Read by QxMD icon Read


Benjamin Johansson, Helka Sahi, Virve Koljonen, Tom Böhling
BACKGROUND: Merkel cell carcinoma (MCC) tumor samples frequently express B-lymphoid lineage markers. However, the reasons for expression of specific B-lymphoid lineage markers are still unclear. We studied in a large pool of tissue microarray MCC samples, validate in a larger cohort the expression of TdT and Pax-5, which are two B-lymphoid lineage markers. METHODS: Immunoexpression and staining intensities of TdT and Pax-5 were statistically correlated with patient, tumor, Merkel cell polyoma virus (MCV), and disease-specific parameters...
October 12, 2018: Journal of Cutaneous Pathology
Taíse Lima de Oliveira Cerqueira, Yanne Rocha Ramos, Giorgia Bruna Strappa, Mariana Souza de Jesus, Jailciele Gonzaga Santos, Camila Sousa, Gildásio Carvalho, Vladimir Fernandes, Ney Boa-Sorte, Tatiana Amorim, Thiago Magalhães Silva, Ana Marice Teixeira Ladeia, Angelina Xavier Acosta, Helton Estrela Ramos
OBJECTIVE: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. SUBJECTS AND METHODS: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realized by investigating the presence of mutations in the transcription factor genes involved in thyroid development...
August 2018: Archives of Endocrinology and Metabolism
Prosun Das, Kylee J Veazey, Hieu T Van, Saakshi Kaushik, Kevin Lin, Yue Lu, Masaru Ishii, Junichi Kikuta, Kai Ge, Andre Nussenzweig, Margarida A Santos
The bone is essential for locomotion, calcium storage, and harboring the hematopoietic stem cells (HSCs) that supply the body with mature blood cells throughout life. HSCs reside at the interface of the bone and bone marrow (BM), where active bone remodeling takes place. Although the cellular components of the BM niche have been characterized, little is known about its epigenetic regulation. Here we find that the histone methylation regulator PTIP (Pax interaction with transcription-activation domain protein-1) is required to maintain the integrity of the BM niche by promoting osteoclast differentiation...
October 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
Lester D R Thompson, Kelly R Magliocca, Simon Andreasen, Katlin Kiss, Lisa Rooper, Edward Stelow, Bruce M Wenig, Justin A Bishop
Endolymphatic sac tumors (ELSTs) are rare, slowly growing temporal bone neoplasms which show a high association with von Hippel-Lindau (VHL) syndrome. The immunohistochemistry evaluation of these papillary-cystic neoplasms frequently raises the differential diagnosis with renal cell carcinoma, among other metastatic neoplasms, whether in VHL patients or not. A cohort of 26 patients with ELSTs were evaluated for histologic features, immunohistochemistry findings, and association with VHL. Standard immunohistochemistry evaluation was performed...
October 5, 2018: Head and Neck Pathology
Leal Herlitz, Ondrej Hes, Michal Michal, Maria Tretiakova, Miguel Reyes-Múgica, Jane K Nguyen, Megan L Troxell, Christopher G Przybycin, Cristina Magi-Galluzzi, Jesse K McKenney
Renal mass lesions with a follicular architecture resembling atrophic kidney have been described, but their distinction from thyroid-like follicular carcinoma of the kidney remains controversial. We collected 8 cases of this purported "atrophic kidney"-like lesion to fully describe their clinical and histologic spectrum, their possible etiology, and to discuss their distinction from other renal neoplasms. Eight total cases were identified with patient ages ranging from 9 to 48 years (mean: 29 y; median: 28...
October 3, 2018: American Journal of Surgical Pathology
Richard Benedict Supan Roxas, Marie Christine Fajatin Bernardo, Araceli Pacis Jacoba, Janet Lim-Dy, Anarose Cariaga Alvarado, Jasna Metovic, Laura Annaratone, Mauro Papotti
We describe the first case of primary thymic adenocarcinoma with signet ring cell features. The patient was a 39-year-old Filipino male who presented with a huge anterior mediastinal mass extending to the left supraclavicular fossa, which underwent an incisional biopsy. Extensive clinicoradiological work-up showed no evidence of any primary tumor in other organs, and radiological imaging confirmed a primary tumor location in the thymic area. He later developed bilateral pleural and pericardial effusions and eventually died of his tumor...
September 27, 2018: International Journal of Surgical Pathology
Graciliano Nicolás Marichal, Deivis Ávila, Ángela Hernández, Isidro Padrón, Cristina Castejón
In this article, a study of characteristic vibrations of marine oils separation system is presented. Vibrations analysis allows for the extraction of representative features that could be related to the lifetime of their pieces. Actual measurements were carried out on these systems on Ro-Pax vessels to transport passengers and freight. The vibrations obtained were processed in the frequency domain and following this, they were used in a Genetic Neuro-Fuzzy System in order to design new predictive maintenance strategies...
September 19, 2018: Sensors
Huiying He, Kiril Trpkov, Petr Martinek, Ozlem Tanas Isikci, Cristina Maggi-Galuzzi, Reza Alaghehbandan, Anthony J Gill, Maria Tretiakova, Jose Ignacio Lopez, Sean R Williamson, Delia Perez Montiel, Maris Sperga, Eva Comperat, Fadi Brimo, Ali Yilmaz, Kristyna Pivovarcikova, Kveta Michalova, David Slouka, Kristyna Prochazkova, Milan Hora, Michael Bonert, Michal Michal, Ondrej Hes
The spectrum of the renal oncocytic tumors has been expanded in recent years to include several novel and emerging entities. We describe a cohort of novel, hitherto unrecognized and morphologically distinct high-grade oncocytic tumors (HOT), currently diagnosed as "unclassified" in the WHO classification. We identified 14 HOT by searching multiple institutional archives. Morphologic, immunohistochemical (IHC), molecular genetic, and molecular karyotyping studies were performed to investigate these tumors...
September 19, 2018: Virchows Archiv: An International Journal of Pathology
Matthew R Hart, Donovan J Anderson, Christopher C Porter, Tobias Neff, Michael Levin, Marshall S Horwitz
PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and heterozygous germline loss-of-function PAX5 mutations cause autosomal dominant predisposition to ALL. At least in mice, Pax5 is required for pre-B cell maturation, and leukemic remission occurs when Pax5 expression is restored in a Pax5-deficient mouse model of ALL...
September 2018: PLoS Genetics
Nicolas Leblanc, Jason Harquail, Nicolas Crapoulet, Rodney J Ouellette, Gilles A Robichaud
BACKGROUND/AIM: In breast cancer, Pax-5 promotes pro-epithelial features and suppresses malignant cancer processes. However, the molecular mechanism of this antitumor activity remains largely unknown. This study aimed to identify the cellular roles of Pax-5-regulated miRNAs in breast cancer progression. MATERIALS AND METHODS: After transient transfection of Pax-5 in MDA-MB-231 breast cancer cells, Pax-5-regulated miRNA expression was examined by next-generation sequencing...
September 2018: Anticancer Research
Luiza S Cruz, Thais L de Oliveira, Carla C Kanunfre, Katia S Paludo, Bruno R Minozzo, Ana P Prestes, Mei Wang, Daniel Fernandes, Fábio A Dos Santos, Vamshi K Manda, Shabana I Khan, Zulfiqar Ali, Iara J de Messias-Reason, Bharathi Avula, Ikhlas A Khan, Flávio L Beltrame
BACKGROUND: Medicinal plants are an important source to identify new active pharmaceutical compounds. Traditionally, the sap of Euphorbia umbellata is widely used to treat cancer and inflammatory conditions. These effects have been attributed to the presence of terpenes and phenolic compounds in the extracts of this plant. Euphol, a tetracyclic triterpene alcohol, is one of the major compounds present in Euphorbia species, and some biological activities have been attributed to this compound...
August 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Kosuke Ueda, Akihide Watanabe, Norihiko Yokoi, Manabu Sugimoto, Hideki Fukuoka, Katsuhiko Shinomiya, Shigeru Kinoshita, Saul Rajak, Dinesh Selva
PURPOSE: The purpose of this article is to present a novel technique, as well the histopathological findings, of dacryoendoscopic guided nasolacrimal duct (NLD) biopsy for recurrent nasolacrimal duct obstruction (NLDO). METHODS: This study involved subjects with recurrent NLDO. Direct endoscopic probing or sheath-guided endoscopic probing was used for the initial intubation in all treated eyes, and the stent had been removed at between 2 and 11 months (mean 3.5 months) post-intubation with dacryoendoscopic confirmation of patency and mucosal regeneration...
August 24, 2018: Orbit
L-C Horn, S Opitz, R Handzel, C E Brambs
Ectopic pregnancies are the main sources of pregnancy-related morbidity and mortality in the first trimester. They are usually located in the ampullary part of the fallopian tube and the incidence increases in the setting of assisted reproductive techniques, older age at the time of the first pregnancy, and prior adnexal procedures. The clinical aspects and diagnostic challenges of an ectopic pregnancy for the pathologist are to be outlined. A review of the relevant literature was performed. Proof of gestational tissue is of utmost importance in the pathological-anatomical evaluation of an ectopic pregnancy...
September 2018: Der Pathologe
Fatima Maqoud, Angela Curci, Rosa Scala, Alessandra Pannunzio, Federica Campanella, Mauro Coluccia, Giuseppe Passantino, Nicola Zizzo, Domenico Tricarico
The effects of Ca2+ -activated K⁺ (BK) channel modulation by Paxilline (PAX) (10-7 ⁻10-4 M), Iberiotoxin (IbTX) (0.1⁻1 × 10-6 M) and Resveratrol (RESV) (1⁻2 × 10-4 M) on cell cycle and proliferation, AKT1pSer473 phosphorylation, cell diameter, and BK currents were investigated in SH-SY5Y cells using Operetta-high-content-Imaging-System, ELISA-assay, impedentiometric counting method and patch-clamp technique, respectively. IbTX (4 × 10-7 M), PAX (5 × 10-5 M) and RESV (10-4 M) caused a maximal decrease of the outward K⁺ current at +30 mV (Vm) of -38...
August 18, 2018: International Journal of Molecular Sciences
W B Yang, X W Zhang, J Yang, Q Li, T Xu, W J Bai
Multilocular prostatic cystadenoma (MPC) is a rare benign tumor that originates from the prostate itself. MPC is usually characterized by large multilocular cysts located between the rectum and bladder. The clinical presentation includes obstructive voiding symptoms, such as poor stream, intermittency, sensation of incomplete emptying, acute urinary retention and sometimes constipation symptoms due to mechanical compression of the lower intestine. Most of the previously reported patients with MPC underwent open surgery...
August 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Peter M Kopittke, Tracy Punshon, David J Paterson, Ryan V Tappero, Peng Wang, F Pax C Blamey, Antony van der Ent, Enzo Lombi
Understanding the distribution of elements within plant tissues is important across a range of fields in plant science. In this review, we examine synchrotron-based x-ray fluorescence microscopy (XFM) as an elemental imaging technique in plant sciences, considering both its historical and current uses as well as discussing emerging approaches. XFM offers several unique capabilities of interest to plant scientists, including in vivo analyses at room temperature and pressure, good detection limits (approximately 1-100 mg kg-1 ), and excellent resolution (down to 50 nm)...
October 2018: Plant Physiology
Laura R Hardy, Amrita Salvi, Joanna E Burdette
High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian tube or the ovarian surface epithelium. The PAX (paired box) genes PAX2 and PAX8 are lineage-specific transcription factors required during development of the fallopian tube but not in the development of the ovary. PAX2 expression is lost early in serous cancer progression, while PAX8 is expressed ubiquitously. These proteins are implicated in migration, invasion, proliferation, cell survival, stem cell maintenance, and tumor growth...
August 8, 2018: Cancers
Mika Shimamura, Nobuyuki Shibusawa, Tomomi Kurashige, Zhanna Mussazhanova, Hiroki Matsuzaki, Masahiro Nakashima, Masanobu Yamada, Yuji Nagayama
The BRAFV600E mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAFV600E under elevated TSH levels induced thyroid cancers in several genetically engineered mouse models. In contrast, we found that postnatal expression of BRAFV600E under physiologic TSH levels failed to develop thyroid cancers in conditional transgenic Tg(LNL-BrafV600E) mice injected in the thyroid with adenovirus expressing Cre under control of the thyroglobulin promoter (Ad-TgP-Cre)...
2018: PloS One
Audrey Deeken-Draisey, Guang-Yu Yang, Juehua Gao, Borislav A Alexie
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of thyroid cancer. A single institution thyroid cancer cohort of ATC was identified within the last ten years at our institution. Retrospective analysis revealed that the frequency of ATC was 0.5% (11/2106 thyroid carcinomas). The average age at diagnosis of ATC was 74 years, and the female to male ratio was 1.2:1. ATC presented as a rapidly enlarging neck mass involving predominantly the left thyroid lobe (7/11, 64%). Cervical adenopathy was present in 7/11 (64%) of cases...
July 31, 2018: Human Pathology
Maysa Al-Hussaini, Isam Lataifeh, Imad Jaradat, Ghadeer Abdeen, Lian Otay, Osama Badran, Areej Abu Sheikha, Abdulmajeed Dayyat, Mousa El Khaldi, Shaymaa Ashi Al-Loh
Undifferentiated endometrial carcinoma (UEC) is a rare and poorly recognized entity, associated with a poor outcome. The clinical, pathologic, and immunohistochemical features of 17 cases diagnosed at our center are described. The median age was 60 yr. Postmenopausal bleeding was the most common presenting symptom (76.9%). Most patients presented with advanced stage (64.7%). Total hysterectomy with bilateral salpingo-oophorectomy was the commonly offered surgical treatment (80.0%). Nine (52.9%) patients received adjuvant treatment...
November 2018: International Journal of Gynecological Pathology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"