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https://www.readbyqxmd.com/read/29221447/disruption-of-postnatal-folliculogenesis-and-development-of-ovarian-tumor-in-a-mouse-model-with-aberrant-transforming-growth-factor-beta-signaling
#1
Yang Gao, Xin Fang, David F Vincent, David W Threadgill, Laurent Bartholin, Qinglei Li
BACKGROUND: Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine potential effects of dysregulated TGFB signaling in the ovary using Cre recombinase driven by growth differentiation factor 9 (Gdf9) promoter known to be expressed in oocytes. METHODS: A mouse model containing constitutively active TGFBR1 (TGFBR1CA) using Gdf9-iCre (termed TGFBR1-CAG9Cre) was generated...
December 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29208899/in-vivo-transplantation-of-3d-encapsulated-ovarian-constructs-in-rats-corrects-abnormalities-of-ovarian-failure
#2
Sivanandane Sittadjody, Justin M Saul, John P McQuilling, Sunyoung Joo, Thomas C Register, James J Yoo, Anthony Atala, Emmanuel C Opara
Safe clinical hormone replacement (HR) will likely become increasingly important in the growing populations of aged women and cancer patients undergoing treatments that ablate the ovaries. Cell-based HRT (cHRT) is an alternative approach that may allow certain physiological outcomes to be achieved with lower circulating hormone levels than pharmacological means due to participation of cells in the hypothalamus-pituitary-ovary feedback control loop. Here we describe the in vivo performance of 3D bioengineered ovarian constructs that recapitulate native cell-cell interactions between ovarian granulosa and theca cells as an approach to cHRT...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29207291/transcriptome-analysis-of-ovine-granulosa-cells-reveals-differences-between-small-antral-follicles-collected-during-the-follicular-and-luteal-phases
#3
Reza Talebi, Ahmad Ahmadi, Fazlollah Afraz, Julien Sarry, Florence Plisson-Petit, Carine Genêt, Stéphane Fabre
Ovarian follicular growth occurs in both the follicular and luteal phases of the estrous cycle but in very different endocrine contexts. In both phases, many small antral follicles with similar morphologic and histologic characteristics are present within the ovaries as a reserve for the terminal folliculogenesis. However, there are several gaps in our molecular knowledge of the gene expression profiles of small antral follicles in the follicular and luteal phases. The aim of the present study was to use RNA sequencing to compare and analyze the global transcriptional profile of ovine granulosa cells collected from small antral follicles (1-3 mm) either during the follicular or the luteal phase of the estrous cycle, with the hypothesis that they should be differential...
November 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29207252/role-of-activin-c-in-normal-ovaries-and-granulosa-cell-tumours-of-mice-and-humans
#4
Karen L Reader, Francesco E Marino, Helen D Nicholson, Gail P Risbridger, Elspeth J Gold
Activins and inhibins play important roles in the development, growth and function of the ovary. Mice lacking inhibin develop granulosa cell tumours in their ovaries that secrete activin A, and these tumours are modulated by increased activin C expression. The aim of the present study was to identify where activin C is expressed in mouse and human ovaries and whether overexpression of activin C modulates normal follicular development in mice. Immunohistochemical staining for the activin βC subunit was performed on sections from mouse and human ovaries and human adult granulosa cell tumours...
December 6, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29207017/a-common-african-variant-of-human-connexin%C3%A2-37-is-associated-with-caucasian-primary-ovarian-insufficiency-and-has-a-deleterious-effect-in%C3%A2-vitro
#5
Anne Bachelot, Jerome Gilleron, Geri Meduri, Mihelai Guberto, Jerome Dulon, Sylviane Boucherie, Philippe Touraine, Micheline Misrahi
Folliculogenesis requires communication between granulosa cells and oocytes, mediated by connexin-based gap junctions. Connexin 37 (Cx37)-deficient female mice are infertile. The present study assessed Cx37 deficiency in patients with primary ovarian insufficiency (POI). A candidate gene study was performed in patients and controls from the National Genotyping Center (Evry, France) including 58 Caucasian patients with idiopathic isolated POI and 142 Caucasian controls. Direct genomic sequencing of the coding regions of the GJA4 gene (encoding Cx37) was performed with the aim to identify a deleterious variant associated with POI and absent in ethnically matched controls...
November 16, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#6
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29205955/selection-of-antioxidants-against-ovarian-oxidative-stress-in-mouse-model
#7
Bojiang Li, Qiannan Weng, Zequn Liu, Ming Shen, Jiaqing Zhang, Wangjun Wu, Honglin Liu
Oxidative stress (OS) plays an important role in the process of ovarian granulosa cell apoptosis and follicular atresia. The aim of this study was to select antioxidant against OS in ovary tissue. Firstly, we chose the six antioxidants and analyzed the reactive oxygen species (ROS) level in the ovary tissue. The results showed that proanthocyanidins, gallic acid, curcumin, and carotene decrease the ROS level compared with control group. We further demonstrated that both proanthocyanidins and gallic acid increase the antioxidant enzymes activity...
December 4, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29205453/localization-of-thrombospondin-1-and-its-receptor-cd36-in-the-ovary-of-the-ostrich-struthio-camelus
#8
D Rodler, F Sinowatz
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a decisive role for the rapid growth of avian follicles. Compared to mammals, few data on the angiogenesis in the avian ovary are available. However, whereas several pro-angiogenic factors in the avian ovary have been recently studied in detail, little information is available on the localization of anti-angiogenic factors. The aim of this study was to determine the localization and possible function of the anti-angiogenic factor thrombospondin-1 (TSP-1) and its receptor CD36 in the ovary of the ostrich using immunohistochemistry and to correlate the results with ultrastructural data...
December 4, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29200893/epidemiology-of-ovarian-cancers-in-zaria-northern-nigeria-a-10-year-study
#9
Marliyya Sanusi Zayyan, Saad Aliyu Ahmed, Adekunle O Oguntayo, Abimbola O Kolawole, Tajudeen Ayodeji Olasinde
Background: Globally, the absence of a premalignant stage of ovarian cancer and a reliable screening tool make early diagnosis difficult. Locally, poverty, ignorance, and lack of organized cancer services make prognosis poor. We describe the epidemiological features of ovarian cancer seen at Ahmadu Bello University Teaching Hospital Zaria, Northern Nigeria, a tertiary referral center, over a 10-year period in this challenging setting. Methods: All cases of histologically diagnosed ovarian cancer between January 1, 2004 and December 31, 2013 were included in the study...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29198337/ovarian-sex-cord-stromal-tumours-and-small-cell-tumours-pathological-genetic-and-management-aspects
#10
REVIEW
Stergios Boussios, Michele Moschetta, George Zarkavelis, Alexandra Papadaki, Aristides Kefas, Konstantina Tatsi
Non-epithelial ovarian cancers (NEOC) constitute a group of uncommon malignancies and their treatment is still a challenging task. Collectively, these tumours account for about 10% of all ovarian cancers and occur in all age groups from childhood to old-age. They include malignancies of germ cell origin, sex cord-stromal cell origin, and a variety of extremely rare ovarian cancers, such as small-cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. It is imperative that these rare tumours are managed with accurate diagnosis, staging, and treatment, to optimise the outcome...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198156/mixed-ovarian-tumor-composed-of-brenner-tumor-and-adult-type-granulosa-cell-tumor-a-case-report-of-a-very-rare-mixed-ovarian-tumor-and-a-review-of-the-literature
#11
Judit Tamás, Ildikó Vereczkey, Erika Tóth, Erzsébet Csernák, Katalin Purcsi, Imre Pete
A combination of ovarian tumors with the same histogenetic origin but different histologic subtype is relatively common, whereas a co-occurrence of tumors with different histogenetic origin is rare. We report a case of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor, a combination that to the best of our knowledge has not been reported in the literature until now.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29196492/high-fat-diet-exposure-from-pre-pubertal-age-induces-pcos-in-rats
#12
Roshni S Patel, Gaurang B Shah
Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, oligo-anovulation, polycystic ovaries and metabolic syndrome. Many researchers reported that PCOS often starts with menarche in adolescents. Presently available animal models focuses on ovarian but not metabolic features of PCOS. Therefore, we hypothesized that high fat diet feeding to pre-pubertal female rats results in both reproductive and metabolic features of PCOS. Pre-pubertal female rats were divided into two groups: group I received normal pellet diet and group II received high fat diet (HFD)...
December 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29192811/effects-of-vitamin-d-on-ovary-in-dhea-treated-pcos-rat-model-a-light-and-electron-microscopic-study
#13
Latife Seyran Çelik, Yurdun Kuyucu, Ebru Dündar Yenilmez, Abdullah Tuli, Kenan Dağlıoğlu, Ufuk Özgü Mete
AIM: The aim of this study was to investigate the effects of vitamin D treatment on ovary in experimentally designed polycystic ovary syndrome of female rats using light and electron microscopic techniques. METHODS: Twenty-four female pre-pubertal rats were divided into control, DHEA and DHEA+Vit.D groups. In DHEA group, the PCOS rat model was developed by 6mg/kg/day dehydroepiandrosterone administration as subcutaneously injections. In DHEA+Vit.D group, 6 mg/kg/day DHEA and 120ng/100g/week 1,25(OH)2D3 was performed simultaneously...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29187833/transcriptome-analysis-on-single-small-yellow-follicles-reveals-that-wnt4-is-involved-in-chicken-follicle-selection
#14
Yiya Wang, Qiuyue Chen, Zemin Liu, Xiaoli Guo, Yanzhi Du, Zhenjie Yuan, Miao Guo, Li Kang, Yi Sun, Yunliang Jiang
Ovarian follicle selection is an important process impacting the laying performance and fecundity of hens, and is regulated by follicle-stimulating hormone (FSH) through binding to its receptor [follicle-stimulating hormone receptor (FSHR)]. In laying hens, the small yellow follicle (6-8 mm in diameter) with the highest expression of FSHR will be recruited into the preovulatory hierarchy during ovarian follicle development. The study of molecular mechanism of chicken follicle selection is helpful for the identification of genes underlying egg-laying traits in chicken and other poultry species...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29180105/sex-hormone-binding-globulin-b-expression-in-the-rainbow-trout-ovary-prior-to-sex-differentiation
#15
Claudio Pérez, Cristian Araneda, Francisco Estay, Nelson F Díaz, Denise Vizziano-Cantonnet
Salmonids have two sex hormone-binding globulin (Shbg) paralogs. Shbga is mainly expressed in the liver, while Shbgb is secreted by the granulosa cells of the rainbow trout ovary. Coexpression of shbgb and the gonadal aromatase cyp19a1a mRNAs been observed in granulosa cells, suggesting a physiological coordination between Shbgb expression and estrogen synthesis. As estrogens are essential for female sex determination in the fish ovary, we propose that Shbgb participates in early ovarian differentiation, either by binding with estrogen or through another mechanism that remains to be discovered...
November 24, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29179771/paracrine-effects-of-human-amniotic-epithelial-cells-protect-against-chemotherapy-induced-ovarian-damage
#16
Qiuwan Zhang, Shixia Bu, Junyan Sun, Minhua Xu, Xiaofen Yao, Kunyan He, Dongmei Lai
BACKGROUND: Human amniotic epithelial cells (hAECs) are attractive candidates for regenerative medical therapy, with the potential to replace deficient cells and improve functional recovery after injury. Previous studies have demonstrated that transplantation of hAECs effectively alleviate chemotherapy-induced ovarian damage via inhibiting granulose cells apoptosis in animal models of premature ovarian failure/insufficiency (POF/POI). However, the underlying molecular mechanism accounting for hAECs-mediated ovarian function recovery is not fully understood...
November 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29177442/increased-27-hydroxycholesterol-production-during-luteolysis-may-mediate-the-progressive-decline-in-progesterone-secretion
#17
Yafei Xu, Scot M Hutchison, José J Hernández-Ledezma, Randy L Bogan
STUDY QUESTION: Does 27-hydroxycholesterol (27OH) actively facilitate the progression of luteolysis? SUMMARY ANSWER: There is increased mRNA expression of the enzyme that produces 27OH during luteolysis in vivo in rhesus macaques and sheep, and 27OH reduces progesterone secretion from human luteinized granulosa cells. WHAT IS KNOWN ALREADY: There is an increase in mRNA expression of liver x receptor (LXR) and a decrease in sterol regulatory element binding protein 2 (SREBP2) target genes during spontaneous luteolysis in primates, which could result in reduced cholesterol availability for steroidogenesis...
November 21, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29177034/maximum-likelihood-approaches-reveal-signatures-of-positive-selection-in-bmp15-and-gdf9-genes-modulating-ovarian-function-in-mammalian-female-fertility
#18
Hafiz Ishfaq Ahmad, Guiqiong Liu, Xunping Jiang, Shishay Girmay Edallew, Teketay Wassie, Birhanu Tesema, Yu Yun, Liu Pan, Chenhui Liu, Yuqing Chong, Zhao Jia Yu, Han Jilong
Bone morphogenetic proteins (BMPs) and the growth factors (GDFs) play an important role in ovarian folliculogenesis and essential regulator of processes of numerous granulosa cells. BMP15 gene variations linked to various ovarian phenotypic consequences subject to the species, from infertility to improved prolificacy in sheep, primary ovarian insufficiency in women or associated with minor subfertility in mouse. To study the evolving role of BMP15 and GDF9, a phylogenetic analysis was performed. To find out the candidate gene associated with prolificacy in mammals, the nucleotide sequence of BMP15 and GDF9 genes was recognized under positive selection in various mammalian species...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29175835/paediatric-ovarian-tumours-and-their-associated-cancer-susceptibility-syndromes
#19
REVIEW
Catherine Goudie, Leora Witkowski, Stephanie Vairy, W Glenn McCluggage, William D Foulkes
Non-epithelial ovarian tumours are rare neoplasms that occasionally arise in childhood and adolescence. They can be associated with various cancer susceptibility syndromes. The morphological overlap seen across these tumours and their rarity can make the diagnosis challenging. In the case of an incorrect diagnosis, the underlying genetic susceptibility may be missed. In this review, we outline the genetic background of ovarian non-epithelial tumours arising in children, emphasizing the genes harbouring pathogenic germline variants associated with each tumour type...
November 24, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29175649/anti-m%C3%A3-llerian-hormone-genetic-and-environmental-effects
#20
REVIEW
Seyedeh Zahra Shahrokhi, Faranak Kazerouni, Firouzeh Ghaffari
Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein produced by granulosa cells of growing ovarian follicles. AMH appears to have an inhibitory effect on both primordial follicle recruitment and responsiveness of growing follicles to follicle-stimulating hormone (FSH). This hormone is considered to be a reliable marker of ovarian reserve; therefore, it is crucial to determine which factors influence AMH levels for prognostic and diagnostic purposes. In this review we intend to discuss the effect of genetic and environmental factors which may lead to AMH interindividual variability...
November 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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