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Bryony A Caswell, Miranda Paine, Christopher L J Frid
Climate change and anthropogenic nutrient enrichment are driving rapid increases in ocean deoxygenation. These changes cause biodiversity loss and have severe consequences for marine ecosystem functioning and in turn the delivery of ecosystem services upon which humanity depends (e.g. fisheries). We seek to understand how such changes will impact seafloor functioning using biological traits analysis. Results from a sewage-sludge disposal site in the Firth of Clyde, UK spanning 26 years of monitoring showed that substantial changes in macrobenthic nutrient cycling and the provision of food for predators occurred, with elevated functioning on the margins 1-2 km from the centre of the disposal grounds...
November 2018: Marine Pollution Bulletin
Guy Keller, Orli Binyamin, Kati Frid, Ann Saada, Ruth Gabizon
Mitochondrial malfunction is a common feature in advanced stages of neurodegenerative conditions, as is the case for the accumulation of aberrantly folded proteins, such as PrP in prion diseases. In this work, we investigated mitochondrial activity and expression of related factors vis a vis PrP accumulation at the subclinical stages of TgMHu2ME199K mice, modeling for genetic prion diseases. While these mice remain healthy until 5-6 months of age, they succumb to fatal disease at 12-14 months. We found that mitochondrial respiratory chain enzymatic activates and ATP/ROS production, were abnormally elevated in asymptomatic mice, concomitant with initial accumulation of disease related PrP...
November 10, 2018: Neurobiology of Disease
Sanjay Kalra, Laurence J Hirsch, Anders Frid, Asma Deeb, Kenneth W Strauss
In the original publication, fourth author name was incorrectly published as Asthma Deeb in author group.
October 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Marit Slåttelid Skeie, Paula Frid, Manal Mustafa, Jörg Aßmus, Annika Rosén
Objectives: The objectives of this study were to assess the interexaminer agreement between one "reference" (gold standard) and each of two examiners, using the DC/TMD examination method, Axis I and to evaluate whether a recalibration changed reliability values. Methods: Participants (4 healthy and 12 TMD patients) in 2013 underwent a clinical examination according to DC/TMDs, Axis I. In 2014, additionally 16 participants (4 healthy and 12 TMD patients) were recruited...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
Natalie C Ban, Alejandro Frid, Mike Reid, Barry Edgar, Danielle Shaw, Peter Siwallace
No abstract text is available yet for this article.
November 2018: Nature Ecology & Evolution
Hanneke Stam, Johannes C van der Wouden, Jacqueline G Hugtenburg, Jos W R Twisk, Henriëtte E van der Horst, Otto R Maarsingh
OBJECTIVES: Dizziness is common in older people. Physicians are often unable to identify a specific cause for dizziness in older people, even after an extensive diagnostic work-up. A prognosis-oriented approach, i.e. treating modifiable risk factors for an unfavourable course of dizziness, may reduce dizziness-related impairment in older people in primary care. DESIGN: Cluster randomized controlled trial. SETTING: 45 primary care practices in The Netherlands...
2018: PloS One
Bilal Sirhan, Lior Frid, Alon Kalron
The objective of the study was to investigate cognitive-motor interference of walking while texting in people with multiple sclerosis (PwMS). The study included 30 PwMS, mean disease duration 11.8 (SD = 6.8) years, and 15 healthy controls. The investigation included a cognitive assessment; texting assessment based on 100 typed characters; and gait assessment under two different conditions: normal walking and walking while texting. Outcome measures included the Symbol Digit Modalities Test to assess cognition...
December 2018: Journal of Neural Transmission
Andrea Correa-Pérez, Eva Delgado-Silveira, Sagrario Martín-Aragón, Aurora M Rojo-Sanchís, Alfonso J Cruz-Jentoft
BACKGROUND: Polypharmacy and fall-risk increasing drugs (FRIDS) have been associated with injurious falls. We aimed to estimate the prevalence of polypharmacy and FRIDS in older patients discharged from an Orthogeriatric Unit after a hip fracture surgery. METHODS: This study describes the baseline findings of a 2-year retrospective cohort study. We included patients older than 80 years discharged from an Orthogeriatric Unit who were able to walk before surgery...
October 1, 2018: Aging Clinical and Experimental Research
Sanjay Kalra, Laurence J Hirsch, Anders Frid, Asma Deeb, Kenneth W Strauss
INTRODUCTION: The 2015 Insulin Injection Technique Questionnaire survey involving 13,289 patients included 898 (6.8%) patients in the pediatric age range (≤ 18 years). METHODS: The younger patients included in the questionnaire survey were grouped according to age: Group 1 (G1), 0-6 years, n = 85; Group 2(G2), 7-13, n = 423; Group 3 (G3), 14-18, n = 390. The injection technique was evaluated by means of a questionnaire and nurse assessment. RESULTS: Nurses found lipohypertrophy at injection sites in 41...
September 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Fiona E Culhane, Christoper L J Frid, Eva Royo Gelabert, Lydia White, Leonie A Robinson
Marine ecosystems support supply of ecosystem services (ESs) through processes and functions carried out by diverse biological elements. Managing sustainability of ES use requires linking services to the parts of ecosystems supplying them. We specified marine service providing units (SPUs) as plausible combinations of a biotic group (e.g., bacteria, seabirds) with an associated major habitat (e.g., sublittoral sediment). We developed a network model for large marine ecosystems, documenting 2,916 links between 153 SPUs with 31 services...
October 2018: Ecological Applications: a Publication of the Ecological Society of America
Ulf Nyman, Joanna Ahlkvist, Peter Aspelin, Torkel Brismar, Anders Frid, Mikael Hellström, Per Liss, Gunnar Sterner, Peter Leander
A side-by-side comparison of updated guidelines regarding contrast medium-induced acute kidney injury (CI-AKI) from the Swedish Society of Uroradiology (SSUR) and the European Society of Urogenital Radiology (ESUR) is presented. The major discrepancies include a higher glomerular filtration rate (GFR) threshold as a risk factor for CI-AKI and for discontinuation of metformin by SSUR, i.e., < 45 ml/min versus < 30 ml/min/1.73 m2 by ESUR, when intravenous or intra-arterial contrast media (CM) with second-pass renal exposure is administered...
December 2018: European Radiology
Mauricio Ostrosky-Frid, María Castañeda-Bueno, Gerardo Gamba
The renal thiazide-sensitive NaCl cotransporter (NCC) is the major salt transport pathway in the distal convoluted tubule of the mammalian nephron. NCC activity is critical for modulation of arterial blood pressure and serum potassium levels. Reduced activity of NCC in genetic diseases results in arterial hypotension and hypokalemia, while increased activity results in genetic diseases featuring hypertension and hyperkalemia. Several hormones and physiological conditions modulate NCC activity through a final intracellular complex pathway involving kinases and ubiquitin ligases...
August 8, 2018: American Journal of Physiology. Renal Physiology
Yoonyoung Choi, Benjamin Staley, Carl Henriksen, Dandan Xu, Gloria Lipori, Babette Brumback, Almut G Winterstein
PURPOSE: Construction and validation of a fall risk prediction model specific to inpatients receiving fall risk-increasing drugs (FRIDs) are described. METHODS: In a retrospective cohort study of 75,036 admissions to 2 hospitals over a designated 22-month period that involved FRID exposure during the first 5 hospital days, factors influencing fall risk were investigated via logistic regression. The resultant risk prediction model was internally validated and its performance compared with that of a model based on Morse Fall Scale (MFS) scores...
September 1, 2018: American Journal of Health-system Pharmacy: AJHP
Anna Axmon, Magnus Sandberg, Gerd Ahlström, Patrik Midlöv
BACKGROUND: Falls are the most common cause of injury for older people in the general population as well as among those with intellectual disability. There are many risk factors for falls, including a range of drugs which are considered to be fall-risk-increasing (FRIDs). The aim of the present study was to describe prescription patterns of FRIDs in itself as well as in relation to falls requiring health care among older people with intellectual disability and their age-peers in the general population...
2018: PloS One
Lisa Söderström, Eva Thors Adolfsson, Andreas Rosenblad, Hanna Frid, Anja Saletti, Leif Bergkvist
No abstract text is available yet for this article.
June 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Eduardo R Argaiz, Maria Chavez-Canales, Mauricio Ostrosky-Frid, Alejandro Rodríguez-Gama, Norma Vázquez, Xochiquetzal Gonzalez-Rodriguez, Jesus Garcia-Valdes, Juliette Hadchouel, David Ellison, Gerardo Gamba
Familial hyperkalemic hypertension (FHHt) can be mainly attributed to increased activity of the renal Na+ :Cl- cotransporter (NCC), which is caused by altered expression and regulation of the with-no-lysine (K) 1 (WNK1) or WNK4 kinases. The WNK1 gene gives rise to a kidney-specific isoform that lacks the kinase domain (KS-WNK1), the expression of which occurs primarily in the distal convoluted tubule. The role played by KS-WNK1 in the modulation of the WNK/STE20-proline-alanine rich kinase (SPAK)/NCC pathway remains elusive...
September 1, 2018: American Journal of Physiology. Renal Physiology
Kati Frid, Orli Binyamin, Nina Fainstein, Guy Keller, Tamir Ben-Hur, Ruth Gabizon
TgMHu2ME199K mice, a transgenic line mimicking genetic prion disease, are born healthy and gradually deteriorate to a terminal neurological condition concomitant with the accumulation of disease-related PrP. To investigate whether transplantation of neural progenitor cells (NPCs) to these mice can delay disease aggravation, we first tested the properties of mutant PrP in homogenates and enriched NPCs from TgMHu2ME199K embryos, as compared to PrP in sick TgMHu2ME199K brains. Next, we tested the clinical effect of NPCs transplantation into newborn TgMHu2ME199K mice...
May 2018: Neurobiology of Aging
Ingrid Frid, Johan Ågren, Mattias Kjellberg, Erik Normann, Richard Sindelar
AIM: This study evaluated the medical quality of acute airborne transports carried out by a neonatal emergency transport service in a Swedish healthcare region from 2012 to 2015. METHODS: The transport charts and patient records of all infants transported to the regional centre were reviewed for transport indications and vital parameters and outcomes. RESULTS: We identified 187 acute airborne transports and the main indications for referral were therapeutic hypothermia after perinatal asphyxia, extremely preterm birth and respiratory failure...
August 2018: Acta Paediatrica
Kurt R Stenmark, Maria G Frid, Brian B Graham, Rubin M Tuder
Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular tone and a complex series of cellular and molecular events termed 'vascular remodelling'. The remodelling process, which can involve the entirety of pulmonary arterial vasculature, almost universally involves medial thickening, driven by increased numbers and hypertrophy of its principal cellular constituent, smooth muscle cells (SMCs). It is noted, however that SMCs comprise heterogeneous populations of cells, which can exhibit markedly different proliferative, inflammatory, and extracellular matrix production changes during remodelling...
March 15, 2018: Cardiovascular Research
Alon Kalron, Roy Aloni, Mark Dolev, Lior Frid, Uri Givon, Shay Menascu
The objective of the study was to determine if cognitive function is associated with step time variability in people with multiple sclerosis (PwMS). The study included 355 PwMS (218 women), average age 41.1 (SD = 13.5), disease duration 5.9 (SD = 7.3) years, and a median expanded disability status scale score of 2.5. We separately analyzed the sample group of fallers and non-fallers based on their fall history. Gait variability was measured by an electronic walkway and all participants completed a computerized cognitive test battery designed to evaluate multiple cognitive domains...
June 2018: Journal of Neural Transmission
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