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Oral SCC

Sayed Akbar Abbas, Javeria Saeed, Muhammad Usman Tariq, Ahmed Raheem Baksh, Salman Hashmi
Locoregional recurrence accounts for majority of the treatment failures in oral cancer patients. Current study aimed to determine the predictors of recurrence and survival in patients with biopsy proven Squamous Cell Carcinoma (SCC) of the oral cavity. This study included 88 patients of squamous cell carcinoma treated at our institution from 2007 till 2013. Primary intervention was surgery in all patients with radiation and chemotherapy in selected patients. Primary end point was locoregional recurrence, distant metastasis and death...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Jae Ryung Lee, Jong-Lyel Roh, Sun Mi Lee, Yangsoon Park, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: This study analyzed the expression of CD44 and cystine-glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival. METHODS: Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS)...
October 10, 2018: Head & Neck
Lijun Liu, Xiaofeng Wang, Wenzhang Ge
BACKGROUND Oral tongue squamous cell carcinoma (OTSCC) is the most common malignancy of the oral cavity. Here we explore the potential effects of EphA8, which is one of the receptors in Ephs subfamily of RTKs (receptor tyrosine kinases), in the progression and prognosis of OTSCC. MATERIAL AND METHODS A total of 119 OTSCC patients were enrolled in this retrospective study. Immunohistochemistry (IHC) staining and quantitative polymerase chain reaction (Q-PCR) were utilized to examine the expression of EphA8 in OTSSC tissues and adjacent non-tumor tissues...
October 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sun Ningning, Sun Libo, Wu Chuanbin, Sun Haijiang, Zhou Qing
Oral cancer being one of the lethal cancers is generally detected at advanced stages and causes significant mortality world over. The unavailability of the reliable biomarkers and therapeutic targets/agents forms a bottleneck in the treatment of oral cancer. MicroRNAs are considered of immense therapeutic potential for the treatment of cancer. Consistently, in this study the role and therapeutic potential of miR-650 was explored in oral cancer. The analysis of miR-650 expression by qRT-PCR revealed significant (p < 0...
October 5, 2018: Biochimie
Ichiro Ogura, Ken Nakahara, Yoshihiko Sasaki, Mikiko Sue, Takaaki Oda
Purpose: To evaluate the usefulness of shear wave elastography in the diagnosis of oral and maxillofacial diseases. Materials and Methods: Ten patients with oral and maxillofacial diseases and 28 volunteers drawn from our student doctors were examined by shear wave elastography with a 14-MHz linear transducer using an Aplio 300 apparatus (Canon Medical Systems, Otawara, Japan). A statistical analysis of the shear elastic modulus (kPa) of healthy tissue (the sublingual gland, submandibular gland, anterior belly of the digastric muscle, and geniohyoid muscle) in the 28 volunteers was performed using 1-way repeated measures analysis of variance with the Tukey honest significant difference test...
September 2018: Imaging Science in Dentistry
Britta Kaltoft Welinder, Mads Lawaetz, Laura M Dines, Preben Homøe
We conducted a retrospective follow-up study to determine if adjunctive radiotherapy (RT) affected disease-free survival in patients with oral squamous cell carcinoma (SCC) who were found to have close surgical margins after tumor resection. Our study population was made up of 110 patients-72 men and 38 women, aged 30 to 94 years (median: 66) at the time of diagnosis. Their follow-up ranged from 12 days to 5.2 years (median: 3.6 yr). Of this group, 40 patients had free margins, 55 patients had close margins, and 15 had involved margins after surgery...
September 2018: Ear, Nose, & Throat Journal
Wenzhang Ge, Jianli Xie, Lianzhen Chang
Introduction: Although red blood cell distribution width (RDW) has been reported to reflect inflammation and nutritional status and to predict prognosis in several different types of cancer, little is known about how RDW might be related to oral squamous cell carcinoma (OSCC). The present study aimed to investigate the prognostic value of preoperative RDW in OSCC patients. Materials and methods: We included 236 OSCC patients from Jinan Stomatological Hospital (Shandong, People's Republic of China) in this retrospective study...
2018: Cancer Management and Research
Emily Vogtmann, Jun Chen, Muhammad G Kibriya, Amnon Amir, Jianxin Shi, Yu Chen, Tariqul Islam, Mahbubul Eunes, Alauddin Ahmed, Jabun Naher, Anisur Rahman, Bhaswati Barmon, Rob Knight, Nicholas Chia, Habibul Ahsan, Christian C Abnet, Rashmi Sinha
BACKGROUND: A number of cohort studies have collected Scope mouthwash samples by mail which are being used for microbiota measurements. We evaluated the stability of Scope mouthwash samples at ambient temperature and determined the comparability of Scope mouthwash with saliva collection using the OMNIgene ORAL kit. METHODS: Fifty-three healthy volunteers from Mayo Clinic and fifty cohort members from Bangladesh provided oral samples. One aliquot of the OMNIgene ORAL and Scope mouthwash were frozen immediately and one aliquot of the Scope mouthwash remained at ambient temperature for four days and then was frozen...
September 27, 2018: Cancer Epidemiology, Biomarkers & Prevention
Tatiana Dias Schalch, Maria Helena Fernandes, Maria Fernanda Setúbal Destro Rodrigues, Douglas Magno Guimarães, Fabio Daumas Nunes, João Costa Rodrigues, Mônica Pereira Garcia, Raquel Agnelli Mesquita Ferrari, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes
The treatment of squamous cell carcinoma (SCC) involves surgery, chemotherapy, and/or radiotherapy, which can cause mucositis (inflammation of the oral mucosa that causes considerable pain and can compromise the continuity of oncological treatment). Photobiomodulation (PBM) has been successfully used in the treatment of mucositis, but doubts arise regarding the use of laser for areas in which tumor cells may remain. In this study, the effect of PBM on the viability, mitochondrial activity, proliferation, apoptosis, and migration of cells derived from oral SCC was evaluated...
September 19, 2018: Lasers in Medical Science
Ji-Won Jung, Margaret Veitch, Jennifer A Bridge, Nana H Overgaard, Jazmina L Cruz, Richard Linedale, Michael E Franklin, Nicholas A Saunders, Fiona Simpson, Ian H Frazer, Raymond J Steptoe, James W Wells
Patients receiving immunosuppressive drugs to prevent organ transplant rejection exhibit a greatly increased risk of developing cutaneous squamous cell carcinoma (SCC). However, not all immunosuppressive drugs confer the same risk. Randomised, controlled trials demonstrate that switching renal transplant recipients receiving calcineurin inhibitor-based therapies to mammalian target of rapamycin (mTOR) inhibitors results in a reduced incidence of de novo SSC formation, and can even result in the regression of pre-existing premalignant lesions...
2018: Oncoimmunology
Mohammad-Hossein Taziki, Abdolreza Fazel, Fatemeh Salamat, Seyed-Mehdi Sedaghat, Mohammad Ashaari, Hossein Poustchi, Ramin Shakeri, Reza Hoseinpoor, Susan Hasanpour-Heidari, Gholamreza Roshandel
BACKGROUND: Golestan province, in Northern Iran, is a high-risk area for esophageal squamous cell carcinoma (SCC). SCC is also the most common histological type of cancers of the head and neck region including cancers of oral cavity, oropharynx, hypopharynx and larynx. We aimed to present the incidence rate of head and neck SCC (HNSCC) in Golestan province during 2004 and 2013. METHODS: Data on HNSCC were obtained from Golestan population-based cancer registry (GPCR)...
September 1, 2018: Archives of Iranian Medicine
D A Mitchell, A Kanatas, C Murphy, P Chengot, A B Smith, T K Ong
In the surgical management of oral squamous cell carcinoma (SCC) we aim to resect the tumour with clear margins in all planes. The aim of this study was to identify and compare overall survival in a group of 591 patients who had resections, and to relate this to the clearance of margins at the tumour bed. We used life tables to calculate survival at one, two, three, five, and 10 years after diagnosis by margin (clear=5mm or more; close=2-5mm; and involved=less than 2mm). Kaplan-Meier curves were produced for the margins alone, which were defined as clear in 480 patients (81%), close in 63 (11%), and involved in 48 (8%)...
September 13, 2018: British Journal of Oral & Maxillofacial Surgery
A J Dalal, J Ingham, B Collard, G Merrick
We provide a non-melanoma skin cancer (NMSC) service for skin cancers of the head and neck in the south-west of England. We hypothesised that certain anatomical sites such as the nose and eyelid would have a higher incidence of close or involved margins than others, and that the choice of repair might influence the excised margins. We therefore retrospectively analysed the data of 500 consecutive NMSC that were operated on in the oral and maxillofacial surgery unit of Taunton and Somerset NHS Trust. The database reports were crosschecked against the Trust's own pathology reporting system to ensure that they were accurate...
September 12, 2018: British Journal of Oral & Maxillofacial Surgery
Zhangfan Ding, Tingying Xiao, Jie Huang, Yihang Yuan, Qingsong Ye, Ming Xuan, Huixu Xie, Xiaoyi Wang
PURPOSE: To assess the possible benefits of elective neck dissection (END) in patients with squamous cell carcinoma (SCC) of the oral cavity and clinically N0 neck. MATERIALS AND METHODS: Medline, Embase, the China National Knowledge Infrastructure, and the Wan Fang Database were systematically searched. A meta-analysis was performed to evaluate the possible benefits of END to such patients. RESULTS: Six prospective studies involving 865 patients fulfilled the inclusion criteria...
August 22, 2018: Journal of Oral and Maxillofacial Surgery
Yahya Açil, Kaspar Torz, Aydin Gülses, Henning Wieker, Mirko Gerle, Nicolai Purcz, Olga Marie Will, Jens Eduard Meyer, Jörg Wiltfang
PURPOSE: The aim of this study was to investigate the oncolytic properties of KI-21-3, a shortened fragment of LL-37, against oral squamous cell carcinoma (OSCC) in an animal model. MATERIALS AND METHODS: Twelve athymic nude mice were divided into a therapy and a control group of six animals each. In both groups, SCC-4 cells were administered extraorally into the floor of the mouth in order to create an OSCC model. In the study group, KI-21-3 was applied intravenously during the 8th and 9th weeks...
September 2018: Journal of Cranio-maxillo-facial Surgery
Kalavani Peddapelli, Guttikonda Venkateswara Rao, Taneeru Sravya, Sravya Ravipati
Basaloid squamous cell carcinoma (BSCC) is a histologically distinct variant of SCC in the head-and-neck region it occurs most commonly in older men with a history of heavy smoking and alcohol abuse and usually presents as a high stage disease with widespread metastases and hence poor prognosis. BSCC is believed to arise from a totipotential primitive cell in the basal layer of the surface epithelium or from the salivary duct lining epithelium. BSCC is an uncommon tumor with a predilection for the upper aerodigestive tract, is a distinct variant of squamous carcinoma, due to its unique histological features and ominous clinical behavior...
May 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Douwe Hoornstra, Jenni Vesterlin, Pirjo Pärnänen, Ahmed Al-Samadi, Ayelet Zlotogorski-Hurvitz, Marilena Vered, Tuula Salo
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) cells are highly proliferative and invasive. Lingonberry contains several polyphenolic compounds similar to curcumin. We hypothesize that fermented lingonberry juice (FLJ) has an anti-invasive and anti-proliferative effect on OTSCC cells similarly to curcumin, which is known to be anti-carcinogenic. MATERIALS AND METHODS: FLJ, curcumin dissolved in ethanol, or curcumin loaded in Candida extracellular vesicles (EVs) were added to more (HSC-3) and less aggressive (SCC-25) OTSCC cells...
September 2018: In Vivo
T-D Nóbrega, S-I-M-L Queiroz, E-M Santos, A-L-L Costa, L Pereira-Pinto, L-B de Souza
BACKGROUND: Early detection of oral cancer is the most effective means of reducing morbidity, complexity, and extent of treatment. This study evaluated the clinicopathological profile of epidermoid carcinoma of the tongue, including treatment and survival. MATERIAL AND METHODS: This observational, retrospective cross-sectional study evaluated patients with squamous cell carcinoma of the tongue treated at the Dr. Luiz Antônio Hospital, Natal, Brazil, from January 2001 to December 2011...
September 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Yoshimasa Sumita, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Jun-Ichi Tanuma
Transcription factor SRY‑box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral squamous cell carcinoma (OSCC) remains elusive. The aim of the present study was to investigate the expression profiles of SOX9 in various oral epithelial lesions, including OSCC. We performed immunohistochemical analysis of SOX9 expression in surgical specimens of OSCC, which simultaneously exhibited different grades of epithelial lesions, and analyzed the correlation between SOX9 expression and several clinicopathological factors...
November 2018: Oncology Reports
Chakra P Chaulagain, Kellie A Sprague, Monika Pilichowska, Janet Cowan, Andreas K Klein, Esha Kaul, Kenneth B Miller
The risk of late complications including secondary malignancies is increased in long-term survivors of allogeneic hematopoietic stem cell transplants (HSCT). There is limited literature on the biological behavior and clinical features of squamous cell carcinoma (SCC) of head and neck post-HSCT. We present the clinical and pathologic characteristics on six patients who were diagnosed with SCC while in remission following an allogeneic HSCT. Median follow-up was 8 years. Five patients (83%) developed SCC of tongue and one developed esophageal SCC...
August 20, 2018: Bone Marrow Transplantation
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