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gastric cancer AND pathology

Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang, Jinshui Zhu
BACKGROUND: Circular RNAs (circRNAs) are a new type of non-coding RNAs and their functions in gastric cancer (GC) remain unclear. Recent studies have revealed that circRNAs play an important role in cancer development and certain types of pathological responses, acting as microRNA (miRNA) sponges to regulate gene expression. METHODS: CircNet was used to screen potential circRNAs and validated circYAP1 expression levels in 17 GC tissues by quantitative real-time PCR (qRT-PCR) and another 80 paired GC tissues by FISH...
October 18, 2018: Molecular Cancer
Massimo Rugge, Robert M Genta, Matteo Fassan, Elisa Valentini, Irene Coati, Stefano Guzzinati, Edoardo Savarino, Manuel Zorzi, Fabio Farinati, Peter Malfertheiner
OBJECTIVES: Gastritis OLGA-staging ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This long-term follow-up study quantifies the GC risk associated with each OLGA stage. METHODS: Consecutive patients (7436) underwent esophagogastroscopy (T-0), with mapped gastric biopsies, OLGA staging, and H. pylori status assessment. Patients with neoplastic lesion (invasive or non-invasive) at the index endoscopy (and/or within 12 months) were excluded. All patients were followed-up (T-1) by combining different sources of clinical/pathological information (Regional Registries of: (i) esophagogastroduodenoscopies; (ii) pathology reports; (iii) cancer, (iv) mortality)...
October 17, 2018: American Journal of Gastroenterology
Ernesto Quaresma Mendonça, Fernanda Cristina Simões Pessorrusso, Marcus Fernando Kodama Pertille Ramos, Carlos Eduardo Jacob, Joel Fernandez de Oliveira, Maria Sylvia Ribeiro, Adriana Safatle-Ribeiro, Bruno Zilberstein, Ulysses Ribeiro Júnior, Fauze Maluf-Filho
OBJECTIVE: Our aim was to evaluate the Japan Gastroenterological Endoscopy Society criteria for endoscopic submucosal resection of early gastric cancer (EGC) based on the experience in a Brazilian cancer center. METHODS: We included all patients who underwent endoscopic submucosal resection for gastric lesions between February 2009 and October 2016. Demographic data and information regarding the endoscopic resection, pathological report and follow-up were obtained...
October 11, 2018: Clinics
Jiayi Cao, Nan Wu, Yuying Han, Qiuqiu Hou, Yu Zhao, Yanan Pan, Xin Xie, Fulin Chen
DEAD (Asp-Glu-Ala-Asp) cassette helicase 21 (DDX21) is an ATP-dependent RNA helicase that is overexpressed in various malignancies. There is increasing evidence that DDX21 is involved in carcinogenesis and cancer progression by promoting cell proliferation. However, the functional role of DDX21 in gastric cancer is largely unknown. In this study, we observed that DDX21 was significantly up-regulated in gastric cancer tissues compared to paired adjacent normal tissues. The expression of DDX21 was closely related to the pathological stage of gastric cancer...
October 12, 2018: Biochemical and Biophysical Research Communications
Risa Kanai, Kenta Tane, Genichiro Ishii, Jun Suzuki, Takashi Sakai, Satoshi Okada, Tomohiro Miyoshi, Keiju Aokage, Masahiro Tsuboi
Background: Gastric cancer metastasis to the lung can rarely manifest as solitary pulmonary nodule. The surgical strategies are different between metastasis from gastric cancer and primary lung cancer; therefore, the clinical prediction of solitary pulmonary nodule is important. Methods: Between September 2006 and September 2016, 38 patients with a history of curative resection for gastric cancer who subsequently underwent lung resection for solitary pulmonary nodule at our institution were evaluated...
October 15, 2018: Japanese Journal of Clinical Oncology
Anthony M Villano, Alexander Lofthus, Thomas J Watson, Nadim G Haddad, M Blair Marshall
BACKGROUND: A minimally invasive intragastric approach to the gastroesophageal junction (GEJ) allows resection of intramural pathology while avoiding disruption of the lower esophageal sphincter (LES) and vagi. Few surgeons use this approach, thus little is known regarding its indications, feasibility, technical aspects, complication profile, and long-term outcomes. We reviewed our experience with this technique. METHODS: We performed a retrospective review of a prospectively maintained IRB-approved database covering the time period 01/01/2005-8/01/2017...
October 10, 2018: Annals of Thoracic Surgery
Kristy Lee, Kate Krempely, Maegan E Roberts, Michael J Anderson, Fatima Carneiro, Elizabeth Chao, Katherine Dixon, Joana Figueiredo, Rajarshi Ghosh, David Huntsman, Pardeep Kaurah, Chimene Kesserwan, Tyler Landrith, Shuwei Li, Arjen R Mensenkamp, Carla Oliveira, Carolina Pardo, Tina Pesaran, Matthew Richardson, Thomas P Slavin, Amanda B Spurdle, Mackenzie Trapp, Leora Witkowski, Charles S Yi, Liying Zhang, Sharon E Plon, Kasmintan A Schrader, Rachid Karam
The variant curation guidelines published in 2015 by the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) provided the genetics community with a framework to assess variant pathogenicity; however, these rules are not gene specific. Germline pathogenic variants in the CDH1 gene cause hereditary diffuse gastric cancer and lobular breast cancer, a clinically challenging cancer predisposition syndrome that often requires a multidisciplinary team of experts to be properly managed...
November 2018: Human Mutation
Seong Woo Jeon, Hyun Woo Park, Yong Hwan Kwon, Su Youn Nam, Hyun Seok Lee
BACKGROUND: The inappropriate selection of patients with early gastric cancer (EGC) for endoscopic submucosal dissection (ESD) may lead to additional surgery because of a non-curative resection. This study was performed to assess the accuracy of clinical decisions in ESD for EGC. METHODS: A total of 607 cases of EGC treated by ESD were prospectively enrolled from January 2011 to June 2014 at a single academic hospital. The 607 EGCs were divided into three groups (overestimated, same-estimated, and underestimated) based on pre-procedure endoscopic findings (indication) and pathological diagnosis after ESD (criteria)...
October 11, 2018: Digestive Diseases and Sciences
Ki Bum Park, Oh Kyoung Kwon, Wansik Yu
Purpose: This study evaluated midterm changes in body composition after open distal gastrectomy for early gastric cancer. Methods: Data from 138 gastric cancer patients who underwent open distal gastrectomy at Kyungpook National University Chilgok Hospital between January 2011 and December 2012 were collected and reviewed. Patients with pathological stage I gastric cancer and with no comorbidities at diagnosis were enrolled. Body composition data from segmental multifrequency bioelectrical impedance analysis were obtained preoperatively and at 1, 2, and 3 years after surgery...
October 2018: Annals of Surgical Treatment and Research
Miao-Zhen Qiu, Zi-Xian Wang, Yi-Xin Zhou, Da-Jun Yang, Feng-Hua Wang, Rui-Hua Xu
Background: The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gastric cancer incorporated several new changes. We aimed to assess the comparative prognostic values of the 7th and 8th AJCC pTNM staging systems in patients with gastric cancer (GC), and accordingly, to put forward a refined staging classification. Methods: The SEER database was queried to identify GC patients between 2004 and 2009. GC patients from Sun Yat-sen University Cancer Center (SYSUCC) were used as external validation data...
2018: Journal of Cancer
Bianca N Lourenço, Tiago Dos Santos, Carla Oliveira, Cristina C Barrias, Pedro L Granja
The field of stomach-directed therapeutics and diagnosis is still hampered by the lack of reliable in vitro models that closely mimic the gastric mucosa where gastric cancer cells are generally confined. Here we propose a rapid, complex, and innovative 3D in vitro model of the gastric mucosa, by extending a conventional gastric monolayer model to an inner stratum of the mucosa - the lamina propria. The developed model comprises normal stomach fibroblasts embedded in a 3D alginate-RGD hydrogel prepared on the basolateral side of a Transwell® insert, mimicking the extracellular matrix and cellular component of the lamina propria, onto which a moderately differentiated adenocarcinoma stomach cell line (MKN74) was seeded, reproducing the physiological conditions of the gastric barrier...
October 8, 2018: Acta Biomaterialia
Zeyang Wang, Zhi Lv, Hanxi Ding, Qian Xu, Liping Sun, Jingjing Jing, Yuan Yuan
The study aimed to investigate the role of serum EBV-VCA IgG in assessing gastric cancer (GC) risk and prognosis. A total of 1790 Northern Chinese participants with pathologically confirmed disease underwent EBV-VCA IgG serologic testing using enzyme-linked immunosorbent assay (ELISA), including 821 controls, 410 atrophic gastritis (AG) patients, and 559 GC patients. We found that positive EBV-VCA IgG was significantly associated with GC and its precursor, conferring a 1.55- and 1.36-fold increased risk of GC and AG, respectively (P = 0...
October 10, 2018: Cancer Medicine
Guangfei Cui, Feng Cai, Zhanwei Ding, Ling Gao
HMGB2 is an important protein in carcinogenesis. However, little is known regarding the specific role of HMGB2 in gastric cancer. In present study, HMGB2 expression was evaluated in 198 primary gastric cancer tissues and their adjacent non-tumor controls. The correlation between HMGB2 expression and clinic pathological features and survival was assessed. The effect of HMGB2 on cell proliferation, invasion, and glycolysis was examined in vitro. The expression of HMGB2 was significantly increased in human gastric cancer when compared with non-tumor tissues (P<...
October 5, 2018: Human Pathology
Bowen Shi, Fei Yuan, Fuhua Yan, Huan Zhang, Zilai Pan, Weibo Chen, Guilong Wang, Jingwen Tan, Yang Zhang, Yuqi Ren, Lianjun Du
BACKGROUND: Accurate and complete response evaluation after treatment is important to implement individualized therapy for gastric cancer. PURPOSE: To investigate the effectiveness of diffusion kurtosis imaging (DKI) and in-line X-ray phase contrast imaging (ILXPCI) in the assessment of the therapeutic efficacy by transforming growth factor beta 1 (TGF-β1) inhibition. STUDY TYPE: Prospective animal study. ANIMAL MODEL: Thirty nude mice subcutaneous xenotransplantation tumor model of gastric cancer for DKI and 10 peritoneal metastasis nude mice model for ILXPCI...
October 6, 2018: Journal of Magnetic Resonance Imaging: JMRI
Michelle L MacKintosh, Abigail E Derbyshire, Rhona J McVey, James Bolton, Mahshid Nickkho-Amiry, Catherine L Higgins, Martyna Kamieniorz, Philip W Pemberton, Bilal H Kirmani, Babur Ahmed, Akheel A Syed, Basil J Ammori, Andrew G Renehan, Henry C Kitchener, Emma J Crosbie
Obesity is the strongest risk factor for endometrial cancer (EC). To inform targeted screening and prevention strategies, we assessed the impact of obesity and subsequent bariatric surgery-induced weight loss on endometrial morphology and molecular pathways implicated in endometrial carcinogenesis. Blood and endometrial tissue were obtained from women with class III-IV obesity (body mass index ≥40kg/m2 and ≥50kg/m2 , respectively) immediately prior to gastric bypass or sleeve gastrectomy, and at two and 12 months' follow up...
October 5, 2018: International Journal of Cancer. Journal International du Cancer
Anbang He, Shiming He, Xuesong Li, Liqun Zhou
Long noncoding RNAs (lncRNAs) are a class of noncoding, endogenous, single-stranded RNAs longer than 200 nucleotides in length that are transcribed by RNA polymerase II. Mounting evidence has indicated that lncRNAs play key roles in several physiological and pathological processes by modifying gene expression at the transcriptional, posttranscriptional, epigenetic, and translation levels. Many reports have demonstrated that lncRNAs function as potential oncogene or tumour suppressors and thus play vital regulatory roles in tumourigenesis and tumour progression...
October 5, 2018: Cell Proliferation
Dong Won Baek, Byung Woog Kang, Jong Gwang Kim
The present study evaluated the survival impact of standard adjuvant chemotherapy and prognostic differences between Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) and EBV-negative gastric cancer (EBVnGC). A total of 276 patients were enrolled according to the following criteria: 1) pathologically diagnosed with primary gastric adenocarcinoma, 2) test results from EBV-encoded RNA in situ hybridization, 3) stage II/III according to the 7th edition of UICC/AJCC staging system for gastric cancer, and 4) postoperative adjuvant chemotherapy...
September 2018: Chonnam Medical Journal
Yi Hou, Xudong Wang, Jing Chen
BACKGROUND: To demonstrate the prognostic significance and value of lymph node ratio (LNR) and evaluate the possibility of becoming a new indicator to enhance the current Union for International Cancer Control (UICC)/American Joint Committee on Cancer (AJCC) tumor, lymph node, metastasis (TNM) staging system. METHODS: Our retrospective study included 221 patients who got gastric cancer and underwent curative gastrectomy between 2005 and 2012 at the Fourth Hospital Affiliated of China Medical University...
October 4, 2018: World Journal of Surgical Oncology
Kei Hosoda, Mizutomo Azuma, Chikatoshi Katada, Hiromitsu Moriya, Hiroaki Mieno, Kenji Ishido, Akira Ema, Hideki Ushiku, Takuya Wada, Marie Washio, Akinori Watanabe, Katsuhiko Higuchi, Satoshi Tanabe, Wasaburo Koizumi, Masahiko Watanabe, Keishi Yamashita
BACKGROUND: The prognosis of patients with gastric cancer with bulky node metastasis, linitis plastica (type 4), or large ulcero-invasive-type tumors (type 3) remains poor. We conducted a phase II study to evaluate the safety and efficacy of neoadjuvant chemotherapy with docetaxel, cisplatin, and S-1 (DCS) for establishing a new treatment modality that improves prognosis. METHODS: Patients received up to four 28-day cycles of DCS therapy (docetaxel at 40 mg/m2 , cisplatin at 60 mg/m2 on day 1, and S-1 at 40 mg/m2 twice daily for 2 weeks) followed by gastrectomy with D2 nodal dissection...
October 3, 2018: Gastric Cancer
Y-F Li, G-Y Zhu, Y Ma, H-Y Qu
OBJECTIVE: To investigate the expression of human myozenin 2 (MYOZ2) in cancer tissues and its effect on the prognosis of patients with gastric cancer. PATIENTS AND METHODS: Gastric cancer tissue and adjacent normal tissue specimens were obtained from a total of 258 patients together with complete clinicopathological data. Those patients were treated in Harbin Medical University Cancer Hospital from March 2007 to March 2012. Quantitative Real Time-Polymerase Chain Reaction (RT-PCR) was used to detect the expression of MYOZ2 messenger RNA (mRNA) in gastric cancer tissues and normal gastric tissues, and correlations between the expression level of MYOZ2 in gastric cancer tissues and the clinicopathological parameters of patients were analyzed...
September 2018: European Review for Medical and Pharmacological Sciences
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