keyword
https://read.qxmd.com/read/38490062/targeting-kelch-like-klhl-proteins-achievements-challenges-and-perspectives
#21
REVIEW
Yangguo Zhou, Qiong Zhang, Ziquan Zhao, Xiuqi Hu, Qidong You, Zhengyu Jiang
Kelch-like proteins (KLHLs) are a large family of BTB-containing proteins. KLHLs function as the substrate adaptor of Cullin 3-RING ligases (CRL3) to recognize substrates. KLHLs play pivotal roles in regulating various physiological and pathological processes by modulating the ubiquitination of their respective substrates. Mounting evidence indicates that mutations or abnormal expression of KLHLs are associated with various human diseases. Targeting KLHLs is a viable strategy for deciphering the KLHLs-related pathways and devising therapies for associated diseases...
February 29, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38490013/parapharyngeal-and-retropharyngeal-infections-in-children-kawasaki-disease-needs-vigilance
#22
JOURNAL ARTICLE
Jia Liu, Shui-Hong Zhou
OBJECTIVE: Kawasaki Disease (KD) may mimic Parapharyngeal (PPI) and Retropharyngeal Infections (RPI), leading to misdiagnosis as Deep Neck Infections (DNIs). The treatment plans for the two diseases are different, and delayed treatment can lead to serious complications. Therefore, prompt diagnosis and management are necessary. This study was performed to evaluate the clinical features of KD mimicking DNIs and explore the treatment options. METHODS: Children with cellulitis or abscess in parapharyngeal or retropharyngeal space in neck CT were included in this study...
February 22, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38490010/identification-of-core-gene-in-chronic-rhinosinusitis-with-nasal-polyps-and-correlations-with-inflammation-related-genes
#23
JOURNAL ARTICLE
Jingpu Yang, Chang Liu, Jinzhang Cheng, Yunmeng Wang, Zonggui Wang, Wei Zhong
OBJECTIVE: Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes. METHODS: GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG...
March 1, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38489882/insight-into-the-improvement-mechanism-of-gel-properties-of-pea-protein-isolate-based-on-the-synergistic-effect-of-cellulose-nanocrystals-and-calcium-ions
#24
JOURNAL ARTICLE
Jinglei Zhang, Huajian Xu, Huixia Liu, Wenqi Wang, Mingming Zheng, Yingnan Liu, Yibin Zhou, Yueshuang Li, Xiaonan Sui, Yaqing Xiao
Here, the influence and potential mechanism by which cellulose nanocrystals (CNC) collaborated with Ca2+ enhancing the heat-induced gelation of pea protein isolate (PPI) were investigated. It was found that the combination of 0.45% CNC and 15 mM Ca2+ synergistically increased the gel strength (from 14.18 to 65.42 g) and viscoelasticity of PPI while decreased the water holding capacity. The improved particle size, turbidity, and thermostability as well as the reduced solubility, crystallinity, and gel porosity were observed in CNC/CaCl2 composite system...
March 11, 2024: Food Chemistry
https://read.qxmd.com/read/38489741/comprehensive-analysis-of-the-clinical-and-biological-significances-for-chemokine-cxcl3-in-cholangiocarcinoma
#25
JOURNAL ARTICLE
Hongyue Ren, Xiaofan Yang, Wenrong Hou, Jiarong Meng, Deqing Luo, Chunbin Zhang
Cholangiocarcinoma (CHOL) is a race malignant cancer arising from bile duct epithelial cells in clinical practice. C-X-C motif chemokine ligand 3 (CXCL3) is a member of chemokines family, which participates in the pathogenesis of various tumors. However, the association between CXCL3 and CHOL is unclear. This present study was to assess the role of CXCL3 expression in the progress of CHOL. TIMER, GEPIA, UALCAN, GSCA, LinkedOmics, Metascape and STRING databases were performed to evaluate the clinical and biological significances for CXCL3 with CHOL patients including expression, clinicopathological factors, immune cell infiltration, GO enrichment and KEGG pathway analyses, as well as PPI network analysis...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38486764/study-on-the-mechanism-of-shugan-lidan-xiaoshi-granule-in-preventing-acute-pancreatitis-based-on-network-pharmacology-and-molecular-docking
#26
JOURNAL ARTICLE
Jiaxing Wang, Yang Wang, Zitong Chen, Bin Liu, Wujie Wang, Yuliang Li
BACKGROUND: Shugan Lidan Xiaoshi granules (SLXG) is a herbal granule formulation developed by extensively modifying multiple traditional Chinese medicine compound prescriptions known for their ability to dissolve stones. It is primarily used for the prevention and treatment of cholelithiasis and possesses significant therapeutic potential in both preventing and treating acute pancreatitis. However, the preventive effects of SLXG on cholelithiasis-related complications, such as acute pancreatitis (AP), have been inadequately researched...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486369/use-of-proton-pump-inhibitors-is-associated-with-increased-risk-of-out-of-hospital-cardiac-arrest-in-the-general-population-a-nested-case-control-study
#27
JOURNAL ARTICLE
Talip E Eroglu, Ruben Coronel, Gunnar H Gislason
AIMS: Proton pump inhibitors (PPIs) impair cardiac repolarization and prolong the QT interval and may potentially be proarrhythmic. However, risk of out-of-hospital cardiac arrest (OHCA) is scarcely investigated. We studied whether past or current PPI use is associated with OHCA in the general population. METHODS AND RESULTS: We conducted a nationwide nested case-control study with OHCA-cases of presumed cardiac causes and age/sex/OHCA-date-matched non-OHCA-controls from the general population...
March 14, 2024: European Heart Journal. Cardiovascular Pharmacotherapy
https://read.qxmd.com/read/38485992/deprescribing-potential-of-commonly-used-medications-among-community-dwelling-older-adults-insights-from-a-pharmacist-s-geriatric-assessment
#28
JOURNAL ARTICLE
Iva Bužančić, Margita Držaić, Ingrid Kummer, Maja Ortner Hadžiabdić, Jovana Brkić, Daniela Fialová
Pharmacist's geriatric assessment can provide valuable insights into potential deprescribing targets, while including important information on various health-related domains. Data collected from a geriatric assessment questionnaire, for 388 patients, from the Croatian cohort of the EuroAgeism H2020 ESR 7 international project, along with guideline-based deprescribing criteria, were used to analyse potentially inappropriate prescribing of four medication groups (benzodiazepines (BZN), proton pump inhibitors (PPI), opioids, and non-steroidal anti-inflammatory drugs (NSAID)), and to assess the deprescribing potential...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38485838/upregulation-of-lnc-foxd2-as1-cdc45-and-cdk1-in-patients-with-primary-non-m3-aml-is-associated-with-a-worse-prognosis
#29
JOURNAL ARTICLE
Saba Manoochehrabadi, Morteza Talebi, Hossein Pashaiefar, Soudeh Ghafouri-Fard, Mohammad Vaezi, Mir Davood Omrani, Mohammad Ahmadvand
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with an unfavorable outcome. The present research aimed to identify novel biological targets for AML diagnosis and treatment. In this study, we performed an in-silico method to identify antisense RNAs (AS-RNAs) and their related co-expression genes. GSE68172 was selected from the AML database of the Gene Expression Omnibus and compared using the GEO2R tool to find DEGs. Antisense RNAs were selected from all the genes that had significant expression and a survival plot was drawn for them in the GEPIA database, FOXD2-AS1 was chosen for further investigation based on predetermined criteria (logFC ≥|1| and P < 0...
February 19, 2024: Blood Research
https://read.qxmd.com/read/38485036/analysis-and-validation-of-hub-genes-in-neutrophil-extracellular-traps-for-the-long-term-prognosis-of-myocardial-infarction
#30
JOURNAL ARTICLE
Xuan Li, Wenyu Wu, Huan He, Lin Guan, Guancheng Chen, Zhijun Lin, Huan Li, Jialin Jiang, Xin Dong, Zhuoji Guan, Pinliang Chen, Zigang Pan, Weiwei Huang, Runjia Yu, Wenxin Song, Lu Lu, Zhongqi Yang, Zixin Chen, Lingjun Wang, Shaoxiang Xian, Jie Chen
INTRODUCTION: The study focuses on the long-term prognosis of myocardial infarction (MI) influenced by neutrophil extracellular traps (NETs). It also aims to analyze and validate relative hub genes in this process, in order to further explore new therapeutic targets that can improve the prognosis of MI. MATERIALS AND METHODS: We established a MI model in mice by ligating the left anterior descending branch (LAD) and conducted an 8-week continuous observation to study the dynamic changes in the structure and function of the heart in these mice...
March 12, 2024: Gene
https://read.qxmd.com/read/38484574/identification-of-hk3-as-a-promising-immunomodulatory-and-prognostic-target-in-sepsis-induced-acute-lung-injury
#31
JOURNAL ARTICLE
Mingyu Zhu, Xiaokai Tang, Jingjing Xu, Yuanqi Gong
BACKGROUND: Sepsis is a life-threatening global disease with a significant impact on human health. Acute lung injury (ALI) has been identified as one of the primary causes of mortality in septic patients. This study aimed to identify candidate genes involved in sepsis-induced ALI through a comprehensive approach combining bioinformatics analysis and experimental validation. METHODS: The datasets GSE65682 and GSE32707 obtained from the Gene Expression Omnibus database were merged to screen for sepsis-induced ALI related differentially expressed genes (DEGs)...
March 11, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38484140/network-pharmacology-and-experimental-evaluation-strategies-to-decipher-the-underlying-pharmacological-mechanism-of-traditional-chinese-medicine-cff-1-against-prostate-cancer
#32
JOURNAL ARTICLE
Yong Wei, Mingxia Zhu, Ye Chen, Qianying Ji, Jun Wang, Luming Shen, Xin Yang, Haibin Hu, Xin Zhou, Qingyi Zhu
Prostate cancer (PCa) is a common malignancy in elderly men. We have applied Traditional Chinese Medicine CFF-1 in clinical treatments for PCa for several years. Here, we aimed to identify the underlying mechanism of CFF-1 on PCa using network pharmacology and experimental validation. Active ingredients, potential targets of CFF-1 were acquired from the public databases. Subsequently, protein-protein interaction (PPI) and the herbs-active ingredients-target network was constructed. A prognostic model for PCa was also constructed based on key targets...
March 13, 2024: Aging
https://read.qxmd.com/read/38483957/the-candidate-proteins-associated-with-keratoconus-a-meta-analysis-and-bioinformatic-analysis
#33
JOURNAL ARTICLE
Ting Song, Jie Song, Jingyi Li, Halima Ben Hilal, Xiaona Li, Pengfei Feng, Weiyi Chen
PURPOSE: Keratoconus (KC) is a multifactorial disorder. This study aimed to conduct a systematic meta-analysis to exclusively explore the candidate proteins associated with KC pathogenesis. METHODS: Relevant literature published in the last ten years in Pubmed, Web of Science, Cochrane, and Embase databases were searched. Protein expression data were presented as the standard mean difference (SMD) and 95% confidence intervals (CI). The meta-analysis is registered on PROSPERO, registration number CRD42022332442 and was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PRISMA)...
2024: PloS One
https://read.qxmd.com/read/38483115/potassium-competitive-acid-blockers-and-acid-related-disorders
#34
JOURNAL ARTICLE
Kevin Z Huang, H Christian Weber
PURPOSE OF THE REVIEW: Potassium-competitive acid blockers (PCABs) represent a new class of compounds for the treatment of acid-related disorders. Recent FDA approval of the PCAB vonoprazan for erosive esophagitis has started an important new approach to acid-related disorders. RECENT FINDINGS: Compared to conventional proton pump inhibitors (PPIs), PCABs provide more rapid, potent, and sustained suppression of gastric acid with faster and more durable symptom relief...
March 15, 2024: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/38482392/prescribing-portraits-to-optimize-prescribing-of-proton-pump-inhibitors-in-long-term-care-ppi-t-stop-study
#35
JOURNAL ARTICLE
Ying Wang, Lori Spence, Anthony Tung, Carolyn D Bubbar, Wade Thompson, Aaron M Tejani
BACKGROUND: Proton pump inhibitors (PPIs) are among the most commonly prescribed medications in Canada, particularly for older adults (at least 65 years of age). Overprescribing of long-term PPIs leads to health care system waste and is associated with adverse effects, including infections and fractures. The high prevalence of PPI prescribing in long-term care (LTC) facilities prompted an evaluation of systematic approaches to PPI deprescribing. OBJECTIVE: To assess the impact of individualized prescribing portraits, a type of audit-and-feedback quality improvement intervention, on PPI deprescribing in the LTC setting...
2024: Canadian Journal of Hospital Pharmacy
https://read.qxmd.com/read/38481549/network-pharmacology-analysis-of-a-patented-chinese-herbal-medicine-for-alleviating-anxiety-disorder-in-in-vitro-fertilization-embryo-transfer
#36
JOURNAL ARTICLE
Chang Liu, Weihuan Hu, Xiaoling Feng, Fan Qu
OBJECTIVE: Qu's formula 3 (QUF3) is a patented Chinese herbal medicine used to alleviate anxiety disorders during in vitro fertilization-embryo transfer (IVF-ET). This study aimed to identify the potential active constituents and molecular mechanisms of action of QUF3 in alleviating anxiety disorders during IVF-ET. METHODS: The active constituents of QUF3 were identified from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and literatures...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38481330/network-pharmacology-and-molecular-docking-analysis-on-shenfu-qiangxin-indicate-mtor-is-a-potential-target-to-treat-heart-failure
#37
JOURNAL ARTICLE
Peilin Zou, Jiajun Li, Yucong Zhang, Zonghao Qian, Hao Nie, Ni Yang, Le Zhang, Li Lin, Dewei Peng, Cuntai Zhang
BACKGROUND: Heart failure (HF) is one of the major causes of mortality worldwide with high recurrence rate and poor prognosis. Our study aimed to investigate potential mechanisms and drug targets of Shenfu Qiangxin (SFQX), a cardiotonic-diuretic traditional Chinese medicine, in treating HF. METHODS: An HF-related and SFQX-targeted gene set was established using disease-gene databases and the Traditional Chinese Medicine Systems Pharmacology database. We performed gene function and pathway enrichment analysis and constructed protein-protein interaction (PPI) network to investigate the potential mechanisms...
March 13, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38481183/exploring-the-role-of-mitochondrial-associated-and-peripheral-neuropathy-genes-in-the-pathogenesis-of-diabetic-peripheral-neuropathy
#38
JOURNAL ARTICLE
Ruojing Bai, Yuanyuan Luo
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a prevalent and serious complication of diabetes mellitus, impacting the nerves in the limbs and leading to symptoms like pain, numbness, and diminished function. While the exact molecular and immune mechanisms underlying DPN remain incompletely understood, recent findings indicate that mitochondrial dysfunction may play a role in the advancement of this diabetic condition. METHODS: Two RNA transcriptome datasets (codes: GSE185011 and GSE95849), comprising samples from diabetic peripheral neuropathy (DPN) patients and healthy controls (HC), were retrieved from the Gene Expression Omnibus (GEO) database hosted by the National Center for Biotechnology Information (NCBI)...
March 13, 2024: BMC Neurology
https://read.qxmd.com/read/38480622/a-comprehensive-review-on-potential-drug-drug-interactions-of-proton-pump-inhibitors-with-antidiabetic-drugs-metformin-and-dpp-4-inhibitors
#39
REVIEW
Jarin Tasnim, Najihah Mohd Hashim, Heh Choon Han
A drug interaction is a condition in which two or more drugs are taken at the same time. Type 2 diabetes mellitus is a significant contributor to polypharmacy. Proton pump inhibitors (PPIs) are often prescribed in combination with metformin or DPP-4 inhibitors (sitagliptin, saxagliptin, linagliptin, and alogliptin) or a combined dose of metformin and DPP-4 inhibitor to treat gastritis in diabetic patients. This review article mainly focused on evaluating the potential drug-drug interactions (DDIs) between PPIs (i...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38480492/integrated-transcriptome-and-proteome-analyses-of-%C3%AE-conglycinin-induced-intestinal-damage-in-piglets
#40
JOURNAL ARTICLE
Bojiang Li, Shugui Zheng, Shuangyang Yin, Jing Chen, Yu He, Jiaqi Yao, Simiao Liu
β-conglycinin (β-CG) induces intestinal damage in piglets; however, its regulatory mechanisms are not fully understood. This study aimed to investigate the molecular mechanisms by which β-CG regulates intestinal injury in piglets through downstream genes and proteins. Our findings revealed that β-CG significantly reduced villus height while increasing the crypt depth. In addition, we analyzed the transcriptome and proteome of jejunum tissues after the β-CG treatment. In total, 382 differentially expressed genes (DEGs) and 292 differentially expressed proteins (DEPs) were identified between the treatment and the control groups...
March 13, 2024: Journal of Agricultural and Food Chemistry
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