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Preterm AND Epigenetic

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https://www.readbyqxmd.com/read/30101715/preterm-birth-long-term-cardiovascular-and-renal-consequences
#1
Hassib Chehade, Umberto Simeoni, Jean-Pierre Guignard, Farid Boubred
Cardiovascular and chronic kidney diseases are part of non-communicable chronic diseases, the leading causes of premature death worldwide. They are recognized as having early origins through altered developmental programming, due to adverse environmental conditions during development. Preterm birth is increasingly recognized as such an adverse factor. Rates of preterm birth have increased the last decades, however, with the improvement in perinatal and neonatal care, a growing cohort have survived to the neonatal period and are now entering adulthood...
August 13, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/30045669/long-noncoding-rna-expression-in-the-cervix-mid-pregnancy-is-associated-with-the-length-of-gestation-at-delivery
#2
Heather H Burris, Allan C Just, Miriam J Haviland, Dayna T Neo, Andrea A Baccarelli, Alexandra E Dereix, Kasey J Brennan, Rodosthenis S Rodosthenous, Steven J Ralston, Jonathan L Hecht, Michele R Hacker
Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of gestation. However, no study has examined the role of long noncoding RNAs (lncRNAs) in the cervix during pregnancy. To determine whether expression of lncRNAs is associated with length of gestation at delivery, we analyzed RNA from cervical swabs obtained from 78 women during pregnancy (mean 15...
August 10, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29983834/epigenetic-signature-of-preterm-birth-in-adult-twins
#3
Qihua Tan, Shuxia Li, Morten Frost, Marianne Nygaard, Mette Soerensen, Martin Larsen, Kaare Christensen, Lene Christiansen
Background: Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental to health later in life. Methods: We performed a genome-wide DNA methylation profiling in adult twins of premature birth to identify genomic regions under differential epigenetic regulation in 144 twins with a median age of 33 years (age range 30-36)...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29938128/intrauterine-inflammation-epigenetics-and-microbiome-influences-on-preterm-infant-health
#4
REVIEW
Lei Lu, Erika C Claud
Purpose of Review: Significant research reveals that the microbiome modulates perinatal and postnatal health. This review aims to examine mechanisms by which intrauterine infection, the epigenome, and microbiome specifically influence preterm infant health outcomes. Recent Findings: Intrauterine infection is a primary cause of preterm birth and can cause alterations in gene expression and epigenetic programming as well as postnatal inflammatory responses in the offspring...
2018: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29852488/perinatal-origins-of-adult-disease
#5
Umberto Simeoni, Jean-Baptiste Armengaud, Benazir Siddeek, Jean-François Tolsa
Epidemiological and experimental studies have shown that the peri-conception period, pregnancy, and infancy are windows of particular sensibility to environmental clues which influence lifelong trajectories across health and disease. Nutrition, stress, and toxins induce epigenetic marks that control long-term gene expression patterns and can be transmitted transgenerationally. Chronic diseases of adulthood such as hypertension, diabetes, and obesity thus have early, developmental origins in the perinatal period...
2018: Neonatology
https://www.readbyqxmd.com/read/29741588/paternal-developmental-toxicant-exposure-is-associated-with-epigenetic-modulation-of-sperm-and-placental-pgr-and-igf2-in-a-mouse-model
#6
Tianbing Ding, Shilpa Mokshagundam, Paolo F Rinaudo, Kevin G Osteen, Kaylon L Bruner-Tran
Preterm birth (PTB), parturition prior to 37 weeks gestation, is the leading cause of neonatal mortality. The causes of spontaneous PTB are poorly understood; however, recent studies suggest this condition may arise as a consequence of the parental fetal environment. Specifically, we previously demonstrated that developmental exposure of male mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with reduced sperm quantity/quality in adulthood and control female partners frequently delivered preterm...
May 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29705119/relationship-between-epigenetic-maturity-and-respiratory-morbidity-in-preterm-infants
#7
Anna K Knight, Alicia K Smith, Karen N Conneely, Philippa Dalach, Yuk J Loke, Jeanie L Cheong, Peter G Davis, Jeffrey M Craig, Lex W Doyle, Christiane Theda
OBJECTIVE: To assess associations between epigenetic maturity of extremely preterm babies (born at less than 28 weeks of gestation), neonatal interventions, and respiratory outcomes, including the administration of surfactant and postnatal corticosteroids, duration of assisted ventilation, and development of bronchopulmonary dysplasia (BPD). STUDY DESIGN: DNA was extracted from neonatal blood spots collected after birth from 143 extremely preterm infants born 1991-1992 in Victoria, Australia and used to determined DNA methylation (DNAm)...
July 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29587528/diet-dependent-changes-in-the-intestinal-dna-methylome-after-introduction-of-enteral-feeding-in-preterm-pigs
#8
Xiaoyu Pan, Desheng Gong, Fei Gao, Per Torp Sangild
AIM: To examine how enteral feeding affects the intestinal epigenome and gene expression just after preterm birth. MATERIALS & METHODS: Intestinal tissue from preterm pigs, modeling preterm infants, was collected at birth and 5 days after gradual introduction of infant formula or bovine colostrum. The intestinal tissue was analyzed by reduced representation bisulfite sequencing and real-time qPCR. RESULTS: Relative to colostrum, formula increased bacterial epithelial adherence and lipopolysaccharide binding protein (LBP) expression, which was regulated by promoter methylation...
April 1, 2018: Epigenomics
https://www.readbyqxmd.com/read/29543532/crh-crhr1-mediates-prenatal-synthetic-glucocorticoid-programming-of-depression-like-behavior-across-2-generations
#9
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29526602/epigenome-wide-study-for-the-offspring-exposed-to-maternal-hbv-infection-during-pregnancy-a-pilot-study
#10
Qijun Cheng, Bin Zhao, Zhenxiang Huang, Yanhua Su, Biqin Chen, Songjing Yang, Xueqi Peng, Qilin Ma, Xiaoshan Yu, Benhua Zhao, Xiayi Ke
BACKGROUND & AIM: Hepatitis B virus (HBV) can be transmitted to infants, and is related to infants' later disease risk. Epigenetic change (such as DNA methylation) may be mechanism underlying the relationship. In this study, we aimed to investigate whether prenatal HBV infection could alter DNA methylation status in newborns. METHOD: We selected 12 neonates with intrauterine HBV infection whose mothers were HBsAg-positive during pregnancy, relative to 12 HBV-free neonates with HBsAg-negative mothers...
June 5, 2018: Gene
https://www.readbyqxmd.com/read/29523493/antecedents-of-screening-positive-for-attention-deficit-hyperactivity-disorder-in-ten-year-old-children-born-extremely-preterm
#11
Alan Leviton, Stephen R Hooper, Scott J Hunter, Megan N Scott, Elizabeth N Allred, Robert M Joseph, T Michael O'Shea, Karl Kuban
BACKGROUND: The incidence of attention deficit hyperactivity disorder is higher among children born very preterm than among children who are mature at birth. METHODS: We studied 583 ten-year-old children who were born before 28 weeks of gestation whose IQ was above 84 and had a parent-completed Child Symptom Inventory-4, which allowed classification of the child as having or not having symptoms of attention deficit hyperactivity disorder. For 422 children, we also had a teacher report, and for 583 children, we also had a parent report of whether or not a physician made an attention deficit hyperactivity disorder diagnosis...
April 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29513726/placental-cpg-methylation-of-infants-born-extremely-preterm-predicts-cognitive-impairment-later-in-life
#12
MULTICENTER STUDY
Sloane K Tilley, Elizabeth M Martin, Lisa Smeester, Robert M Joseph, Karl C K Kuban, Tim C Heeren, Olaf U Dammann, T Michael O'Shea, Rebecca C Fry
BACKGROUND: The placenta is the central regulator of maternal and fetal interactions. Perturbations of placental structure and function have been associated with adverse neurodevelopmental outcomes later in life. Placental CpG methylation represents an epigenetic modification with the potential to impact placental function, fetal development and child health later in life. STUDY DESIGN: Genome-wide placental CpG methylation levels were compared between spontaneous versus indicated deliveries from extremely preterm births (EPTBs) (n = 84)...
2018: PloS One
https://www.readbyqxmd.com/read/29493111/neonatal-outcomes-following-fresh-as-compared-to-frozen-thawed-embryo-transfer-in-in-vitro-fertilization
#13
REVIEW
Kristin Van Heertum, Rachel Weinerman
In vitro fertilization (IVF) and embryo cryopreservation have become increasingly common in recent years. As utilization increases, it is important to understand the clinical effects these technologies have on offspring, as well as the mechanisms behind these effects. Many epidemiologic studies have observed that pregnancies following IVF are more likely to be affected by obstetric complications such as pre-eclampsia, preterm birth, and small for gestational age neonates compared with naturally conceived pregnancies...
May 1, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29396320/pain-exposure-associates-with-telomere-length-erosion-in-very-preterm-infants
#14
Livio Provenzi, Roberto Giorda, Monica Fumagalli, Uberto Pozzoli, Francesco Morandi, Giunia Scotto di Minico, Fabio Mosca, Renato Borgatti, Rosario Montirosso
Very preterm (VPT) infants (gestational age < 32 weeks) require long-lasting hospitalization in the Neonatal Intensive Care Unit (NICU), even in absence of severe morbidities. During NICU stay, life-saving interventions occur and include invasive and painful skin-breaking procedures (NICU-related stress), which constitute a major early adverse experience for VPT infants. Telomeres are repeat-sequence at the end of chromosomes, which shorten with age and are highly susceptible to life adversities: the exposure to early adverse experiences is associated with shorter telomere length (TL)...
March 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29378417/epigenetic-modifications-following-noxious-stimuli-in-infants
#15
Linda A Hatfield, Rebecca K Hoffman, Rosemary C Polomano, Yvette Conley
PURPOSE: To recruit healthy full- and preterm infants into genetic research and determine the effectiveness of a noninvasive DNA sampling technique for comparing epigenetic modifications. BACKGROUND: Noxious stimuli during a vulnerable period of infant neuronal plasticity may trigger long-term epigenetic changes affecting neurodevelopment, pain modulation, and reactivity. Recognizing epigenetic pain findings is problematic because parents are reluctant to enroll newborns into genetic research...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29373688/compromised-jmjd6-histone-demethylase-activity-affects-vhl-gene-repression-in-preeclampsia
#16
Sruthi Alahari, Martin Post, Alessandro Rolfo, Rosanna Weksberg, Isabella Caniggia
Context: The von Hippel Lindau (VHL) protein is a key executor of the cellular hypoxic response that is compromised in preeclampsia, a serious disorder complicating 5% to 7% of pregnancies. To date, the mechanisms controlling VHL gene expression in the human placenta remain elusive. Objective: We examined VHL epigenetic regulation in normal pregnancy and in preeclampsia, a pathology characterized by placental hypoxia. Design, Setting, and Participants: Placentae were obtained from early-onset preeclampsia (n = 56; <34 weeks of gestation) and late-onset preeclampsia (n = 19; ≥34 weeks of gestation)...
April 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29365082/early-microbial-colonization-affects-dna-methylation-of-genes-related-to-intestinal-immunity-and-metabolism-in-preterm-pigs
#17
Xiaoyu Pan, Desheng Gong, Duc Ninh Nguyen, Xinxin Zhang, Qi Hu, Hanlin Lu, Merete Fredholm, Per T Sangild, Fei Gao
Epigenetic regulation may play an important role in mediating microbe-host interactions and adaptation of intestinal gene expression to bacterial colonization just after birth. This is particularly important after preterm birth because the immature intestine is hypersensitive to invading bacteria. We compared the intestinal DNA methylome and microbiome between conventional (CON) and antibiotics-treated (AB) preterm pigs, used as a model for preterm infants. Oral AB treatment reduced bacterial density (∼100-fold), diversity and fermentation, improved the resistance to necrotizing enterocolitis (NEC) and changed the genome-wide DNA methylation in the distal small intestine...
January 19, 2018: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29363098/infants-born-preterm-stress-and-neurodevelopment-in-the-neonatal-intensive-care-unit-might-music-have-an-impact
#18
REVIEW
Dane E Anderson, Aniruddh D Patel
AIM: The neonatal intensive care unit (NICU) provides life-saving medical care for an increasing number of newborn infants each year. NICU care, while lifesaving, does have attendant consequences which can include repeated activation of the stress response and reduced maternal interaction, with possible negative long-term impacts on brain development. Here we present a neuroscientific framework for considering the impact of music on neurodevelopment in the NICU of infants born preterm and evaluate current literature on the use of music with this population to determine what is most reliably known of the physiological effects of music interventions...
March 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29304146/from-early-stress-to-12-month-development-in-very-preterm-infants-preliminary-findings-on-epigenetic-mechanisms-and-brain-growth
#19
Monica Fumagalli, Livio Provenzi, Pietro De Carli, Francesca Dessimone, Ida Sirgiovanni, Roberto Giorda, Claudia Cinnante, Letizia Squarcina, Uberto Pozzoli, Fabio Triulzi, Paolo Brambilla, Renato Borgatti, Fabio Mosca, Rosario Montirosso
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development. Recent research suggests that early NICU-related stress contributes to socio-emotional impairments in VPT infants at 3 months through epigenetic regulation (i.e., DNA methylation) of the serotonin transporter gene (SLC6A4). In the present longitudinal study we assessed: (a) the effects of NICU-related stress and SLC6A4 methylation variations from birth to discharge on brain development at term equivalent age (TEA); (b) the association between brain volume at TEA and socio-emotional development (i...
2018: PloS One
https://www.readbyqxmd.com/read/29241278/epigenetic-regulation-of-the-nitric-oxide-pathway-17-%C3%AE-hydroxyprogesterone-caproate-and-recurrent-preterm-birth
#20
Tracy A Manuck, Lisa Smeester, Elizabeth M Martin, Martha S Tomlinson, Christina Smith, Michael W Varner, Rebecca C Fry
OBJECTIVE:  We sought to evaluate nitric oxide pathway placental gene expression and the epigenome (CpG methylation) among women receiving 17-α hydroxyprogesterone caproate (17-OHPC) with and without recurrent preterm birth (PTB). STUDY DESIGN:  This was a case-control study. We prospectively recruited women with ≥ 1 prior singleton spontaneous PTB <34 weeks receiving 17-OHPC. DNA and RNA were isolated from placentas. RNA abundance (gene expression) and the methylome were analyzed for 84 genes in nitric oxide pathways...
July 2018: American Journal of Perinatology
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