keyword
MENU ▼
Read by QxMD icon Read
search

Bisoprolol OR Nebivolol

keyword
https://www.readbyqxmd.com/read/30333393/bisoprolol-successfully-improved-the-intraventricular-pressure-gradient-in-a-patient-with-midventricular-obstructive-hypertrophic-cardiomyopathy-with-an-apex-aneurysm-due-to-apical-myocardial-damage
#1
Ayano Tezuka, Kenjuro Higo, Yuta Nakamukae, Sanae Nishihara, Masaki Kamikawa, Chihiro Shimofuku, Kazumasa Kawazoe, Mitsuru Ohishi
Midventricular obstructive hypertrophic cardiomyopathy (MVOHCM) is a rare form of hypertrophic cardiomyopathy (HCM). An 80-year-old man was administered bisoprolol and warfarin therapies as treatment for MVOHCM with an apex aneurysm due to myocardial damage and intra-aneurysmal thrombus not complicated by atrial fibrillation. The pressure gradient in the midventricle successfully improved from 53.9 to 21.8 mmHg, and the intra-aneurysmal thrombus disappeared.
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30325731/pharmacogenetic-testing-by-polymorphic-markers-g1846a-cyp2d6-4-and-c100t-cyp2d6-10-of-the-cyp2d6-gene-in-coronary-heart-disease-patients-taking-%C3%AE-%C3%AE-blockers-in-the-republic-of-sakha-yakutia
#2
Denis S Fedorinov, Karin B Mirzaev, Violetta R Mustafina, Dmitriy A Sychev, Nadezda R Maximova, Jana V Chertovskikh, Nyurguiana V Popova, Sardana M Tarabukina, Zoya A Rudykh
Background The aim of this study was to determine carrier frequencies of the polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between the administration of higher doses of bisoprolol and metoprolol and the carriage of these polymorphic markers related to the decreased function of the haplotype of CYP2D6 was also studied. Methods The study included 201 CHD patients (aged 66±8.7 years) receiving metoprolol in titrated dose (12...
October 16, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30317846/the-mortality-benefit-of-carvedilol-versus-bisoprolol-in-patients-with-heart-failure-with-reduced-ejection-fraction
#3
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF. Methods: The Korean Acute Heart Failure (KorAHF) registry is a prospective multicenter cohort that includes 5,625 patients who were hospitalized for acute heart failure (AHF). We selected 3,016 patients with HFrEF and divided this study population into two groups: BB at discharge (n = 1,707) or no BB at discharge (n = 1,309)...
October 16, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/30306779/resistance-to-thyroid-hormone-accompanied-by-atrial-fibrillation
#4
Haruhiro Sato, Yuichiro Tomita
Resistance to thyroid hormone (RTH), which is primarily caused by mutations in the thyroid hormone (TH) receptor beta (THRB) gene, is dominantly inherited syndrome of variable tissue hyposensitivity to TH. We herein describe a case involving a 22-year-old Japanese man with RTH and atrial fibrillation (AF) complaining of palpitation and general fatigue. Electrocardiography results revealed AF. He exhibited elevated TH levels and an inappropriately normal level of thyroidstimulating hormone (TSH). Despite being negative for anti-TSH receptor antibody, thyroid-stimulating antibody and anti-thyroperoxidase antibody, the patient was positive for anti-thyroglobulin (Tg) antibody...
September 25, 2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/30295205/-double-blockade-of-aldosterone-receptors-as-a-method-of-elimination-negative-effects-of-non-steroidal-anti-inflammatory-drugs-in-chronic-heart-failure
#5
S A Chepurnenko, N V Burtseva, G V Shavkuta
The article deals with the dynamics of echocardioscopy indices during 1.5 years in a patient who underwent an acute myocardial infarction (MI). Two months after the MI left ventricular (LV) end-diastolic size and LV volume were 61 mm and 190 ml, respectively; LV ejection fraction (EF) was 42%. At the background of maximal possible doses of ramipril, bisoprolol, and selective antagonist of aldosterone receptors eplerenone, and after revascularization, within eight months LV end-diastolic size decreased down to 57 mm, LV volume - to 158 ml, and LVEF increased up to 51%...
September 2018: Kardiologiia
https://www.readbyqxmd.com/read/30291735/nebivolol-enhances-the-effect-of-alendronate-against-methylprednisolone-induced-osteoporosis-in-rats
#6
El-Sayed M El-Sayed, Abd El-Aziz H Abd El-Aziz, Mohamed M Amine
This study aimed to assess the possible modulatory effect of nebivolol against methylprednisolone-induced osteoporosis in rats. Weekly administration of methylprednisolone (7 mg/kg), for six consecutive weeks caused significant increases in serum calcium, bone malondialdehyde, and hydroxyproline as well as serum alkaline phosphatase, but it significantly decreased serum phosphorous and osteocalcin, bone reduced glutathione, and nitric oxide (NO) as well as bone antioxidant enzymes activities compared with the control group...
October 6, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/30289609/insights-on-%C3%AE-blockers-for-the-treatment-of-hypertension-a-survey-of-health-care-practitioners
#7
Brent Egan, John Flack, Mehul Patel, Sofia Lombera
A quantitative survey was completed by 103 primary care physicians (PCPs) and 59 cardiologists who regularly prescribed β-blockers to assess knowledge and use of this heterogeneous drug class for hypertension. More cardiologists than PCPs chose β-blockers as initial antihypertensive therapy (30% vs 17%, P < 0.01). Metoprolol and carvedilol were the most commonly prescribed β-blockers. Cardiologists rated "impact on energy" and "arterial vasodilation" as more important than PCPs (P < 0...
October 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/30268589/molecular-mechanism-of-ion-pair-releasing-from-acrylic-pressure-sensitive-adhesive-containing-carboxyl-group-roles-of-doubly-ionic-hydrogen-bond-in-the-controlled-release-process-of-bisoprolol-ion-pair
#8
Hanqing Zhao, Chao Liu, Degong Yang, Xiaocao Wan, Rui Shang, Peng Quan, Liang Fang
Though ion-pair strategy has been employed as an effective and promising method for controlling transdermal delivery of drugs, investigations into the underlying mechanisms involved in the controlled release process of ion-pairs are still limited. In the present study, a brand-new controlled release system combining acrylic pressure sensitive adhesive containing carboxyl group (carboxylic PSA) with ion-pair strategy was developed, and the molecular mechanism of ion-pair releasing from carboxylic PSA was systemically elucidated...
September 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30259390/cardiovascular-risk-management-and-hepatitis-c-combining-drugs
#9
REVIEW
Elise J Smolders, Peter J G Ter Horst, Sharon Wolters, David M Burger
Direct-acting antivirals (DAAs) are known victims (substrate) and perpetrators (cause) of drug-drug interactions (DDIs). These DAAs are used for the treatment of hepatitis C virus (HCV) infections and are highly effective drugs. Drugs used for cardiovascular risk management are frequently used by HCV-infected patients, whom also are treated with DAAs. Therefore, the aim of this review was to describe DDIs between cardiovascular drugs (CVDs) and DAAs. An extensive literature search was performed containing search terms for the marketed DAAs and CVDs (β-blocking agents, ACE inhibitors, angiotensin II antagonists, renin inhibitors, diuretics, calcium channel blockers, statins/ezetimibe, fibrates, platelet aggregation inhibitors, vitamin K antagonists, heparins, direct Xa inhibitors, nitrates, amiodarone, and digoxin)...
September 27, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/30256522/gentisic-acid-attenuates-pressure-overload-induced-cardiac-hypertrophy-and-fibrosis-in-mice-through-inhibition-of-the-erk1-2-pathway
#10
Simei Sun, Hae Jin Kee, Li Jin, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Myung Ho Jeong
We previously reported that gentisic acid (2,5-dihydroxybenzoic acid) is the third most abundant phenolic component of Dendropanax morbifera branch extracts. Here, we investigated its effects on cardiac hypertrophy and fibrosis in a mouse model of pressure overload and compared them to those of the beta blocker bisoprolol and calcium channel blocker diltiazem. Cardiac hypertrophy was induced in mice by transverse aortic constriction (TAC). Beginning 2 weeks after this procedure, the mice were given daily intraperitoneal injections of gentisic acid (100 mg/kg/d), bisoprolol (5 mg/kg/d) or diltiazem (10 mg/kg/d) for 3 weeks...
September 6, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30232699/bioequivalence-and-pharmacokinetics-of-bisoprolol-amlodipine-5-mg-5-mg-combination-tablet-versus-bisoprolol-5-mg-tablet-and-amlodipine-5-mg-tablet-an-open-label-randomized-two-sequence-crossover-study-in-healthy-chinese-subjects
#11
Chaoying Hu, Xiao Hu, Chunhua Wang, Zirun Zhao, Dan Gao, Xiaoping Chen, Dongli Zhou, Yue Huang, Lin Li, Lan Zhang
BACKGROUND: The pharmacokinetics of bisoprolol and amlodipine administered as a fixed-dose combination (FDC) tablet have not been sufficiently studied in healthy Chinese subjects to support a medical need for using the FDC in hypertension. OBJECTIVE: This study was conducted to compare the pharmacokinetic profiles of the bisoprolol-amlodipine FDC tablet with the bisoprolol tablet and amlodipine tablet administered concomitantly under both fasting and fed conditions...
September 19, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/30191469/risk-of-hospitalization-for-cardiovascular-events-with-%C3%AE-blockers-in-hypertensive-patients-a-retrospective-cohort-study
#12
Jan Basile, Brent Egan, Henry Punzi, Sanjida Ali, Qian Li, Mehul Patel, Joel Neutel
INTRODUCTION: β-Blockers are a heterogenous class of drugs that are no longer recommended for initial antihypertension monotherapy due to unfavorable long-term cardiovascular events observed with non-vasodilatory β-blockers. However, the comparative cardiovascular event risk between the vasodilatory β1 -selective antagonist/β3 agonist nebivolol and non-vasodilatory β1 -blockers, atenolol and metoprolol, is unknown. METHODS: Incident nebivolol, atenolol, or metoprolol monotherapy users with hypertension were identified using US claims data (2007-2014)...
September 6, 2018: Cardiology and Therapy
https://www.readbyqxmd.com/read/30188870/metoprolol-and-nebivolol-prevent-the-decline-of-the-redox-status-of-low-molecular-weight-aminothiols-in-blood-plasma-of-rats-during-acute-cerebral-ischemia
#13
Alexander Vladimirovich Ivanov, Valery Vasil'evich Alexandrin, Alexander Alexandrovich Paltsyn, Edward Danielevich Virus, Ksenya Alexandrovna Nikiforova, Polina Olegovna Bulgakova, Nadezhda Borisovna Sviridkina, Svetlana Alexandrovna Apollonova, Aslan Amirkhanovich Kubatiev
Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) and nebivolol (Neb) on the redox status of these aminothiols during acute cerebral ischemia in rats. We used a model of global cerebral ischemia (bilateral occlusion of common carotid arteries with hypotension lasting for 10 minutes)...
October 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/30188599/hiding-in-plain-sight-nebivolol-exhibits-compelling-tocolytic-properties
#14
Scott D Barnett, Iain L O Buxton
Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA-approved treatment can prevent labour or help a foetus remain in the womb until term. Examination of nitric oxide mediated relaxation signaling in the uterine smooth muscle reveals a role for protein S-nitrosation. The recent discovery of upregulated S-nitrosoglutathione reductase (GSNOR) in spontaneously preterm labouring women has emphasized the need to explore the function of S-nitrosation regulation in the maintenance of uterine quiescence...
September 6, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/30172948/%C3%AE-2-adrenergic-receptor-signaling-mediates-the-preferential-mobilization-of-differentiated-subsets-of-cd8-t-cells-nk-cells-and-non-classical-monocytes-in-response-to-acute-exercise-in-humans
#15
Rachel M Graff, Hawley E Kunz, Nadia H Agha, Forrest L Baker, Mitzi Laughlin, Austin B Bigley, Melissa M Markofski, Emily C LaVoy, Emmanuel Katsanis, Richard A Bond, Catherine M Bollard, Richard J Simpson
Acute exercise preferentially mobilizes cytotoxic T-cells, NK-cells and non-classical monocytes to the bloodstream under the influence of hemodynamic forces and/or β2 -adrenergic receptor (β2 -AR) signaling. However, the relative contribution of these mechanisms to the redeployment of the most exercise-responsive cell types is largely unknown. We determined the lymphocyte and monocyte subtypes mobilized to blood during exercise via β2- AR signaling whilst controlling for β1- AR mediated reductions in hemodynamic forces...
August 30, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/30153111/sympathetic-%C3%AE-1-adrenergic-signaling-contributes-to-regulation-of-human-bone-metabolism
#16
Sundeep Khosla, Matthew T Drake, Tammie L Volkman, Brianne S Thicke, Sara J Achenbach, Elizabeth J Atkinson, Michael J Joyner, Clifford J Rosen, David G Monroe, Joshua N Farr
BACKGROUND: Evidence from rodent studies indicates that the sympathetic nervous system (SNS) regulates bone metabolism, principally via β2-adrenergic receptors (β2-ARs). Given the conflicting human data, we used multiple approaches to evaluate the role of the SNS in regulating human bone metabolism. METHODS: Bone biopsies were obtained from 19 young and 19 elderly women for assessment of ADRB1, ADRB2, and ADRB3 mRNA expression. We examined the relationship of β-blocker use to bone microarchitecture by high-resolution peripheral quantitative CT in a population sample of 248 subjects...
August 28, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30107749/access-to-medicines-for-hypertension-a-survey-in-rural-yogyakarta-province-indonesia
#17
Riana Rahmawati, Beata V Bajorek
INTRODUCTION: Obtaining an adequate supply of medicines is an important step in facilitating medication adherence. This study aimed to determine (1) how people with hypertension in rural villages in Indonesia obtain their supply of anti-hypertensive medications, (2) the type of hypertension medication taken and (3) factors associated with where and how people obtain their medicines supplies. METHOD: Data pertaining to people with hypertension (age &ge;45 years) were collected from eight rural villages in the Bantul district, Yogyakarta province, Indonesia, using a researcher-administered questionnaire...
August 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/30099298/nephroprotective-effects-of-nebivolol-in-2k1c-rats-through-regulation-of-the-kidney-ros-adma-no-pathway
#18
Yan Wang, Mengzhen Niu, Sha Yin, Fei Zhang, Ruizan Shi
BACKGROUND: To evaluate the protective effect of nebivolol against kidney damage and elucidate the underlying mechanism in a two-kidney, one-clip (2K1C) rat model. METHODS: 2K1C rats were obtained by clipping left renal artery of male Wistar rats and were considered hypertensive when systolic blood pressure (SBP) was ≥160mmHg 4 weeks after surgery. The 2K1C hypertensive rats were divided into untreated, nebivolol (10mg/kg, ig), and atenolol (80mg/kg, ig) treatment groups...
October 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/30081801/-new-possibilities-of-using-moxonidin-for-blood-pressure-control-in-female-patients-with-osteopenia
#19
E N Dudinskaya, O N Tkachyeva, E V Bazaeva, N V Sharashkina, I D Strazhesko, Y V Kotovskaya, V N Larina
OBJECTIVE: To assess the effect of moxonidine on bone metabolism and bone mineral density (BMD) in postmenopausal patients with arterial hypertension (AH) and osteopenia. MATERIALS AND METHODS: A randomized, open, clinical trial included 114 postmenopausal patients with AH. All participants were evaluated bone metabolism), BMD, telomerase activity (TA). Randomization was carried out into 2 groups (moxonidine and bisoprolol therapy) using simple envelopes. After 12 months of therapy, a dynamic examination was performed...
2018: Kardiologiia
https://www.readbyqxmd.com/read/30076815/role-of-high-dose-beta-blockers-in-patients-with-heart-failure-with-preserved-ejection-fraction-and-elevated-heart-rate
#20
Phillip H Lam, Neha Gupta, Daniel J Dooley, Steven Singh, Prakash Deedwania, Michael R Zile, Deepak L Bhatt, Charity J Morgan, Bertram Pitt, Gregg C Fonarow, Ali Ahmed
BACKGROUND: Beta-blockers in high target doses are recommended for heart failure with reduced ejection fraction (HFrEF) but not for preserved ejection fraction (HFpEF). Treatment benefits are often more pronounced in high-risk subgroups, and patients with HFpEF with heart rate ≥70 beats per minute have emerged as such a high-risk subgroup. We examined the associations of high-dose beta-blocker use with outcomes in these patients. METHODS: Of the 8462 hospitalized patients with heart failure with ejection fraction ≥50% in the Medicare-linked Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) registry, 5422 had a discharge heart rate ≥70 beats per minute...
August 1, 2018: American Journal of Medicine
keyword
keyword
167308
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"