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Bisoprolol OR Nebivolol

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https://www.readbyqxmd.com/read/30540686/population-pharmacokinetic-analysis-of-bisoprolol-in-patients-with-acute-coronary-syndrome
#1
Stefan Momčilović, Jasmina R Milovanović, Slobodan M Janković, Andriana Jovanović, Suzana Tasić-Otašević, Dragana Stanojević, Miroslav Krstić, Sonja Šalinger-Martinović, Danijela Djordjević Radojković, Miodrag Damjanović, Milan Živković, Bojan Maričić, Goran Ranković, Aleksandar Mihajlović, Valentina N Nikolić
To date, many questions about the extent and cause of pharmacokinetic variability of even the most widely studied and prescribed β1-adrenergic receptor blockers, such as metoprolol and bisoprolol, remain unanswered. Given that there are still no published population pharmacokinetic (PopPK) analyses of bisoprolol in routinely treated patients with acute coronary syndrome (ACS), the aim of this study was to determine its PK variability in 71 Serbian patients with ACS. PopPK analysis was carried out using a non-linear mixed effects model (NONMEM), version 7...
December 10, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/30459608/comparison-of-long-term-clinical-implications-of-beta-blockade-in-patients-with-obstructive-airway-diseases-exposed-to-beta-blockers-with-different-%C3%AE-1-adrenoreceptor-selectivity-an-italian-population-based-cohort-study
#2
Maurizio Sessa, Annamaria Mascolo, Cristina Scavone, Ilaria Perone, Annalisa Di Giorgio, Michele Tari, Annamaria Fucile, Antonella De Angelis, Daniel Bech Rasmussen, Magnus Thorsten Jensen, Kristian Kragholm, Francesco Rossi, Annalisa Capuano, Liberata Sportiello
Rationale: Long-term clinical implications of beta-blockade in obstructive airway diseases remains controversial. We investigated if within the first 5 years of treatment patients with heart failure and obstructive airway diseases using non β1-adrenoreceptor selective beta-blockers have an increased risk of being hospitalized for all-causes, heart failure, and chronic obstructive pulmonary disease (COPD) when compared to patient using selective beta-blockers. Methods: Carvedilol users were propensity matched 1:1 for co-treatments, age, gender, and year of inclusion in the cohort with metoprolol/bisoprolol/nebivolol users...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30449195/clinical-pharmacokinetics-of-drugs-in-cardiopulmonary-associated-cachexia-without-hepatorenal-pathology-a-systematic-review
#3
Safeer Khan, Anum Shahzadi
Cachexia not only has a dramatically harmful impact on a patient's life, but also a poor response to therapeutic agents. The purpose of the present review is to provide updated information concerning the pharmacokinetic aspects of drugs used to treat cardiopulmonary cachexia in patients with no signs of hepatic or renal pathology. A systematic search of PubMed, the Cochrane Central Register of Control Trials, Science Direct, and Clinical Trials Registry (ClinicalTrials.gov), encompassing the period between 2000 and 2017, was conducted in accordance to PRISMA guidelines...
November 18, 2018: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/30449127/nebivolol-valsartan-a-novel-antihypertensive-fixed-dose-combination-tablet
#4
Dawn Battise, Cassie L Boland, Donald S Nuzum
DATA SOURCES: A PubMed (1966 to October 2018) search was conducted using the following keywords: nebivolol, valsartan, and hypertension (HTN). Additional sources were identified by references. STUDY SELECTION AND DATA EXTRACTION: Articles written in English were included if they evaluated the pharmacology, pharmacokinetics, efficacy, safety, or place in therapy of nebivolol/valsartan in human subjects. DATA SYNTHESIS: Most patients with HTN require combination therapy; however, β-adrenergic antagonists and AII type 1 receptor blockers have been considered less effective because of overlapping mechanisms of action...
November 18, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/30426333/a-critical-review-of-nebivolol-and-its-fixed-dose-combinations-in-the-treatment-of-hypertension
#5
REVIEW
Arrigo F G Cicero, Masanari Kuwabara, Claudio Borghi
β-Adrenergic receptor blockers (β-blockers) are well-known useful and cost-effective drugs for managing hypertensive patients with coronary heart disease, stroke, and heart failure. However, it is often difficult to use β-blockers for patients with asthma or chronic obstructive pulmonary disease (COPD). Moreover, most β-blockers negatively influence glucose or lipid metabolism. Nebivolol is a third-generation lipophilic β-1 receptor-selective blocker with nitric oxide-mediated vasodilatory effects, metabolically neutral and usually well tolerated by patients with asthma or COPD...
November 13, 2018: Drugs
https://www.readbyqxmd.com/read/30408572/long-term-effectiveness-of-bisoprolol-in-patients-with-angina-a-real-world-evidence-study
#6
M Sabidó, Hohenberger Thilo, Grassi Guido
A cohort analysis using UK Clinical Practice Research Datalink (CPRD) was performed to compare the effects of bisoprolol, other β-blockers, and drugs other than β-blockers on the long-term risk of mortality and cardiovascular events in patients with angina. Adult patients first diagnosed with angina from 2000 to 2014, with ≥365 days of registration to first angina diagnosis and initiating monotherapies of bisoprolol, other β-blockers, or drugs other than β-blockers within 6 months of angina diagnosis were included...
November 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30390203/effect-of-amlodipine-valsartan-versus-nebivolol-valsartan-fixed-dose-combinations-on-peripheral-and-central-blood-pressure
#7
Selvia M Farag, Hoda M Rabea, Hesham B Mahmoud
INTRODUCTION: Although hypertensive drugs may have the same effect on peripheral blood pressure, they vary in their effect on central blood pressure and its indices. AIM: To evaluate efficacy of fixed-dose combination of amlodipine 10 mg/valsartan 160 mg versus nebivolol 5 mg/valsartan 160 mg in grade 2 or more hypertensive patients assessed by peripheral and central blood pressure. METHODS: A prospective, open label, randomized study done in the outpatient cardiology clinic at Beni-Suef University Hospital...
November 3, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/30372698/primary-cardioprotection-reduces-mortality-in-lymphoma-patients-with-increased-risk-of-anthracycline-cardiotoxicity-treated-by-r-chop-regimen
#8
Monika Długosz-Danecka, Alicja M Gruszka, Sebastian Szmit, Agnieszka Olszanecka, Tomasz Ogórka, Marcin Sobociński, Andrzej Jaroszyński, Katarzyna Krawczyk, Aleksander B Skotnicki, Wojciech Jurczak
BACKGROUND: Advances in anti-lymphoma therapy prolong overall survival, making late adverse effects, like doxorubicin-related cardiotoxicity, an even more important clinical issue. The effectiveness of cardioprotective strategies with close monitoring, angiotensin-converting enzyme inhibitors and/or β-blockers as well as liposomal doxorubicin are still unconfirmed in clinical practice. METHODS: This study evaluated the role of a primary cardioprotection strategy in preventing cardiovascular mortality and heart failure occurrence in non-Hodgkin lymphoma (NHL) patients with a high risk of anthracycline cardiotoxicity...
2018: Chemotherapy
https://www.readbyqxmd.com/read/30370856/comparison-of-the-effects-of-metoprolol-and-bisoprolol-on-lipid-and-glucose-profiles-in-cardiovascular-patients
#9
Ahmad Abdulrahman Almeman, Yasir Ahmed Beshir, Ahmad Hamad Aldosary
BACKGROUND: It is crucial to understand the pharmacological differences between the effects of beta blockers on the lipid and glucose profile. Moreover, the management of lipid and glucose profile is essential in cardiovascular patients. OBJECTIVE: We sought to compare two beta blockers, metoprolol and bisoprolol, as the most commonly used drugs in cardiology in terms of their effects on glucose and lipid profiles in patients with cardiovascular diseases. METHODS: We conducted a retrospective cross-sectional matched study at Prince Sultan Cardiac Center in Burydah in May 2018...
October 28, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/30365028/a-fatal-case-involving-n-ethyldeschloroketamine-2-oxo-pce-and-venlafaxine
#10
Nadine Theofel, Philipp Möller, Elke Vejmelka, Kerstin Kastner, Sonja Roscher, Stefan Scholtis, Michael Tsokos
Methoxetamine, 3-methoxyphencyclidine or 3-methoxyeticyclidine are arylcyclohexylamines which have been abused in the past. However, the market for new psychoactive substances, in particular for research chemicals, is rapidly growing and new compounds are being regularly explored by users. Abuse can lead to clinical case and in the worst-case scenario to fatalities. We present the fatal case of a 52-year-old man, who was found dead in the bedroom by his fiancé. He had abused N-ethyldeschloroketamine and venlafaxine prior to his death...
October 26, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/30339796/low-utilization-of-beta-blockers-among-medicare-beneficiaries-hospitalized-for-heart-failure-with-reduced-ejection-fraction
#11
Matthew Shane Loop, Melissa K van Dyke, Ligong Chen, Monika M Safford, Meredith L Kilgore, Todd M Brown, Raegan W Durant, Emily B Levitan
BACKGROUND: The evidence-based beta-blockers carvedilol, bisoprolol, and metoprolol succinate reduce mortality and hospitalizations among patients with heart failure with reduced ejection fraction (HFrEF). Use of these medications is not well described in the general population of patients with HFrEF, especially among patients with potential contraindications. OBJECTIVES: Our goal was to describe the patterns of prescription fills for carvedilol, bisoprolol, and metoprolol succinate among Medicare beneficiaries hospitalized for HFrEF, as well as to estimate the associations between specific contraindications for beta-blocker therapy and those patterns...
October 16, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30333393/bisoprolol-successfully-improved-the-intraventricular-pressure-gradient-in-a-patient-with-midventricular-obstructive-hypertrophic-cardiomyopathy-with-an-apex-aneurysm-due-to-apical-myocardial-damage
#12
Ayano Tezuka, Kenjuro Higo, Yuta Nakamukae, Sanae Nishihara, Masaki Kamikawa, Chihiro Shimofuku, Kazumasa Kawazoe, Mitsuru Ohishi
Midventricular obstructive hypertrophic cardiomyopathy (MVOHCM) is a rare form of hypertrophic cardiomyopathy (HCM). An 80-year-old man was administered bisoprolol and warfarin therapies as treatment for MVOHCM with an apex aneurysm due to myocardial damage and intra-aneurysmal thrombus not complicated by atrial fibrillation. The pressure gradient in the midventricle successfully improved from 53.9 to 21.8 mmHg, and the intra-aneurysmal thrombus disappeared.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30325731/pharmacogenetic-testing-by-polymorphic-markers-g1846a-cyp2d6-4-and-c100t-cyp2d6-10-of-the-cyp2d6-gene-in-coronary-heart-disease-patients-taking-%C3%AE-%C3%AE-blockers-in-the-republic-of-sakha-yakutia
#13
Denis S Fedorinov, Karin B Mirzaev, Violetta R Mustafina, Dmitriy A Sychev, Nadezda R Maximova, Jana V Chertovskikh, Nyurguiana V Popova, Sardana M Tarabukina, Zoya A Rudykh
Background The aim of this study was to determine carrier frequencies of the polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between the administration of higher doses of bisoprolol and metoprolol and the carriage of these polymorphic markers related to the decreased function of the haplotype of CYP2D6 was also studied. Methods The study included 201 CHD patients (aged 66±8.7 years) receiving metoprolol in titrated dose (12...
December 19, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30317846/the-mortality-benefit-of-carvedilol-versus-bisoprolol-in-patients-with-heart-failure-with-reduced-ejection-fraction
#14
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF. Methods: The Korean Acute Heart Failure (KorAHF) registry is a prospective multicenter cohort that includes 5,625 patients who were hospitalized for acute heart failure (AHF). We selected 3,016 patients with HFrEF and divided this study population into two groups: BB at discharge (n = 1,707) or no BB at discharge (n = 1,309)...
October 16, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30306779/resistance-to-thyroid-hormone-accompanied-by-atrial-fibrillation
#15
Haruhiro Sato, Yuichiro Tomita
Resistance to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to TH. We herein describe a case involving a 22-year-old Japanese man with RTH and atrial fibrillation (AF) complaining of palpitation and general fatigue. Electrocardiography results revealed AF. He exhibited elevated TH levels and an inappropriately normal level of thyroidstimulating hormone (TSH). Despite being negative for anti-TSH receptor antibody, thyroid-stimulating antibody and anti-thyroperoxidase antibody, the patient was positive for anti-thyroglobulin (Tg) antibody...
September 25, 2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/30295205/-double-blockade-of-aldosterone-receptors-as-a-method-of-elimination-negative-effects-of-non-steroidal-anti-inflammatory-drugs-in-chronic-heart-failure
#16
S A Chepurnenko, N V Burtseva, G V Shavkuta
The article deals with the dynamics of echocardioscopy indices during 1.5 years in a patient who underwent an acute myocardial infarction (MI). Two months after the MI left ventricular (LV) end-diastolic size and LV volume were 61 mm and 190 ml, respectively; LV ejection fraction (EF) was 42%. At the background of maximal possible doses of ramipril, bisoprolol, and selective antagonist of aldosterone receptors eplerenone, and after revascularization, within eight months LV end-diastolic size decreased down to 57 mm, LV volume - to 158 ml, and LVEF increased up to 51%...
September 2018: Kardiologiia
https://www.readbyqxmd.com/read/30291735/nebivolol-enhances-the-effect-of-alendronate-against-methylprednisolone-induced-osteoporosis-in-rats
#17
El-Sayed M El-Sayed, Abd El-Aziz H Abd El-Aziz, Mohamed M Amine
This study aimed to assess the possible modulatory effect of nebivolol against methylprednisolone-induced osteoporosis in rats. Weekly administration of methylprednisolone (7 mg/kg), for six consecutive weeks caused significant increases in serum calcium, bone malondialdehyde, and hydroxyproline as well as serum alkaline phosphatase, but it significantly decreased serum phosphorous and osteocalcin, bone reduced glutathione, and nitric oxide (NO) as well as bone antioxidant enzymes activities compared with the control group...
October 6, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/30289609/insights-on-%C3%AE-blockers-for-the-treatment-of-hypertension-a-survey-of-health-care-practitioners
#18
Brent Egan, John Flack, Mehul Patel, Sofia Lombera
A quantitative survey was completed by 103 primary care physicians (PCPs) and 59 cardiologists who regularly prescribed β-blockers to assess knowledge and use of this heterogeneous drug class for hypertension. More cardiologists than PCPs chose β-blockers as initial antihypertensive therapy (30% vs 17%, P < 0.01). Metoprolol and carvedilol were the most commonly prescribed β-blockers. Cardiologists rated "impact on energy" and "arterial vasodilation" as more important than PCPs (P < 0...
October 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30268589/molecular-mechanism-of-ion-pair-releasing-from-acrylic-pressure-sensitive-adhesive-containing-carboxyl-group-roles-of-doubly-ionic-hydrogen-bond-in-the-controlled-release-process-of-bisoprolol-ion-pair
#19
Hanqing Zhao, Chao Liu, Degong Yang, Xiaocao Wan, Rui Shang, Peng Quan, Liang Fang
Though ion-pair strategy has been employed as an effective and promising method for controlling transdermal delivery of drugs, investigations into the underlying mechanisms involved in the controlled release process of ion-pairs are still limited. In the present study, a brand-new controlled release system combining acrylic pressure sensitive adhesive containing carboxyl group (carboxylic PSA) with ion-pair strategy was developed, and the molecular mechanism of ion-pair releasing from carboxylic PSA was systemically elucidated...
September 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30259390/cardiovascular-risk-management-and-hepatitis-c-combining-drugs
#20
REVIEW
Elise J Smolders, Peter J G Ter Horst, Sharon Wolters, David M Burger
Direct-acting antivirals (DAAs) are known victims (substrate) and perpetrators (cause) of drug-drug interactions (DDIs). These DAAs are used for the treatment of hepatitis C virus (HCV) infections and are highly effective drugs. Drugs used for cardiovascular risk management are frequently used by HCV-infected patients, whom also are treated with DAAs. Therefore, the aim of this review was to describe DDIs between cardiovascular drugs (CVDs) and DAAs. An extensive literature search was performed containing search terms for the marketed DAAs and CVDs (β-blocking agents, ACE inhibitors, angiotensin II antagonists, renin inhibitors, diuretics, calcium channel blockers, statins/ezetimibe, fibrates, platelet aggregation inhibitors, vitamin K antagonists, heparins, direct Xa inhibitors, nitrates, amiodarone, and digoxin)...
September 27, 2018: Clinical Pharmacokinetics
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