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C Koç, K Kamburoğlu, G Sönmez, F Yılmaz, O Gülen, S Karahan
AIM: To assess observer performance in detecting endodontic complications using three different CBCT units with and without the application of artefact reduction modes. METHODOLOGY: The study involved 40 freshly extracted human mandibular teeth (n=10 per group) and divided randomly into four endodontic complication groups. Group 1) Instrument fracture; Group 2) Strip perforation; Group 3) Canal underfilling; Group 4) Canal overfilling. Images of each tooth were obtained using three different CBCT units offering artefact reduction algorithms: the ProMax 3D Max, the Pax Flex 3D, and the Dentri S...
December 2, 2018: International Endodontic Journal
Klemen Čamernik, Janja Marc, Janja Zupan
The most studied sources of mesenchymal stem/stromal cells (MSCs) are bone marrow and adipose tissue. However skeletal muscle represents an interesting source of diverse subpopulations of MSCs, such as paired box 7 (Pax-7)-positive satellite cells, fibro-/adipogenic progenitors, PW1-positive interstitial cells and others. The specific properties of some of these muscle-derived cells have encouraged the development of cell therapies for muscle regeneration. However, the identity and multilineage potential of the diverse muscle-resident cells should first be evaluated in vitro, followed by in vivo clinical trials to predict their regenerative capacity...
November 30, 2018: Methods in Molecular Biology
Margaret Cho, Gabriel Acosta-Gonzalez, Tamar C Brandler, Atreyee Basu, Xiao-Jun Wei, Anthony Simms
Papillary thyroid carcinoma (PTC) is generally associated with an excellent long-term outcome. Distant metastasis is rare with only 5-7% of patients developing distant disease. Metastasis of PTC to the pancreas is an exceedingly rare occurrence. To date, few cases have been reported. We present the case of an 81-year-old man with past medical history of PTC status post total thyroidectomy with local recurrence treated with radioactive iodine and selective neck dissection. Ten years after his initial diagnosis, PET-CT scan revealed a new hypermetabolic 1...
November 27, 2018: Diagnostic Cytopathology
Dou-Dou Chen, Tao Yang, Si-Quan Zhu
BACKGROUND: One prominent pathological feature of congenital aniridia is hypoplasia of the iris, often accompanied by other eye abnormalities. The objective of this study is to identify gene mutations responsible for autosomal dominance in a Chinese family with congenital aniridia, progressive cataracts and mental retardation. METHODS: A total of 11 family members, including 6 affected and 5 unaffected individuals were recruited. Whole exome sequencing was performed on the proband and Sanger sequencing was applied to identify the causal mutation in the other family members and control samples...
November 14, 2018: European Journal of Ophthalmology
Yu-Chieh David Chen, Scarlet Jinhong Park, William W Ja, Anupama Dahanukar
In Drosophila , Pox-neuro ( Poxn ) is a member of the Paired box (Pax) gene family that encodes transcription factors with characteristic paired DNA-binding domains. During embryonic development, Poxn is expressed in sensory organ precursor (SOP) cells of poly-innervated external sensory (p-es) organs and is important for specifying p-es organ identity (chemosensory) as opposed to mono-innervated external sensory (m-es) organs (mechanosensory). In Poxn mutants, there is a transformation of chemosensory bristles into mechanosensory bristles...
2018: Frontiers in Cellular Neuroscience
Frederick Adam Zeiler, Ari Ercole, Manuel Cabeleira, Marco Carbonara, Nino Stocchetti, David Menon, Peter Smieleweski, Marek Czosnyka
It has been postulated previously, that individualized cerebral perfusion pressure (CPP) targets can be derived from cerebrovascular reactivity indices. Differences between real CPP and target CPP ( named generically 'optimal CPP' ) has been linked to global outcome in adult traumatic brain injury (TBI). Different vascular reactivity indices can be utilized in the determination. The goal of this study is to evaluate optimal cerebral perfusion pressure (CPPopt) parameter, derived from three intra-cranial pressure (ICP) derived cerebrovascular reactivity indices, and determine which one is superior for 6 to 12-month outcome prediction...
November 1, 2018: Journal of Neurotrauma
Milad Rezaian, Reza Maleki, Mohammad Dahri Dahroud, Abdolmohammad Alamdari, Milad Alimohammadi
Nanotechnology based drug delivery systems for cancer therapy have been the topic of interest for many researchers and scientists. In this research, we have studied the pH sensitive co-adsorption and release of doxorubicin (DOX) and paclitaxel (PAX) by carbon nanotube (CNT), fullerene, and graphene oxide (GO) in combination with N -isopropylacrylamide (PIN). This simulation study has been performed by use of molecular dynamics. Interaction energies, hydrogen bond, and gyration radius were investigated. Results reveal that, compared with fullerene and GO, CNT is a better carrier for the co-adsorption and co-release of DOX and PAX...
October 29, 2018: Biomolecules
Ravnit-Kaur Grewal, Manogari Chetty, Emmanuel-Akinola Abayomi, Ciprian Tomuleasa, Jonathan R Fromm
Hodgkin's lymphoma (HL) has a unique immunophenotype derived from immunohistochemistry (positive for CD15, CD30, and Pax-5; negative for CD3, CD20 in most cases, and CD45). The knowledge gained over recent years enables better diagnosis, prognosis, and treatment of HL. Flow cytometry as a tool for the diagnosis of classic HL has not been useful in the past due to the difficulty in isolating Reed-Sternberg cells as they are admixed in a rich inflammatory background which consists mainly of T cells, B cells, eosinophils, histiocytes, and plasma cells...
October 22, 2018: Cytometry. Part B, Clinical Cytometry
Francesca Diomede, Nicoletta Zini, Jacopo Pizzicannella, Ilaria Merciaro, Giuseppe Pizzicannella, Monica D'Orazio, Adriano Piattelli, Oriana Trubiani
Embryoid bodies (EBs) are three-dimensional aggregates formed by pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells. They are used as an in vitro model to evaluate early extraembryonic tissue formation and differentiation process. In the adult organisms, cell differentiation is controlled and realized through the epigenetic regulation of gene expression, which consists of various mechanisms including DNA methylation. One demethylating agent is represented by 5-Azacytidine (5-Aza), considered able to induce epigenetic changes through gene derepression...
2018: Frontiers in Genetics
Rachel Jester, Iya Znoyko, Maria Garnovskaya, Joseph N Rozier, Ryan Kegl, Sunil Patel, Tuan Tran, Malak Abedalthagafi, Craig M Horbinski, Mary Richardson, Daynna J Wolff, Razvan Lapadat, William Moore, Fausto J Rodriguez, Jason Mull, Adriana Olar
Endolymphatic sac tumor (ELST) is a rare neoplasm arising in the temporal petrous region thought to originate from endolymphatic sac epithelium. It may arise sporadically or in association with Von-Hippel-Lindau syndrome (VHL). The ELST prevalence in VHL ranges from 3 to 16% and may be the initial presentation of the disease. Onset is usually in the 3rd to 5th decade with hearing loss and an indolent course. ELSTs present as locally destructive lesions with characteristic computed tomography imaging features...
October 19, 2018: Acta Neuropathologica Communications
Benjamin Johansson, Helka Sahi, Virve Koljonen, Tom Böhling
BACKGROUND: Merkel cell carcinoma (MCC) tumor samples frequently express B-lymphoid lineage markers. However, the reasons for expression of specific B-lymphoid lineage markers are still unclear. We studied in a large pool of tissue microarray MCC samples, validate in a larger cohort the expression of TdT and Pax-5, which are two B-lymphoid lineage markers. METHODS: Immunoexpression and staining intensities of TdT and Pax-5 were statistically correlated with patient, tumor, Merkel cell polyoma virus (MCV), and disease-specific parameters...
October 12, 2018: Journal of Cutaneous Pathology
Taíse Lima de Oliveira Cerqueira, Yanne Rocha Ramos, Giorgia Bruna Strappa, Mariana Souza de Jesus, Jailciele Gonzaga Santos, Camila Sousa, Gildásio Carvalho, Vladimir Fernandes, Ney Boa-Sorte, Tatiana Amorim, Thiago Magalhães Silva, Ana Marice Teixeira Ladeia, Angelina Xavier Acosta, Helton Estrela Ramos
OBJECTIVE: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. SUBJECTS AND METHODS: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realized by investigating the presence of mutations in the transcription factor genes involved in thyroid development...
August 2018: Archives of Endocrinology and Metabolism
Prosun Das, Kylee J Veazey, Hieu T Van, Saakshi Kaushik, Kevin Lin, Yue Lu, Masaru Ishii, Junichi Kikuta, Kai Ge, Andre Nussenzweig, Margarida A Santos
The bone is essential for locomotion, calcium storage, and harboring the hematopoietic stem cells (HSCs) that supply the body with mature blood cells throughout life. HSCs reside at the interface of the bone and bone marrow (BM), where active bone remodeling takes place. Although the cellular components of the BM niche have been characterized, little is known about its epigenetic regulation. Here we find that the histone methylation regulator PTIP (Pax interaction with transcription-activation domain protein-1) is required to maintain the integrity of the BM niche by promoting osteoclast differentiation...
October 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
Lester D R Thompson, Kelly R Magliocca, Simon Andreasen, Katlin Kiss, Lisa Rooper, Edward Stelow, Bruce M Wenig, Justin A Bishop
Endolymphatic sac tumors (ELSTs) are rare, slowly growing temporal bone neoplasms which show a high association with von Hippel-Lindau (VHL) syndrome. The immunohistochemistry evaluation of these papillary-cystic neoplasms frequently raises the differential diagnosis with renal cell carcinoma, among other metastatic neoplasms, whether in VHL patients or not. A cohort of 26 patients with ELSTs were evaluated for histologic features, immunohistochemistry findings, and association with VHL. Standard immunohistochemistry evaluation was performed...
October 5, 2018: Head and Neck Pathology
Leal Herlitz, Ondrej Hes, Michal Michal, Maria Tretiakova, Miguel Reyes-Múgica, Jane K Nguyen, Megan L Troxell, Christopher G Przybycin, Cristina Magi-Galluzzi, Jesse K McKenney
Renal mass lesions with a follicular architecture resembling atrophic kidney have been described, but their distinction from thyroid-like follicular carcinoma of the kidney remains controversial. We collected 8 cases of this purported "atrophic kidney"-like lesion to fully describe their clinical and histologic spectrum, their possible etiology, and to discuss their distinction from other renal neoplasms. Eight total cases were identified with patient ages ranging from 9 to 48 years (mean: 29 y; median: 28...
December 2018: American Journal of Surgical Pathology
Richard Benedict Supan Roxas, Marie Christine Fajatin Bernardo, Araceli Pacis Jacoba, Janet Lim-Dy, Anarose Cariaga Alvarado, Jasna Metovic, Laura Annaratone, Mauro Papotti
We describe the first case of primary thymic adenocarcinoma with signet ring cell features. The patient was a 39-year-old Filipino male who presented with a huge anterior mediastinal mass extending to the left supraclavicular fossa, which underwent an incisional biopsy. Extensive clinicoradiological work-up showed no evidence of any primary tumor in other organs, and radiological imaging confirmed a primary tumor location in the thymic area. He later developed bilateral pleural and pericardial effusions and eventually died of his tumor...
September 27, 2018: International Journal of Surgical Pathology
Graciliano Nicolás Marichal, Deivis Ávila, Ángela Hernández, Isidro Padrón, Cristina Castejón
In this article, a study of characteristic vibrations of marine oils separation system is presented. Vibrations analysis allows for the extraction of representative features that could be related to the lifetime of their pieces. Actual measurements were carried out on these systems on Ro-Pax vessels to transport passengers and freight. The vibrations obtained were processed in the frequency domain and following this, they were used in a Genetic Neuro-Fuzzy System in order to design new predictive maintenance strategies...
September 19, 2018: Sensors
Huiying He, Kiril Trpkov, Petr Martinek, Ozlem Tanas Isikci, Cristina Maggi-Galuzzi, Reza Alaghehbandan, Anthony J Gill, Maria Tretiakova, Jose Ignacio Lopez, Sean R Williamson, Delia Perez Montiel, Maris Sperga, Eva Comperat, Fadi Brimo, Ali Yilmaz, Kristyna Pivovarcikova, Kveta Michalova, David Slouka, Kristyna Prochazkova, Milan Hora, Michael Bonert, Michal Michal, Ondrej Hes
The spectrum of the renal oncocytic tumors has been expanded in recent years to include several novel and emerging entities. We describe a cohort of novel, hitherto unrecognized and morphologically distinct high-grade oncocytic tumors (HOT), currently diagnosed as "unclassified" in the WHO classification. We identified 14 HOT by searching multiple institutional archives. Morphologic, immunohistochemical (IHC), molecular genetic, and molecular karyotyping studies were performed to investigate these tumors...
December 2018: Virchows Archiv: An International Journal of Pathology
Matthew R Hart, Donovan J Anderson, Christopher C Porter, Tobias Neff, Michael Levin, Marshall S Horwitz
PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and heterozygous germline loss-of-function PAX5 mutations cause autosomal dominant predisposition to ALL. At least in mice, Pax5 is required for pre-B cell maturation, and leukemic remission occurs when Pax5 expression is restored in a Pax5-deficient mouse model of ALL...
September 2018: PLoS Genetics
Nicolas Leblanc, Jason Harquail, Nicolas Crapoulet, Rodney J Ouellette, Gilles A Robichaud
BACKGROUND/AIM: In breast cancer, Pax-5 promotes pro-epithelial features and suppresses malignant cancer processes. However, the molecular mechanism of this antitumor activity remains largely unknown. This study aimed to identify the cellular roles of Pax-5-regulated miRNAs in breast cancer progression. MATERIALS AND METHODS: After transient transfection of Pax-5 in MDA-MB-231 breast cancer cells, Pax-5-regulated miRNA expression was examined by next-generation sequencing...
September 2018: Anticancer Research
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