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Oral SCC

Manzar Alam, Tanushree Kashyap, Prajna Mishra, Aditya K Panda, Siddavaram Nagini, Rajakishore Mishra
BACKGROUND: Bax, a proapoptotic protein but its regulation during oral cancer progression and resistance remains elusive. METHODS: A total of 127 samples including adjacent normal, primary tumor, and resistance to chemoradiation therapy (RCRT) samples from oral squamous cell carcinoma (OSCC) patients were used. The status of Bax was analyzed at DNA/mRNA/protein levels and the results were correlated with p53 and Akt expression in tissue samples/cisplatin-resistant oral tongue SCC (SCC9/SCC4-CisR) cell line...
December 14, 2018: Head & Neck
Nitasha Gandhi, Harit Talwar, Sumir Gandhi, Vijay Alageshan, George Abraham, Surbhi Mehdiratta
Squamous cell carcinoma (SCC) of the oral cavity is relatively common in the Indian subcontinent with surgical resection and adjuvant radiotherapy/chemotherapy being the treatment modality of choice. Prosthetic rehabilitation with an obturator following resection is more economical and yields satisfactory results. Better patient acceptance and comfort necessitates hollowing the prosthesis to a great extent. This novel method modifies the existing lost-wax technique in fabricating a definitive hollow maxillary obturator...
July 2018: National Journal of Maxillofacial Surgery
Won-Bum Lee, Won-Hyuk Choi, Hyeong-Geun Lee, Na-Rae Choi, Dae-Seok Hwang, Uk-Kyu Kim
Background: After the resection at the mandibular site involving oral cancer, free vascularized fibular graft, a type of vascularized autograft, is often used for the mandibular reconstruction. Titanium mesh (T-mesh) and particulate cancellous bone and marrow (PCBM), however, a type of non-vascularized autograft, can also be used for the reconstruction. With the T-mesh applied even in the chin and angle areas, an aesthetic contour with adequate strength and stable fixation can be achieved, and the pores of the mesh will allow the rapid revascularization of the bone graft site...
December 2018: Maxillofacial Plastic and Reconstructive Surgery
Y-F Qiu, M-X Wang, L-N Meng, R Zhang, W Wang
OBJECTIVE: MicroRNA (miRNA) can widely regulate gene expression. More importantly, various miRNA molecules have been found with regulatory functions for tumor cell proliferation or apoptosis. The study showed that miR-21 inhibited apoptosis of cultured cancer cells, whilst tumor necrosis factor α (TNF-α) plays important roles in the proliferation of tumor cells. This study manipulated miR-21 expression in cultured oral cancer cells and aimed to investigate its effects on TNF-α expression, and on proliferation or apoptosis of cancer cells...
November 2018: European Review for Medical and Pharmacological Sciences
Wei-Na Zhou, Yi-Fei Du, Yang Zheng, Wei Zhang, Yu-Nong Wu, Xiao-Meng Song, Jin Bai
The function of runt‑related transcription factor 3 (RUNX3) in oral cancer remains controversial. The present study aimed to determine the status of RUNX3 protein expression and its association with clinicopathological characteristics in tongue squamous cell carcinomas (SCC). The present study used three pairs of tongue SCC and non‑cancerous tissues to assess RUNX3 protein expression by western blot analysis, and two tongue SCC cell lines to determine RUNX3 protein localization by immunofluorescence and immunocytochemistry...
November 29, 2018: Molecular Medicine Reports
Mauricio E Gamez, Ryan Kraus, Michael L Hinni, Eric J Moore, Daniel J Ma, Stephen J Ko, Jean Claude M Rwigema, Lisa A McGee, Michele Y Halyard, Matthew R Buras, Robert L Foote, Samir H Patel
OBJECTIVES: The natural history of squamous cell carcinoma (SCC) of the oral cavity (OC) in young adults is unknown. We sought to provide an updated report on treatment outcomes of patients with OC SCC who were 40 years or younger. MATERIALS AND METHODS: We performed a retrospective analysis of 124 consecutive patients with primary OC SCC treated at Mayo Clinic (1980-2014). Patient and tumor characteristics and treatment approach were abstracted from patient charts...
December 2018: Oral Oncology
Megan L Ludwig, Aditi Kulkarni, Andrew C Birkeland, Nicole L Michmerhuizen, Susan K Foltin, Jacqueline E Mann, Rebecca C Hoesli, Samantha N Devenport, Brittany M Jewell, Andrew G Shuman, Matthew E Spector, Thomas E Carey, Hui Jiang, J Chad Brenner
OBJECTIVES: We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer cell lines that have remained uncharacterized despite being used as model systems for decades. MATERIALS AND METHODS: We performed exome sequencing on 14 oral cavity UM-SCC cell lines and denote the mutational profile of each line. We used a SNP array to profile the multiple copy number variations of each cell line and use immunoblotting to compare alterations to protein expression of commonly amplified genes (EGFR, PIK3CA, etc...
December 2018: Oral Oncology
Yuyang Li, Zhiming Xu, Jia Li, Shuofeng Ban, Congcong Duan, Weiwei Liu
Oral squamous cell carcinoma (OSCC) is one of the most common head and neck malignancies. Advanced stages of the disease are associated with poor survival, highlighting a need for new treatment modalities. We previously showed that the proinflammatory cytokine interleukin-18 (IL-18) has a tumor suppressive role in OSCC. Here, we investigated the effects of IL-18 on proliferation, migration, and invasion of OSCC cells ex vivo and in vitro , and in nude mouse xenografts. We report that expression of tankyrase 2 (TNKS2), β-catenin, and N-cadherin was higher in tumor cells than in normal mucosae, whereas the expression of IL-18 and E-cadherin was higher in normal than in tumor tissues...
December 2018: FEBS Open Bio
Linda Humbert, Marjorie Cornu, Emmanuelle Proust-Lemoine, Jagadeesh Bayry, Jean-Louis Wemeau, Marie-Christine Vantyghem, Boualem Sendid
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinoma (SCC), and may lead to death. The role of chronic Candida infection in the etiopathogenesis of oral SCC is unclear. Long-term use of fluconazole has led to the emergence of Candida albicans strains with decreased susceptibility to azoles...
2018: Frontiers in Immunology
Sebastian Prochnow, W Wilczak, V Bosch, T S Clauditz, A Muenscher
OBJECTIVES: Nucleotide excision repair protein expression has been claimed to be responsible for platinum-based chemotherapy resistance. ERCC1, XPF and XPA, core proteins in DNA repair, were evaluated regarding their prognostic value in patients with head and neck squamous cell carcinoma by looking at overall survival and time to recurrence. MATERIALS AND METHODS: Tissue microarrays were constructed from 453 cases of HNSCC, including 222 oral (49%), 126 oropharyngeal (27...
November 29, 2018: Clinical Oral Investigations
Seyedali Seyedmajidi, Maryam Seyedmajidi, Ramin Foroughi, Amir Zahedpasha, Zahra Zolfaghari Saravi, Roghayeh Pourbagher, Ali Bijani, Mina Motallebnejad, Ali Monfared Shabestani, Amrollah Mostafazadeh
Background: The most common type of oral cancer is oral squamous cell carcinoma. If it is diagnosed in the early stages; the success of the treatment can be increased. It seems that ELISA-based techniques as a screening tool for society are the most cost-effective methods for early diagnosis. CD44 is a key marker for the detection of SCC stem cells. The aim of this study was to compare the level of soluble CD44 in saliva and serum between patients with oral SCC and healthy controls. Materials and Methods: Saliva and serum were collected from 20 patients with primary OSCC and 20 healthy persons as control group...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Pei-Feng Liu, Hsueh-Wei Chang, Jin-Shiung Cheng, Huai-Pao Lee, Ching-Yu Yen, Wei-Lun Tsai, Jiin-Tsuey Cheng, Yi-Jing Li, Wei-Chieh Huang, Cheng-Hsin Lee, Luo-Pin Ger, Chih-Wen Shu
Oral squamous cell carcinoma (OSCC) is one of the most common cancer types worldwide and can be divided into three major subsites: buccal mucosal SCC (BMSCC), tongue SCC (TSCC), and lip SCC (LSCC). The autophagy marker microtubule-associated protein light chain 3B (MAP1LC3B) and adaptor sequestosome 1(SQSTM1) are widely used proteins to evaluate autophagy in tumor tissues. However, the role of MAP1LC3B and SQSTM1 in OSCC is not fully understood, particularly in certain subsites. With a tissue microarray comprised of 498 OSCC patients, including 181 BMSCC, 244 TSCC, and 73 LSCC patients, we found that the expression levels of MAP1LC3B and cytoplasmic SQSTM1 were elevated in the tumor tissues of three subsites compared with those in adjacent normal tissues...
November 24, 2018: Journal of Clinical Medicine
Francesco Broccolo, Giulia Ciccarese, Agostino Rossi, Luca Anselmi, Francesco Drago, Antonio Toniolo
Background: Oral and oropharyngeal squamous cell carcinomas (OSCC and OPSCC) represent the majority of head and neck squamous cell carcinomas (HNSCC). Human papillomavirus (HPV) is an important etiologic factor together with Epstein-Barr virus (EBV). Little is known on the prevalence of major herpesviruses [EBV, cytomegalovirus (CMV) and HHV-6, - 7 and - 8] in HNSCCs. Methods: Fifty-one formalin-fixed paraffin-embedded (FFPE) tissue samples taken at surgery (40 oropharyngeal, 11 oral) were analyzed for 40 HPV genotypes (20 high-risk types), EBV, CMV, HHV-6, - 7 and - 8 by quantitative PCR...
2018: Infectious Agents and Cancer
Ezhilarasan Devaraj, Apoorva S Velluru, Ashok Vardhan Nandhigam
BACKGROUND: Syzygium cumini (L.) Skeels (jambolan) is commonly used in Indian traditional medicine to treat a variety of diseases such as obesity, diabetes etc. The cytotoxic potential of Syzygium cumini (SC) against oral cancer cell line is remains elusive. Therefore, in this study, we evaluated the cytotoxic effect of S. cumini in human oral squamous cell carcinoma (OSCC) cell line (SCC-25 cells). MATERIAL AND METHODS: OSCC cells are treated with different concentrations (10, 20 and 40 μg/mL) of S...
November 19, 2018: Journal of Oral Pathology & Medicine
Laetitia Gambotti, Emilie Schwob, Thomas Schouman, Gregory Murcier, Patrick Goudot, Alain Mallet, Chloé Bertolus
OBJECTIVES: There is no consensus for the specific management of elderly patients presenting with oral cavity squamous cell carcinomas (OC SCC). We report our findings in the treatment of primary OC SCC, for patients of 70 years of age or more, in a French university hospital center. PATIENTS AND METHODS: One hundred and twenty five patients diagnosed between 2000 and 2010, were included retrospectively. Independent risk factors of post-operative complications were identified using a logistic regression...
December 2018: Surgical Oncology
Magda Eline Guerrart Portugal, Sonia Mra Raboni, Meri Bordignon Nogueira, Luine Rosele Renaud Vidal, Amanda Helena Dingueleski, Edelaine Kluk, Carmem Bonfim, Lisandro Lima Ribeiro, Cassius Carvalho Torres-Pereira
BACKGROUND: Fanconi anemia (FA) is a rare genetic disease usually characterized by bone marrow failure and congenital malformations. The risk of development of malignancies in the oral cavity of FA patients, such as squamous cell carcinoma (SCC), increases significantly after a hematopoietic stem cells transplant (HSCT), and may also be linked with the presence of human papillomavirus (HPV) infections in the oral cavity. We investigated the prevalence and the HPV genotypes in oral mucosa of Brazilian FA patients...
November 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
M Lesnik, O De Crouy Chanel, M Lefèvre, S Samaha, S Périe, J Lacau St Guily, B Baujat
OBJECTIVES: Osteoradionecrosis (ORN) of the mandible is a common complication of head and neck radiotherapy and often requires surgical treatment. Squamous cell carcinoma (SCC) can be exceptionally discovered within zones of ORN on histological examination of the operative specimen. The authors discuss the management of these lesions based on a short patient series. MATERIALS AND METHODS: This single-centre retrospective study was based on patients managed between 2012 and 2014 for ORN with incidental discovery of microscopic SCC...
November 14, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Paolo Cariati, Almudena Cabello-Serrano, Fernando Monsalve-Iglesias, Jose Fernadez-Solis, Ildefonso Martinez-Lara
PURPOSE: The main aim of the present study is to analyze the behavior of squamous cell carcinoma (SCC) of maxillary gingiva, alveolus, and hard palate and to determine the utility of selective neck dissection in clinically N0 patients at early stages. MATERIAL AND METHOD: Twenty-nine previously untreated patients with SCC of maxillary gingiva, alveolus, and hard palate were diagnosed and treated with at least a tumorectomy and selective neck dissection at HUVN and included in the study...
November 12, 2018: Current Problems in Cancer
Fei Liu, Shuai Yuan, Qigen Fang, Qiang Sun
The natural history of untreated head and neck squamous cell carcinoma (SCC) was not well defined. A total of 206 patients with untreated head and neck SCC were retrospectively enrolled. The 1-year survival rate for cancers arising in oral cavity, oropharynx, throat, and hypopharynx was 31%, 20%, 0%, and 3%, respectively, the difference was significant (p<0.001). 57.2% of the patients died within 12 months, median survival time was 11 months. The prognosis of untreated head and neck SCC patients is extremely unfavorable...
November 16, 2018: Clinical Otolaryngology
Kalpajyoti Bhattacharjee, H C Girish, Sanjay Murgod, Alshame M J Alshame, K Shyamala, Vaidhehi N Nayak
Aims and Objectives: Squamous cell carcinoma (SCC) is a common oral malignancy with a poor survival rate. Early tumorigenesis is marked by transdifferentiation of fibroblasts to myofibroblasts (MFs), which is supported by growth factors and cytokines expressed by tumor cells. The expression of alpha-smooth muscle actin (αSMA) marker correlates with the activation of MFs. This study was undertaken to compare the frequency and distribution of αSMA immunoexpression in oral epithelial dysplasia (OED) and OSCC...
September 2018: Journal of International Society of Preventive & Community Dentistry
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