keyword
MENU ▼
Read by QxMD icon Read
search

Preterm AND Epigenetic

keyword
https://www.readbyqxmd.com/read/30254992/differential-expression-and-methylation-of-integrin-subunit-alpha-11-and-thrombospondin-in-the-amnion-of-preterm-birth
#1
Jae Young Yoo, Young-Ah You, Eun Jin Kwon, Mi Hye Park, Sunah Shim, Young Ju Kim
Objective: This study aimed to investigate the association between preterm birth and epigenetic mechanisms in the amnion. Methods: We examined the association between differentially methylated regions (DMRs) and differentially expressed genes (DEG) using a cytosine-phosphate-guanine methylation array and whole-transcriptome sequencing from the amnion (preterm birth, n=5; full term, n=5). We enrolled 35 participants for mRNA expression analysis and pyrosequencing: 16 full-term and 19 preterm subjects...
September 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/30239759/epigenetic-changes-in-reterm-birth-placenta-suggest-a-role-for-adamts-genes-in-spontaneous-preterm-birth
#2
Sneha Mani, Jayashri Ghosh, Yemin Lan, Suneeta Senapati, Teri Ord, Carmen Sapienza, Christos Coutifaris, Monica Mainigi
PTB affects approximately 1 in 10 pregnancies and contributes to approximately 50% of neonatal mortality. However, despite decades of research, little is understood about the etiology of Preterm Birth (PTB), likely due to the multifactorial nature of the disease. In this study, we examined preterm and term placentas, from unassisted conceptions and those conceived using in vitro fertilization (IVF). IVF increases the risk of PTB and causes epigenetic change in the placenta and fetus, therefore we utilized these patients as a unique population with a potential common etiology...
September 18, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30233496/the-implications-of-vitamin-d-status-during-pregnancy-on-mother-and-her-developing-child
#3
REVIEW
Carol L Wagner, Bruce W Hollis
Pregnancy is a time of tremendous growth and physiological changes for mother and her developing fetus with lifelong implications for the child. The concert of actions that must occur so mother does not reject the foreign tissue of the fetus is substantial. There must be exquisite balance between maternal tolerance to these foreign proteins of paternal origin but also immune surveillance and function such that the mother is not immunocompromised. When this process goes awry, the mother may experience such pregnancy complications as preeclampsia and infections...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30172660/necrotizing-enterocolitis-the-intestinal-microbiome-metabolome-and-inflammatory-mediators
#4
REVIEW
Josef Neu, Mohan Pammi
Necrotizing enterocolitis (NEC) is a disease of preterm infants and associated with significant mortality and morbidity. Although the pathogenesis of NEC is not clear, microbial dysbiosis, with a bloom of the phylum Proteobacteria, has been reported. Antibiotics and the use of H2 blockers, which affect the gut microbiome, are associated with increased incidence of NEC. In association with dysbiosis, inflammatory processes are upregulated with increased Toll-like receptor signaling, leading to translocation of nuclear factor kappa-β, a transcription factor that induces transcription of various pro-inflammatory cytokines and chemokines...
August 17, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30172427/the-oxygen-load-supplied-during-delivery-room-stabilization-of-preterm-infants-modifies-the-dna-methylation-profile
#5
Sheila Lorente-Pozo, Anna Parra-Llorca, Antonio Núñez-Ramiro, María Cernada, David Hervás, Nuria Boronat, Juan Sandoval, Maximo Vento
OBJECTIVES: To determine whether the amount of oxygen provided during postnatal stabilization changes the DNA methylome in preterm infants. STUDY DESIGN: This prospective, observational study included 32 preterm infants ≤32 weeks of gestation who received oxygen in the delivery room. Patients were monitored using a respiratory function monitor to determine the amount of oxygen received upon stabilization. Blood samples were processed for comparison of DNA methylation before and after resuscitation using a DNA methylation high-resolution microarray Infinium Human DNA methylation EPIC 850K BeadChip...
August 29, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30144857/prevention-of-prematurity-advances-and-opportunities
#6
REVIEW
Balaji Govindaswami, Priya Jegatheesan, Matthew Nudelman, Sudha Rani Narasimhan
Preterm birth (PTB) rate varies widely and has significant racial and ethnic disparities. Although causal mechanisms are ill understood, socioenvironment, phenotype, and genotype provide insight into pathways for preventing PTB. Data suggest varied response to current medical interventions is explicable Approved by underlying pharmacogenomics. Currently, prevention focuses on minimizing iatrogenic PTB and risk reduction especially in those with prior PTB using proven medical and public health strategies. In the future, preventive approaches will be based on better understanding of sociodemography, nutrition, lifestyles, and underlying individual genetic and epigenetic variation...
September 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/30131711/the-role-of-abnormal-placentation-in-congenital-heart-disease-cause-correlate-or-consequence
#7
Jennifer A Courtney, James F Cnota, Helen N Jones
Congenital heart disease (CHD) is the most common birth defect, affecting ~1% of all live births (van der Linde et al., 2011). Despite improvements in clinical care, it is the leading cause of infant mortality related to birth defects (Yang et al., 2006) and burdens survivors with significant morbidity (Gilboa et al., 2016). Furthermore, CHD accounts for the largest proportion (26.7%) of birth defect-associated hospitalization costs-up to $6.1 billion in 2013 (Arth et al., 2017). Yet after decades of research with a primary focus on genetic etiology, the underlying cause of these defects remains unknown in the majority of cases (Zaidi and Brueckner, 2017)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30101715/preterm-birth-long-term-cardiovascular-and-renal-consequences
#8
Hassib Chehade, Umberto Simeoni, Jean-Pierre Guignard, Farid Boubred
Cardiovascular and chronic kidney diseases are part of non-communicable chronic diseases, the leading causes of premature death worldwide. They are recognized as having early origins through altered developmental programming, due to adverse environmental conditions during development. Preterm birth is increasingly recognized as such an adverse factor. Rates of preterm birth have increased the last decades, however, with the improvement in perinatal and neonatal care, a growing cohort have survived to the neonatal period and are now entering adulthood...
August 13, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/30045669/long-noncoding-rna-expression-in-the-cervix-mid-pregnancy-is-associated-with-the-length-of-gestation-at-delivery
#9
Heather H Burris, Allan C Just, Miriam J Haviland, Dayna T Neo, Andrea A Baccarelli, Alexandra E Dereix, Kasey J Brennan, Rodosthenis S Rodosthenous, Steven J Ralston, Jonathan L Hecht, Michele R Hacker
Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of gestation. However, no study has examined the role of long noncoding RNAs (lncRNAs) in the cervix during pregnancy. To determine whether expression of lncRNAs is associated with length of gestation at delivery, we analyzed RNA from cervical swabs obtained from 78 women during pregnancy (mean 15...
2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29983834/epigenetic-signature-of-preterm-birth-in-adult-twins
#10
Qihua Tan, Shuxia Li, Morten Frost, Marianne Nygaard, Mette Soerensen, Martin Larsen, Kaare Christensen, Lene Christiansen
Background: Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors, and these could be persistent and detrimental to health later in life. Methods: We performed a genome-wide DNA methylation profiling in adult twins of premature birth to identify genomic regions under differential epigenetic regulation in 144 twins with a median age of 33 years (age range 30-36)...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29938128/intrauterine-inflammation-epigenetics-and-microbiome-influences-on-preterm-infant-health
#11
REVIEW
Lei Lu, Erika C Claud
Purpose of Review: Significant research reveals that the microbiome modulates perinatal and postnatal health. This review aims to examine mechanisms by which intrauterine infection, the epigenome, and microbiome specifically influence preterm infant health outcomes. Recent Findings: Intrauterine infection is a primary cause of preterm birth and can cause alterations in gene expression and epigenetic programming as well as postnatal inflammatory responses in the offspring...
2018: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29852488/perinatal-origins-of-adult-disease
#12
Umberto Simeoni, Jean-Baptiste Armengaud, Benazir Siddeek, Jean-François Tolsa
Epidemiological and experimental studies have shown that the peri-conception period, pregnancy, and infancy are windows of particular sensibility to environmental clues which influence lifelong trajectories across health and disease. Nutrition, stress, and toxins induce epigenetic marks that control long-term gene expression patterns and can be transmitted transgenerationally. Chronic diseases of adulthood such as hypertension, diabetes, and obesity thus have early, developmental origins in the perinatal period...
2018: Neonatology
https://www.readbyqxmd.com/read/29741588/paternal-developmental-toxicant-exposure-is-associated-with-epigenetic-modulation-of-sperm-and-placental-pgr-and-igf2-in-a-mouse-model
#13
Tianbing Ding, Shilpa Mokshagundam, Paolo F Rinaudo, Kevin G Osteen, Kaylon L Bruner-Tran
Preterm birth (PTB), parturition prior to 37 weeks gestation, is the leading cause of neonatal mortality. The causes of spontaneous PTB are poorly understood; however, recent studies suggest this condition may arise as a consequence of the parental fetal environment. Specifically, we previously demonstrated that developmental exposure of male mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with reduced sperm quantity/quality in adulthood and control female partners frequently delivered preterm...
May 7, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29705119/relationship-between-epigenetic-maturity-and-respiratory-morbidity-in-preterm-infants
#14
Anna K Knight, Alicia K Smith, Karen N Conneely, Philippa Dalach, Yuk J Loke, Jeanie L Cheong, Peter G Davis, Jeffrey M Craig, Lex W Doyle, Christiane Theda
OBJECTIVE: To assess associations between epigenetic maturity of extremely preterm babies (born at less than 28 weeks of gestation), neonatal interventions, and respiratory outcomes, including the administration of surfactant and postnatal corticosteroids, duration of assisted ventilation, and development of bronchopulmonary dysplasia (BPD). STUDY DESIGN: DNA was extracted from neonatal blood spots collected after birth from 143 extremely preterm infants born 1991-1992 in Victoria, Australia and used to determined DNA methylation (DNAm)...
July 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29587528/diet-dependent-changes-in-the-intestinal-dna-methylome-after-introduction-of-enteral-feeding-in-preterm-pigs
#15
Xiaoyu Pan, Desheng Gong, Fei Gao, Per Torp Sangild
AIM: To examine how enteral feeding affects the intestinal epigenome and gene expression just after preterm birth. MATERIALS & METHODS: Intestinal tissue from preterm pigs, modeling preterm infants, was collected at birth and 5 days after gradual introduction of infant formula or bovine colostrum. The intestinal tissue was analyzed by reduced representation bisulfite sequencing and real-time qPCR. RESULTS: Relative to colostrum, formula increased bacterial epithelial adherence and lipopolysaccharide binding protein (LBP) expression, which was regulated by promoter methylation...
April 1, 2018: Epigenomics
https://www.readbyqxmd.com/read/29543532/crh-crhr1-mediates-prenatal-synthetic-glucocorticoid-programming-of-depression-like-behavior-across-2-generations
#16
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
August 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29526602/epigenome-wide-study-for-the-offspring-exposed-to-maternal-hbv-infection-during-pregnancy-a-pilot-study
#17
Qijun Cheng, Bin Zhao, Zhenxiang Huang, Yanhua Su, Biqin Chen, Songjing Yang, Xueqi Peng, Qilin Ma, Xiaoshan Yu, Benhua Zhao, Xiayi Ke
BACKGROUND & AIM: Hepatitis B virus (HBV) can be transmitted to infants, and is related to infants' later disease risk. Epigenetic change (such as DNA methylation) may be mechanism underlying the relationship. In this study, we aimed to investigate whether prenatal HBV infection could alter DNA methylation status in newborns. METHOD: We selected 12 neonates with intrauterine HBV infection whose mothers were HBsAg-positive during pregnancy, relative to 12 HBV-free neonates with HBsAg-negative mothers...
June 5, 2018: Gene
https://www.readbyqxmd.com/read/29523493/antecedents-of-screening-positive-for-attention-deficit-hyperactivity-disorder-in-ten-year-old-children-born-extremely-preterm
#18
Alan Leviton, Stephen R Hooper, Scott J Hunter, Megan N Scott, Elizabeth N Allred, Robert M Joseph, T Michael O'Shea, Karl Kuban
BACKGROUND: The incidence of attention deficit hyperactivity disorder is higher among children born very preterm than among children who are mature at birth. METHODS: We studied 583 ten-year-old children who were born before 28 weeks of gestation whose IQ was above 84 and had a parent-completed Child Symptom Inventory-4, which allowed classification of the child as having or not having symptoms of attention deficit hyperactivity disorder. For 422 children, we also had a teacher report, and for 583 children, we also had a parent report of whether or not a physician made an attention deficit hyperactivity disorder diagnosis...
April 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29513726/placental-cpg-methylation-of-infants-born-extremely-preterm-predicts-cognitive-impairment-later-in-life
#19
MULTICENTER STUDY
Sloane K Tilley, Elizabeth M Martin, Lisa Smeester, Robert M Joseph, Karl C K Kuban, Tim C Heeren, Olaf U Dammann, T Michael O'Shea, Rebecca C Fry
BACKGROUND: The placenta is the central regulator of maternal and fetal interactions. Perturbations of placental structure and function have been associated with adverse neurodevelopmental outcomes later in life. Placental CpG methylation represents an epigenetic modification with the potential to impact placental function, fetal development and child health later in life. STUDY DESIGN: Genome-wide placental CpG methylation levels were compared between spontaneous versus indicated deliveries from extremely preterm births (EPTBs) (n = 84)...
2018: PloS One
https://www.readbyqxmd.com/read/29493111/neonatal-outcomes-following-fresh-as-compared-to-frozen-thawed-embryo-transfer-in-in-vitro-fertilization
#20
REVIEW
Kristin Van Heertum, Rachel Weinerman
In vitro fertilization (IVF) and embryo cryopreservation have become increasingly common in recent years. As utilization increases, it is important to understand the clinical effects these technologies have on offspring, as well as the mechanisms behind these effects. Many epidemiologic studies have observed that pregnancies following IVF are more likely to be affected by obstetric complications such as pre-eclampsia, preterm birth, and small for gestational age neonates compared with naturally conceived pregnancies...
May 1, 2018: Birth Defects Research
keyword
keyword
167290
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"