keyword
https://read.qxmd.com/read/38497905/role-of-pea-protein-isolate-in-modulating-pea-starch-digestibility-insights-from-physicochemical-and-microstructural-analysis
#1
JOURNAL ARTICLE
Jiwei Kuang, Xijuan Yang, Ke Xu, Wancai Zheng, Bin Dang
BACKGROUND: Understanding the interactions between protein and starch was crucial in revealing the mechanisms by which protein influence starch digestibility. This study investigated the impact of different contents of pea protein isolate (PPI) on the physicochemical properties and digestibility of pea starch (PS). RESULTS: The results demonstrated that as the content of PPI increased from 0 to 12%, the digestion of PS decreased by 12.3%. Rheological analysis indicated that PPI primarily interacted with molecular chains of PS through hydrogen bonds...
March 18, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38497849/identifying-critical-genes-and-pathways-of-doxorubicin-induced-cardiomyopathy-via-bioinformatics-analysis
#2
JOURNAL ARTICLE
G Fan, X Shi, C Huo, H Zuo
OBJECTIVE: The pathogenesis of doxorubicin (DOX) induced cardiomyopathy (DCM) is still uncertain. We aimed to identify the critical genes and pathways involved in DCM based on bioinformatics analysis. MATERIALS AND METHODS: The GSE59672 and GSE23598 mice heart tissue microarray data were obtained from Gene Expression Omnibus (GEO) database. The "limma" package of R software was used to screen the differently expressed genes (DEGs). GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analyses were performed on DEGs by using "clusterProfiler" package in R software...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497142/does-the-presence-of-an-esophageal-motor-disorder-influence-the-response-to-anti-reflux-mucosectomy-arms-for-refractory-gerd
#3
JOURNAL ARTICLE
Philippe Onana Ndong, Jean-Michel Gonzalez, Ana Beyrne, Marc Barthet, Veronique Vitton
INTRODUCTION: The prevalence of esophageal motor disorders (EMD) in PPI-refractory gastroesophageal reflux disease (GERD) is substantial. However, limited data exist on their impact on the efficacy of endoscopic treatments like anti-reflux mucosectomy (ARMS). This study aimed to evaluate the influence of EMD on ARMS efficacy in patients with PPI-refractory GERD. METHOD: This single-center retrospective study enrolled patients with refractory GERD treated with ARMS-b (anti-reflux mucosectomy band-ligation)...
March 18, 2024: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/38497073/insights-into-amyloid-precursor-protein-target-through-ppi-network-analysis
#4
JOURNAL ARTICLE
Annu Grewal, Deepak Sheokand, Raveena Chauhan, Vandana Saini, Ajit Kumar
Alzheimer's disease (AD) is the leading cause of dementia worldwide with therapeutic lacunae till date. The beta-amyloid (Aβ) accumulation triggers AD pathogenesis, though clinical trials lowering Aβ have not altered disease outcomes suggesting other interacting factors to be identified for drug design of AD. Therefore, it is of interest to identify potential hub proteins interlinked with disease-driving pathways using a network-based approach for AD therapeutic designing. Literature mining was done to identify proteins implicated in AD etiology...
2024: Bioinformation
https://read.qxmd.com/read/38496849/mechanisms-of-action-of-shizhenqing-granules-for-eczema-treatment-network-pharmacology-analysis-and-experimental-validation
#5
JOURNAL ARTICLE
Hairong Zhang, Zhenbo Li, Yike Sun, Wenna Li, Xiao Sun, Yapeng Zhang, Leilei Liu, Shuran Ma
BACKGROUND: Jiuwan decoction has been used to treat chronic eczema since the Qing Dynasty. According to clinical experience, Shizhenqing granules (SZQG), derived from the Jiuwan decoction, exert beneficial clinical effects on acute eczema and reduce recurrence. Therefore, we elucidated the underlying mechanisms of SZQG through network pharmacology, molecular docking, and experimental validation. METHODS: The main chemical components of SZQG were identified by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496585/multi-omics-integration-identifies-genes-influencing-traits-associated-with-cardiovascular-risks-the-long-life-family-study
#6
Sandeep Acharya, Shu Liao, Wooseok J Jung, Yu S Kang, Vaha A Moghaddam, Mary Feitosa, Mary Wojczynski, Shiow Lin, Jason A Anema, Karen Schwander, Jeff O Connell, Mike Province, Michael R Brent
The Long Life Family Study (LLFS) enrolled 4,953 participants in 539 pedigrees displaying exceptional longevity. To identify genetic mechanisms that affect cardiovascular risks in the LLFS population, we developed a multi-omics integration pipeline and applied it to 11 traits associated with cardiovascular risks. Using our pipeline, we aggregated gene-level statistics from rare-variant analysis, GWAS, and gene expression-trait association by Correlated Meta-Analysis (CMA). Across all traits, CMA identified 64 significant genes after Bonferroni correction (p ≤ 2...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38496269/elucidating-the-anti-hypertensive-mechanisms-of-uncaria-rhynchophylla-alisma-plantago-aquatica-l-an-integrated-network-pharmacology-cluster-analysis-and-molecular-docking-approach
#7
JOURNAL ARTICLE
Tong Yin, Han Zhang, Xingfang Liu, Dongfeng Wei, Cong Ren, Liangyu Cui, Yukun Li, Linshuang Wang, Jiaheng Wang, Zhiwei Zhao, Dasheng Liu, Liying Wang, Xuejie Han
Background: With the increasing global prevalence of hypertension, a condition that can severely affect multiple organs, there is a growing need for effective treatment options. Uncaria rhynchophylla-Alisma plantago-aquatica L. (UR-AP) is a traditional drug pair used for treating hypertension based on the liver-kidney synergy concept. However, the detailed molecular mechanisms underlying its efficacy remain unclear. Methods: This study utilized an integrative approach combining network pharmacology, cluster analysis, and molecular docking to uncover the bioactive components and targets of UR-AP in the treatment of hypertension...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38495343/the-critical-role-of-pyroptosis-in-peri-implantitis
#8
JOURNAL ARTICLE
Liangwen Chen, Ziqiao Tang, Liangliang Fu, Yang Xie, Junyi Xu, Haibin Xia, Ting Xia, Min Wang
BACKGROUND: Peri-implantitis (PI) is a prevalent complication of implant treatment. Pyroptosis, a distinctive inflammatory programmed cell death, is crucial to the pathophysiology of PI. Despite its importance, the pyroptosis-related genes (PRGs) influencing PI's progression remain largely unexplored. METHODS: This study conducted histological staining and transcriptome analyze from three datasets. The intersection of differentially expressed genes (DEGs) and PRGs was identified as pyroptosis-related differentially expressed genes (PRDEGs)...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38494963/-the-mechanism-of-scutellarin-inhibiting-oral-leukoplakia-carcinogenesis-based-on-network-pharmacology-and-in-vitro-cytology
#9
JOURNAL ARTICLE
Sai Ye, Ying Zhang, Rong-Hui Xia, Yong-Mei Zhou, Lan Wu
PURPOSE: To investigate the potential mechanisms of scutellarin on oral leukoplakia (OLK) by network pharmacology and further verify by cytology. METHODS: The potential targets of scutellarin acting on OLK were excavated through network pharmacology. PPI network was constructed, and the possible targets and pathways of scutellarin were predicted by GO and KEGG enrichment analysis. CCK-8 and Transwell assays were used to verify the effects of scutellarin on proliferation, migration and invasion of Leuk-1 and Cal-27 cell lines...
December 2023: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://read.qxmd.com/read/38494845/cpa4-as-a-biomarker-promotes-the-proliferation-migration-and-metastasis-of-clear-cell-renal-cell-carcinoma-cells
#10
JOURNAL ARTICLE
Kongjia Wang, Yixin Ding, Yunbo Liu, Mingyu Ma, Ji Wang, Zengshun Kou, Shuo Liu, Bo Jiang, Sichuan Hou
Clear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types, but its role in ccRCC remains unexplored. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized in order to investigate the differential expression patterns of CPA4...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38494267/subtractive-genomics-study-of-xanthomonas-oryzae-pv-oryzae-reveals-repurposable-drug-candidate-for-the-treatment-of-bacterial-leaf-blight-in-rice
#11
JOURNAL ARTICLE
Ishtiaque Ahammad, Tabassum Binte Jamal, Anika Bushra Lamisa, Arittra Bhattacharjee, Nayeematul Zinan, Md Zahid Hasan Chowdhury, Shah Mohammad Naimul Islam, Kazi Md Omar Faruque, Zeshan Mahmud Chowdhury, Mohammad Uzzal Hossain, Keshob Chandra Das, Chaman Ara Keya, Md Salimullah
BACKGROUND: Xanthomonas oryzae pv. oryzae is a plant pathogen responsible for causing one of the most severe bacterial diseases in rice, known as bacterial leaf blight that poses a major threat to global rice production. Even though several experimental compounds and chemical agents have been tested against X. oryzae pv. oryzae, still no approved drug is available. In this study, a subtractive genomic approach was used to identify potential therapeutic targets and repurposible drug candidates that could control of bacterial leaf blight in rice plants...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38494075/exploring-the-ire1-interactome-from-canonical-signaling-functions-to-unexpected-roles
#12
REVIEW
Simon Le Goupil, Hadrien Laprade, Marc Aubry, Eric Chevet
The unfolded protein response (UPR) is a mechanism aiming at restoring endoplasmic reticulum (ER) homeostasis and is likely involved in other adaptive pathways. The UPR is transduced by three proteins acting as sensors and triggering downstream signaling pathways. Among them, IRE1α (referred to as IRE1 hereafter), an ER-resident type I transmembrane protein, exerts its function through both kinase and endoribonuclease activities, resulting in both XBP1 mRNA splicing and RNA degradation (Regulated IRE1 Dependent Decay, RIDD)...
March 15, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38493432/design-of-inhibitor-peptide-sequences-based-on-the-interfacial-knowledge-of-the-protein-g-igg-crystallographic-complex-and-their-binding-studies-with-igg
#13
JOURNAL ARTICLE
Neetu Tanwar, Rupal Ojha, Soumya Aggarwal, Vijay Kumar Prajapati, Manoj Munde
Protein-protein interactions (PPI) have emerged as valuable targets in medicinal chemistry due to their key roles in important biological processes. The modulation of PPI by small peptides offers an excellent opportunity to develop drugs against human diseases. Here, we exploited the knowledge of the binding interface of the IgG-protein G complex (PDB:1FCC) for designing peptides that can inhibit these complexes. Herein, we have designed several closely related peptides, and the comparison of results from experiments and computational studies indicated that all the peptides bind close to the expected binding site on IgG and the complexes are stable...
March 17, 2024: European Biophysics Journal: EBJ
https://read.qxmd.com/read/38493179/identification-and-validation-of-irf6-related-to-ovarian-cancer-and-biological-function-and-prognostic-value
#14
JOURNAL ARTICLE
Shihao Hong, Ni Fu, Shanliang Sang, Xudong Ma, Fangying Sun, Xiao Zhang
BACKGROUND: Ovarian cancer (OC) is a severe gynecological malignancy with significant diagnostic and therapeutic challenges. The discovery of reliable cancer biomarkers can be used to adjust diagnosis and improve patient care. However, serous OC lacks effective biomarkers. We aimed to identify novel biomarkers for OC and their pathogenic causes. METHODS: The present study used the differentially expressed genes (DEGs) obtained from the "Limma" package and WGCNA modules for intersection analysis to obtain DEGs in OC...
March 16, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38493120/using-protein-language-models-for-protein-interaction-hot-spot-prediction-with-limited-data
#15
JOURNAL ARTICLE
Karen Sargsyan, Carmay Lim
BACKGROUND: Protein language models, inspired by the success of large language models in deciphering human language, have emerged as powerful tools for unraveling the intricate code of life inscribed within protein sequences. They have gained significant attention for their promising applications across various areas, including the sequence-based prediction of secondary and tertiary protein structure, the discovery of new functional protein sequences/folds, and the assessment of mutational impact on protein fitness...
March 16, 2024: BMC Bioinformatics
https://read.qxmd.com/read/38492288/reproductive-endocrine-disruption-effect-and-mechanism-in-male-zebrafish-after-life-cycle-exposure-to-environmental-relevant-triclosan
#16
JOURNAL ARTICLE
Fan Wang
Triclosan (TCS) is a wide-spectrum antibacterial agent that is found in various water environments. It has been reported to have estrogenic effects. However, the impact of TCS exposure on the reproductive system of zebrafish (Danio rerio) throughout their life cycle is not well understood. In this study, zebrafish fertilized eggs were exposed to 0, 10, and 50 μg/L TCS for 120 days. The study investigated the effects of TCS exposure on brain and testis coefficients, the expression of genes related to the hypothalamus-pituitary-gonadal (HPG) axis, hormone levels, vitellogenin (VTG) content, histopathological sections, and performed RNA sequencing of male zebrafish...
March 13, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38492232/harnessing-the-predicted-maize-pan-interactome-for-putative-gene-function-prediction-and-prioritization-of-candidate-genes-for-important-traits
#17
JOURNAL ARTICLE
Elly Poretsky, H Busra Cagirici, Carson M Andorf, Taner Z Sen
The recent assembly and annotation of the 26 maize nested association mapping (NAM) population founder inbreds have enabled large-scale pan-genomic comparative studies. These studies have expanded our understanding of agronomically important traits by integrating pan-transcriptomic data with trait-specific gene candidates from previous association mapping results. In contrast to the availability of pan-transcriptomic data, obtaining reliable protein-protein interaction (PPI) data has remained a challenge due to its high cost and complexity...
March 16, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38491247/single-cell-transcriptome-analysis-upon-ecm-remodeling-meningioma-cells
#18
JOURNAL ARTICLE
Wen-Qiang Che, Yu-Jiao Wang, Liu Yang, Hong-Qin Wang, Xiang-Yu Wang, Jun Lyu
Meningiomas are the most common tumours that primarily arise in the central nervous system, but their intratumoural heterogeneity has not yet been thoroughly studied. We aimed to investigate the transcriptome characteristics and biological properties of ECM-remodeling meningioma cells. Single-cell RNA sequencing (ScRNA-seq) data from meningioma samples were acquired and used for analyses. We conducted comprehensive bioinformatics analyses, including screening for differentially expressed genes (DEGs), Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway and Gene Ontology (GO) term enrichment analyses, Gene Set Enrichment Analysis (GSEA), protein-protein interaction (PPI) analysis, and copy number variation (CNV) analysis on single-cell sequencing data from meningiomas...
March 16, 2024: Neurosurgical Review
https://read.qxmd.com/read/38491124/identification-of-hedyotis-diffusa-willd-specific-mrna-mirna-lncrna-network-in-rheumatoid-arthritis-based-on-network-pharmacology-bioinformatics-analysis-and-experimental-verification
#19
JOURNAL ARTICLE
Jing Jiang, Meng Huang, Si-Si Zhang, Yong-Gang Wu, Xiao-Long Li, Hui Deng, Xin-Yu Qili, Jian-Lin Chen, Yao Meng, Wen-Kui Sun
Hedyotis diffusa Willd (HDW) possesses heat-clearing, detoxification, anti-cancer, and anti-inflammatory properties. However, its effects on rheumatoid arthritis (RA) remain under-researched. In this study, we identified potential targets of HDW and collected differentially expressed genes of RA from the GEO dataset GSE77298, leading to the construction of a drug-component-target-disease regulatory network. The intersecting genes underwent GO and KEGG analysis. A PPI protein interaction network was established in the STRING database...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490288/effects-of-viscum-coloratum-kom-nakai-on-collagen-induced-rheumatoid-arthritis
#20
JOURNAL ARTICLE
Yanfu Wang, Zhichao Hao, Dongxu Lu, Anam Naseem, Ye Sun, Yan Sun, Jianzhe Li, Haixue Kuang, Yan Liu, Bingyou Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Viscum coloratum (Kom.) Nakai has been traditionally used in China for nearly a thousand years to treat rheumatic diseases. However, its efficacy and mechanisms in treating rheumatoid arthritis (RA) have not been demonstrated. AIM OF THE STUDY: To investigate the anti-arthritic effects and molecular mechanisms of Viscum coloratum (Kom.) Nakai on collagen-induced arthritic mice through network pharmacology technology and experimental validation...
March 13, 2024: Journal of Ethnopharmacology
keyword
keyword
16731
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.