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https://www.readbyqxmd.com/read/30514220/a-case-of-hepatic-anisakiasis-caused-by-pseudoterranova-decipiens-mimicking-metastatic-liver-cancer
#1
Yasuhiro Murata, Katsuhiko Ando, Masanobu Usui, Hiromu Sugiyama, Akinobu Hayashi, Akihiro Tanemura, Hiroyuki Kato, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno, Hiroyuki Sakurai, Shuji Isaji
BACKGROUND: Anisakid nematodes (Anisakis spp. or Pseudoterranova spp.) usually infect gastric or intestinal walls, while they rarely infect in extra-gastrointestinal sites of human body. Generally, Anisakis spp. larvae are highly infected in fish intermediate hosts, whereas Pseudoterranova spp. larvae are very rarely infected. To the best of our knowledge, there have been no reports which have documented cases of hepatic anisakiasis caused by Pseudoterranova spp. This report describes the first documented case of hepatic anisakiasis due to infection with Pseudoterranova decipiens and clinical features of the hepatic anisakiasis through literature review...
December 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30513960/combined-gastric-and-colorectal-cancer-screening-a-new-strategy
#2
Michael Selgrad, Jan Bornschein, Arne Kandulski, Jochen Weigt, Albert Roessner, Thomas Wex, Peter Malfertheiner
BACKGROUND: Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates. METHODS: Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61.6%) also underwent gastroscopy to correlate the results for serum pepsinogen I and II (sPG-I and sPG-II), sPG-I/II ratio, and anti- H. pylori antibodies with gastric histopathology findings (graded according to the updated Sydney classification and the Operative Link of Gastritis Assessment (OLGA) and the Operative Link for Gastric Intestinal Metaplasia assessment (OLGIM) systems)...
December 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30510446/circ-sfmbt2-promotes-the-proliferation-of-gastric-cancer-cells-through-sponging-mir-182-5p-to-enhance-creb1-expression
#3
Handong Sun, Pengcheng Xi, Zhiqiang Sun, Qian Wang, Bin Zhu, Jian Zhou, Hui Jin, Wubin Zheng, Weiwei Tang, Hongyong Cao, Xiufeng Cao
Background: Circular RNAs(circRNAs) have been reported as a diverse class of endogenous RNA that regulate gene expression in eukaryotes. Recent evidence suggested that many circular RNAs can act as oncogenes or tumor suppressors through sponging microRNAs. However, the function of circular RNAs in gastric cancer remains largely unknown. Materials and methods: The circRNA levels in gastric carcinoma tissues and plasmas were detected by real-time quantitative reverse transcription-polymerase chain reaction...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/30510337/estimating-the-net-survival-of-patients-with-gastric-cancer-in-iran-in-a-relative-survival-framework
#4
Fatemeh Paknazar, Mahmood Mahmoudi, Kazem Mohammad, Hojjat Zeraati, Mohammad Ali Mansournia, Mahdi Yaseri
Background: Iran is an Eastern Mediterranean region country with the highest rate of gastric cancer. The present study aimed to evaluate the 5-year net survival of patients with gastric cancer in Iran using a relative survival framework. Methods: In a cross-sectional study, using life-table estimation of relative survival, we reported 1- to 5-year relative survival regarding age, sex, disease stage, pathology, and adjuvant therapies via modeling excess mortality...
November 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/30506538/-application-of-intraoperative-ultrasound-in-laparoscopic-lymphadenectomy-of-gastric-cancer
#5
Aolin Shen, Shengyun Wan, Bo Qian, Long Ma, Shuhan Yang, Biao Liu, Lei Zhang, Guodong Shen
OBJECTIVE: To explore the application value of intraoperative ultrasound (IU) in laparoscopic lymphadenectomy of gastric cancer. METHODS: Patients with gastric cancer undergoing laparoscopic radical D2 gastrectomy at General Surgery of the Second Affiliated Hospital of Anhui Medical University between August 2016 and May 2018 were prospectively enrolled and were randomly divided into IU group (n=78) and conventional group (n=91). The conventional group underwent laparoscopy only...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30501533/value-of-multi-slice-spiral-computed-tomography-in-the-diagnosis-of-metastatic-lymph-nodes-and-n-stage-of-gastric-cancer
#6
Min Jiang, Xiaoxiao Wang, Xiuhong Shan, Donggang Pan, Yingjun Jia, Enzhen Ni, Yuan Hu, Hao Huang
OBJECTIVE: To establish new diagnostic criteria for improvement of the accuracy of multi-slice spiral computed tomography (MSCT) in diagnosing the N-stage and lymph node (LN) metastasis of gastric cancer (GC). METHODS: MSCT was performed with plain and triphasic dynamic contrast enhancement. Different regions of LN metastasis and N-staging were determined according to the herein-proposed combined diagnostic criteria and were then correlated with the pathological analysis...
December 2, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30497877/pathologic-analyses-of-peritoneal-nodules-in-gastric-cancer-patients-during-surgery-a-single-cancer-center-experience-with-diagnostic-pitfalls
#7
Hyunsik Bae, Hyunjin Kim, Jinah Chu, Yunjeong Jang, Hyun Hee Koh, Hera Jung, Sang Yun Ha, Kee-Taek Jang, Kyoung-Mee Kim
BACKGROUND: Gastric carcinoma (GC) is the second most common cause of cancer-related deaths worldwide. During operations, nodular lesions of the peritoneum are often sent for frozen section (FS). For pathologists, FS of the peritoneum is challenging due to sparse and discohesive tumor cells in a fibrotic background. METHODS: To explore diagnostic accuracy and diagnostic pitfalls of FS in this setting, we retrospectively collected 252 peritoneal biopsies in cases with GC from January 2006 to May 2017 and compared corresponding permanent sections and patient prognosis...
November 15, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30488834/use-of-peritoneal-washing-cytology-for-the-detection-of-free-peritoneal-cancer-cells-before-and-after-surgical-treatment-of-gastric-adenocarcinoma
#8
Mustafa Hasbahceci, Adem Akcakaya, Beril Guler, Enver Kunduz, Fatma Umit Malya, Mahmut Muslumanoglu
Aim: Cytological detection of peritoneal-free gastric cancer cells is considered as the gold standard with variable sensitivity. Seeding of cancer cells after radical surgery for gastric cancer is a controversial issue. In this study, it was aimed to detect the rate of positive peritoneal washing cytology and the incidence of spreading of tumor cells after radical surgery. Materials and Methods: Patients with pathologically proven and surgically treated gastric adenocarcinoma were enrolled...
October 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30487955/raman-spectroscopy-for-the-diagnosis-of-unlabeled-and-unstained-histopathological-tissue-specimens
#9
Haruo Ikeda, Hiroaki Ito, Muneaki Hikita, Noriko Yamaguchi, Naoyuki Uragami, Noboru Yokoyama, Yuko Hirota, Miki Kushima, Yoichi Ajioka, Haruhiro Inoue
AIM: To investigate the possibility of diagnosing gastric cancer from an unstained pathological tissue using Raman spectroscopy, and to compare the findings to those obtained with conventional histopathology. METHODS: We produced two consecutive tissue specimens from areas with and without cancer lesions in the surgically resected stomach of a patient with gastric cancer. One of the two tissue specimens was stained with hematoxylin and eosin and used as a reference for laser irradiation positioning by the spectroscopic method...
November 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30487702/association-between-helicobacter-pylori-epstein-barr-virus-human-papillomavirus-and-gastric-adenocarcinomas
#10
Carolina Rosal Teixeira de Souza, Marcelli Carolini Alves Almeida, André Salim Khayat, Emerson Lucena da Silva, Paulo Cardoso Soares, Luiz Cláudio Chaves, Rommel Mario Rodríguez Burbano
AIM: To correlate Helicobacter pylori ( H. pylori ), Epstein-Barr virus (EBV) and human papillomavirus (HPV) with gastric cancer (GC) cases in Pará State, Brazil. METHODS: Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori , and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR...
November 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30487159/prognostic-values-of-inhibitory-kappa-b-kinases-mrna-expression-in-human-gastric-cancer
#11
David David Timothy Gayed, Jayant Wodeyar, Zi-Xiang Wang, Xiang Wei, Yi-Yi Yao, Xiao-Xi Chen, Zhou Du, Ji-Cai Chen
BackgroundInhibitory kappa B Kinases (IKKs) play a key role in modulating proinflammatory and growth stimulating signals through their regulation of the nuclear factor kappa B (NF-κB) cascade. Therefore, the level of expression of IKKs represents a viable prognostic predictor with regards to various pathological processes. The prognostic value of IKKs expression in gastric cancer remains unclear.MethodsWe used the 'Kaplan-Meier plotter' (KM plotter) online database, to explore the predictive prognostic value of individual IKKs members' mRNA expression to overall survival (OS) in different clinical data including pathological staging, histology and therapies employed...
November 28, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30486559/-comparison-of-two-serological-methods-in-screening-gastric-cancer-and-its-precancerous-condition
#12
M Y Li, D Q Zhang, X Lu, W C Chen
Objective: To compare the diagnostic value of the old "ABC" method [serum pepsinogen(PG) combined with Helicobacter pylori (Hp) IgG antibody] and the new "ABC" method [serum pepsinogen plus gastrin-17(G-17)] in screening gastric cancer and its precancerous condition. Methods: Serum PG, G-17 and Hp-IgG were quantified by enzyme-linked immunosorbent assay (ELISA) in 278 subjects. Subjects were grouped according to the criteria of two methods. The gastroscopy and pathological biopsy were gold standard...
December 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/30483985/number-of-retrieved-lymph-nodes-is-an-independent-prognostic-factor-after-total-gastrectomy-for-patients-with-stage-iii-gastric-cancer-propensity-score-matching-analysis-of-a-multi-institution-dataset
#13
Shogo Hayashi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
BACKGROUND: The prognostic significance of the number of retrieved lymph nodes (RLNs) in gastric cancer remains controversial. Therefore, we designed a multicenter collaborative database to investigate the correlation between the number of RLNs and prognosis of patients with advanced gastric cancer after curative resection. METHODS: We retrospectively analyzed 1103 patients who underwent gastrectomy for stage II/III gastric cancer between 2010 and 2014. Lymph nodes, which were retrieved by surgeons from surgically resected specimens, were validated by pathologists...
November 27, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/30473775/computational-assessment-of-stomach-tumor-volume-from-multi-slice-computerized-tomography-images-in-presence-of-type-2-cancer
#14
Gerardo Chacón, Johel E Rodríguez, Valmore Bermúdez, Miguel Vera, Juan Diego Hernández, Sandra Vargas, Aldo Pardo, Carlos Lameda, Delia Madriz, Antonio J Bravo
Background: The multi-slice computerized tomography (MSCT) is a medical imaging modality that has been used to determine the size and location of the stomach cancer. Additionally, MSCT is considered the best modality for the staging of gastric cancer. One way to assess the type 2 cancer of stomach is by detecting the pathological structure with an image segmentation approach. The tumor segmentation of MSCT gastric cancer images enables the diagnosis of the disease condition, for a given patient, without using an invasive method as surgical intervention...
2018: F1000Research
https://www.readbyqxmd.com/read/30467591/population-pharmacokinetic-and-covariate-analyses-of-intravenous-trastuzumab-herceptin-%C3%A2-a-her2-targeted-monoclonal-antibody-in-patients-with-a-variety-of-solid-tumors
#15
Angelica L Quartino, Hanbin Li, Whitney P Kirschbrown, Ranvir Mangat, D Russell Wada, Amit Garg, Jin Y Jin, Bert Lum
PURPOSE: The aim of the study was to characterize the population pharmacokinetics (PK) of the intravenous formulation of trastuzumab, assess the impact of patient and pathological covariates on trastuzumab PK, and perform simulations to support dosing recommendations in special situations. METHODS: Serum trastuzumab concentrations were obtained from 1582 patients with metastatic breast cancer (MBC), early breast cancer (EBC), advanced gastric cancer (AGC), or other tumor types/healthy volunteers in 18 phase I, II, and III trials and analyzed by nonlinear mixed-effects modeling...
November 22, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/30466290/is-prophylactic-gastrectomy-indicated-for-healthy-carriers-of-cdh1-gene-mutations-associated-with-hereditary-diffuse-gastric-cancer
#16
Vicente Munitiz Ruiz, Pilar Jimeno, David Ruiz de Angulo, Ángeles Ortiz, Luisa F Martínez de Haro, Miguel Marín, Pedro Cascales, Gema Ruiz García, Eduardo Ortiz Ruiz, Pascual Parrilla
INTRODUCTION: hereditary diffuse gastric cancer (HDGC) is a recently reported hereditary cancer syndrome. Patients with suspected HDGC must be under surveillance via endoscopy and multiple biopsies. As an alternative, some studies suggest prophylactic gastrectomy (PG) for disease carriers. The goal of this article was to report our experience with a CDH1 mutation positive family who underwent PG. PATIENTS AND METHODS: the index case was a 34-year-old female diagnosed with diffuse gastric adenocarcinoma and massive carcinomatosis...
November 23, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/30465515/single-chain-antibody-against-reg4-suppresses-gastric-cancer-cell-growth-and-enhances-5-fu-induced-cell-death-in-vitro
#17
Xue-Qing Zhang, Lu-Ting Yu, Pei Du, Tian-Qi Yin, Zhi-Yuan Zhang, Ying Xu, Xiang Li, You-Jie Li, Min Wang, Chen Luo
Regenerating islet-derived gene family member 4 (Reg4), a well-investigated growth factor in the regenerative pancreas, has recently been reported to be highly associated with a majority of gastrointestinal cancers. Pathological hyper-expression or artificial over-expression of Reg4 causes acceleration of tumor growth, migration, and resistance to chemotherapeutic 5-Fluorouracil (5-FU). Until now, no method has been successfully established for eliminating the effects of Reg4 protein. This study reports the production of an engineered immunoglobin, a single-chain variable fragment (scFv-Reg4), to specifically bind Reg4 and block the bioactivity...
November 21, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30460342/recent-updates-in-perioperative-chemotherapy-and-recurrence-pattern-of-gastric-cancer
#18
REVIEW
Shingo Kanaji, Satoshi Suzuki, Yoshiko Matsuda, Hiroshi Hasegawa, Masashi Yamamoto, Kimihiro Yamashita, Taro Oshikiri, Takeru Matsuda, Tetsu Nakamura, Yasuo Sumi, Yoshihiro Kakeji
Gastrectomy with D2 lymph node dissection has become the global standard procedure for locally advanced gastric cancer to maximally reduce locoregional recurrence. In East Asia, based on the evidence of the ACTS-GC and the CLASSIC trials, postadjuvant chemotherapy with S-1 monotherapy or capecitabine and oxaliplatin after curative D2 gastrectomy is the current standard strategy. However, approximately 20% to 30% of patients still develop distant recurrence even after these postadjuvant chemotherapies, especially in those with pathological stage III disease...
November 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/30457887/biobanking-of-fresh-frozen-gastric-cancer-tissues-impact-of-long-term-storage-and-clinicopathological-variables-on-rna-quality
#19
Xia Zhang, Qiu-Yue Han, Zhang-Sheng Zhao, Jian-Gang Zhang, Wen-Jun Zhou, Aifen Lin
BACKGROUND: Molecular research is increasingly dependent on high-quality biobanked biospecimens. Preanalytical variables in tissue processing and preservation may influence the RNA quality and research results. Hence, the effect of long-term storage and clinicopathological parameters on RNA quality needs to be elucidated. METHODS: Ninety gastric cancer tissue samples were collected and fresh-frozen in a -80°C freezer for 12 years (2006-2017). The histology was assessed and RNA integrity number (RIN) was detected by an Agilent 2100 Bioanalyzer...
November 20, 2018: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/30456678/survival-outcomes-of-two-phase-2-studies-of-adjuvant-chemotherapy-with-s-1-plus-oxaliplatin-or-capecitabine-plus-oxaliplatin-for-patients-with-gastric-cancer-after-d2-gastrectomy
#20
Yoshiaki Nakamura, Takeharu Yamanaka, Keisho Chin, Haruhiko Cho, Hitoshi Katai, Masanori Terashima, Kazunari Misawa, Motohiro Hirao, Kazuhiro Yoshida, Eiji Oki, Mitsuru Sasako, Yasunori Emi, Hideaki Bando, Yoshiyuki Kawashima, Tetsu Fukunaga, Masahiro Gotoh, Takako Ishibashi, Kohei Shitara
BACKGROUND: Two phase 2 trials of oxaliplatin-containing adjuvant therapy for patients with gastric cancer (GC) after D2 gastrectomy were conducted in Japan. The SOXaGC trial evaluated the tolerability and safety of adjuvant therapy with S-1 plus oxaliplatin (SOX), whereas the J-CLASSIC trial evaluated the feasibility of adjuvant therapy with capecitabine plus oxaliplatin (CAPOX). Because both were studies that did not evaluate survival results as study end points, the authors evaluated the survival outcomes for the patients in the two trials...
November 19, 2018: Annals of Surgical Oncology
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