((1)H NMR), Matrix Assisted Laser Desorption Ionization-Time of Flight-Mass Spectrometry (MALDI-TOF-MS) and Fourier Transform-Ion Cyclotron Resonance (FT-ICR). Molecular modeling is utilized to better understand the impact that species could have on physical parameters associated with Lipinski's Rule of Five, such as logP and TPSA...
April 22, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28494869/mitochondrial-ros-production-protects-the-intestine-from-inflammation-through-functional-m2-macrophage-polarization
#20
Laura Formentini, Fulvio Santacatterina, Cristina Núñez de Arenas, Konstantinos Stamatakis, David López-Martínez, Angela Logan, Manuel Fresno, Ron Smits, Michael P Murphy, José M Cuezva
Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine of transgenic mice triggers an anti-inflammatory response through NFκB activation mediated by mitochondrial mtROS. This shielding phenotype is revealed when mice are challenged by DSS-induced colitis, which, in control animals, triggers inflammation, recruitment of M1 pro-inflammatory macrophages, and the activation of the pro-oncogenic STAT3 and Akt/mTOR pathways...
May 9, 2017: Cell Reports
keyword
keyword
16735
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"