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Skin cancer. Melanoma

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https://www.readbyqxmd.com/read/30539505/immunotherapy-for-melanoma
#1
Isabella C Glitza Oliva, Rana Alqusairi
While melanoma is less common than some other skin cancers, it is responsible for nearly 10,000 deaths in the USA each year alone. For many decades, very limited treatment options were available for patients with metastatic melanoma. However, recent breakthroughs have brought new hopes for patients and providers.While targeted therapy with BRAF and MEK inhibitors represents an important cornerstone in the treatment of metastatic melanoma, this chapter carefully reviews the past and current therapy options available, with a significant focus on immunotherapy-based approaches...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30539467/monoclonal-antibodies-for-the-treatment-of-melanoma-present-and-future-strategies
#2
Madhuri Bhandaru, Anand Rotte
Metastatic melanoma is a dreadful type of skin cancer arising due to uncontrolled proliferation of melanocytes. It has very poor prognosis, low 5-year survival rates and until recently there were only handful of treatment options for metastatic melanoma patients. The drugs that were approved for the treatment had low response rates and were associated with severe adverse events. With the introduction of monoclonal antibodies against inhibitory immune checkpoints the treatment landscape for metastatic melanoma has changed dramatically...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30539405/optical-coherence-tomography-imaging-of-melanoma-skin-cancer
#3
Ali Rajabi-Estarabadi, Julie M Bittar, Caiwei Zheng, Vanessa Nascimento, Isabella Camacho, Lynn G Feun, Mohammadreza Nasiriavanaki, Michael Kunz, Keyvan Nouri
No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies...
December 11, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30538498/quaternized-chitosan-promotes-the-antiproliferative-effect-of-vemurafenib-in-melanoma-cells-by-increasing-cell-permeability
#4
Min Li, Ying Yang
Background: As one of the most invasive cutaneous carcinomas among all types of skin cancer, malignant melanoma remains a severe challenge in oncology and plastic surgery. Selective small-molecule inhibitors of V600E-mutant B-Raf (vemurafenib, for instance) have demonstrated satisfactory therapeutic efficacy in melanoma patients. However, acquired resistance during the period of drug administration has limited their clinical application. Materials and methods: In the present study, human melanoma cells with the B-RafV600E mutation were treated with the indicated concentrations of vemurafenib, quaternized chitosan, or a combination of vemurafenib and quaternized chitosan...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30537068/cutaneous-malignant-melanoma-of-the-oral-cavity-following-skin-graft-reconstruction-case-report
#5
Zachary Mayo, Steven Seyedin, Michael Marquardt, Imran Mohiuddin, Mohammed Milhem, Vincent Liu, Nitin Pagedar, Carryn Anderson
BACKGROUND: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature. METHODS: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue. RESULTS: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Five years later the patient was seen with a 1-cm nodule and surrounding erythroplakia at the recipient site of the graft...
December 7, 2018: Head & Neck
https://www.readbyqxmd.com/read/30535094/abatacept-initiation-in-rheumatoid-arthritis-and-the-risk-of-cancer-a-population-based-comparative-cohort-study
#6
François Montastruc, Christel Renoux, Sophie Dell'Aniello, Teresa A Simon, Laurent Azoulay, Marie Hudson, Samy Suissa
Objective: To assess whether abatacept as initial biological DMARD (bDMARD) in the treatment of RA, when compared with other bDMARDs, is associated with an increased risk of cancer overall and by specific cancer sites (breast, lung, lymphoma, melanoma and non-melanoma skin cancer). Methods: We performed a population-based cohort study among patients newly treated with bDMARDs within the US-based Truven MarketScan population and Supplemental US Medicare from 2007 to 2014...
December 7, 2018: Rheumatology
https://www.readbyqxmd.com/read/30527711/skin-shop-a-new-model-for-high-volume-skin-cancer-care
#7
M Taib, B M Adams
INTRODUCTION: Non-melanoma skin cancer incidence is increasing in New Zealand. Increased cost of care has led to service pressure and a review of models of care. A high-volume skin surgery service at Waikato Hospital has been developed to reduce service costs. This study examines the oncological safety of the new model. METHODS: Prospective data for all skin lesions excised were collected from December 2014 to December 2016. Primary outcomes were rate of complete excision, rate of incomplete excision and rate of narrow excision...
November 15, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30527378/nation-wide-survey-of-advanced-non-melanoma-skin-cancers-treated-at-dermatology-departments-in-japan
#8
Yasuhiro Fujisawa, Takeru Funakoshi, Yoshiyuki Nakamura, Maki Ishii, Jun Asai, Takatoshi Shimauchi, Kazuyasu Fujii, Manabu Fujimoto, Norito Katoh, Hironobu Ihn
BACKGROUND: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan. OBJECTIVE: To investigate the actual number of advanced NMSC patients in Japan. METHODS: A questionnaire survey was sent to 668 institutes to educe information on: 1) the numbers of patients with squamous cell carcinoma (SCC), extramammary Paget disease (EMPD), other skin origin carcinomas, and cutaneous angiosarcoma (CAS) admitted in 2016 and 2017; 2) the preferred first- and second-line chemotherapies; and 3) the anticipated for future development...
November 3, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/30526186/factorial-design-based-curcumin-ethosomal-nanocarriers-for-the-skin-cancer-delivery-in-vitro-evaluation
#9
Malleswara Rao Peram, Sunil S Jalalpure, Vijay M Kumbar, Sachin R Patil, Sumit A Joshi, Kishore G Bhat, Prakash V Diwan
Melanoma is the most deadly and life-threatening form of skin cancer with progressively higher rates of incidence worldwide. The objective of the present investigation is to develop and to statistically optimize and characterize curcumin (CUR) loaded ethosomes for treatment of melanoma. A two factor, three level (32 ) factorial design approach was employed for the optimization of ethosomes. The prepared ethosomes were evaluated for size, zeta potential, entrapment efficiency, in vitro skin permeation and deposition ability...
December 10, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/30523912/dosimetry-of-indigenously-developed-177lu-patch-source-for-surface-brachytherapy-experimental-and-monte-carlo-methods
#10
Sridhar Sahoo, Vandana Srivastava, T Palani Selvam, A K Bakshi, Rajesh Kumar, Rama Prajith, D Datta, Chinnaesakki S, S K Saxena, Yogendra Kumar, A Dash
This paper describes the evaluation of dosimetry characteristics of an in-house developed 177Lu skin patch source for treatment of non-melanoma skin cancer. A 177Lu skin patch source based on Nafion-115 membrane backbone containing 3.46 ± 0.01 mCi of activity was used. Activity measurement of the patch source was based on gamma ray spectrometry using a HPGe detector. The efficiencies of the HPGe detector were fitted using an orthogonal polynomial function. The absorbed dose rate to water at 5 µm depth in water was determined using an extrapolation chamber, EBT3 Gafchromic film and compared with Monte Carlo methods...
November 6, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/30522515/the-risks-of-cancer-development-in-systemic-lupus-erythematosus-sle-patients-a-systematic-review-and-meta-analysis
#11
Lebin Song, Yi Wang, Jiayi Zhang, Ninghong Song, Xiaoyun Xu, Yan Lu
BACKGROUND: Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types. METHODS: Online databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Pooled standardized incidence rates (SIRs) with 95% confidence intervals (CIs) were utilized to reveal their associations...
December 6, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30521691/computer-assisted-diagnosis-techniques-dermoscopy-and-spectroscopy-based-for-diagnosing-skin-cancer-in-adults
#12
REVIEW
Lavinia Ferrante di Ruffano, Yemisi Takwoingi, Jacqueline Dinnes, Naomi Chuchu, Susan E Bayliss, Clare Davenport, Rubeta N Matin, Kathie Godfrey, Colette O'Sullivan, Abha Gulati, Sue Ann Chan, Alana Durack, Susan O'Connell, Matthew D Gardiner, Jeffrey Bamber, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521690/optical-coherence-tomography-for-diagnosing-skin-cancer-in-adults
#13
REVIEW
Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Jonathan J Deeks, Naomi Chuchu, Susan E Bayliss, Clare Davenport, Yemisi Takwoingi, Kathie Godfrey, Colette O'Sullivan, Rubeta N Matin, Hamid Tehrani, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521689/exfoliative-cytology-for-diagnosing-basal-cell-carcinoma-and-other-skin-cancers-in-adults
#14
REVIEW
Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Naomi Chuchu, Susan E Bayliss, Yemisi Takwoingi, Clare Davenport, Rubeta N Matin, Colette O'Sullivan, Derek Roskell, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management, reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin but has potential to infiltrate and damage surrounding tissue, while cutaneous squamous cell carcinoma (cSCC) and melanoma have a much higher potential to metastasise and ultimately lead to death. Exfoliative cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521688/visual-inspection-and-dermoscopy-alone-or-in-combination-for-diagnosing-keratinocyte-skin-cancers-in-adults
#15
REVIEW
Jacqueline Dinnes, Jonathan J Deeks, Naomi Chuchu, Rubeta N Matin, Kai Yuen Wong, Roger Benjamin Aldridge, Alana Durack, Abha Gulati, Sue Ann Chan, Louise Johnston, Susan E Bayliss, Jo Leonardi-Bee, Yemisi Takwoingi, Clare Davenport, Colette O'Sullivan, Hamid Tehrani, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521687/reflectance-confocal-microscopy-for-diagnosing-keratinocyte-skin-cancers-in-adults
#16
REVIEW
Jacqueline Dinnes, Jonathan J Deeks, Naomi Chuchu, Daniel Saleh, Susan E Bayliss, Yemisi Takwoingi, Clare Davenport, Lopa Patel, Rubeta N Matin, Colette O'Sullivan, Rakesh Patalay, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is important to guide appropriate management and improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damage surrounding tissue, whereas cutaneous squamous cell carcinoma (cSCC) and melanoma are higher risk skin cancers with the potential to metastasise and ultimately lead to death. When used in conjunction with clinical or dermoscopic suspicion of malignancy, or both, reflectance confocal microscopy (RCM) may help to identify cancers eligible for non-surgical treatment without the need for a diagnostic biopsy, particularly in people with suspected BCC...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521686/teledermatology-for-diagnosing-skin-cancer-in-adults
#17
REVIEW
Naomi Chuchu, Jacqueline Dinnes, Yemisi Takwoingi, Rubeta N Matin, Susan E Bayliss, Clare Davenport, Jacqueline F Moreau, Oliver Bassett, Kathie Godfrey, Colette O'Sullivan, Fiona M Walter, Richard Motley, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521685/smartphone-applications-for-triaging-adults-with-skin-lesions-that-are-suspicious-for-melanoma
#18
REVIEW
Naomi Chuchu, Yemisi Takwoingi, Jacqueline Dinnes, Rubeta N Matin, Oliver Bassett, Jacqueline F Moreau, Susan E Bayliss, Clare Davenport, Kathie Godfrey, Susan O'Connell, Abhilash Jain, Fiona M Walter, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for most skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and potentially offer an instant risk assessment of the likelihood of malignancy so that the right people seek further medical attention from a clinician for more detailed assessment of the lesion. There is, however, a risk that melanomas will be missed and treatment delayed if the application reassures the user that their lesion is low risk...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521684/visual-inspection-for-diagnosing-cutaneous-melanoma-in-adults
#19
REVIEW
Jacqueline Dinnes, Jonathan J Deeks, Matthew J Grainge, Naomi Chuchu, Lavinia Ferrante di Ruffano, Rubeta N Matin, David R Thomson, Kai Yuen Wong, Roger Benjamin Aldridge, Rachel Abbott, Monica Fawzy, Susan E Bayliss, Yemisi Takwoingi, Clare Davenport, Kathie Godfrey, Fiona M Walter, Hywel C Williams
BACKGROUND: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious lesion by a clinician is usually the first in a series of 'tests' to diagnose skin cancer. Establishing the accuracy of visual inspection alone is critical to understating the potential contribution of additional tests to assist in the diagnosis of melanoma...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521683/high-frequency-ultrasound-for-diagnosing-skin-cancer-in-adults
#20
REVIEW
Jacqueline Dinnes, Jeffrey Bamber, Naomi Chuchu, Susan E Bayliss, Yemisi Takwoingi, Clare Davenport, Kathie Godfrey, Colette O'Sullivan, Rubeta N Matin, Jonathan J Deeks, Hywel C Williams
BACKGROUND: Early, accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers with the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions...
December 3, 2018: Cochrane Database of Systematic Reviews
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