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https://www.readbyqxmd.com/read/29777995/environmental-governance-in-china-interactions-between-the-state-and-nonstate-actors
#1
Dan Guttman, Oran Young, Yijia Jing, Barbara Bramble, Maoliang Bu, Carmen Chen, Kathinka Furst, Tao Hu, Yifei Li, Kate Logan, Lingxuan Liu, Lydia Price, Michael Spencer, Sangwon Suh, Xiaopu Sun, Bowen Tan, Harold Wang, Xin Wang, Juan Zhang, Xinxin Zhang, Rodrigo Zeidan
In the West, limited government capacity to solve environmental problems has triggered the rise of a variety of "nonstate actors" to supplement government efforts or provide alternative mechanisms for addressing environmental issues. How does this development - along with our efforts to understand it - map onto environmental governance processes in China? China's efforts to address environmental issues reflect institutionalized governance processes that differ from parallel western processes in ways that have major consequences for domestic environmental governance practices and the governance of China "going abroad...
May 16, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29777020/diet-patterns-a-neglected-aspect-of-hemodialysis-care
#2
EDITORIAL
Alexander G Logan, Andrew Mente
No abstract text is available yet for this article.
May 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29777006/in-vivo-characterization-and-quantification-of-neurofibrillary-tau-pet-radioligand-18-f-mk-6240-in-humans-from-alzheimer-s-disease-dementia-to-young-controls
#3
Tobey J Betthauser, Karly A Cody, Matthew D Zammit, Dhanabalan Murali, Alexander K Converse, Todd E Barnhart, Charles K Stone, Howard A Rowley, Sterling C Johnson, Bradley T Christian
Tau positron emission tomography (PET) imaging has potential for elucidating changes in the deposition of neuropathological tau aggregates that are occurring during the progression of Alzheimer's disease (AD). This work investigates in vivo kinetics, quantification strategies and imaging characteristics of a novel tau PET radioligand [18 F]MK-6240 in humans. Methods: Fifty-one individuals ranging from cognitively normal young controls to persons with dementia underwent T1-weighted magnetic resonance imaging (MRI), and [11 C]PiB and [18 F]MK-6240 PET imaging...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29776789/transdiagnostic-effects-of-ventromedial-prefrontal-cortex-transcranial-magnetic-stimulation-on-cue-reactivity
#4
Tonisha E Kearney-Ramos, Logan T Dowdle, Daniel H Lench, Oliver J Mithoefer, William H Devries, Mark S George, Raymond F Anton, Colleen A Hanlon
BACKGROUND: Elevated frontal and striatal reactivity to drug cues is a transdiagnostic hallmark of substance use disorders. The goal of these experiments was to determine if it is possible to decrease frontal and striatal reactivity to drug cues in both cocaine users and heavy alcohol users through continuous theta burst stimulation (cTBS) to the left ventromedial prefrontal cortex (VMPFC). METHODS: Two single-blinded, within-subject, active sham-controlled experiments were performed wherein neural reactivity to drug/alcohol cues versus neutral cues was evaluated immediately before and after receiving real or sham cTBS (110% resting motor threshold, 3600 pulses, Fp1 location; N = 49: 25 cocaine users [experiment 1], 24 alcohol users [experiment 2]; 196 total functional magnetic resonance imaging scans)...
April 10, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29775330/constraining-alternative-theories-of-gravity-using-pulsar-timing-arrays
#5
Neil J Cornish, Logan O'Beirne, Stephen R Taylor, Nicolás Yunes
The opening of the gravitational wave window by ground-based laser interferometers has made possible many new tests of gravity, including the first constraints on polarization. It is hoped that, within the next decade, pulsar timing will extend the window by making the first detections in the nanohertz frequency regime. Pulsar timing offers several advantages over ground-based interferometers for constraining the polarization of gravitational waves due to the many projections of the polarization pattern provided by the different lines of sight to the pulsars, and the enhanced response to longitudinal polarizations...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774201/investigation-of-experimental-factors-that-underlie-brca1-2-mrna-isoform-expression-variation-recommendations-for-utilizing-targeted-rna-sequencing-to-evaluate-potential-spliceogenic-variants
#6
Vanessa L Lattimore, John F Pearson, Margaret J Currie, Amanda B Spurdle, Bridget A Robinson, Logan C Walker
PCR-based RNA splicing assays are commonly used in diagnostic and research settings to assess the potential effects of variants of uncertain clinical significance in BRCA1 and BRCA2 . The Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium completed a multicentre investigation to evaluate differences in assay design and the integrity of published data, raising a number of methodological questions associated with cell culture conditions and PCR-based protocols. We utilized targeted RNA-seq to re-assess BRCA1 and BRCA2 mRNA isoform expression patterns in lymphoblastoid cell lines (LCLs) previously used in the multicentre ENIGMA study...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29770180/factors-impacting-arthroscopic-rotator-cuff-repair-operational-throughput-time-at-an-ambulatory-care-center
#7
Emily J Curry, Catherine Logan, Kaytelin Suslavich, Kaitlyn Whitlock, Eric Berkson, Elizabeth Matzkin
Identifying patient factors influencing operational throughput time is becoming more imperative due to an increasing focus on value and cost savings in healthcare. The primary objective of this study was to determine patient factors influencing throughput time for primary rotator cuff repairs. Demographic information, medical history and operative reports of 318 patients from one ambulatory care center were retrospectively reviewed. Operating room set up, incision to closure and recovery room time were collected from anesthesia records...
March 29, 2018: Orthopedic Reviews
https://www.readbyqxmd.com/read/29767777/prison-staff-and-prisoner-views-on-a-prison-smoking-ban-evidence-from-the-tobacco-in-prisons-study
#8
Ashley Brown, Helen Sweeting, Greig Logan, Evangelia Demou, Kate Hunt
Introduction: In jurisdictions permitting prisoner smoking, rates are high (c75%), with smoking embedded in prison culture, leading to secondhand smoke exposures among staff and prisoners and challenges for smoking cessation. Momentum is building to ban smoking in prisons, but research on staff and prisoner views is lacking. We address this gap, providing evidence on staff and prisoner views throughout all Scottish prisons. Methods: Data were collected prior to announcement of a (November 2018) prison smoking ban throughout Scotland...
May 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29766558/a-cure-rate-model-for-q-learning-estimating-an-adaptive-immunosuppressant-treatment-strategy-for-allogeneic-hematopoietic-cell-transplant-patients
#9
Erica E M Moodie, David A Stephens, Shomoita Alam, Mei-Jie Zhang, Brent Logan, Mukta Arora, Stephen Spellman, Elizabeth F Krakow
Cancers treated by transplantation are often curative, but immunosuppressive drugs are required to prevent and (if needed) to treat graft-versus-host disease. Estimation of an optimal adaptive treatment strategy when treatment at either one of two stages of treatment may lead to a cure has not yet been considered. Using a sample of 9563 patients treated for blood and bone cancers by allogeneic hematopoietic cell transplantation drawn from the Center for Blood and Marrow Transplant Research database, we provide a case study of a novel approach to Q-learning for survival data in the presence of a potentially curative treatment, and demonstrate the results differ substantially from an implementation of Q-learning that fails to account for the cure-rate...
May 16, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29764283/minimally-invasive-thread-trigger-digit-release-a-preliminary-report-on-34-digits-of-the-adult-hands
#10
Danqing Guo, Logan McCool, Alexander Senk, Brionn Tonkin, Joseph Guo, Rachel M Lytie, Danzhu Guo
The trigger finger release was performed in 34 digits (11 thumbs and 23 fingers) of 24 patients through the thread transecting technique with the tip-to-tip approach, in which a 22-gauge needle inserts into a 18-gauge needle when both needles are inside the hand, guiding the 22-gauge needle to exit the hand at the same access point of 18-gauge needle. We prospectively evaluated the effectiveness and functional recovery of these patients. In all 34 digits, triggering and locking were resolved, and complete extension and flexion occurred immediately following the release...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29762188/the-reliability-of-radiostereometric-analysis-in-determining-physeal-motion-in-slipped-capital-femoral-epiphysis-in-standard-uniplanar-and-low-dose-eos-biplanar-radiography-a-phantom-model-study
#11
Jennifer K Hurry, Saad Rehan, Alan J Spurway, Elise K Laende, Janie L Astephen Wilson, Karl J Logan, Michael J Dunbar, Ron El-Hawary
Physeal closure after slipped capital femoral epiphysis fixation can be difficult to assess on two-dimensional conventional radiographs. Radiostereometric analysis offers improved motion detection over conventional radiography, whereas the EOS biplanar imager provides a means for low radiation weight-bearing images. This phantom study assessed the reliability of measuring motion using radiostereometric analysis in the EOS using a slipped capital femoral epiphysis model. The accuracy and precision were better than 0...
May 14, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/29761423/advanced-parental-age-as-risk-factor-for-childhood-acute-lymphoblastic-leukemia-results-from-studies-of-the-childhood-leukemia-international-consortium
#12
Eleni Th Petridou, Marios K Georgakis, Friederike Erdmann, Xiaomei Ma, Julia E Heck, Anssi Auvinen, Beth A Mueller, Logan G Spector, Eve Roman, Catherine Metayer, Corrado Magnani, Maria S Pombo-de-Oliveira, Sameera Ezzat, Michael E Scheurer, Ana Maria Mora, John D Dockerty, Johnni Hansen, Alice Y Kang, Rong Wang, David R Doody, Eleanor Kane, Waffa M Rashed, Nick Dessypris, Joachim Schüz, Claire Infante-Rivard, Alkistis Skalkidou
Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015)...
May 14, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29754823/pol%C3%AE%C2%B5-instability-drives-replication-stress-abnormal-development-and-tumorigenesis
#13
Roberto Bellelli, Valerie Borel, Clare Logan, Jennifer Svendsen, Danielle E Cox, Emma Nye, Kay Metcalfe, Susan M O'Connell, Gordon Stamp, Helen R Flynn, Ambrosius P Snijders, François Lassailly, Andrew Jackson, Simon J Boulton
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε complex, leading to embryonic lethality in inbred strains and extensive developmental abnormalities, leukopenia, and tumor predisposition in outbred strains. Comparable phenotypes of growth retardation and immunodeficiency are also observed in human patients harboring destabilizing mutations in POLE1...
May 3, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29754212/matrix-metalloproteinase-expression-is-altered-in-the-small-and-large-intestine-following-fractionated-radiation-in-vivo
#14
Romany L Stansborough, Noor Al-Dasooqi, Emma H Bateman, Joanne M Bowen, Dorothy M K Keefe, Richard M Logan, Ann S J Yeoh, Eric E K Yeoh, Andrea M Stringer, Rachel J Gibson
PURPOSE: Radiotherapy-induced gut toxicity (RIGT) is associated with significant diarrhoea, pain and rectal bleeding. Matrix metalloproteinases (MMPs) have been reported to be involved in chemotherapy-induced gut toxicity and RIGT following single-dose irradiation in vivo. We therefore proposed MMPs would be involved in the pathobiology of RIGT following fractionated irradiation. METHODS: Dark Agouti rats were treated with fractionated radiation (3 × 2.5 Gy/week for 6 weeks)...
May 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29753938/electrotrophic-activity-and-electrosynthetic-acetate-production-by-desulfobacterium-autotrophicum-hrm2
#15
Zehra Zaybak, Bruce E Logan, John M Pisciotta
Electroautotrophic microorganisms accept electrons from a cathode as source of reducing equivalents to drive CO2 fixation by poorly understood mechanisms. Acetogenic bacteria were the first group found to possess the capability for electroautotrophic metabolism in pure culture with associated electrosynthesis of acetate as primary metabolite. Identification of additional electrotrophic species can contribute to our understanding of this unusual form of metabolism. Here, bioelectrochemical techniques, chemical analysis and microscopy were used to determine electrotrophic metabolism of Desulfobacterium autotrophicum HRM2...
May 4, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29752435/author-correction-towards-an-arthritis-flare-responsive-drug-delivery-system
#16
Nitin Joshi, Jing Yan, Seth Levy, Sachin Bhagchandani, Kai V Slaughter, Nicholas E Sherman, Julian Amirault, Yufeng Wang, Logan Riegel, Xueyin He, Tan Shi Rui, Michael Valic, Praveen K Vemula, Oscar R Miranda, Oren Levy, Ellen M Gravallese, Antonios O Aliprantis, Joerg Ermann, Jeffrey M Karp
In the original version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support from the National Football League Players Association.
May 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29750250/analysis-of-fentanyl-and-18-novel-fentanyl-analogs-and-metabolites-by-lc-ms-ms-and-report-of-fatalities-associated-with-methoxyacetylfentanyl-and-cyclopropylfentanyl
#17
Melissa F Fogarty, Donna M Papsun, Barry K Logan
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter report of 2017 to have been chemically identified seven and five times, respectively, from drug evidence analyzed by the DEA's lab system; Q3 was the first time cyclopropylfentanyl was identified by the DEA's lab system, while methoxyacetylfentanyl was reported one time in Q2 2017...
May 10, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29749279/building-a-database-for-brain-18-kda-translocator-protein-imaged-using-11-c-pbr28-in-healthy-subjects
#18
Soumen Paul, Evan Gallagher, Jeih-San Liow, Sanche Mabins, Katharine Henry, Sami S Zoghbi, Roger N Gunn, William C Kreisl, Erica M Richards, Paolo Zanotti-Fregonara, Cheryl L Morse, Jinsoo Hong, Aneta Kowalski, Victor W Pike, Robert B Innis, Masahiro Fujita
Translocator protein 18 kDa (TSPO) has been widely imaged as a marker of neuroinflammation using several radioligands, including [11 C]PBR28. In order to study the effects of age, sex, and obesity on TSPO binding and to determine whether this binding can be accurately assessed using fewer radio high-performance liquid chromatography (radioHPLC) measurements of arterial blood samples, we created a database of 48 healthy subjects who had undergone [11 C]PBR28 scans (23 high-affinity binders (HABs) and 25 mixed-affinity binders (MABs), 20 F/28 M, age: 40...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29743938/dysbiotic-drift-and-biopsychosocial-medicine-how-the-microbiome-links-personal-public-and-planetary-health
#19
Susan L Prescott, Ganesa Wegienka, Alan C Logan, David L Katz
The emerging concept of planetary health emphasizes that the health of human civilization is intricately connected to the health of natural systems within the Earth's biosphere; here, we focus on the rapidly progressing microbiome science - the microbiota-mental health research in particular - as a way to illustrate the pathways by which exposure to biodiversity supports health. Microbiome science is illuminating the ways in which stress, socioeconomic disadvantage and social polices interact with lifestyle and behaviour to influence the micro and macro-level biodiversity that otherwise mediates health...
2018: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/29743257/thermal-physiology-and-thermoregulatory-behaviour-exhibit-low-heritability-despite-genetic-divergence-between-lizard-populations
#20
Michael L Logan, John David Curlis, Anthony L Gilbert, Donald B Miles, Albert K Chung, Joel W McGlothlin, Robert M Cox
Ectothermic species are particularly sensitive to changes in temperature and may adapt to changes in thermal environments through evolutionary shifts in thermal physiology or thermoregulatory behaviour. Nevertheless, the heritability of thermal traits, which sets a limit on evolutionary potential, remains largely unexplored. In this study, we captured brown anole lizards ( Anolis sagrei ) from two populations that occur in contrasting thermal environments. We raised offspring from these populations in a laboratory common garden and compared the shape of their thermal performance curves to test for genetic divergence in thermal physiology...
May 16, 2018: Proceedings. Biological Sciences
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