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https://www.readbyqxmd.com/read/30089030/regulation-of-the-renal-nacl-cotransporter-by-the-wnk-spak-pathway-lessons-learned-from-genetically-altered-animals
#1
Mauricio Ostrosky-Frid, María Castañeda-Bueno, Gerardo Gamba
The renal thiazide-sensitive NaCl cotransporter (NCC) is the major salt transport pathway in the distal convoluted tubule of the mammalian nephron. NCC activity is critical for modulation of arterial blood pressure and serum potassium levels. Reduced activity of NCC in genetic diseases results in arterial hypotension and hypokalemia, while increased activity results in genetic diseases featuring hypertension and hyperkalemia. Several hormones and physiological conditions modulate NCC activity through a final intracellular complex pathway involving kinases and ubiquitin ligases...
August 8, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30037814/a-dynamic-risk-model-for-inpatient-falls
#2
Yoonyoung Choi, Benjamin Staley, Carl Henriksen, Dandan Xu, Gloria Lipori, Babette Brumback, Almut G Winterstein
PURPOSE: Construction and validation of a fall risk prediction model specific to inpatients receiving fall risk-increasing drugs (FRIDs) are described. METHODS: In a retrospective cohort study of 75,036 admissions to 2 hospitals over a designated 22-month period that involved FRID exposure during the first 5 hospital days, factors influencing fall risk were investigated via logistic regression. The resultant risk prediction model was internally validated and its performance compared with that of a model based on Morse Fall Scale (MFS) scores...
July 23, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29920564/fall-risk-increasing-drugs-and-falls-requiring-health-care-among-older-people-with-intellectual-disability-in-comparison-with-the-general-population-a-register-study
#3
Anna Axmon, Magnus Sandberg, Gerd Ahlström, Patrik Midlöv
BACKGROUND: Falls are the most common cause of injury for older people in the general population as well as among those with intellectual disability. There are many risk factors for falls, including a range of drugs which are considered to be fall-risk-increasing (FRIDs). The aim of the present study was to describe prescription patterns of FRIDs in itself as well as in relation to falls requiring health care among older people with intellectual disability and their age-peers in the general population...
2018: PloS One
https://www.readbyqxmd.com/read/29907352/corrigendum-to-mealtime-habits-and-meal-provision-are-associated-with-malnutrition-among-elderly-patients-admitted-to-hospital-clin-nutr-32-2-2013-281-288
#4
Lisa Söderström, Eva Thors Adolfsson, Andreas Rosenblad, Hanna Frid, Anja Saletti, Leif Bergkvist
No abstract text is available yet for this article.
June 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29846116/kidney-specific-wnk1-isoform-ks-wnk1-is-a-potent-activator-of-wnk4-and-ncc
#5
Eduardo R Argaiz, Maria Chavez-Canales, Mauricio Ostrosky-Frid, Alejandro Rodriguez-Gama, Norma Vázquez, Xochiquetzal Gonzalez-Rodriguez, Jesus Garcia-Valdés, Juliette Hadchouel, David H Ellison, Gerardo Gamba
Familial Hyperkalemic Hypertension (FHHt) can be mainly attributed to increased activity of the renal Na+:Cl- cotransporter (NCC), which is caused by altered expression and regulation of the WNK1 and WNK4 kinases. The WNK1 gene gives rise to a kidney-specific isoform that lacks the kinase domain (KS-WNK1), the expression of which occurs primarily in the distal convoluted tubule. The role played by KS-WNK1 in the modulation of the WNK/SPAK/NCC pathway remains elusive. In the present study, we assessed the effect of human KS-WNK1 on NCC activity and on the WNK4-SPAK pathway...
May 30, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29494865/autologous-neural-progenitor-cell-transplantation-into-newborn-mice-modeling-for-e200k-genetic-prion-disease-delays-disease-progression
#6
Kati Frid, Orli Binyamin, Nina Fainstein, Guy Keller, Tamir Ben-Hur, Ruth Gabizon
TgMHu2ME199K mice, a transgenic line mimicking genetic prion disease, are born healthy and gradually deteriorate to a terminal neurological condition concomitant with the accumulation of disease-related PrP. To investigate whether transplantation of neural progenitor cells (NPCs) to these mice can delay disease aggravation, we first tested the properties of mutant PrP in homogenates and enriched NPCs from TgMHu2ME199K embryos, as compared to PrP in sick TgMHu2ME199K brains. Next, we tested the clinical effect of NPCs transplantation into newborn TgMHu2ME199K mice...
May 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29480945/critically-ill-neonates-displayed-stable-vital-parameters-and-reduced-metabolic-acidosis-during-neonatal-emergency-airborne-transport-in-sweden
#7
Ingrid Frid, Johan Ågren, Mattias Kjellberg, Erik Normann, Richard Sindelar
AIM: This study evaluated the medical quality of acute airborne transports carried out by a neonatal emergency transport service in a Swedish healthcare region from 2012 to 2015. METHODS: The transport charts and patient records of all infants transported to the regional centre were reviewed for transport indications and vital parameters and outcomes. RESULTS: We identified 187 acute airborne transports and the main indications for referral were therapeutic hypothermia after perinatal asphyxia, extremely preterm birth and respiratory failure...
August 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29385432/dynamic-and-diverse-changes-in-the-functional-properties-of-vascular-smooth-muscle-cells-in-pulmonary-hypertension
#8
Kurt R Stenmark, Maria G Frid, Brian B Graham, Rubin M Tuder
Pulmonary hypertension (PH) is the end result of interaction between pulmonary vascular tone and a complex series of cellular and molecular events termed 'vascular remodelling'. The remodelling process, which can involve the entirety of pulmonary arterial vasculature, almost universally involves medial thickening, driven by increased numbers and hypertrophy of its principal cellular constituent, smooth muscle cells (SMCs). It is noted, however that SMCs comprise heterogeneous populations of cells, which can exhibit markedly different proliferative, inflammatory, and extracellular matrix production changes during remodelling...
March 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29350300/the-relationship-between-gait-variability-and-cognitive-functions-differs-between-fallers-and-non-fallers-in-ms
#9
Alon Kalron, Roy Aloni, Mark Dolev, Lior Frid, Uri Givon, Shay Menascu
The objective of the study was to determine if cognitive function is associated with step time variability in people with multiple sclerosis (PwMS). The study included 355 PwMS (218 women), average age 41.1 (SD = 13.5), disease duration 5.9 (SD = 7.3) years, and a median expanded disability status scale score of 2.5. We separately analyzed the sample group of fallers and non-fallers based on their fall history. Gait variability was measured by an electronic walkway and all participants completed a computerized cognitive test battery designed to evaluate multiple cognitive domains...
June 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28972001/metabolic-and-proliferative-state-of-vascular-adventitial-fibroblasts-in-pulmonary-hypertension-is-regulated-through-a-microrna-124-ptbp1-polypyrimidine-tract-binding-protein-1-pyruvate-kinase-muscle-axis
#10
Hui Zhang, Daren Wang, Min Li, Lydie Plecitá-Hlavatá, Angelo D'Alessandro, Jan Tauber, Suzette Riddle, Sushil Kumar, Amanda Flockton, B Alexandre McKeon, Maria G Frid, Julie A Reisz, Paola Caruso, Karim C El Kasmi, Petr Ježek, Nicholas W Morrell, Cheng-Jun Hu, Kurt R Stenmark
BACKGROUND: An emerging metabolic theory of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We and others have previously demonstrated the existence of hyperproliferative, apoptosis-resistant, proinflammatory adventitial fibroblasts from human and bovine hypertensive pulmonary arterial walls (PH-Fibs) that exhibit constitutive reprogramming of glycolytic and mitochondrial metabolism, accompanied by an increased ratio of glucose catabolism through glycolysis versus the tricarboxylic acid cycle...
December 19, 2017: Circulation
https://www.readbyqxmd.com/read/28971999/identification-of-microrna-124-as-a-major-regulator-of-enhanced-endothelial-cell-glycolysis-in-pulmonary-arterial-hypertension-via-ptbp1-polypyrimidine-tract-binding-protein-and-pyruvate-kinase-m2
#11
Paola Caruso, Benjamin J Dunmore, Kenny Schlosser, Sandra Schoors, Claudia Dos Santos, Carol Perez-Iratxeta, Jessie R Lavoie, Hui Zhang, Lu Long, Amanda R Flockton, Maria G Frid, Paul D Upton, Angelo D'Alessandro, Charaka Hadinnapola, Fedir N Kiskin, Mohamad Taha, Liam A Hurst, Mark L Ormiston, Akiko Hata, Kurt R Stenmark, Peter Carmeliet, Duncan J Stewart, Nicholas W Morrell
BACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms underlying alterations in energy production have not been identified. METHODS: Here, we examined the miRNA and proteomic profiles of blood outgrowth endothelial cells (BOECs) from patients with heritable PAH caused by mutations in the bone morphogenetic protein receptor type 2 ( BMPR2 ) gene and patients with idiopathic PAH to determine mechanisms underlying abnormal endothelial glycolysis...
December 19, 2017: Circulation
https://www.readbyqxmd.com/read/28916557/study-of-fall-risk-increasing-drugs-in-elderly-patients-before-and-after-a-bone-fracture
#12
Mónica Beunza-Sola, Ángel M Hidalgo-Ovejero, Jon Martí-Ayerdi, José Germán Sánchez-Hernández, Miguel Menéndez-García, Serafín García-Mata
BACKGROUND: Accidental falls have a significant economic and human impact. The use of certain drugs is one of the modifiable risk factors associated with these events. OBJECTIVE: The aim of this study was to determine the prevalence of use and to explore changes in treatment with fall-related drugs in patients over 65 years of age admitted as a result of a fall-related fracture. METHODS: Observational and prospective study performed in a tertiary level hospital...
February 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28912266/lysine-trimethylation-regulates-78-kda-glucose-regulated-protein-proteostasis-during-endoplasmic-reticulum-stress
#13
Jonas Sieber, Nicolas Wieder, Mauricio Ostrosky-Frid, Moran Dvela-Levitt, Ozan Aygün, Namrata D Udeshi, Steven A Carr, Anna Greka
The up-regulation of chaperones such as the 78-kDa glucose-regulated protein (GRP78, also referred to as BiP or HSPA5) is part of the adaptive cellular response to endoplasmic reticulum (ER) stress. GRP78 is widely used as a marker of the unfolded protein response, associated with sustained ER stress. Here we report the discovery of a proteostatic mechanism involving GRP78 trimethylation in the context of ER stress. Using mass spectrometry-based proteomics, we identified two GRP78 fractions, one homeostatic and one induced by ER stress...
November 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28895878/effect-of-oral-pre-meal-administration-of-betaglucans-on-glycaemic-control-and-variability-in-subjects-with-type-1-diabetes
#14
RANDOMIZED CONTROLLED TRIAL
Anders Frid, Andrea Tura, Giovanni Pacini, Martin Ridderstråle
We conducted a double-blind placebo-controlled crossover pilot study to investigate the effect of oat betaglucans (β-glucan) on glycaemic control and variability in adults with type 1 diabetes (T1D; n = 14). Stomacol® tablets (1.53 g of β-glucan) or placebo (Plac) were administered three times daily before meals for two weeks. Glucose levels were monitored during the second week by continuous glucose monitoring (CGM). There was an increase in basic measures of glycaemic control (maximal glucose value 341 ± 15 vs...
September 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28852707/design-and-rationale-for-examining-neuroimaging-genetics-in-ischemic-stroke-the-mri-genie-study
#15
Anne-Katrin Giese, Markus D Schirmer, Kathleen L Donahue, Lisa Cloonan, Robert Irie, Stefan Winzeck, Mark J R J Bouts, Elissa C McIntosh, Steven J Mocking, Adrian V Dalca, Ramesh Sridharan, Huichun Xu, Petrea Frid, Eva Giralt-Steinhauer, Lukas Holmegaard, Jaume Roquer, Johan Wasselius, John W Cole, Patrick F McArdle, Joseph P Broderick, Jordi Jimenez-Conde, Christina Jern, Brett M Kissela, Dawn O Kleindorfer, Robin Lemmens, Arne Lindgren, James F Meschia, Tatjana Rundek, Ralph L Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Vincent Thijs, Daniel Woo, Bradford B Worrall, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, Polina Golland, Ona Wu, Natalia S Rost
OBJECTIVE: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study. METHODS: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 international SiGN sites contributed MRIs of 3,301 patients with AIS. Detailed clinical phenotyping with the web-based Causative Classification of Stroke (CCS) system and genome-wide genotyping data were available for all participants...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28847567/continues-administration-of-nano-pso-significantly-increased-survival-of-genetic-cjd-mice
#16
Orli Binyamin, Guy Keller, Kati Frid, Liraz Larush, Shlomo Magdassi, Ruth Gabizon
We have shown previously that Nano-PSO, a nanodroplet formulation of pomegranate seed oil, delayed progression of neurodegeneration signs when administered for a designated period of time to TgMHu2ME199K mice, modeling for genetic prion disease. In the present work, we treated these mice with a self-emulsion formulation of Nano-PSO or a parallel Soybean oil formulation from their day of birth until a terminal disease stage. We found that long term Nano-PSO administration resulted in increased survival of TgMHu2ME199K lines by several months...
December 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28823890/forehearing-words-pre-activation-of-word-endings-at-word-onset
#17
Mikael Roll, Pelle Söderström, Johan Frid, Peter Mannfolk, Merle Horne
Occurring at rates up to 6-7 syllables per second, speech perception and understanding involves rapid identification of speech sounds and pre-activation of morphemes and words. Using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the time-course and neural sources of pre-activation of word endings as participants heard the beginning of unfolding words. ERPs showed a pre-activation negativity (PrAN) for word beginnings (first two segmental phonemes) with few possible completions...
September 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28793815/elderly-users-of-fall-risk-increasing-drug-perceptions-of-fall-risk-and-the-relation-to-their-drug-use-a-qualitative-study
#18
Hege Therese Bell, Aslak Steinsbekk, Anne Gerd Granas
OBJECTIVE: The aim of the study was to explore how home-dwelling elderly who use fall-risk-increasing drugs (FRIDs) perceive their fall risk and how they relate this to their drug use. DESIGN, SETTING AND SUBJECTS: A qualitative study with 14 home-dwelling elderly FRID users between 65 and 97 years in Central Norway participating in semi-structured individual interviews. The data were analyzed thematically by using systematic text condensation. RESULTS: The main finding was that the informants did not necessarily perceive the use of FRIDs to be a prominent risk factor for falls...
September 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28771244/de-novo-and-rare-inherited-copy-number-variations-in-the-hemiplegic-form-of-cerebral-palsy
#19
Mehdi Zarrei, Darcy L Fehlings, Karizma Mawjee, Lauren Switzer, Bhooma Thiruvahindrapuram, Susan Walker, Daniele Merico, Guillermo Casallo, Mohammed Uddin, Jeffrey R MacDonald, Matthew J Gazzellone, Edward J Higginbotham, Craig Campbell, Gabrielle deVeber, Pam Frid, Jan Willem Gorter, Carolyn Hunt, Anne Kawamura, Marie Kim, Anna McCormick, Ronit Mesterman, Dawa Samdup, Christian R Marshall, Dimitri J Stavropoulos, Richard F Wintle, Stephen W Scherer
PurposeHemiplegia is a subtype of cerebral palsy (CP) in which one side of the body is affected. Our earlier study of unselected children with CP demonstrated de novo and clinically relevant rare inherited genomic copy-number variations (CNVs) in 9.6% of participants. Here, we examined the prevalence and types of CNVs specifically in hemiplegic CP.MethodsWe genotyped 97 unrelated probands with hemiplegic CP and their parents. We compared their CNVs to those of 10,851 population controls, in order to identify rare CNVs (<0...
February 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28605455/risk-profiles-for-injurious-falls-in-people-over-60-a-population-based-cohort-study
#20
Stina Ek, Debora Rizzuto, Laura Fratiglioni, Kristina Johnell, Weili Xu, Anna-Karin Welmer
Background: Although falls in older adults are related to multiple risk factors, these factors have commonly been studied individually. We aimed to identify risk profiles for injurious falls in older adults by detecting clusters of established risk factors and quantifying their impact on fall risk. Methods: Participants were 2,566 people, aged 60 years and older, from the population-based Swedish National Study on Aging and Care in Kungsholmen. Injurious falls was defined as hospitalization for or receipt of outpatient care because a fall...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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