keyword
https://read.qxmd.com/read/38536655/18f-fdg-pet-ct-metabolism-multi-parameter-prediction-of-chemotherapy-efficacy-in-locally-progressive-gastric-cancer
#1
JOURNAL ARTICLE
Luqiang Jin, Linghe Zhang, Liping Fu, Fahuan Song, Aiping Cheng
PURPOSE: This study aimed to use an 18 F-FDG PET/CT multiparametric quantitative analysis to determine the efficacy of neoadjuvant chemotherapy in patients with locally progressive gastric cancer. MATERIALS AND METHODS: We conducted a retrospective analysis of 34 patients with pathologically identified gastric cancer who received neoadjuvant chemotherapy and surgery. Chemotherapy regimens were followed and 18 F-FDG PET/CT was conducted. We ascertained multiparamaters of the target lesions pre- and post-treatment and determined the ideal cutoff values for the percentage change in biomarkers...
March 27, 2024: Annals of Nuclear Medicine
https://read.qxmd.com/read/38532588/-propensity-score-matching-analysis-of-the-short-term-efficacy-of-kamikawa-versus-double-tract-reconstruction-in-laparoscopic-proximal-gastric-cancer-surgery
#2
JOURNAL ARTICLE
H C Yang, J X He, Y Yang, Z Han, B Zhang, S Zhou, T Wu, Q Qiao, X L He, N Wang
Objective: To compare the short-term efficacy of Kamikawa anastomosis and double-tract reconstruction (DTR) after proximal gastrectomy. Methods: This was a propensity score matched, retrospective, cohort study. Inclusion criteria comprised age 20-70 years, diagnosis of gastric cancer by pathological examination of preoperative endoscopic biopsies, tumor diameter ≤4 cm, and location in the upper 1/3 of the stomach (including the gastroesophageal junction), and TNM stage IA, IB, or IIA. The study cohort comprised 73 patients who had undergone laparoscopic proximal gastric cancer radical surgery in the Department of Gastroenterology, Tangdu Hospital, Air Force Medical University between June 2020 and February 2023, 19 of whom were in the Kamikawa group and 54 in the DTR group...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532198/analysis-of-endoscopic-and-pathological-features-of-6961-cases-of-gastric-cancer
#3
JOURNAL ARTICLE
Junhui Lu, Qing Wang, Hezhao Zhang, Jingwei Liu, Jinnan Ren, Jing Fan, Jingwen Gong, Yue Sui, Xing Chen
Gastric cancer (GC) stage and tissue differentiation affect treatment efficacy and prognosis, highlighting the importance of understanding the risk factors that affect these parameters. Therefore, this study analyzed risk factors affecting the GC stage and differentiation and the relationships between the cancer site and the sex and age of the patient. We collected clinical data from 6961 patients with GC, including sex, age, endoscopic lesion location, and pathological differentiation. Patients were grouped based on GC stage (early or advanced), differentiation (well or poorly differentiated), and lesion site (upper stomach [cardia and fundus], middle stomach [gastric body], and lower stomach [gastric antrum])...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531046/experience-with-laparoscopic-and-robotic-colon-surgery-together-with-other-major-minimally-invasive-procedures-for-unrelated-pathologies
#4
JOURNAL ARTICLE
Hugo J R Bonatti
Background: Indications for combined colon surgery together with other procedures include oncologic multivisceral resections and abdominal trauma. It is unclear if combining minimally invasive (MI) colon surgery with unrelated other procedures increases the risk for complications. Patients and Methods: The surgical database from two institutions during a 10-year period was queried for combined colon surgeries together with other interventions. All open cases, combined cases performed for one pathology and MI colectomies together with a minor procedure, were excluded...
March 27, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38524749/lifestyle-factors-on-the-long-term-survival-of-gastric-cancer-patients-after-radical-resection-a-cohort-study
#5
JOURNAL ARTICLE
Huadong Wu, Jinjia Zhang, Baojun Zhou
BACKGROUND: This retrospective cohort study aimed to evaluate the effect of lifestyle factors (e.g., smoking, drinking, physical exercise, and sleep duration) on the long-term survival of gastric cancer (GC) patients after radical resection. MATERIALS AND METHODS: GC patients after radical resection were enrolled from January 2016 to December 2017. Their baseline clinical data, lifestyle factors, and prognosis were collected. The primary endpoint was all-cause death...
2024: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/38523553/nomogram-for-predicting-pathological-response-to-neoadjuvant-treatment-in-patients-with-locally-advanced-gastric-cancer-data-from-a-phase-iii-clinical-trial
#6
JOURNAL ARTICLE
Han Shao, Nai Li, Yi-Hong Ling, Ji-Jin Wang, Yi Fang, Ming Jing, Zhi-Wei Zhou, Yu-Jing Zhang
PURPOSE: This study aimed to establish a nomogram using routinely available clinicopathological parameters to predict the pathological response in patients with locally advanced gastric cancer (LAGC) undergoing neoadjuvant treatment. MATERIALS AND METHODS: We conducted this study based on the ongoing Neo-CRAG trial, a prospective study focused on preoperative treatment in patients with LAGC. A total of 221 patients who underwent surgery following neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) at Sun Yat-sen University Cancer Center between June 2013 and July 2022 were included in the analysis...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38519974/development-and-validation-of-a-radiopathomics-model-based-on-ct-scans-and-whole-slide-images-for-discriminating-between-stage-i-ii-and-stage-iii-gastric-cancer
#7
JOURNAL ARTICLE
Yang Tan, Li-Juan Feng, Ying-He Huang, Jia-Wen Xue, Zhen-Bo Feng, Li-Ling Long
OBJECTIVE: This study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative hematoxylin and eosin (HE) stained slides to predict the pathological staging of gastric cancer (stage I-II and stage III). METHODS: This study included a total of 202 gastric cancer patients with confirmed pathological staging (training cohort: n = 141; validation cohort: n = 61). Pathological histological features were extracted from HE slides, and pathological models were constructed using logistic regression (LR), support vector machine (SVM), and NaiveBayes...
March 22, 2024: BMC Cancer
https://read.qxmd.com/read/38518198/the-pathological-roles-and-potential-mechanisms-of-vascular-endothelial-growth-factor-receptor-3-in-gastric-cancer
#8
JOURNAL ARTICLE
Xiu-Feng Li, Xiu-Juan Zhang, Fu-Rong Hao, Xiao-Tong Dong, Guo-Dong Xu, Yun-Xiang Zhang
OBJECTIVE: To investigate the roles and underlying mechanisms of vascular endothelial growth factor receptor-3 (VEGFR-3) in gastric cancer (GC). METHODS: VEGFR-3 gene expression profiles in human gastric adenocarcinoma (GAC) tissues were analysed using The Cancer Genome Atlas database. Human GC cell lines and were used for in vitro studies. Mouse models of GC and distant metastasis were used for in vivo studies. Silencing of VEGFR-3 gene expression was achieved using small interfering RNA...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38518078/comment-on-association-of-systemic-inflammatory-markers-and-tertiary-lymphoid-structure-with-pathological-complete-response-in-gastric-cancer-patients-receiving-preoperative-treatment-a-retrospective-cohort-study
#9
JOURNAL ARTICLE
Shanshan Xie, Yong Zhi, Changming Shao, Binfang Zeng
No abstract text is available yet for this article.
March 21, 2024: International Journal of Surgery
https://read.qxmd.com/read/38515955/endoscopic-features-and-treatments-of-gastric-cystica-profunda
#10
JOURNAL ARTICLE
Zi-Han Geng, Yan Zhu, Pei-Yao Fu, Yi-Fan Qu, Wei-Feng Chen, Xia Yang, Ping-Hong Zhou, Quan-Lin Li
BACKGROUND: Gastric cystica profunda (GCP) represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal layers. GCP is often linked to, or may progress into, early gastric cancer (EGC). AIM: To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment, thereby offering guidance for diagnosis and treatment. METHODS: This retrospective study involved 104 patients with GCP who underwent endoscopic resection...
February 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38514081/-18-f-bms-986229-pet-to-assess-programmed-death-ligand-1-status-in-gastroesophageal-cancer
#11
JOURNAL ARTICLE
Samuel L Cytryn, Neeta Pandit-Taskar, Melissa A Lumish, Steven B Maron, Ping Gu, Geoffrey Y Ku, Joanne F Chou, Marinela Capanu, Ariel Antoine, Diane Loegel, Lara Feder, Steven Philemond, Serge K Lyashchenko, Jason S Lewis, Viktoriya Paroder, Amitabh Srivastava, Laura H Tang, Heiko Schoder, Yelena Y Janjigian
Anti-programmed death 1 (PD-1) inhibitors are the standard of care for advanced gastroesophageal cancer. Although recommendations and approval by regulatory agencies are often based on programmed death ligand 1 (PD-L1) expression, pathologic assessments of PD-L1 status have several limitations. Single-site biopsies do not adequately capture disease heterogeneity within individual tumor lesions or among several lesions within the same patient, the PD-L1 combined positive score is a dynamic biomarker subject to evolution throughout a patient's disease course, and repeated biopsies are invasive and not always feasible...
March 21, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38513167/peritoneal-tumor-dna-as-a-prognostic-biomarker-in-gastric-cancer-a-systematic-review-and-meta-analysis
#12
REVIEW
Zexi Allan, Sasha Witts, Darren J Wong, Margaret M Lee, Jeanne Tie, Niall C Tebbutt, Nicholas J Clemons, David S Liu
PURPOSE: Gastric cancers commonly spread to the peritoneum. Its presence significantly alters patient prognosis and treatment-intent; however, current methods of peritoneal staging are inaccurate. Peritoneal tumor DNA (ptDNA) is tumor-derived DNA detectable in peritoneal lavage fluid. ptDNA positivity may indicate peritoneal micrometastasis and may be more sensitive than cytology in staging the peritoneum. In this meta-analysis, we evaluated the prognostic potential of ptDNA in gastric cancer...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38511028/a-rare-case-of-primary-gastric-signet-ring-cell-carcinoma-a-review-of-guidelines-for-the-management-of-gastric-cancer
#13
Ronald Mauricio Blanco Montecino, Mikhail Sukhorosl, Mayi Ann Francis, Neeraj Kancherla, Ogbonnaya Akuma, Nkiruka Lauretta Nwangene, Shreyas Nandyal, Rohan Raj, Chinaza Mercy Akuma, Tamer Zahdeh, Sharanya Kaushik, Adil M Khan
Gastric carcinoma is the fifth most common and the third leading cause of cancer deaths worldwide. The incidence of diffuse-type gastric cancer, of which signet ring cell carcinoma is a subtype, is rising in the world. Due to non-specific gastritis-like symptoms, difficulty in assessing true tumor characteristics owing to its horizontal spread, and non-distinguishable endoscopic appearance from other gastric pathologies, the diagnosis of this subtype is challenging. We present a case of a 67-year-old woman with progressively worsening abdominal pain who came for an endoscopic ultrasound evaluation of an incidentally noted pancreatic cyst on a previous MRI...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38509147/the-e3-ligase-trim7-suppresses-the-tumorigenesis-of-gastric-cancer-by-targeting-slc7a11
#14
JOURNAL ARTICLE
Qishuai Chen, Tongtong Zhang, Runzhi Zeng, Kunmiao Zhang, Bingjun Li, Zhenguo Zhu, Xiaomin Ma, Yun Zhang, Linchuan Li, Jiankang Zhu, Guangyong Zhang
Tripartite motif-containing protein 7 (TRIM7), as an E3 ligase, plays an important regulatory role in various physiological and pathological processes. However, the role of TRIM7 in gastric cancer (GC) is still undefined. Our study detected the expression of TRIM7 in clinical specimens and investigated the regulatory effect and molecular mechanism of TRIM7 on GC progression through in vitro and in vivo experiments. Our finding showed that TRIM7 was significantly downregulated in GC, and patients with high expression of TRIM7 showed long overall survival...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38507065/dna-methylation-profiling-identifies-epigenetic-signatures-of-early-gastric-cancer
#15
JOURNAL ARTICLE
Zhongyue Shi, Xinmeng Guo, Xiumei Hu, Ruiqi Li, Xue Li, Jun Lu, Mulan Jin, Xingran Jiang
Research on the DNA methylation status of gastric cancer (GC) has primarily focused on identifying invasive GC to develop biomarkers for diagnostic. However, DNA methylation in noninvasive GC remains unclear. We conducted a comprehensive DNA methylation profiling study of differentiated-type intramucosal GCs (IMCs). Illumina 850K microarrays were utilized to assess the DNA methylation profiles of formalin-fixed paraffin-embedded tissues from eight patients who were Epstein-Barr virus-negative and DNA mismatch repair proficient, including IMCs and paired adjacent nontumor mucosa...
March 20, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38506237/body-composition-change-indices-combined-with-prognostic-nutritional-index-predicts-the-clinical-outcomes-of-patients-with-gastric-cancer-treated-with-immune-checkpoint-inhibitor
#16
JOURNAL ARTICLE
Guiming Deng, Dayong Zhu, Zhongze Du, Yingwei Xue, Hongjiang Song, Yuanzhou Li
OBJECTIVE: This study aimed to investigate the prognostic significance of the Prognostic Nutritional Index (PNI) in conjunction with body composition change indices, namely subcutaneous fat area (SFA) and skeletal muscle index (SMI), with regard to clinical outcomes in patients with gastric cancer (GC) undergoing immune checkpoint inhibitors (ICIs) treatment. METHODS: This retrospective investigation encompassed patients with comprehensive clinical and pathological data, inclusive of portal phase enhanced CT images...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38505912/a-systems-biology-approach-unveils-a-critical-role-of-dpp4-in-upper-gastrointestinal-cancer-patient-outcomes
#17
JOURNAL ARTICLE
Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M Yallapu, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan
Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive...
2024: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/38500887/case-report-a-case-of-advanced-gastric-cancer-with-multiple-skin-metastases-with-significant-relief-from-immunotherapy
#18
Wen Hao, Ruimin Chang, Jingxin Liu, Yibing Wang, Meijin Ren, Kai Xin, Baorui Liu, Jiaqi Xie, Yang Yang
Gastric cancer is the fifth leading cause of cancer-related mortality worldwide, with a low 5-year survival rate in advanced stages. Cutaneous metastasis is rare in gastric cancer, with only 0.8-1% incidence. We reported a rare case of female gastric cancer. The patient had undergone subtotal gastrectomy and chemotherapy 13 years ago, followed by a subsequent surgery of residual stomach, partial jejunum, and partial colon resection 11 years later. The pathological examination revealed poorly differentiated stomach adenocarcinoma, Lauren classification: diffuse type...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38500767/case-report-cutaneous-metastases-as-a-first-manifestation-from-breast-cancer-with-concurrent-gastric-metastases
#19
Lulu Xu, Congcong Wang, Xiaoling Yang, Liangliang Dong
Background: Breast cancer represents a leading cause of malignancy among Chinese women, posing a significant health burden. The diagnosis of metastatic breast cancer, particularly to uncommon sites like the skin and stomach, presents distinct challenges. Case introduction: This case report describes a 71-year-old Chinese women with a persistent back rash lasting more than 6 months. Physical examination revealed red papules on her back. Immunohistochemistry confirmed positive for cytokeratin 7(CK7), GATA-3 and GCDFP15, as well as negative staining of cytokeratin 20 (CK20), suggesting breast cancer metastasis...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38496754/prediction-of-lymph-node-metastasis-in-advanced-gastric-adenocarcinoma-based-on-dual-energy-ct-radiomics-focus-on-the-features-of-lymph-nodes-with-a-short-axis-diameter-%C3%A2-6-mm
#20
JOURNAL ARTICLE
Yang You, Yan Wang, Xianbo Yu, Fengxiao Gao, Min Li, Yang Li, Xiangming Wang, Litao Jia, Gaofeng Shi, Li Yang
OBJECTIVE: To explore the value of the features of lymph nodes (LNs) with a short-axis diameter ≥6 mm in predicting lymph node metastasis (LNM) in advanced gastric adenocarcinoma (GAC) based on dual-energy CT (DECT) radiomics. MATERIALS AND METHODS: Data of patients with GAC who underwent radical gastrectomy and LN dissection were retrospectively analyzed. To ensure the correspondence between imaging and pathology, metastatic LNs were only selected from patients with pN3, nonmetastatic LNs were selected from patients with pN0, and the short-axis diameters of the enrolled LNs were all ≥6 mm...
2024: Frontiers in Oncology
keyword
keyword
167296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.