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Cell Pathway And Malignancy

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https://www.readbyqxmd.com/read/30341906/circ-u2af1-promotes-human-glioma-via-derepressing-neuro-oncological-ventral-antigen-2-by-sponging-hsa-mir-7-5p
#1
Guoxiong Li, Min Huang, Yingqian Cai, Yuantao Yang, Xinlin Sun, Yiquan Ke
The prognosis for human glioma, a malignant tumor of the central nervous system, is poor due to its rapid growth, genetic heterogeneity, and inadequate understanding of its underlying molecular mechanisms. Circular RNAs composed of exonic sequences, represent an understudied form of noncoding RNAs (ncRNAs) that was discovered more than a decade ago, function as microRNA sponges. We aimed to assess the relationship between circ-U2AF1 (CircRNA ID: hsa_circ_0061868) and hsa-mir-7-5p and examine their effects on proliferation, apoptosis, and the metastatic phenotype of glioma cells regulated by neuro-oncological ventral antigen 2 (NOVA2)...
October 20, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30341788/the-nedd8-activating-enzyme-inhibitor-mln4924-tak-924-pevonedistat-induces-apoptosis-via-c-myc-noxa-axis-in-head-and-neck-squamous-cell-carcinoma
#2
Wenjuan Zhang, Yupei Liang, Lihui Li, Xiaofang Wang, Zi Yan, Changsheng Dong, Mu-Sheng Zeng, Qian Zhong, Xue-Kui Liu, Jinha Yu, Shuyang Sun, Xiaojun Liu, Jihui Kang, Hu Zhao, Lak Shin Jeong, Yanmei Zhang, Lijun Jia
OBJECTIVES: The present study aimed to reveal expression status of the neddylation enzymes in HNSCC and to elucidate the anticancer efficacy and the underlying mechanisms of inhibiting neddylation pathway. MATERIALS AND METHODS: The expression levels of neddylation enzymes were estimated by Western blotting in human HNSCC specimens and bioinformatics analysis of the cancer genome atlas (TCGA) database. Cell apoptosis was evaluated by Annexin V fluorescein isothiocyanate/propidium iodide (Annexin V-FITC/PI) stain and fluorescence-activated cell sorting (FACS)...
October 19, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/30338598/h19-regulation-of-oestrogen-induction-of-symmetric-division-is-achieved-by-antagonizing-let-7c-in-breast-cancer-stem-like-cells
#3
Meng Wang, Yuan Li, Guo-Dong Xiao, Xiao-Qiang Zheng, Ji-Chang Wang, Chong-Wen Xu, Sida Qin, Hong Ren, Shou-Ching Tang, Xin Sun
OBJECTIVES: Breast cancer stem-like cells (BrCSCs) are the major reason for tumour generation, resistance and recurrence. The turbulence of their self-renewal ability could help to constrain the stem cell expansion. The way BrCSCs divided was related to their self-renewal capacity, and the symmetric division contributed to a higher ability. Non-coding long RNA of H19 was involved in multiple malignant procedures; the role and mechanistic proof of non-coding long RNA of H19 in controlling the divisions of BrCSCs were barely known...
October 18, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/30338041/concomitant-targeting-of-the-mtor-mapk-pathways-novel-therapeutic-strategy-in-subsets-of-rictor-kras-altered-non-small-cell-lung-cancer
#4
Dennis Ruder, Vassiliki Papadimitrakopoulou, Kazuhiko Shien, Carmen Behrens, Neda Kalhor, Huiqin Chen, Li Shen, J Jack Lee, Waun Ki Hong, Ximing Tang, Luc Girard, John D Minna, Lixia Diao, Jing Wang, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Nana E Hanson, James Sun, Vincent Miller, Joel Greenbowe, Garrett Frampton, Roy S Herbst, Veera Baladandayuthapani, Ignacio I Wistuba, Julie G Izzo
Despite a therapeutic paradigm shift into targeted-driven medicinal approaches, resistance to therapy remains a hallmark of lung cancer, driven by biological and molecular diversity. Using genomic and expression data from advanced non-small cell lung cancer (NSCLC) patients enrolled in the BATTLE-2 clinical trial, we identified RICTOR alterations in a subset of lung adenocarcinomas and found RICTOR expression to carry worse overall survival. RICTOR-altered cohort was significantly enriched in KRAS/MAPK axis mutations, suggesting a co-oncogenic driver role in these molecular settings...
September 21, 2018: Oncotarget
https://www.readbyqxmd.com/read/30337526/btk-a-two-faced-effector-in-cancer-and-tumour-suppression
#5
Miran Rada, Nickolai Barlev, Salvador Macip
Many genes of the human genome display pleiotropic activity, playing an important role in two or more unrelated pathways. Surprisingly, some of these functions can even be antagonistic, often letting to divergent functional outcomes depending on microenviromental cues and tissue/cell type-dependent parameters. Lately, the Bruton's tyrosine kinase (BTK) has emerged as one of such pleiotropic genes, with opposing effects in cancer pathways. While it has long been considered oncogenic in the context of B cell malignancies, recent data shows that BTK can also act as a tumour suppressor in other cells, as an essential member of the p53 and p73 responses to damage...
October 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30337520/cancer-associated-fibroblasts-promote-progression-and-gemcitabine-resistance-via-the-sdf-1-satb-1-pathway-in-pancreatic-cancer
#6
Lusheng Wei, Huilin Ye, Guolin Li, Yuanting Lu, Quanbo Zhou, Shangyou Zheng, Qing Lin, Yimin Liu, Zhihua Li, Rufu Chen
Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance in pancreatic cancer, partially owing to paracrine induction of SATB-1 in pancreatic cancer cells. CAF-secreted SDF-1 upregulated the expression of SATB-1 in pancreatic cancer cells, which contributed to the maintenance of CAF properties, forming a reciprocal feedback loop...
October 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30336537/the-effect-of-over-expression-of-mir-20a-on-cell-proliferation-of-human-t-cell-leukemia-cell-line
#7
Razavi Hashemi M, Vahabpour R, Ranji N, Sanati Mh, Mapar M, Sadat Sm
BACKGROUND: Acute T Cell Leukemia (ALL) is an aggressive and prevalent human malignancy. Chemotherapy is the most frequent therapeutic strategy; however, cytotoxicity and recurrence of cancer are the main concerns. The discovery of microRNA (miRNA) drew the attention of scientists who were working on targeted cancer therapy to use the potential of gene regulation by using this small RNAs. METHODS: miRanda, TargetScan, miRDB databases, and miRWalk software were applied to find probable miRNAs targeting 3'UTR of JAK1, STAT3, SOCS6, AKT1, APAF, BID, and Caspase9 mRNA...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336305/anticancer-activities-of-zanthoxylum-bungeanum-seed-oil-on-malignant-melanoma
#8
Wenwen Pang, Shan Liu, Fangting He, Xinyang Li, Baloch Saira, Tianli Zheng, Jiayi Chen, Ke Dong, Xiao-Fang Pei
ETHNOPHARMACOLOGICAL RELEVANCE: Zanthoxylum bungeanum Maxim. (ZBM), a Chinese herb medicine and food additive, has been shown to have broad-spectrum beneficial effects. However, the anticancer activities of its seed have not been reported. AIM OF THE STUDY: for the first time investigated the anti-proliferation activity of seed oil of ZBM (ZBSO) on melanoma A375 cells as well as the underlying mechanisms. MATERIALS AND METHODS: The chemical composition of ZBSO was analyzed by Ultra Performance Liquid Chromatography...
October 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30335765/phosphoglucomutase-1-inhibits-hepatocellular-carcinoma-progression-by-regulating-glucose-trafficking
#9
Guang-Zhi Jin, Yajuan Zhang, Wen-Ming Cong, Xueyuan Wu, Xiongjun Wang, Siyang Wu, Siyao Wang, Weiping Zhou, Shengxian Yuan, Hong Gao, Guanzhen Yu, Weiwei Yang
Glycogen metabolism commonly altered in cancer is just beginning to be understood. Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis of glycogen. Here, we show that PGM1 is down-regulated in hepatocellular carcinoma (HCC), which is associated with the malignancy and poor prognosis of HCC. Decreased PGM1 expression obstructed glycogenesis pathway, which leads to the increased flow of glucose into glycolysis, thereby promoting tumor cell proliferation and HCC development...
October 2018: PLoS Biology
https://www.readbyqxmd.com/read/30334557/mirna-182-5p-via-hif2%C3%AE-contributes-to-arsenic-carcinogenesis-evidence-from-human-renal-epithelial-cells
#10
Xin Fang, Ru Sun, Yuxin Hu, Huihui Wang, Yi Guo, Bei Yang, Jingbo Pi, Yuanyuan Xu
Chronic exposure to high levels of arsenic has been associated with high risks for many cancers, including renal cell carcinoma (RCC). However the underlying mechanisms are not clear. In the present study, chronic arsenite exposure (2 μM or 5 μM, 30 weeks) induced malignant transformation of HK-2 human renal epithelial cells as indicated by elevated colony formation (6.2- and 5.4-fold increase, respectively), secreted MMP-9 activity (10.1- and 11.3-fold increase, respectively) and proliferation rate (1.2- and 1...
October 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/30334373/euxanthone-impairs-the-metastatic-potential-of-osteosarcoma-by-reducing-cox-2-expression
#11
Xiaodong Chen, Min Deng, Xinshe Zhou, Xuyi Wang, Yuchen Ye, Jun Zhu, Huafeng Jiang, Xiaotian Chen, Wenju Zha
OBJECTIVE: Osteosarcoma (OS) is one of the most common malignancies of bone. This study was aimed to explore the anti-metastatic effect of euxanthone on OS. MATERIALS AND METHODS: Adhesion assay and Transwell assay were used to examine the effect of euxanthone on adhesion, migration and invasion of OS cells. COX-2-over-expressing plasmid was applied to transfect OS cells to assess whether COX-2 affects the anti-metastatic function of euxanthone. PDCD4 knockdown and miR-21 mimic were applied to assess whether euxanthone suppresses the transactivation of c-jun via modulating miR-21-PDCD4 signaling...
October 17, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30334367/maternal-embryonic-leucine-zipper-kinase-a-novel-biomarker-and-a-potential-therapeutic-target-of-cervical-cancer
#12
Juan Wang, Yamei Wang, Fangrong Shen, Yanting Xu, Yinghui Zhang, Xinwei Zou, Jinhua Zhou, Youguo Chen
Maternal embryo leucine zipper kinase (MELK) is highly expressed in a variety of malignant tumors and involved in cell cycle regulation, cell proliferation, apoptosis, tumor formation etc However, the biological effects of MELK in cervical cancer are still uninvestigated. This study aimed to explore the expression of MELK in cervical cancer, as well as its effects on the proliferation, apoptosis, DNA damage repair on cervical cancer cell line in vitro and to provide novel ideas for further improving the clinical efficacy of cervical cancer...
October 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30333956/curcumin-mediated-degradation-of-s-phase-kinase-protein-2-induces-cytotoxic-effects-in-human-papillomavirus-positive-and-negative-squamous-carcinoma-cells
#13
Abdul Q Khan, Kodappully S Siveen, Kirti S Prabhu, Shilpa Kuttikrishnan, Sabah Akhtar, Abdullah Shaar, Afsheen Raza, Fatima Mraiche, Said Dermime, Shahab Uddin
S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell cycle progression through ubiquitin mediated degradation of G1-checkpoint CDK inhibitors-p21 (CDKN1A) and p27 (CDKN1B). We investigated the role of Skp2 and its ubiquitin-proteasome pathway in head and neck squamous cell carcinoma (HNSCC) using a panel of cell lines with and without human papillomavirus (HPV+ , HPV- )...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30333875/antitumorigenic-effect-of-damnacanthal-on-melanoma-cell-viability-through-p53-and-nf-%C3%AE%C2%BAb-caspase-3-signaling-pathways
#14
Xin Zhang, Ping Fang, Zigang Zhao, Xiangyu Ding, Fang Xie, Yilin Wang, Chengxin Li
Melanoma is highly malignant, particularly prone to metastasizing to the skin. The incidence of melanoma varies markedly between countries, and is relatively low in China. The aim of the present study was to investigate the antitumorigenic effect of damnacanthal on melanoma cells, and its molecular mechanism. MUM-2B cells were treated with 0-20 µM damnacanthal for 12, 24 and 48 h. In vitro , it was demonstrated that damnacanthal inhibited proliferation and promoted apoptosis of melanoma cells in a dose- and time-dependent manner...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333865/atp-binding-cassette-transporter-a7-accelerates-epithelial-to-mesenchymal-transition-in-ovarian-cancer-cells-by-upregulating-the-transforming-growth-factor-%C3%AE-signaling-pathway
#15
Xia Liu, Qing Li, Jing Zhou, Su Zhang
Ovarian cancer (OC) has the highest fatality rates of all gynecological malignancies worldwide. The epithelial-to-mesenchymal transition (EMT) serves an essential role in the progression of OC. An improved understanding of the molecular mechanism underlying EMT in OC may increase the survival rate. ATP-binding cassette transporter A7 (ABCA7) is a candidate regulator of OC progression. However, the role of ABCA7 in OC is unclear. Using the PROGgeneV2 platform, the present study revealed that increased expression of ABCA7 is associated with poor outcomes in OC...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333528/farnesyl-diphosphate-synthase-is-important-for-the-maintenance-of-glioblastoma-stemness
#16
Hee Yeon Kim, Dong Keon Kim, Seung-Hyun Bae, HyeRan Gwak, Ji Hoon Jeon, Jong Kwang Kim, Byung Il Lee, Hye Jin You, Dong Hoon Shin, Young-Ho Kim, Soo Youl Kim, Sung-Sik Han, Jin-Kyoung Shim, Ji-Hyun Lee, Seok-Gu Kang, Hyonchol Jang
Glioblastoma is a highly malignant tumor that easily acquires resistance to treatment. The stem-cell-like character (stemness) has been thought to be closely associated with the treatment resistance of glioblastoma cells. In this study, we determined that farnesyl diphosphate synthase (FDPS), a key enzyme in isoprenoid biosynthesis, plays an important role in maintaining glioblastoma stemness. A comparison of the mRNA expression in patient-derived glioblastoma sphere cells, which maintain stemness, and their differentiated counterparts, which lose stemness, via RNA sequencing showed that most of the altered genes were networked in the cholesterol biosynthesis pathway...
October 17, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/30333481/mina53-deficiency-leads-to-glioblastoma-cell-apoptosis-via-inducing-dna-replication-stress-and-diminishing-dna-damage-response
#17
Fan Xuan, Mengying Huang, Erhu Zhao, Hongjuan Cui
MYC-induced nuclear antigen (MINA53) is a JmjC (jumonji C domain)-containing protein, which is highly expressed in many cancers including glioblastoma. We have revealed in our previous report that MINA53 is a poor prognostic indicator for glioblastoma patients, and knockdown of MINA53 could reduce glioblastoma malignancy. In this study, we found that MINA53 knockdown could decrease the DNA replication initiation in glioblastoma cells. Through further investigations, we revealed that MINA53 could regulate the expression of the CDC45-MCM-GINS (CMG) complex genes, which are vital for DNA replication initiation...
October 17, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30333224/cerdulatinib-pharmacodynamics-and-relationships-to-tumor-response-following-oral-dosing-in-patients-with-relapsed-refractory-b-cell-malignancies
#18
Greg P Coffey, Greg P Coffey, Andreas Betz, Jiajia Feng, Anjali Pandey, Matt Birrell, Janet M Leeds, Kenneth Der, Sabah Kadri, Pin Lu, Jeremy P Segal, Y Lynn Wang, Glenn Michelson, John T Curnutte, Pamela B Conley
PURPOSE: Preclinical studies suggest SYK and JAK contribute to tumor intrinsic and microenvironment-derived survival signals. The pharmacodynamics of cerdulatinib, a dual SYK/JAK inhibitor, and associations with tumor response were investigated. EXPERIMENTAL DESIGN: In a phase I dose-escalation study in adults with relapsed/refractory B-cell malignancies, cerdulatinib was administered orally to sequential dose-escalation cohorts using once-daily or twice-daily schedules...
October 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30333093/arctigenin-shows-preferential-cytotoxicity-to-acidity-tolerant-prostate-carcinoma-pc-3-cells-through-ros-mediated-mitochondrial-damage-and-the-inhibition-of-pi3k-akt-mtor-pathway
#19
Yoon-Jin Lee, Jeong-Eun Oh, Sang-Han Lee
Extracellular acidity in the tumor microenvironment contributes to chemoresistance of malignant tumors. The objective of this study was to determine anticancer effects of arctigenin, a novel anti-inflammatory lignan extracted from seeds of Arctium lappa, on acidity-tolerant prostate cancer PC-3AcT cells. The PC-3AcT cells manifested increased tolerance to low-pH media with enhanced percent cell viability and increased resistance to docetaxel compared to their parental PC-3 cells. Arctigenin alone or in combination with docetaxel induced potent cytotoxicity...
October 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30332502/the-role-of-phosphodiesterase-4-in-the-pathophysiology-of-atopic-dermatitis-and-the-perspective-for-its-inhibition
#20
REVIEW
Emma Guttman-Yassky, Jon M Hanifin, Mark Boguniewicz, Andreas Wollenberg, Robert Bissonnette, Vivek Purohit, Iain Kilty, Anna M Tallman, Michael A Zielinski
Atopic dermatitis (AD) is a highly prevalent, chronic inflammatory skin disease that affects children and adults. The pathophysiology of AD is complex and involves skin barrier and immune dysfunction. Many immune cytokine pathways are amplified in AD, including T helper (Th) 2, Th22, Th17 and Th1. Current treatment guidelines recommend topical medications as initial therapy; however, until recently, only two drug classes were available: topical corticosteroids (TCSs) and topical calcineurin inhibitors (TCIs)...
October 17, 2018: Experimental Dermatology
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