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Skin cancer. Melanoma

Rubén D Piacentini, Lara Sofía Della Ceca, Adriana Ipiña
Climate change is affecting both the environment and human behaviour. One significant impact is related to health, as detailed in the IPCC 2014 report. In the present work, and as a contribution to this commemorative special issue to Prof. Dr Jan van der Leun, we present the results of the squamous (SCC) and basal-cell carcinoma (BCC) incidence change in relation to the ambient temperature increase. This increase is produced by global warming, mainly induced by anthropogenic atmospheric emissions of greenhouse gases...
October 18, 2018: Photochemical & Photobiological Sciences
Jan Rožanc, Theodore Sakellaropoulos, Asier Antoranz, Cristiano Guttà, Biswajit Podder, Vesna Vetma, Nicole Rufo, Patrizia Agostinis, Vaia Pliaka, Thomas Sauter, Dagmar Kulms, Markus Rehm, Leonidas G Alexopoulos
Malignant melanoma is a highly aggressive form of skin cancer responsible for the majority of skin cancer-related deaths. Recent insight into the heterogeneous nature of melanoma suggests more personalised treatments may be necessary to overcome drug resistance and improve patient care. To this end, reliable molecular signatures that can accurately predict treatment responsiveness need to be identified. In this study, we applied multiplex phosphoproteomic profiling across a panel of 24 melanoma cell lines with different disease-relevant mutations, to predict responsiveness to MEK inhibitor trametinib...
October 15, 2018: Cell Death and Differentiation
Frederick C Morgan, Juanita Duran, Belen Fraile, Pritesh S Karia, Jennifer Y Lin, Patrick A Ott, Emily Stamell Ruiz, David M Wang, Yichen Zhang, Chrysalyne D Schmults
BACKGROUND: Temporal analyses of skin cancer costs are needed to examine how expenditure differences between diagnoses are changing. OBJECTIVE: To tabulate the costs of skin cancer-related care (SCRC), including both screening and treatment, at an academic cancer center at 2 time points. METHODS: Cost data (insurance and patient payments) at an academic cancer center from 2008 and 2013 were queried for International Classification of Diseases, Ninth Revision, codes pertaining to skin cancer...
November 2018: Journal of the American Academy of Dermatology
Adam B Raff, Carina N Thomas, Gary S Chuang, Mathew M Avram, Monica H Le, R Rox Anderson, Martin Purschke
OBJECTIVE: Lidocaine acts as a local anesthetic by blocking transmembrane sodium channel permeability, but also induces the synthesis of heat shock proteins and sensitizes cells to hyperthermia. A previous study reported two cases of deep focal skin ulceration at points corresponding to depot local lidocaine injection sites after treatment with non-ablative fractional resurfacing and it was hypothesized that lidocaine had focally sensitized keratinocytes to the thermal damage of laser treatment...
October 15, 2018: Lasers in Surgery and Medicine
Laura Antonio-Herrera, Oscar Badillo-Godinez, Oscar Medina-Contreras, Araceli Tepale-Segura, Alberto García-Lozano, Lourdes Gutierrez-Xicotencatl, Gloria Soldevila, Fernando R Esquivel-Guadarrama, Juliana Idoyaga, Laura C Bonifaz
CD4+ T cells are major players in the immune response against several diseases; including AIDS, leishmaniasis, tuberculosis, influenza and cancer. Their activation has been successfully achieved by administering antigen coupled with antibodies, against DC-specific receptors in combination with adjuvants. Unfortunately, most of the adjuvants used so far in experimental models are unsuitable for human use. Therefore, human DC-targeted vaccination awaits the description of potent, yet nontoxic adjuvants. The nontoxic cholera B subunit (CTB) can be safely used in humans and it has the potential to activate CD4+ T cell responses...
2018: Frontiers in Immunology
Feudjio Ndemanou Yolande, Bhattacharyya Sayantan, Ghosh Paramita, Sarkar Deblina, Mouokeu Raymond Simplice, Tume B Christopher, Murmu Nabendu
Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer-related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied...
2018: Journal of Environmental Pathology, Toxicology and Oncology
M Ren, Y Y Kong, X X Shen, X Cai, J C Kong
Objective: To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Methods: Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Results: Of total 24 cases, there were 7 cases of LM and 17 cases of LMM; 10 males and 14 females. The age of patients ranged from 32 to 88 years (mean 67 years)...
October 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Emanuele Crocetti, Ignazio Stanganelli, Silvia Mancini, Rosa Vattiato, Orietta Giuliani, Alessandra Ravaioli, Chiara Balducci, Fabio Falcini, Nicola Pimpinelli
BACKGROUND: The 8th edition of TNM has introduced new rules for staging cutaneous melanoma. OBJECTIVE: To compare TNM 7th and 8th editions in defining pathological stages of melanoma. METHODS: A population-based series of 1847 skin melanoma from Romagna cancer registry (Italy) incident during 2003-2012 has been used to measure the agreement (with Cohen's kappa) between TNM 8th and 7th editions in defining melanoma stage. Disease specific survival has been computed for each stage according to TNM 7th and 8th...
October 13, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Melissa M Melough, Ock K Chun
Furocoumarins are a class of compounds produced by several plant species, including some popularly consumed by humans. Furocoumarins are known to be well absorbed from food sources, and can be rapidly distributed into several tissues including the skin. In human skin, when exposed to UV radiation, furocoumarins may become photoactivated and form interstrand crosslinks with DNA, thereby disrupting DNA transcription. Because of this property, furocoumarins have been combined as topical or oral agents with UV irradiation as a phototherapy to treat multiple skin conditions, yet these treatments have been shown to increase risk of both melanoma and non-melanoma skin cancer...
October 11, 2018: Food and Chemical Toxicology
Youngmin Moon, Jung Hyun Han, Jang-Hee Choi, Sungho Shin, Yong-Chul Kim, Sungho Jeong
Surgical excision (Mohs micrographic surgery) is the standard procedure to treat a melanoma, in which an in situ histologic examination of sectioned skin is carried out repeatedly until no cancer cells are detected. The possibility to identify melanoma from the surrounding skin by femtosecond laser-induced breakdown spectroscopy (fs-LIBS) is investigated. For experiments, melanoma induced on a hairless mouse by injection of B16/F10 murine melanoma cell was sampled in the form of frozen tissue sections as in Mohs surgery and analyzed by fs-LIBS (λ  =  1030  nm, τ  =  550  fs)...
October 2018: Journal of Biomedical Optics
Shannon L Nowotarski, Robert P Feehan, Christopher Presloid, Lisa M Shantz
Non-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer in the United States. Ultraviolet-B (UVB) irradiation is the primary carcinogen responsible for stimulating NMSC development. Ornithine Decarboxylase (ODC), the first rate-limiting enzyme in the synthesis of polyamines, is upregulated in response to a variety of proliferation stimuli, including UVB exposure. Our previous studies have demonstrated regulation of ODC synthesis by the mammalian target of rapamycin complex 1 (mTORC1) in cells transformed by oncogenic Ras...
October 9, 2018: Biochemical and Biophysical Research Communications
Eric Romer, Anita Thyagarajan, Smita Krishnamurthy, Christine M Rapp, Langni Liu, Katherine Fahy, Azeezat Awoyemi, Ravi P Sahu
Platelet-activating factor-receptor (PAF-R) agonists are pleiotropic lipid factors that influence multiple biological processes, including the induction and resolution of inflammation as well as immunosuppression. PAF-R agonists have been shown to modulate tumorigenesis and/or tumor growth in various skin cancer models by suppressing either cutaneous inflammation and/or anti-tumoral adaptive immunity. We have previously shown that a chronic systemic PAF-R agonist administration of mice enhances the growth of subcutaneously implanted melanoma tumors...
October 11, 2018: International Journal of Molecular Sciences
Brian Køster, Maria Meyer, Therese Andersson, Gerda Engholm, Peter Dalum
Exposure to ultraviolet radiation is the main risk factor for skin cancer. Denmark has one of the highest incidences of skin cancer in the world. In 2007, a long-term sun safety campaign was launched in Denmark. We have evaluated the effects on prevalence of sunburn and modeled the effects on future melanoma incidence.Sunburn was evaluated by annual cross-sectional surveys representative for the Danish population on age, gender, and region. During 2007-2015, survey data were collected for 33.315 Danes. Cutaneous Melanoma incidences were modeled in the Prevent program, using population projections, historic incidence, sunburn exposure, and relative risk of sunburn on melanoma...
October 2018: Medicine (Baltimore)
Debora Levy, Thatiana Correa de Melo, Bianca Yumi Ohira, Maíra Luísa Fidelis, Jorge L M Ruiz, Alessandro Rodrigues, Sergio P Bydlowski
Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of several oxysterols to induce short-term death in cancerous (human breast cancer and mouse skin melanoma cells) and non-cancerous (human endothelial cells and lung fibroblasts) cell lines. We determined cell viability, Ki67 expression, cell cycle regulation, and apoptosis after 24-h incubations with oxysterols. We found that different oxysterols had different effects on the studied parameters...
October 9, 2018: Biochemical and Biophysical Research Communications
Anna M Mancha-Ramirez, Xiaoyu Yang, Huiyun Liang, Jacob Junco, Kevin P Lee, Sarah F Bovio, Maricruz Espinoza, Julia Wool, Andrew Slaga, Daniel C Glade, Martha Hanes, Gunjan Malik, Dae Joon Kim, John DiGiovanni, Thomas J Slaga
Despite effective surgical methods for non-melanoma skin cancer (NMSC), patients suffer from tissue damage, scarring, or even disfigurement; thus, there is a need for chemopreventive approaches. Because of the complex interplay between glucocorticoids (GCs), inflammation, and cancer, we sought to determine the role of 11β-hydroxysteroid dehydrogenase 1 and 2 (11βHSD1 and 2) in regulating GCs during skin cancer development and progression. 11βHSDs modulate the activation of GCs in a tissue-specific manner and have been reported to play a role in development and progression of other types of cancer, but their role has not yet been reported in NMSC...
October 9, 2018: Molecular Carcinogenesis
Zhiwei Sun, Shixia Zhou, Junling Tang, Ting Ye, Jingyuan Li, Doudou Liu, Jian Zhou, Jianyu Wang, H Rosie Xing
BACKGROUND: Cancer treatment is based on tumor staging. Curative intent is only applied to localized tumors. Recent studies show that oligometastatic patients who have limited number of metastases may benefit from metastasis-directed local treatments to achieve long-term survival. However, mechanisms underlying oligometastatic to polymetastatic progression remains elusive. METHODS: The effects of miR-200c and Sec23a on tumor metastasis were verified both in vitro and in vivo...
October 6, 2018: EBioMedicine
Bettina Huber
No abstract text is available yet for this article.
October 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Natalie H Matthews, Katherine Fitch, Wen-Qing Li, J Steven Morris, David C Christiani, Abrar A Qureshi, Eunyoung Cho
Exposure to environmental trace elements has been studied in relation to many cancers. However, an association between exposure to trace elements and skin cancer remains less understood. Therefore, we conducted a systematic review of published epidemiologic literature examining the association between exposure to trace elements, and risk of melanoma and keratinocyte carcinoma in humans. We identified epidemiologic studies investigating exposure to arsenic, cadmium, chromium, copper, iron, selenium, and zinc and risk of skin cancer in humans...
October 8, 2018: Cancer Epidemiology, Biomarkers & Prevention
Lisa Altieri, Megan Eguchi, David H Peng, Myles Cockburn
BACKGROUND: Mucosal melanomas are rare and aggressive neoplasms, with little published population-based data on predictors of survival. OBJECTIVE: To assess the influences of race/ethnicity, sex, tumor stage, tumor thickness, and anatomic site on mucosal melanoma survival estimates. METHODS: We analyzed 132,751 cases of melanoma, including 1,824 mucosal melanomas, diagnosed between 1994 and 2015 and reported to the California Cancer Registry...
October 5, 2018: Journal of the American Academy of Dermatology
Dong-Ho Kim, Kye-Seong Kim, Suresh Ramakrishna
Malignant melanoma is one of the most fatal and aggressive skin cancers, originating from pigment-containing melanocytes. Despite progress in clinical research, treatment options for malignant melanoma have been limited. The nuclear factor of activated T-cell 5 (NFAT5), originally identified as tonicity regulated transcription factor Ton/EBP, is now known as a carcinogenic gene in several types of cancer pathology. In this study, we knocked down NFAT5 to investigate its role in melanoma cancer. shRNA-mediated knockdown of NFAT5 led to a significant decrease in cell proliferation in vitro...
October 5, 2018: Biochemical and Biophysical Research Communications
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