Hui-Yu Liu, Xiao-Jiao Sun, Si-Yu Xiu, Xiang-Yu Zhang, Zhi-Qi Wang, Yan-Lun Gu, Chu-Xiao Yi, Jun-Yan Liu, Yu-Song Dai, Xia Yuan, Hua-Peng Liao, Zhen-Ming Liu, Xiao-Cong Pang, Tian-Cheng Li
Frizzled receptors (FZDs) are key contributors intrinsic to the Wnt signaling pathway, activation of FZDs triggering the Wnt signaling cascade is frequently observed in human tumors and intimately associated with an aggressive carcinoma phenotype. It has been shown that the abnormal expression of FZD receptors contributes to the manifestation of malignant characteristics in human tumors such as enhanced cell proliferation, metastasis, chemotherapy resistance as well as the acquisition of cancer stemness. Given the essential roles of FZD receptors in the Wnt signaling in human tumors, this review aims to consolidate the prevailing knowledge on the specific status of FZD receptors (FZD1-10) and elucidate their respective functions in tumor progression...
April 17, 2024: Acta Pharmacologica Sinica